Sex Drives Dimorphic Immune Responses to Viral Infections

Estrogenic compounds reduce influenza A virus replication in primary human nasal epithelial cells derived from female, but not male, donors

(2016) Jackye Peretz et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The making of a Barr body: the mosaic of factors that eXIST on the mammalian inactive X chromosome

(2016) Thomas Dixon-McDougall et al.   Biochemistry and Cell Biology

Estrogen Accelerates Cutaneous Wound Healing by Promoting Proliferation of Epidermal Keratinocytes via Erk/Akt Signaling Pathway

(2016) Tao Zhou et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

17β-Oestradiol enhances the expansion and activation of myeloid-derived suppressor cells via signal transducer and activator of transcription (STAT)−3 signalling in human pregnancy

(2016) T. Pan et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Progesterone augments cell susceptibility to HIV-1 and HIV-1/HSV-2 co-infections

(2016) Viswanath Ragupathy et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Prenatal androgen exposure alters girls' responses to information indicating gender-appropriate behaviour

(2016) Melissa Hines et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Unusual maintenance of X chromosome inactivation predisposes female lymphocytes for increased expression from the inactive X

(2016) Jianle Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CCR5 interaction with HIV-1 Env contributes to Env-induced depletion of CD4 T cells in vitro and in vivo

(2016) Li-Chung Tsao et al.   Retrovirology

Sex differences in HIV-1-mediated immunopathology

(2016) Susanne Ziegler et al.   Current Opinion in HIV and AIDS

Studies of gonadal sex differentiation

(2016) Zograb Makiyan   Organogenesis

SeXX Matters in Infectious Disease Pathogenesis

(2016) Landon G. vom Steeg et al.   PLoS Pathogens

Sexually dimorphic gene expression emerges with embryonic genome activation and is dynamic throughout development

(2015) Robert Lowe et al.   BMC GENOMICS

Estrogen receptors regulate innate immune cells and signaling pathways

(2015) Susan Kovats   CELLULAR IMMUNOLOGY

Sex differences in immune responses to infectious diseases

(2015) Julia Fischer et al.   INFECTION

Liver transplant recipients and prioritization of anti-HCV therapy: an Italian cohort analysis

(2015) Simone Lanini et al.   LIVER INTERNATIONAL

Sex-based differences in immune function and responses to vaccination

(2015) S. L. Klein et al.   TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE

Sex differences in H7N9 influenza A virus pathogenesis

(2015) Julia Hoffmann et al.   VACCINE

The Complex Role of STAT3 in Viral Infections

(2015) Suresh V. Kuchipudi   Journal of Immunology Research

Membrane-Localized Estrogen Receptor α Is Required for Normal Organ Development and Function

(2014) Ali Pedram et al.   DEVELOPMENTAL CELL

Estrogen Receptor  , but Not  , Is Required for Optimal Dendritic Cell Differentiation and CD40-Induced Cytokine Production

(2014) V. Douin-Echinard et al.   JOURNAL OF IMMUNOLOGY

NK Cells Expressing a Progesterone Receptor Are Susceptible to Progesterone-Induced Apoptosis

(2014) L. Arruvito et al.   JOURNAL OF IMMUNOLOGY

X-Chromosome Complement and Estrogen Receptor Signaling Independently Contribute to the Enhanced TLR7-Mediated IFN-α Production of Plasmacytoid Dendritic Cells from Women

(2014) Sophie Laffont et al.   JOURNAL OF IMMUNOLOGY

Sex-based Biology and the Rational Design of Influenza Vaccination Strategies

(2014) S. L. Klein et al.   JOURNAL OF INFECTIOUS DISEASES

Animal models of herpes simplex virus immunity and pathogenesis

(2014) Christina M. Kollias et al.   JOURNAL OF NEUROVIROLOGY

Immunomodulatory Effects of Sex Hormones: Requirements for Pregnancy and Relevance in Melanoma

(2014) Elizabeth Ann L. Enninga et al.   MAYO CLINIC PROCEEDINGS

Oestrogen increases haematopoietic stem-cell self-renewal in females and during pregnancy

(2014) Daisuke Nakada et al.   NATURE

Androgens alter T-cell immunity by inhibiting T-helper 1 differentiation

(2014) Haydn T. Kissick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MeCP2 Reinforces STAT3 Signaling and the Generation of Effector CD4+ T Cells by Promoting miR-124-Mediated Suppression of SOCS5

(2014) S. Jiang et al.   Science Signaling

Plasmacytoid Dendritic Cells Suppress HIV-1 Replication but Contribute to HIV-1 Induced Immunopathogenesis in Humanized Mice

(2014) Guangming Li et al.   PLoS Pathogens

SOX9 Regulates MicroRNA miR-202-5p/3p Expression During Mouse Testis Differentiation1

(2013) Elanor N. Wainwright et al.   BIOLOGY OF REPRODUCTION

miR-124 Inhibits STAT3 Signaling to Enhance T Cell–Mediated Immune Clearance of Glioma

(2013) Jun Wei et al.   CANCER RESEARCH

Distinct Th17 inductions contribute to the gender bias in CVB3-induced myocarditis

(2013) Zhenping Li et al.   CARDIOVASCULAR PATHOLOGY

MASpromoter regulation: a role for Sry and tyrosine nitration of the KRAB domain of ZNF274 as a feedback mechanism

(2013) Jeremy W. Prokop et al.   CLINICAL SCIENCE

Neonatal expression of amh, sox9 and sf-1 mRNA in Caiman latirostris and effects of in ovo exposure to endocrine disrupting chemicals

(2013) Milena Durando et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Estradiol downregulates NF-κb translocation by Ikbkg transcriptional repression in dendritic cells

(2013) S Lasarte et al.   GENES AND IMMUNITY

Toll-Like Receptors in Antiviral Innate Immunity

(2013) Sandra N. Lester et al.   JOURNAL OF MOLECULAR BIOLOGY

Estrogen receptor-β ligand treatment after disease onset is neuroprotective in the multiple sclerosis model

(2013) Amy J. Wisdom et al.   JOURNAL OF NEUROSCIENCE RESEARCH

High-resolution Xist binding maps reveal two-step spreading during X-chromosome inactivation

(2013) Matthew D. Simon et al.   NATURE

Regulation of estrogen receptor   by histone methyltransferase SMYD2-mediated protein methylation

(2013) X. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FDA-Approved Selective Estrogen Receptor Modulators Inhibit Ebola Virus Infection

(2013) L. M. Johansen et al.   Science Translational Medicine

Androgen Receptor Influences on Body Defense System via Modulation of Innate and Adaptive Immune Systems

(2012) Jiann-Jyh Lai et al.   AMERICAN JOURNAL OF PATHOLOGY

Progesterone Enhances Immunoregulatory Activity of Human Mesenchymal Stem Cells Via PGE2 and IL-6

(2012) Xiaoyin Zhao et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Sex influences immune responses to viruses, and efficacy of prophylaxis and treatments for viral diseases

(2012) Sabra L. Klein   BIOESSAYS

Perforin Expression by CD4+ Regulatory T Cells Increases at Multiple Sclerosis Relapse: Sex Differences

(2012) Marta Tejera-Alhambra et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sex Differences in the Response to Viral Infections: TLR8 and TLR9 Ligand Stimulation Induce Higher IL10 Production in Males

(2012) Maria Gabriella Torcia et al.   PLoS One

Sex Bias in Susceptibility to MCMV Infection: Implication of TLR9

(2012) Stephanie Traub et al.   PLoS One

Chromosome Y Regulates Survival Following Murine Coxsackievirus B3 Infection

(2012) Laure K. Case et al.   G3-Genes Genomes Genetics

Testicular Differentiation Occurs in Absence of R-spondin1 and Sox9 in Mouse Sex Reversals

(2012) Rowena Lavery et al.   PLoS Genetics

17β-estradiol induces CD40 expression in dendritic cells via MAPK signaling pathways in a minichromosome maintenance protein 6-dependent manner

(2011) Hao Xie et al.   ARTHRITIS AND RHEUMATISM

The influence of sex and gender on the immune response

(2011) Sabine Oertelt-Prigione   AUTOIMMUNITY REVIEWS

Sex differences in resident immune cell phenotype underlie more efficient acute inflammatory responses in female mice

(2011) R. S. Scotland et al.   BLOOD

Epigenetic impact of simulated maternal grooming on estrogen receptor alpha within the developing amygdala

(2011) Michelle N. Edelmann et al.   BRAIN BEHAVIOR AND IMMUNITY

Histone Deacetylation during Brain Development Is Essential for Permanent Masculinization of Sexual Behavior

(2011) Ken Ichi Matsuda et al.   ENDOCRINOLOGY

Antagonistic regulation of Cyp26b1 by transcription factors SOX9/SF1 and FOXL2 during gonadal development in mice

(2011) Kenichi Kashimada et al.   FASEB JOURNAL

Sexual dimorphism in lung function responses to acute influenza A infection

(2011) Alexander N. Larcombe et al.   Influenza and Other Respiratory Viruses

Sex Hormones, Insulin Resistance, and Diabetes Mellitus Among Men With or at Risk for HIV Infection

(2011) Anne K Monroe et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Sex chromosome aneuploidies among men with systemic lupus erythematosus

(2011) Skyler P. Dillon et al.   JOURNAL OF AUTOIMMUNITY

Sex differences in murine susceptibility to systemic viral infections

(2011) Theresa L. Geurs et al.   JOURNAL OF AUTOIMMUNITY

Mechanisms of sex disparities in influenza pathogenesis

(2011) Sabra L. Klein et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Increased prevalence of sexually transmitted viral infections in women: the role of female sex hormones in regulating susceptibility and immune responses

(2011) Charu Kaushic et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

DMRT1 prevents female reprogramming in the postnatal mammalian testis

(2011) Clinton K. Matson et al.   NATURE

Reframing sexual differentiation of the brain

(2011) Margaret M McCarthy et al.   NATURE NEUROSCIENCE

Transcriptional sexual dimorphism during preimplantation embryo development and its consequences for developmental competence and adult health and disease

(2011) P Bermejo-Alvarez et al.   REPRODUCTION

Elevated 17β-Estradiol Protects Females from Influenza A Virus Pathogenesis by Suppressing Inflammatory Responses

(2011) Dionne P. Robinson et al.   PLoS Pathogens

Sex chromosome complement contributes to sex differences in coxsackievirus B3 but not influenza A virus pathogenesis

(2011) Dionne P Robinson et al.   Biology of Sex Differences

A Global Perspective on Hantavirus Ecology, Epidemiology, and Disease

(2010) C. B. Jonsson et al.   CLINICAL MICROBIOLOGY REVIEWS

Developmental and Hormone-Induced Epigenetic Changes to Estrogen and Progesterone Receptor Genes in Brain Are Dynamic across the Life Span

(2010) Jaclyn M. Schwarz et al.   ENDOCRINOLOGY

Sex differences in histone modifications in the neonatal mouse brain

(2010) Houng-Wei Tsai et al.   Epigenetics

CARM1 mediates the ligand-independent and tamoxifen-resistant activation of the estrogen receptor   by cAMP

(2010) S. Carascossa et al.   GENES & DEVELOPMENT

Sex steroids as inflammatory regulators

(2010) Stephen C. Gilliver   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-α–PU.1 pathway

(2010) Eugene D Ponomarev et al.   NATURE MEDICINE

The impact of sex, gender and pregnancy on 2009 H1N1 disease

(2010) Sabra L Klein et al.   Biology of Sex Differences

Somatic Sex Reprogramming of Adult Ovaries to Testes by FOXL2 Ablation

(2009) N. Henriette Uhlenhaut et al.   CELL

Tissue-Specific Deletion of the Coxsackievirus and Adenovirus Receptor Protects Mice from Virus-Induced Pancreatitis and Myocarditis

(2009) Nicole L. Kallewaard et al.   Cell Host & Microbe

The organizational–activational hypothesis as the foundation for a unified theory of sexual differentiation of all mammalian tissues

(2009) Arthur P. Arnold   HORMONES AND BEHAVIOR

Monocyte/macrophage androgen receptor suppresses cutaneous wound healing in mice by enhancing local TNF-α expression

(2009) Jiann-Jyh Lai et al.   JOURNAL OF CLINICAL INVESTIGATION

Neutropenia with impaired host defense against microbial infection in mice lacking androgen receptor

(2009) Kuang-Hsiang Chuang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Sex differences in the Toll-like receptor–mediated response of plasmacytoid dendritic cells to HIV-1

(2009) Angela Meier et al.   NATURE MEDICINE

Estradiol Regulates Expression of Estrogen Receptor ERα46 in Human Macrophages

(2009) Amy J. Murphy et al.   PLoS One

Human cytomegalovirus suppresses type I interferon secretion by plasmacytoid dendritic cells through its interleukin 10 homolog

(2009) W.L. William Chang et al.   VIROLOGY

The immune risk profile is associated with age and gender: findings from three Swedish population studies of individuals 20–100 years of age

(2008) Anders Wikby et al.   BIOGERONTOLOGY

Cloning and expression of R-Spondin1 in different vertebrates suggests a conserved role in ovarian development

(2008) Craig A Smith et al.   BMC DEVELOPMENTAL BIOLOGY

Sex differences and estrogen modulation of the cellular immune response after injury

(2008) Melanie D. Bird et al.   CELLULAR IMMUNOLOGY

R-spondin1 plays an essential role in ovarian development through positively regulating Wnt-4 signaling

(2008) Kazuma Tomizuka et al.   HUMAN MOLECULAR GENETICS

Activation of  -catenin signaling by Rspo1 controls differentiation of the mammalian ovary

(2008) A.-A. Chassot et al.   HUMAN MOLECULAR GENETICS

A role for sex chromosome complement in the female bias in autoimmune disease

(2008) Deborah L. Smith-Bouvier et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Corticosteroids modulate Seoul virus infection, regulatory T-cell responses and matrix metalloprotease 9 expression in male, but not female, Norway rats

(2008) J. D. Easterbrook et al.   JOURNAL OF GENERAL VIROLOGY

Sex determination involves synergistic action of SRY and SF1 on a specific Sox9 enhancer

(2008) Ryohei Sekido et al.   NATURE

Adverse event reports following yellow fever vaccination

(2008) Nicole P. Lindsey et al.   VACCINE

Sex differences in the recognition of and innate antiviral responses to Seoul virus in Norway rats

(2007) Michele F. Hannah et al.   BRAIN BEHAVIOR AND IMMUNITY