Sex Hormones Regulate Innate Immune Cells and Promote Sex Differences in Respiratory Virus Infection

Single-Cell Chromatin Modification Profiling Reveals Increased Epigenetic Variations with Aging

(2018) Peggie Cheung et al.   CELL

The Confluence of Sex Hormones and Aging on Immunity

(2018) Melanie R. Gubbels Bupp et al.   Frontiers in Immunology

Androgen-Induced Immunosuppression

(2018) Melanie R. Gubbels Bupp et al.   Frontiers in Immunology

Androgen signaling negatively controls group 2 innate lymphoid cells

(2017) Sophie Laffont et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Sex Drives Dimorphic Immune Responses to Viral Infections

(2017) Soumitra Ghosh et al.   JOURNAL OF IMMUNOLOGY

Sex-Based Differences in Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Infection

(2017) Rudragouda Channappanavar et al.   JOURNAL OF IMMUNOLOGY

IL-33–Responsive Group 2 Innate Lymphoid Cells Are Regulated by Female Sex Hormones in the Uterus

(2017) Kathleen Bartemes et al.   JOURNAL OF IMMUNOLOGY

Eosinophils Promote Antiviral Immunity in Mice Infected with Influenza A Virus

(2017) Amali E. Samarasinghe et al.   JOURNAL OF IMMUNOLOGY

Estrogen Signaling Contributes to Sex Differences in Macrophage Polarization during Asthma

(2017) Aleksander Keselman et al.   JOURNAL OF IMMUNOLOGY

Progesterone-based compounds affect immune responses and susceptibility to infections at diverse mucosal sites

(2017) Olivia J Hall et al.   Mucosal Immunology

IFN-γ increases susceptibility to influenza A infection through suppression of group II innate lymphoid cells

(2017) D Califano et al.   Mucosal Immunology

New fronts emerge in the influenza cytokine storm

(2017) Xi-zhi J. Guo et al.   Seminars in Immunopathology

Testosterone Attenuates Group 2 Innate Lymphoid Cell-Mediated Airway Inflammation

(2017) Jacqueline-Yvonne Cephus et al.   Cell Reports

Sex Differences in Asthma: A Key Role of Androgen-Signaling in Group 2 Innate Lymphoid Cells

(2017) Sophie Laffont et al.   Frontiers in Immunology

Vγ4+γδT Cells Aggravate Severe H1N1 Influenza Virus Infection-Induced Acute Pulmonary Immunopathological Injury via Secreting Interleukin-17A

(2017) Chunxue Xue et al.   Frontiers in Immunology

Estrogen Receptor-Dependent Regulation of Dendritic Cell Development and Function

(2017) Sophie Laffont et al.   Frontiers in Immunology

A Role for Neutrophils in Viral Respiratory Disease

(2017) Jeremy V. Camp et al.   Frontiers in Immunology

Differential Susceptibility to Infectious Respiratory Diseases between Males and Females Linked to Sex-Specific Innate Immune Inflammatory Response

(2017) Mustapha Chamekh et al.   Frontiers in Immunology

Age and testosterone mediate influenza pathogenesis in male mice

(2016) Landon G. vom Steeg et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

17-β-estradiol Decreases Neutrophil Superoxide Production through Rac1

(2016) I. Marczell et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

IRF4 and IRF8 Act in CD11c+Cells To Regulate Terminal Differentiation of Lung Tissue Dendritic Cells

(2016) Sandra Bajaña et al.   JOURNAL OF IMMUNOLOGY

The effect of sex on immune cells in healthy aging: Elderly women have more robust natural killer lymphocytes than do elderly men

(2016) Ahmad Al-Attar et al.   MECHANISMS OF AGEING AND DEVELOPMENT

The cytokine profile of human NKT cells and PBMCs is dependent on donor sex and stimulus

(2016) Hannah Bernin et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

IL-1 is a critical regulator of group 2 innate lymphoid cell function and plasticity

(2016) Yoichiro Ohne et al.   NATURE IMMUNOLOGY

IL-1β, IL-4 and IL-12 control the fate of group 2 innate lymphoid cells in human airway inflammation in the lungs

(2016) Suzanne M Bal et al.   NATURE IMMUNOLOGY

Inflammatory triggers associated with exacerbations of COPD orchestrate plasticity of group 2 innate lymphoid cells in the lungs

(2016) Jonathan S Silver et al.   NATURE IMMUNOLOGY

The host immune response in respiratory virus infection: balancing virus clearance and immunopathology

(2016) Amy H. Newton et al.   Seminars in Immunopathology

Aging and sex hormones in males

(2016) Maria Chiara Decaroli et al.   Virulence

SeXX Matters in Infectious Disease Pathogenesis

(2016) Landon G. vom Steeg et al.   PLoS Pathogens

Progesterone-Based Therapy Protects Against Influenza by Promoting Lung Repair and Recovery in Females

(2016) Olivia J. Hall et al.   PLoS Pathogens

Characterization and Quantification of Innate Lymphoid Cell Subsets in Human Lung

(2016) Katrien C. De Grove et al.   PLoS One

High Physiological Concentrations of Progesterone Reverse Estradiol-Mediated Changes in Differentiation and Functions of Bone Marrow Derived Dendritic Cells

(2016) Fangming Xiu et al.   PLoS One

Suppressive effects of androgens on the immune system

(2015) Abhishek Trigunaite et al.   CELLULAR IMMUNOLOGY

Estrogen receptors regulate innate immune cells and signaling pathways

(2015) Susan Kovats   CELLULAR IMMUNOLOGY

Emerging Functions of Amphiregulin in Orchestrating Immunity, Inflammation, and Tissue Repair

(2015) Dietmar M.W. Zaiss et al.   IMMUNITY

Sex differences in immune responses to infectious diseases

(2015) Julia Fischer et al.   INFECTION

Natural helper cells contribute to pulmonary eosinophilia by producing IL-13 via IL-33/ST2 pathway in a murine model of respiratory syncytial virus infection

(2015) Jing Liu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Alveolar macrophage–derived type I interferons orchestrate innate immunity to RSV through recruitment of antiviral monocytes

(2015) Michelle Goritzka et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Estrogen Receptor α Deficiency Modulates TLR Ligand–Mediated PDC-TREM Expression in Plasmacytoid Dendritic Cells in Lupus-Prone Mice

(2015) Jennifer L. Scott et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: c-Kit Signaling Differentially Regulates Type 2 Innate Lymphoid Cell Accumulation and Susceptibility to Central Nervous System Demyelination in Male and Female SJL Mice

(2015) Abigail E. Russi et al.   JOURNAL OF IMMUNOLOGY

Sex Differences in Plasmacytoid Dendritic Cell Levels of IRF5 Drive Higher IFN-  Production in Women

(2015) M. Griesbeck et al.   JOURNAL OF IMMUNOLOGY

The biology of innate lymphoid cells

(2015) David Artis et al.   NATURE

Transcriptional programs define molecular characteristics of innate lymphoid cell classes and subsets

(2015) Michelle L Robinette et al.   NATURE IMMUNOLOGY

Sex steroid signaling: Implications for lung diseases

(2015) Venkatachalem Sathish et al.   PHARMACOLOGY & THERAPEUTICS

Sex differences in H7N9 influenza A virus pathogenesis

(2015) Julia Hoffmann et al.   VACCINE

Estrogen Signaling Modulates Allergic Inflammation and Contributes to Sex Differences in Asthma

(2015) Aleksander Keselman et al.   Frontiers in Immunology

Respiratory Syncytial Virus Fusion Protein Promotes TLR-4–Dependent Neutrophil Extracellular Trap Formation by Human Neutrophils

(2015) Giselle A. Funchal et al.   PLoS One

Aromatase and regulation of the estrogen-to-androgen ratio in synovial tissue inflammation: common pathway in both sexes

(2014) Silvia Capellino et al.   Annals of the New York Academy of Sciences

Inflammatory monocyte effector mechanisms

(2014) Grégoire Lauvau et al.   CELLULAR IMMUNOLOGY

The immune profile associated with acute allergic asthma accelerates clearance of influenza virus

(2014) Amali E Samarasinghe et al.   IMMUNOLOGY AND CELL BIOLOGY

Expression and functional roles of G-protein-coupled estrogen receptor (GPER) in human eosinophils

(2014) Mami Tamaki et al.   IMMUNOLOGY LETTERS

GATA binding protein 3+ group 2 innate lymphoid cells are present in cord blood and in higher proportions in male than in female neonates

(2014) Anna Forsberg et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Progesterone-induced activation of membrane-bound progesterone receptors in murine macrophage cells

(2014) Jing Lu et al.   JOURNAL OF ENDOCRINOLOGY

Chronic Estradiol Administration In Vivo Promotes the Proinflammatory Response of Macrophages to TLR4 Activation: Involvement of the Phosphatidylinositol 3-Kinase Pathway

(2014) B. Calippe et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Progesterone Regulates IFN-  Production by Plasmacytoid Dendritic Cells

(2014) G. C. Hughes et al.   JOURNAL OF IMMUNOLOGY

Estradiol Acts Directly on Bone Marrow Myeloid Progenitors to Differentially Regulate GM-CSF or Flt3 Ligand-Mediated Dendritic Cell Differentiation

(2014) E. Carreras et al.   JOURNAL OF IMMUNOLOGY

17 -Estradiol Alters the Activity of Conventional and IFN-Producing Killer Dendritic Cells

(2014) M. C. Siracusa et al.   JOURNAL OF IMMUNOLOGY

NK Cells Expressing a Progesterone Receptor Are Susceptible to Progesterone-Induced Apoptosis

(2014) L. Arruvito et al.   JOURNAL OF IMMUNOLOGY

Pulmonary V 4+    T Cells Have Proinflammatory and Antiviral Effects in Viral Lung Disease

(2014) J. Dodd et al.   JOURNAL OF IMMUNOLOGY

X-Chromosome Complement and Estrogen Receptor Signaling Independently Contribute to the Enhanced TLR7-Mediated IFN-α Production of Plasmacytoid Dendritic Cells from Women

(2014) Sophie Laffont et al.   JOURNAL OF IMMUNOLOGY

Sex, Immunity and Influenza

(2014) G. Gabriel et al.   JOURNAL OF INFECTIOUS DISEASES

Estrogen Receptor-Alpha Promotes Alternative Macrophage Activation during Cutaneous Repair

(2014) Laura Campbell et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

17 -Estradiol Protects Females against Influenza by Recruiting Neutrophils and Increasing Virus-Specific CD8 T Cell Responses in the Lungs

(2014) D. P. Robinson et al.   JOURNAL OF VIROLOGY

Oestrogen increases haematopoietic stem-cell self-renewal in females and during pregnancy

(2014) Daisuke Nakada et al.   NATURE

Pulmonary transplantation of macrophage progenitors as effective and long-lasting therapy for hereditary pulmonary alveolar proteinosis

(2014) C. Happle et al.   Science Translational Medicine

Viral infection of the lung: Host response and sequelae

(2013) Jae-Kwang Yoo et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Estradiol Promotes Functional Responses in Inflammatory and Steady-State Dendritic Cells through Differential Requirement for Activation Function-1 of Estrogen Receptor  

(2013) C. Seillet et al.   JOURNAL OF IMMUNOLOGY

Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position

(2013) Jason D Buenrostro et al.   NATURE METHODS

Group 2 Innate Lymphoid Cell Production of IL-5 Is Regulated by NKT Cells during Influenza Virus Infection

(2013) Stacey Ann Gorski et al.   PLoS Pathogens

Plasmacytoid dendritic cell interferon-α production to R-848 stimulation is decreased in male infants

(2012) Jennifer P Wang et al.   BMC IMMUNOLOGY

Estrogen receptor alpha modulates toll-like receptor signaling in murine lupus

(2012) Melissa A. Cunningham et al.   CLINICAL IMMUNOLOGY

Estrogen receptors regulate an inflammatory pathway of dendritic cell differentiation: Mechanisms and implications for immunity

(2012) Susan Kovats   HORMONES AND BEHAVIOR

Age- and gender-related differences in circulating natural killer T cells and their subset levels in healthy Korean adults

(2012) Seung-Jung Kee et al.   HUMAN IMMUNOLOGY

Physiological Changes in Hematological Parameters During Pregnancy

(2012) Surabhi Chandra et al.   INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION

Sex Differences in the Response to Viral Infections: TLR8 and TLR9 Ligand Stimulation Induce Higher IL10 Production in Males

(2012) Maria Gabriella Torcia et al.   PLoS One

Recent insights into pulmonary repair following virus-induced inflammation of the respiratory tract

(2012) Stacey A Gorski et al.   Current Opinion in Virology

Sex differences in resident immune cell phenotype underlie more efficient acute inflammatory responses in female mice

(2011) R. S. Scotland et al.   BLOOD

The TLR-mediated response of plasmacytoid dendritic cells is positively regulated by estradiol in vivo through cell-intrinsic estrogen receptor   signaling

(2011) C. Seillet et al.   BLOOD

Gender effect on in vitro lymphocyte subset levels of healthy individuals

(2011) Maha Abdullah et al.   CELLULAR IMMUNOLOGY

Sexual dimorphism in lung function responses to acute influenza A infection

(2011) Alexander N. Larcombe et al.   Influenza and Other Respiratory Viruses

Age-associated alteration of γδ T-cell repertoire and different profiles of activation-induced death of Vδ1 and Vδ2 T cells

(2011) Yoshihiro Michishita et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Mechanisms of sex disparities in influenza pathogenesis

(2011) Sabra L. Klein et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity

(2011) Ya-Jen Chang et al.   NATURE IMMUNOLOGY

Sex- and Age-Related Differences in Morbidity Rates of 2009 Pandemic Influenza A H1N1 Virus of Swine Origin in Japan

(2011) Nobuoki Eshima et al.   PLoS One

Myeloid-specific estrogen receptor   deficiency impairs metabolic homeostasis and accelerates atherosclerotic lesion development

(2011) V. Ribas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antibody responses and cross protection against lethal influenza A viruses differ between the sexes in C57BL/6 mice

(2011) Maria E. Lorenzo et al.   VACCINE

Elevated 17β-Estradiol Protects Females from Influenza A Virus Pathogenesis by Suppressing Inflammatory Responses

(2011) Dionne P. Robinson et al.   PLoS Pathogens

Estrogen receptor profiles in human peripheral blood lymphocytes

(2010) Marina Pierdominici et al.   IMMUNOLOGY LETTERS

Sex hormone modulation of proinflammatory cytokine and C-reactive protein expression in macrophages from older men and postmenopausal women

(2010) Michael P Corcoran et al.   JOURNAL OF ENDOCRINOLOGY

Differential Modulation of TLR3- and TLR4-Mediated Dendritic Cell Maturation and Function by Progesterone

(2010) L. A. Jones et al.   JOURNAL OF IMMUNOLOGY

A Detrimental Effect of Interleukin-10 on Protective Pulmonary Humoral Immunity during Primary Influenza A Virus Infection

(2010) K. Sun et al.   JOURNAL OF VIROLOGY

Macrophages

(2009) Barbro N. Melgert et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Estrogen receptor signaling promotes dendritic cell differentiation by increasing expression of the transcription factor IRF4

(2009) E. Carreras et al.   BLOOD

Differential Macrophage Polarization in Male and Female BALB/c Mice Infected With Coxsackievirus B3 Defines Susceptibility to Viral Myocarditis

(2009) Kang Li et al.   CIRCULATION RESEARCH

Critically Ill Patients With 2009 Influenza A(H1N1) Infection in Canada

(2009) Anand Kumar   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Monocyte/macrophage androgen receptor suppresses cutaneous wound healing in mice by enhancing local TNF-α expression

(2009) Jiann-Jyh Lai et al.   JOURNAL OF CLINICAL INVESTIGATION

Neutropenia with impaired host defense against microbial infection in mice lacking androgen receptor

(2009) Kuang-Hsiang Chuang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

H1N1 2009 influenza virus infection during pregnancy in the USA

(2009) Denise J Jamieson et al.   LANCET

Sex differences in the Toll-like receptor–mediated response of plasmacytoid dendritic cells to HIV-1

(2009) Angela Meier et al.   NATURE MEDICINE

Severe 2009 H1N1 Influenza in Pregnant and Postpartum Women in California

(2009) Janice K. Louie et al.   NEW ENGLAND JOURNAL OF MEDICINE

Estradiol Regulates Expression of Estrogen Receptor ERα46 in Human Macrophages

(2009) Amy J. Murphy et al.   PLoS One

Novel H1N1 Virus Infection and Pregnancy

(2009) Hemant K. Satpathy et al.   POSTGRADUATE MEDICINE

A critical review of fundamental controversies in the field of GPR30 research

(2009) Gernot Langer et al.   STEROIDS

Recruitment of circulating NK cells through decidual tissues: a possible mechanism controlling NK cell accumulation in the uterus during early pregnancy

(2008) C. Carlino et al.   BLOOD

Testosterone Reduces Macrophage Expression in the Mouse of Toll-Like Receptor 4, a Trigger for Inflammation and Innate Immunity

(2007) Jennifer A. Rettew et al.   BIOLOGY OF REPRODUCTION

Sex differences in the recognition of and innate antiviral responses to Seoul virus in Norway rats

(2007) Michele F. Hannah et al.   BRAIN BEHAVIOR AND IMMUNITY