The Potential Role of circRNA in Tumor Immunity Regulation and Immunotherapy

Circular RNA – New member of noncoding RNA with novel functions

(2017) Kuei-Yang Hsiao et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Circular RNA circMTO1 acts as the sponge of microRNA-9 to suppress hepatocellular carcinoma progression

(2017) Dan Han et al.   HEPATOLOGY

MiR-15a/16 deficiency enhances anti-tumor immunity of glioma-infiltrating CD8+ T cells through targeting mTOR

(2017) Jiao Yang et al.   INTERNATIONAL JOURNAL OF CANCER

The Characterization of GSDMB Splicing and Backsplicing Profiles Identifies Novel Isoforms and a Circular RNA That Are Dysregulated in Multiple Sclerosis

(2017) Giulia Cardamone et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Novel Role of FBXW7 Circular RNA in Repressing Glioma Tumorigenesis

(2017) Yibing Yang et al.   JNCI-Journal of the National Cancer Institute

Cord blood NK cells engineered to express IL-15 and a CD19-targeted CAR show long-term persistence and potent antitumor activity

(2017) E Liu et al.   LEUKEMIA

Circles reshaping the RNA world: from waste to treasure

(2017) Jing Liu et al.   Molecular Cancer

CircRNA: functions and properties of a novel potential biomarker for cancer

(2017) Shujuan Meng et al.   Molecular Cancer

Translation of CircRNAs

(2017) Nagarjuna Reddy Pamudurti et al.   MOLECULAR CELL

Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis

(2017) Ivano Legnini et al.   MOLECULAR CELL

Sensing Self and Foreign Circular RNAs by Intron Identity

(2017) Y. Grace Chen et al.   MOLECULAR CELL

Antiviral Immunity and Circular RNA: No End in Sight

(2017) Cristhian Cadena et al.   MOLECULAR CELL

Coordinated circRNA Biogenesis and Function with NF90/NF110 in Viral Infection

(2017) Xiang Li et al.   MOLECULAR CELL

The Circular RNA Interacts with STAT3, Increasing Its Nuclear Translocation and Wound Repair by Modulating Dnmt3a and miR-17 Function

(2017) Zhen-Guo Yang et al.   MOLECULAR THERAPY

First-Line Nivolumab in Stage IV or Recurrent Non–Small-Cell Lung Cancer

(2017) David P. Carbone et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1

(2017) Kotb Abdelmohsen et al.   RNA Biology

Silencing CDR1as inhibits colorectal cancer progression through regulating microRNA-7

(2017) Wentao Tang et al.   OncoTargets and Therapy

The circular RNA circBIRC6 participates in the molecular circuitry controlling human pluripotency

(2017) Chun-Ying Yu et al.   Nature Communications

Ash1l and lnc-Smad3 coordinate Smad3 locus accessibility to modulate iTreg polarization and T cell autoimmunity

(2017) Meng Xia et al.   Nature Communications

Rational combination of oncolytic vaccinia virus and PD-L1 blockade works synergistically to enhance therapeutic efficacy

(2017) Zuqiang Liu et al.   Nature Communications

Chimeric-antigen receptor T (CAR-T) cell therapy for solid tumors: challenges and opportunities

(2017) An-Liang Xia et al.   Oncotarget

A Circular RNA Binds To and Activates AKT Phosphorylation and Nuclear Localization Reducing Apoptosis and Enhancing Cardiac Repair

(2017) Yan Zeng et al.   Theranostics

Novel Role of FBXW7 Circular RNA in Repressing Glioma Tumorigenesis

(2017) Yibing Yang et al.   JNCI-Journal of the National Cancer Institute

Enhancement of PSMA-Directed CAR Adoptive Immunotherapy by PD-1/PD-L1 Blockade

(2017) Inna Serganova et al.   Molecular Therapy-Oncolytics

Long noncoding RNAs in B-cell development and activation

(2016) Tiago F. Brazão et al.   BLOOD

Oncolytic virus therapy: A new era of cancer treatment at dawn

(2016) Hiroshi Fukuhara et al.   CANCER SCIENCE

Oncogenic Role of Fusion-circRNAs Derived from Cancer-Associated Chromosomal Translocations

(2016) Jlenia Guarnerio et al.   CELL

Induction of tumor apoptosis through a circular RNA enhancing Foxo3 activity

(2016) William W Du et al.   CELL DEATH AND DIFFERENTIATION

Circular RNAs and systemic lupus erythematosus

(2016) Lian-Ju Li et al.   EXPERIMENTAL CELL RESEARCH

Circular RNAs are miRNA sponges and can be used as a new class of biomarker

(2016) Franceli Rodrigues Kulcheski et al.   JOURNAL OF BIOTECHNOLOGY

The circular RNA ciRS-7 (Cdr1as) acts as a risk factor of hepatic microvascular invasion in hepatocellular carcinoma

(2016) Liangliang Xu et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

MicroRNA-487b Is a Negative Regulator of Macrophage Activation by Targeting IL-33 Production

(2016) Yang Xiang et al.   JOURNAL OF IMMUNOLOGY

Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2

(2016) William W. Du et al.   NUCLEIC ACIDS RESEARCH

Inducible RasGEF1B circular RNA is a positive regulator of ICAM-1 in the TLR4/LPS pathway

(2016) Wei Lun Ng et al.   RNA Biology

Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs

(2016) Qiupeng Zheng et al.   Nature Communications

Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans

(2016) Lesca M. Holdt et al.   Nature Communications

Circular RNA ZNF609 functions as a competitive endogenous RNA to regulate AKT3 expression by sponging miR-150-5p in Hirschsprung’s disease

(2016) Lei Peng et al.   Oncotarget

New Insights into Regulatory T Cells: Exosome- and Non-Coding RNA-Mediated Regulation of Homeostasis and Resident Treg Cells

(2016) Peiyao Li et al.   Frontiers in Immunology

Mini Review: Circular RNAs as Potential Clinical Biomarkers for Disorders in the Central Nervous System

(2016) Dan Lu et al.   Frontiers in Genetics

Circular RNAs Co-Precipitate with Extracellular Vesicles: A Possible Mechanism for circRNA Clearance

(2016) Erika Lasda et al.   PLoS One

Circular RNAs are down-regulated in KRAS mutant colon cancer cells and can be transferred to exosomes

(2016) Yongchao Dou et al.   Scientific Reports

MicroRNA-17-92 controls T-cell responses in graft-versus-host disease and leukemia relapse in mice

(2015) Y. Wu et al.   BLOOD

PRC2 Epigenetically Silences Th1-Type Chemokines to Suppress Effector T-Cell Trafficking in Colon Cancer

(2015) Nisha Nagarsheth et al.   CANCER RESEARCH

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

(2015) Chih-Hao Chang et al.   CELL

Using circular RNA as a novel type of biomarker in the screening of gastric cancer

(2015) Peifei Li et al.   CLINICA CHIMICA ACTA

The Next Immune-Checkpoint Inhibitors: PD-1/PD-L1 Blockade in Melanoma

(2015) Kathleen M. Mahoney et al.   CLINICAL THERAPEUTICS

Immune Checkpoint Inhibitors for Cancer Therapy: Clinical Efficacy and Safety

(2015) Saїd Azoury et al.   CURRENT CANCER DRUG TARGETS

Oncolytic Virus Immunotherapy for Melanoma

(2015) Neal Dharmadhikari et al.   CURRENT TREATMENT OPTIONS IN ONCOLOGY

Mechanisms and Αpplications of Ιnterleukins in Cancer Immunotherapy

(2015) Doxakis Anestakis et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cancer immunotherapy: harnessing the immune system to battle cancer

(2015) Yiping Yang   JOURNAL OF CLINICAL INVESTIGATION

Exosome mediated communication within the tumor microenvironment

(2015) Lara Milane et al.   JOURNAL OF CONTROLLED RELEASE

PD-1/PD-L1 Blockade Together With Vaccine Therapy Facilitates Effector T-Cell Infiltration Into Pancreatic Tumors

(2015) Kevin C. Soares et al.   JOURNAL OF IMMUNOTHERAPY

PDL1 Regulation by p53 via miR-34

(2015) Maria Angelica Cortez et al.   JNCI-Journal of the National Cancer Institute

Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed

(2015) Agnieszka Rybak-Wolf et al.   MOLECULAR CELL

DDX5 and its associated lncRNA Rmrp modulate TH17 cell effector functions

(2015) Wendy Huang et al.   NATURE

Epigenetic silencing of TH1-type chemokines shapes tumour immunity and immunotherapy

(2015) Dongjun Peng et al.   NATURE

Oncolytic viruses: a new class of immunotherapy drugs

(2015) Howard L. Kaufman et al.   NATURE REVIEWS DRUG DISCOVERY

Exon-intron circular RNAs regulate transcription in the nucleus

(2015) Zhaoyong Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

MiR-138 exerts anti-glioma efficacy by targeting immune checkpoints

(2015) Jun Wei et al.   NEURO-ONCOLOGY

Long noncoding RNA derived from CD244 signaling epigenetically controls CD8+T-cell immune responses in tuberculosis infection

(2015) Yang Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression and functions of long noncoding RNAs during human T helper cell differentiation

(2015) Charles F. Spurlock et al.   Nature Communications

Exon-intron circular RNAs regulate transcription in the nucleus

(2015) Zhaoyong Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The lncRNA H19 promotes epithelial to mesenchymal transition by functioning as miRNA sponges in colorectal cancer

(2015) Wei-Cheng Liang et al.   Oncotarget

LncRNA NALT interaction with NOTCH1 promoted cell proliferation in pediatric T cell acute lymphoblastic leukemia

(2015) Yaping Wang et al.   Scientific Reports

Cancer vaccines

(2015) L. H. Butterfield   BMJ-British Medical Journal

MicroRNAs and oncolytic viruses

(2015) Autumn J Ruiz et al.   Current Opinion in Virology

Cancer vaccines

(2015) L. H. Butterfield   BMJ-British Medical Journal

PDL1 Regulation by p53 via miR-34

(2015) Maria Angelica Cortez et al.   JNCI-Journal of the National Cancer Institute

Tumor-derived exosomes promote tumor progression and T-cell dysfunction through the regulation of enriched exosomal microRNAs in human nasopharyngeal carcinoma

(2015) Shu-biao Ye et al.   Oncotarget

The circular RNA Cdr1as, via miR-7 and its targets, regulates insulin transcription and secretion in islet cells

(2015) Huanyu Xu et al.   Scientific Reports

Biochemical Signaling of PD-1 on T Cells and Its Functional Implications

(2014) Vassiliki A. Boussiotis et al.   CANCER JOURNAL

Genome-wide Mapping and Characterization of Notch-Regulated Long Noncoding RNAs in Acute Leukemia

(2014) Thomas Trimarchi et al.   CELL

Tumor-secreted miR-214 induces regulatory T cells: a major link between immune evasion and tumor growth

(2014) Yuan Yin et al.   CELL RESEARCH

Ovarian tumor-associated microRNA-20a decreases natural killer cell cytotoxicity by downregulating MICA/B expression

(2014) Jingyan Xie et al.   Cellular & Molecular Immunology

Immuno-miRs: critical regulators of T-cell development, function and ageing

(2014) Bart-Jan Kroesen et al.   IMMUNOLOGY

The Role of MicroRNAs in the Control of Innate Immune Response in Cancer

(2014) Simon Jasinski-Bergner et al.   JNCI-Journal of the National Cancer Institute

Long non-coding RNAs and control of gene expression in the immune system

(2014) Maninjay K. Atianand et al.   TRENDS IN MOLECULAR MEDICINE

Immune checkpoints in cancer clinical trials

(2014) Elad Sharon et al.   Chinese Journal of Cancer

Ribosome Profiling Provides Evidence that Large Noncoding RNAs Do Not Encode Proteins

(2013) Mitchell Guttman et al.   CELL

Gene regulation by non-coding RNAs

(2013) Veena S. Patil et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Long noncoding RNAs in innate and adaptive immunity

(2013) Katherine A. Fitzgerald et al.   CURRENT OPINION IN IMMUNOLOGY

Cancer immunotherapies, their safety and toxicity

(2013) Gheath Alatrash et al.   Expert Opinion On Drug Safety

Adoptive T Cell Transfer for Cancer Immunotherapy in the Era of Synthetic Biology

(2013) Michael Kalos et al.   IMMUNITY

Role of microRNAs and long-non-coding RNAs in CD4+T-cell differentiation

(2013) Massimiliano Pagani et al.   IMMUNOLOGICAL REVIEWS

Circular Intronic Long Noncoding RNAs

(2013) Yang Zhang et al.   MOLECULAR CELL

Natural RNA circles function as efficient microRNA sponges

(2013) Thomas B. Hansen et al.   NATURE

Expression and regulation of intergenic long noncoding RNAs during T cell development and differentiation

(2013) Gangqing Hu et al.   NATURE IMMUNOLOGY

p53 regulates mesenchymal stem cell-mediated tumor suppression in a tumor microenvironment through immune modulation

(2013) Y Huang et al.   ONCOGENE

A Long Noncoding RNA Mediates Both Activation and Repression of Immune Response Genes

(2013) S. Carpenter et al.   SCIENCE

Function of lncRNAs and approaches to lncRNA-protein interactions

(2013) JuanJuan Zhu et al.   Science China-Life Sciences

Microenvironmental regulation of cancer metastasis by miRNAs

(2013) Yun Zhang et al.   TRENDS IN CELL BIOLOGY

Dendritic cell-based vaccines: barriers and opportunities

(2012) Jessica A Cintolo et al.   Future Oncology

Circular RNAs are abundant, conserved, and associated with ALU repeats

(2012) W. R. Jeck et al.   RNA

Epigenetic quantification of tumor-infiltrating T-lymphocytes

(2011) Jalid Sehouli et al.   Epigenetics

Downregulation of microRNA-211 is involved in expression of preferentially expressed antigen of melanoma in melanoma cells

(2011) Chihaya Maesawa   INTERNATIONAL JOURNAL OF ONCOLOGY

Non-coding RNAs in human disease

(2011) Manel Esteller   NATURE REVIEWS GENETICS