Current Concepts of Antigen Cross-Presentation

Blood monocytes sample MelanA/MART1 antigen for long-lasting cross-presentation to CD8+ T cells after differentiation into dendritic cells

(2017) Florence Faure et al.   INTERNATIONAL JOURNAL OF CANCER

Critical role for Sec22b-dependent antigen cross-presentation in antitumor immunity

(2017) Andrés Alloatti et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Sec61 blockade by mycolactone inhibits antigen cross-presentation independently of endosome-to-cytosol export

(2017) Jeff E. Grotzke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MHC Class I Cross-Presentation: Stage Lights on Sec22b

(2017) Sebastian Montealegre et al.   TRENDS IN IMMUNOLOGY

UNC93B1 interacts with the calcium sensor STIM1 for efficient antigen cross-presentation in dendritic cells

(2017) Sophia Maschalidi et al.   Nature Communications

STIM1 promotes migration, phagosomal maturation and antigen cross-presentation in dendritic cells

(2017) Paula Nunes-Hasler et al.   Nature Communications

A Critical Analysis of the Role of SNARE Protein SEC22B in Antigen Cross-Presentation

(2017) S. Julia Wu et al.   Cell Reports

A Discrete Subset of Monocyte-Derived Cells among Typical Conventional Type 2 Dendritic Cells Can Efficiently Cross-Present

(2017) Jianpeng Sheng et al.   Cell Reports

The formation and function of ER-endosome membrane contact sites

(2016) Emily R. Eden   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Mechanistic insights into the inhibition of Sec61-dependent co- and post-translational translocation by mycolactone

(2016) Michael McKenna et al.   JOURNAL OF CELL SCIENCE

Long-Peptide Cross-Presentation by Human Dendritic Cells Occurs in Vacuoles by Peptide Exchange on Nascent MHC Class I Molecules

(2016) Wenbin Ma et al.   JOURNAL OF IMMUNOLOGY

TAP-Dependent and -Independent Peptide Import into Dendritic Cell Phagosomes

(2016) Myriam Lawand et al.   JOURNAL OF IMMUNOLOGY

The lectin Siglec-G inhibits dendritic cell cross-presentation by impairing MHC class I–peptide complex formation

(2016) Yuanyuan Ding et al.   NATURE IMMUNOLOGY

Mannose receptor induces T-cell tolerance via inhibition of CD45 and up-regulation of CTLA-4

(2016) Verena Schuette et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Imaging of the cross-presenting dendritic cell subsets in the skin-draining lymph node

(2016) Masahiro Kitano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid peroxidation causes endosomal antigen release for cross-presentation

(2016) Ilse Dingjan et al.   Scientific Reports

The Translocon Protein Sec61 Mediates Antigen Transport from Endosomes in the Cytosol for Cross-Presentation to CD8+ T Cells

(2015) Matthias Zehner et al.   IMMUNITY

Toll-like Receptor 4 Engagement on Dendritic Cells Restrains Phago-Lysosome Fusion and Promotes Cross-Presentation of Antigens

(2015) Andrés Alloatti et al.   IMMUNITY

Structure of the Complex of F-Actin and DNGR-1, a C-Type Lectin Receptor Involved in Dendritic Cell Cross-Presentation of Dead Cell-Associated Antigens

(2015) Pavel Hanč et al.   IMMUNITY

The transcription factor TFEB acts as a molecular switch that regulates exogenous antigen-presentation pathways

(2015) Mohammad Samie et al.   NATURE IMMUNOLOGY

TLR Signals Induce Phagosomal MHC-I Delivery from the Endosomal Recycling Compartment to Allow Cross-Presentation

(2014) Priyanka Nair-Gupta et al.   CELL

Dendritic cell maturation: functional specialization through signaling specificity and transcriptional programming

(2014) M. Dalod et al.   EMBO JOURNAL

The Relative Efficiency of Acquisition of MHC:Peptide Complexes and Cross-Presentation Depends on Dendritic Cell Type

(2014) L. A. Smyth et al.   JOURNAL OF IMMUNOLOGY

Lymph-borne CD8α+ dendritic cells are uniquely able to cross-prime CD8+ T cells with antigen acquired from intestinal epithelial cells

(2014) V Cerovic et al.   Mucosal Immunology

Cross-Presentation of Synthetic Long Peptides by Human Dendritic Cells: A Process Dependent on ERAD Component p97/VCP but Not sec61 and/or Derlin-1

(2014) Jérémie Ménager et al.   PLoS One

Conformational targeting of intracellular Aβ oligomers demonstrates their pathological oligomerization inside the endoplasmic reticulum

(2014) Giovanni Meli et al.   Nature Communications

The Pathogenic Mechanism of the Mycobacterium ulcerans Virulence Factor, Mycolactone, Depends on Blockade of Protein Translocation into the ER

(2014) Belinda S. Hall et al.   PLoS Pathogens

Ontogenic, Phenotypic, and Functional Characterization of XCR1+ Dendritic Cells Leads to a Consistent Classification of Intestinal Dendritic Cells Based on the Expression of XCR1 and SIRPα

(2014) Martina Becker et al.   Frontiers in Immunology

The Dendritic Cell Lineage: Ontogeny and Function of Dendritic Cells and Their Subsets in the Steady State and the Inflamed Setting

(2013) Miriam Merad et al.   Annual Review of Immunology

HLA-DM and HLA-DO, key regulators of MHC-II processing and presentation

(2013) Elizabeth D Mellins et al.   CURRENT OPINION IN IMMUNOLOGY

IRF4 Transcription Factor-Dependent CD11b+ Dendritic Cells in Human and Mouse Control Mucosal IL-17 Cytokine Responses

(2013) Andreas Schlitzer et al.   IMMUNITY

Similar antigen cross-presentation capacity and phagocytic functions in all freshly isolated human lymphoid organ–resident dendritic cells

(2013) Elodie Segura et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Priming of CD8+ T Cells against Cytomegalovirus-Encoded Antigens Is Dominated by Cross-Presentation

(2013) A. Busche et al.   JOURNAL OF IMMUNOLOGY

No antigen-presentation defect in Unc93b13d/3d (3d) mice

(2013) Jacques Deguine et al.   NATURE IMMUNOLOGY

MHC class I–restricted myelin epitopes are cross-presented by Tip-DCs that promote determinant spreading to CD8+ T cells

(2013) Qingyong Ji et al.   NATURE IMMUNOLOGY

Internalization and endosomal degradation of receptor-bound antigens regulate the efficiency of cross presentation by human dendritic cells

(2012) B. Chatterjee et al.   BLOOD

Intraendosomal flow cytometry: A novel approach to analyze the protein composition of antigen-loaded endosomes

(2012) Matthias Zehner et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Human Tissues Contain CD141hi Cross-Presenting Dendritic Cells with Functional Homology to Mouse CD103+ Nonlymphoid Dendritic Cells

(2012) Muzlifah Haniffa et al.   IMMUNITY

Targeting DC-SIGN via its neck region leads to prolonged antigen residence in early endosomes, delayed lysosomal degradation, and cross-presentation

(2011) P. J. Tacken et al.   BLOOD

Sec22b Regulates Phagosomal Maturation and Antigen Crosspresentation by Dendritic Cells

(2011) Ignacio Cebrian et al.   CELL

TLR3-Specific Double-Stranded RNA Oligonucleotide Adjuvants Induce Dendritic Cell Cross-Presentation, CTL Responses, and Antiviral Protection

(2011) I. Jelinek et al.   JOURNAL OF IMMUNOLOGY

Cross-dressed dendritic cells drive memory CD8+ T-cell activation after viral infection

(2011) Linda M. Wakim et al.   NATURE

Mannose receptor polyubiquitination regulates endosomal recruitment of p97 and cytosolic antigen translocation for cross-presentation

(2011) M. Zehner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The roles of IL-12 and IL-23 in CD8+ T cell-mediated immunity against Listeria monocytogenes: Insights from a DC vaccination model

(2010) Curtis J. Henry et al.   CELLULAR IMMUNOLOGY

The XC chemokine receptor 1 is a conserved selective marker of mammalian cells homologous to mouse CD8α+dendritic cells

(2010) Karine Crozat et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human CD141+(BDCA-3)+dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens

(2010) Sarah L. Jongbloed et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Superior antigen cross-presentation and XCR1 expression define human CD11c+CD141+cells as homologues of mouse CD8+dendritic cells

(2010) Annabell Bachem et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Peripheral CD103+dendritic cells form a unified subset developmentally related to CD8α+conventional dendritic cells

(2010) Brian T. Edelson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Characterization of human DNGR-1+BDCA3+leukocytes as putative equivalents of mouse CD8α+dendritic cells

(2010) Lionel Franz Poulin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Temporal changes in dendritic cell subsets, cross-priming and costimulation via CD70 control CD8+ T cell responses to influenza

(2010) André Ballesteros-Tato et al.   NATURE IMMUNOLOGY

Steady-state cross-presentation of OVA is mannose receptor-dependent but inhibitable by collagen fragments

(2010) S. Burgdorf et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Defective Cross-Presentation of Viral Antigens in GILT-Free Mice

(2010) R. Singh et al.   SCIENCE

Bacteria-Induced Gap Junctions in Tumors Favor Antigen Cross-Presentation and Antitumor Immunity

(2010) F. Saccheri et al.   Science Translational Medicine

The Small GTPase Rac2 Controls Phagosomal Alkalinization and Antigen Crosspresentation Selectively in CD8+ Dendritic Cells

(2009) Ariel Savina et al.   IMMUNITY

Identification of a dendritic cell receptor that couples sensing of necrosis to immunity

(2009) David Sancho et al.   NATURE

Cross-presentation of viral and self antigens by skin-derived CD103+ dendritic cells

(2009) Sammy Bedoui et al.   NATURE IMMUNOLOGY

Different cross-presentation pathways in steady-state and inflammatory dendritic cells

(2009) E. Segura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antigen storage compartments in mature dendritic cells facilitate prolonged cytotoxic T lymphocyte cross-priming capacity

(2009) N. van Montfoort et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IRAP Identifies an Endosomal Compartment Required for MHC Class I Cross-Presentation

(2009) L. Saveanu et al.   SCIENCE

NADPH oxidase controls phagosomal pH and antigen cross-presentation in human dendritic cells

(2008) A. R. Mantegazza et al.   BLOOD

Plasmacytoid dendritic cells efficiently cross-prime naive T cells in vivo after TLR activation

(2008) J. Mouries et al.   BLOOD

The dendritic cell subtype-restricted C-type lectin Clec9A is a target for vaccine enhancement

(2008) I. Caminschi et al.   BLOOD

CD8– dendritic cells preferentially cross-presentSaccharomyces cerevisiae antigens

(2008) Ronald Backer et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

CLEC9A Is a Novel Activation C-type Lectin-like Receptor Expressed on BDCA3+Dendritic Cells and a Subset of Monocytes

(2008) Cristal Huysamen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clearance of influenza virus from the lung depends on migratory langerin+CD11b−but not plasmacytoid dendritic cells

(2008) Corine H. GeurtsvanKessel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes

(2008) You-Me Kim et al.   NATURE

Direct proteasome-independent cross-presentation of viral antigen by plasmacytoid dendritic cells on major histocompatibility complex class I

(2008) Tiziana Di Pucchio et al.   NATURE IMMUNOLOGY

Spatial and mechanistic separation of cross-presentation and endogenous antigen presentation

(2008) Sven Burgdorf et al.   NATURE IMMUNOLOGY

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β

(2008) Jonathan C Kagan et al.   NATURE IMMUNOLOGY