Dendritic cell-based vaccines: barriers and opportunities

Differential Production of IL-23 and IL-12 by Myeloid-Derived Dendritic Cells in Response to TLR Agonists

(2014) R. E. Roses et al.   JOURNAL OF IMMUNOLOGY

Dendritic Cell Differentiation State and Their Interaction with NKT Cells Determine Th1/Th2 Differentiation in the Murine Model of Leishmania major Infection

(2014) C. Wiethe et al.   JOURNAL OF IMMUNOLOGY

Inducing Antitumor T Cell Immunity: Comparative Functional Analysis of Interstitial Versus Langerhans Dendritic Cells in a Human Cell Line Model

(2014) S. J. A. M. Santegoets et al.   JOURNAL OF IMMUNOLOGY

Attenuated Expression of A20 Markedly Increases the Efficacy of Double-Stranded RNA-Activated Dendritic Cells As an Anti-Cancer Vaccine

(2014) K. Breckpot et al.   JOURNAL OF IMMUNOLOGY

Internalization and endosomal degradation of receptor-bound antigens regulate the efficiency of cross presentation by human dendritic cells

(2012) B. Chatterjee et al.   BLOOD

HER-2 pulsed dendritic cell vaccine can eliminate HER-2 expression and impact ductal carcinoma in situ

(2012) Anupama Sharma et al.   CANCER

Metastatic melanoma patients treated with dendritic cell vaccination, Interleukin-2 and metronomic cyclophosphamide: results from a phase II trial

(2012) Eva Ellebaek et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Interleukin-17 Promotes Formation and Growth of Prostate Adenocarcinoma in Mouse Models

(2012) Q. Zhang et al.   CANCER RESEARCH

Prediction of MHC class I binding peptides with a new feature encoding technique

(2012) Murat Gök et al.   CELLULAR IMMUNOLOGY

The Utility and Limitations of Current Web-Available Algorithms To Predict Peptides Recognized by CD4 T Cells in Response to Pathogen Infection

(2012) F. A. Chaves et al.   JOURNAL OF IMMUNOLOGY

Immunomodulating antibodies in the treatment of metastatic melanoma: The experience with anti-CTLA-4, anti-CD137, and anti-PD1

(2012) Ester Simeone et al.   Journal of Immunotoxicology

Dendritic Cells Loaded With mRNA Encoding Full-length Tumor Antigens Prime CD4+ and CD8+ T Cells in Melanoma Patients

(2012) An MT Van Nuffel et al.   MOLECULAR THERAPY

The secret ally: immunostimulation by anticancer drugs

(2012) Lorenzo Galluzzi et al.   NATURE REVIEWS DRUG DISCOVERY

Differentiation and gene expression profile of tumor-associated macrophages

(2012) Astrid Schmieder et al.   SEMINARS IN CANCER BIOLOGY

Dendritic Cells for Active Anti-Cancer Immunotherapy: Targeting Activation Pathways Through Genetic Modification

(2012) Karine Breckpot et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

Predicting peptide binding to Major Histocompatibility Complex molecules

(2011) Webber W.P. Liao et al.   AUTOIMMUNITY REVIEWS

Targeting DC-SIGN via its neck region leads to prolonged antigen residence in early endosomes, delayed lysosomal degradation, and cross-presentation

(2011) P. J. Tacken et al.   BLOOD

Managing resistance in chronic myeloid leukemia

(2011) Sameek Roychowdhury et al.   BLOOD REVIEWS

Maximal T Cell-Mediated Antitumor Responses Rely upon CCR5 Expression in Both CD4+ and CD8+ T Cells

(2011) A. Gonzalez-Martin et al.   CANCER RESEARCH

Peptide-Loaded Langerhans Cells, Despite Increased IL15 Secretion and T-Cell Activation In Vitro, Elicit Antitumor T-Cell Responses Comparable to Peptide-Loaded Monocyte-Derived Dendritic Cells In Vivo

(2011) E. Romano et al.   CLINICAL CANCER RESEARCH

PROVENGE (Sipuleucel-T) in Prostate Cancer: The First FDA-Approved Therapeutic Cancer Vaccine

(2011) M. A. Cheever et al.   CLINICAL CANCER RESEARCH

Tumor-Derived Autophagosome Vaccine: Mechanism of Cross-Presentation and Therapeutic Efficacy

(2011) Y. Li et al.   CLINICAL CANCER RESEARCH

Complexity of dendritic cell subsets and their function in the host immune system

(2011) Rahul Kushwah et al.   IMMUNOLOGY

Tolerogenic pDCs: spotlight on Foxo3

(2011) Vincenzo Bronte   JOURNAL OF CLINICAL INVESTIGATION

FOXO3 programs tumor-associated DCs to become tolerogenic in human and murine prostate cancer

(2011) Stephanie K. Watkins et al.   JOURNAL OF CLINICAL INVESTIGATION

Pilot Clinical Trial of Type 1 Dendritic Cells Loaded with Autologous Tumor Lysates Combined with GM-CSF, Pegylated IFN, and Cyclophosphamide for Metastatic Cancer Patients

(2011) C. Alfaro et al.   JOURNAL OF IMMUNOLOGY

A Novel Dendritic Cell-based Immunization Approach for the Induction of Durable Th1-polarized Anti-HER-2/neu Responses in Women With Early Breast Cancer

(2011) Gary K. Koski et al.   JOURNAL OF IMMUNOTHERAPY

Engineering Dendritic Cells to Enhance Cancer Immunotherapy

(2011) Jeanette E Boudreau et al.   MOLECULAR THERAPY

Senescence surveillance of pre-malignant hepatocytes limits liver cancer development

(2011) Tae-Won Kang et al.   NATURE

Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells

(2011) Maria T Pallotta et al.   NATURE IMMUNOLOGY

Neonatal Fc receptor for IgG (FcRn) regulates cross-presentation of IgG immune complexes by CD8-CD11b+ dendritic cells

(2011) K. Baker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparable T helper 1 (Th1) and CD8 T-cell immunity by targeting HIV gag p24 to CD8 dendritic cells within antibodies to Langerin, DEC205, and Clec9A

(2011) J. Idoyaga et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ImMucin: A novel therapeutic vaccine with promiscuous MHC binding for the treatment of MUC1-expressing tumors

(2011) Riva Kovjazin et al.   VACCINE

Role of dendritic cells in the induction of regulatory T cells

(2011) Rahul Kushwah et al.   Cell and Bioscience

J-LEAPS peptide and LEAPS dendritic cell vaccines

(2011) Ken S. Rosenthal et al.   Microbial Biotechnology

Selective ERK activation differentiates mouse and human tolerogenic dendritic cells, expands antigen-specific regulatory T cells, and suppresses experimental inflammatory arthritis

(2010) Frederick Arce et al.   ARTHRITIS AND RHEUMATISM

Cross-priming CD8+ T cells by targeting antigens to human dendritic cells through DCIR

(2010) E. Klechevsky et al.   BLOOD

CD4+ T Cells Contribute to the Remodeling of the Microenvironment Required for Sustained Tumor Regression upon Oncogene Inactivation

(2010) Kavya Rakhra et al.   CANCER CELL

Development of a live and highly attenuated Listeria monocytogenes-based vaccine for the treatment of Her2/neu-overexpressing cancers in human

(2010) V Shahabi et al.   CANCER GENE THERAPY

Th17 cells: positive or negative role in tumor?

(2010) Yuqiang Ji et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Myeloid-Derived Suppressor Cells in Human Cancer

(2010) Srinivas Nagaraj et al.   CANCER JOURNAL

Maturation of dendritic cell precursors into IL12-producing DCs by J-LEAPS immunogens

(2010) Patricia R. Taylor et al.   CELLULAR IMMUNOLOGY

Myeloid-derived suppressor cell heterogeneity and subset definition

(2010) Elisa Peranzoni et al.   CURRENT OPINION IN IMMUNOLOGY

Tolerogenic plasmacytoid DC

(2010) Benjamin M. Matta et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Immunotherapy using allogeneic squamous cell tumor-dendritic cell fusion hybrids

(2010) Walter T. Lee et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

Fusion of the Human Cytomegalovirus pp65 Antigen with Both Ubiquitin and Ornithine Decarboxylase Additively Enhances Antigen Presentation to CD8+ T Cells in Human Dendritic Cells

(2010) Min-Ji Park et al.   HUMAN GENE THERAPY

Generation of effector CD8+ T cells and their conversion to memory T cells

(2010) Weiguo Cui et al.   IMMUNOLOGICAL REVIEWS

Instructive cytokine signals in dendritic cell lineage commitment

(2010) Michael A. Schmid et al.   IMMUNOLOGICAL REVIEWS

Origin and development of dendritic cells

(2010) Kang Liu et al.   IMMUNOLOGICAL REVIEWS

Induction of CD8+ T-Cell Responses Against Novel Glioma–Associated Antigen Peptides and Clinical Activity by Vaccinations With α-Type 1 Polarized Dendritic Cells and Polyinosinic-Polycytidylic Acid Stabilized by Lysine and Carboxymethylcellulose in Patients With Recurrent Malignant Glioma

(2010) Hideho Okada et al.   JOURNAL OF CLINICAL ONCOLOGY

Antibody-Targeted NY-ESO-1 to Mannose Receptor or DEC-205 In Vitro Elicits Dual Human CD8+ and CD4+ T Cell Responses with Broad Antigen Specificity

(2010) T. Tsuji et al.   JOURNAL OF IMMUNOLOGY

Induction of Cellular Immune Responses in Patients With Stage-I Multiple Myeloma After Vaccination With Autologous Idiotype-pulsed Dendritic Cells

(2010) Christoph Röllig et al.   JOURNAL OF IMMUNOTHERAPY

Integration of autologous dendritic cell-based immunotherapy in the primary treatment for patients with newly diagnosed glioblastoma multiforme: a pilot study

(2010) Hilko Ardon et al.   JOURNAL OF NEURO-ONCOLOGY

Subsets, expansion and activation of myeloid-derived suppressor cells

(2010) Eliana Ribechini et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Enhanced Generation of Cytotoxic T Lymphocytes by Heat Shock Protein 70 Fusion Proteins Harboring Both CD8+T Cell and CD4+T Cell Epitopes

(2010) Seiji Takemoto et al.   MOLECULAR PHARMACEUTICS

Effects of thymic selection of the T-cell repertoire on HLA class I-associated control of HIV infection

(2010) Andrej Košmrlj et al.   NATURE

Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

(2010) Keith T. Flaherty et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Novel Cancer Vaccine Strategy Based on HLA-A*0201 Matched Allogeneic Plasmacytoid Dendritic Cells

(2010) Caroline Aspord et al.   PLoS One

Induction of complete and molecular remissions in acute myeloid leukemia by Wilms' tumor 1 antigen-targeted dendritic cell vaccination

(2010) V. F. Van Tendeloo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

J-LEAPS vaccines initiate murine Th1 responses by activating dendritic cells

(2010) P.R. Taylor et al.   VACCINE

Does IL-17 promote tumor growth?

(2009) P. Muranski et al.   BLOOD

Phenotype, distribution, generation, and functional and clinical relevance of Th17 cells in the human tumor environments

(2009) I. Kryczek et al.   BLOOD

The effects of trastuzumab on the CD4+CD25+FoxP3+ and CD4+IL17A+ T-cell axis in patients with breast cancer

(2009) C Horlock et al.   BRITISH JOURNAL OF CANCER

Integrated data from 2 randomized, double-blind, placebo-controlled, phase 3 trials of active cellular immunotherapy with sipuleucel-T in advanced prostate cancer

(2009) Celestia S. Higano et al.   CANCER

CD4+ T Cells Regulate Pulmonary Metastasis of Mammary Carcinomas by Enhancing Protumor Properties of Macrophages

(2009) David G. DeNardo et al.   CANCER CELL

Patient-derived renal cell carcinoma cells fused with allogeneic dendritic cells elicit anti-tumor activity: in vitro results and clinical responses

(2009) Jun Zhou et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Malignant B Cells Skew the Balance of Regulatory T Cells and TH17 Cells in B-Cell Non-Hodgkin's Lymphoma

(2009) Zhi-Zhang Yang et al.   CANCER RESEARCH

Single-Step Antigen Loading and Activation of Dendritic Cells by mRNA Electroporation for the Purpose of Therapeutic Vaccination in Melanoma Patients

(2009) A. Bonehill et al.   CLINICAL CANCER RESEARCH

Late Developmental Plasticity in the T Helper 17 Lineage

(2009) Yun Kyung Lee et al.   IMMUNITY

Future therapeutics for the induction of peripheral immune tolerance in autoimmune disease and organ transplantation

(2009) Stephen P Cobbold   Immunotherapy

Generation of fusion protein EGFRvIII-HBcAg and its anti-tumor effect in vivo

(2009) Xiao-yi Duan et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

CD207+CD103+dermal dendritic cells cross-present keratinocyte-derived antigens irrespective of the presence of Langerhans cells

(2009) Sandrine Henri et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ubiquitin-Editing Enzyme A20 Promotes Tolerance to Lipopolysaccharide in Enterocytes

(2009) J. Wang et al.   JOURNAL OF IMMUNOLOGY

IL-17 Secreted by Tumor Reactive T Cells Induces IL-8 Release by Human Renal Cancer Cells

(2009) Takashi Inozume et al.   JOURNAL OF IMMUNOTHERAPY

Generation of Human Dendritic Cells That Simultaneously Secrete IL-12 and Have Migratory Capacity by Adenoviral Gene Transfer of hCD40L in Combination With IFN-γ

(2009) Ilka Knippertz et al.   JOURNAL OF IMMUNOTHERAPY

Immunosuppressive CD14+HLA-DRlow/−monocytes in prostate cancer

(2009) Stanimir Vuk-Pavlović et al.   PROSTATE

Immune Responses in Patients with Metastatic Renal Cell Carcinoma Treated with Dendritic Cells Pulsed with Tumor Lysate

(2009) A. Soleimani et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

NADPH oxidase controls phagosomal pH and antigen cross-presentation in human dendritic cells

(2008) A. R. Mantegazza et al.   BLOOD

Tumor-specific Th17-polarized cells eradicate large established melanoma

(2008) P. Muranski et al.   BLOOD

Evaluation of MHC-II peptide binding prediction servers: applications for vaccine research

(2008) Hong Lin et al.   BMC BIOINFORMATICS

Evaluation of MHC class I peptide binding prediction servers: Applications for vaccine research

(2008) Hong Lin et al.   BMC IMMUNOLOGY

Ectopic expression of a truncated CD40L protein from synthetic post-transcriptionally capped RNA in dendritic cells induces high levels of IL-12 secretion

(2008) Irina Y Tcherepanova et al.   BMC MOLECULAR BIOLOGY

Targeting of epidermal Langerhans cells with antigenic proteins: attempts to harness their properties for immunotherapy

(2008) Vincent Flacher et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Type 2 Bias of T Cells Expanded from the Blood of Melanoma Patients Switched to Type 1 by IL-12p70 mRNA-Transfected Dendritic Cells

(2008) K. Minkis et al.   CANCER RESEARCH

Prostate Stem Cell Antigen Vaccination Induces a Long-term Protective Immune Response against Prostate Cancer in the Absence of Autoimmunity

(2008) M. de la Luz Garcia-Hernandez et al.   CANCER RESEARCH

Phenotypic Analysis of Prostate-Infiltrating Lymphocytes Reveals TH17 and Treg Skewing

(2008) K. S. Sfanos et al.   CLINICAL CANCER RESEARCH

Activated plasmacytoid dendritic cells act synergistically with hepatitis B core antigen-pulsed monocyte-derived dendritic cells in the induction of hepatitis B virus-specific CD8 T-cell response

(2008) Weiwei Chen et al.   CLINICAL IMMUNOLOGY

A paradigm shift in therapeutic vaccination of cancer patients: the need to apply therapeutic vaccination strategies in the preventive setting

(2008) Andrew Gray et al.   IMMUNOLOGICAL REVIEWS

Reengineering dendritic cell-based anti-cancer vaccines

(2008) Gary K. Koski et al.   IMMUNOLOGICAL REVIEWS

Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin

(2008) David Sancho et al.   JOURNAL OF CLINICAL INVESTIGATION

Enhancing the T-cell Stimulatory Capacity of Human Dendritic Cells by Co-electroporation With CD40L, CD70 and Constitutively Active TLR4 Encoding mRNA

(2008) Aude Bonehill et al.   MOLECULAR THERAPY

The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues

(2008) Claudia Waskow et al.   NATURE IMMUNOLOGY

Spatial and mechanistic separation of cross-presentation and endogenous antigen presentation

(2008) Sven Burgdorf et al.   NATURE IMMUNOLOGY

A20 is an antigen presentation attenuator and its inhibition overcomes regulatory T cell–mediated suppression

(2008) Xiao-Tong Song et al.   NATURE MEDICINE

A Systematic Assessment of MHC Class II Peptide Binding Predictions and Evaluation of a Consensus Approach

(2008) Peng Wang et al.   PLoS Computational Biology

hDectin-1 is involved in uptake and cross-presentation of cellular antigens

(2007) M. M. Weck et al.   BLOOD