SIRT1-PGC1α-NFκB Pathway of Oxidative and Inflammatory Stress during Trypanosoma cruzi Infection: Benefits of SIRT1-Targeted Therapy in Improving Heart Function in Chagas Disease
Published 2016 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
SIRT1-PGC1α-NFκB Pathway of Oxidative and Inflammatory Stress during Trypanosoma cruzi Infection: Benefits of SIRT1-Targeted Therapy in Improving Heart Function in Chagas Disease
Authors
Keywords
Trypanosoma cruzi, Mitochondria, Mitochondrial DNA, Respiratory infections, Heart, Inflammation, Myocardium, Inflammatory diseases
Journal
PLoS Pathogens
Volume 12, Issue 10, Pages e1005954
Publisher
Public Library of Science (PLoS)
Online
2016-10-21
DOI
10.1371/journal.ppat.1005954
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Sirtuins Link Inflammation and Metabolism
- (2016) Vidula T. Vachharajani et al. Journal of Immunology Research
- Modulation of SIRT1-Foxo1 Signaling axis by Resveratrol: Implications in Skeletal Muscle Aging and Insulin Resistance
- (2015) Thomas K. Sin et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Resveratrol ameliorates cardiac oxidative stress in diabetes through deacetylation of NFkB-p65 and histone 3
- (2015) Pankaj K. Bagul et al. JOURNAL OF NUTRITIONAL BIOCHEMISTRY
- Randomized Trial of Benznidazole for Chronic Chagas’ Cardiomyopathy
- (2015) Carlos A. Morillo et al. NEW ENGLAND JOURNAL OF MEDICINE
- High-frequency speckle tracking echocardiography in the assessment of left ventricular function and remodeling after murine myocardial infarction
- (2014) Amit Bhan et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- The SIRT1 activator SRT1720 reverses vascular endothelial dysfunction, excessive superoxide production, and inflammation with aging in mice
- (2014) Lindsey B. Gano et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Sirtuin 1 Activation Stimulates Mitochondrial Biogenesis and Attenuates Renal Injury After Ischemia-Reperfusion
- (2014) Adam Khader et al. TRANSPLANTATION
- Effects of Resveratrol and SIRT1 on PGC-1α Activity and Mitochondrial Biogenesis: A Reevaluation
- (2013) Kazuhiko Higashida et al. PLOS BIOLOGY
- Innate Immune Responses and Antioxidant/Oxidant Imbalance Are Major Determinants of Human Chagas Disease
- (2013) Monisha Dhiman et al. PLoS Neglected Tropical Diseases
- MnSOD tg Mice Control Myocardial Inflammatory and Oxidative Stress and Remodeling Responses Elicited in Chronic Chagas Disease
- (2013) Monisha Dhiman et al. Journal of the American Heart Association
- Sirtuin activators and inhibitors
- (2012) José M. Villalba et al. BIOFACTORS
- Mechanisms of Trypanosoma cruzi persistence in Chagas disease
- (2012) Fnu Nagajyothi et al. CELLULAR MICROBIOLOGY
- Chagas disease: What is known and what should be improved: a systemic review
- (2012) José Rodrigues Coura et al. Revista da Sociedade Brasileira de Medicina Tropical
- Current understanding of immunity to Trypanosoma cruzi infection and pathogenesis of Chagas disease
- (2012) Fabiana S. Machado et al. Seminars in Immunopathology
- The United States Trypanosoma cruzi Infection Study: evidence for vector-borne transmission of the parasite that causes Chagas disease among United States blood donors
- (2012) Paul T. Cantey et al. TRANSFUSION
- Trypanosoma cruzi and Chagas' Disease in the United States
- (2011) C. Bern et al. CLINICAL MICROBIOLOGY REVIEWS
- Emerging roles of SIRT1 deacetylase in regulating cardiomyocyte survival and hypertrophy
- (2011) Nagalingam R. Sundaresan et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- NADPH oxidase inhibition ameliorates Trypanosoma cruzi-induced myocarditis during Chagas disease
- (2011) Monisha Dhiman et al. JOURNAL OF PATHOLOGY
- SRT1720 improves survival and healthspan of obese mice
- (2011) Robin K. Minor et al. Scientific Reports
- Defective DNA Replication Impairs Mitochondrial Biogenesis In Human Failing Hearts
- (2010) Georgios Karamanlidis et al. CIRCULATION RESEARCH
- Kidney-specific Overexpression of Sirt1 Protects against Acute Kidney Injury by Retaining Peroxisome Function
- (2010) Kazuhiro Hasegawa et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Macrophage α1 AMP-activated Protein Kinase (α1AMPK) Antagonizes Fatty Acid-induced Inflammation through SIRT1
- (2010) Zhenggang Yang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Trypanosoma cruziInduces the Reactive Oxygen Species-PARP-1-RelA Pathway for Up-regulation of Cytokine Expression in Cardiomyocytes
- (2010) Xueqing Ba et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The PGC-1 cascade as a therapeutic target for heart failure
- (2010) Joel Schilling et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- SRT1720 Induces Mitochondrial Biogenesis and Rescues Mitochondrial Function after Oxidant Injury in Renal Proximal Tubule Cells
- (2010) J. A. Funk et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Phenyl-α-tert-butyl-nitrone and Benzonidazole Treatment Controlled the Mitochondrial Oxidative Stress and Evolution of Cardiomyopathy in Chronic Chagasic Rats
- (2010) Jian-Jun Wen et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Chagas disease and stroke
- (2010) Francisco Javier Carod-Artal et al. LANCET NEUROLOGY
- Myeloid Deletion of SIRT1 Induces Inflammatory Signaling in Response to Environmental Stress
- (2010) T. T. Schug et al. MOLECULAR AND CELLULAR BIOLOGY
- Resveratrol Prevents the Development of Pathological Cardiac Hypertrophy and Contractile Dysfunction in the SHR Without Lowering Blood Pressure
- (2009) S. J. Thandapilly et al. AMERICAN JOURNAL OF HYPERTENSION
- Mitochondrial Complex III Defects Contribute to Inefficient Respiration and ATP Synthesis in the Myocardium of Trypanosoma cruzi–Infected Mice
- (2009) Jian-Jun Wen et al. ANTIOXIDANTS & REDOX SIGNALING
- Biochemical effects of SIRT1 activators
- (2009) Joseph A. Baur BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo
- (2009) Jesse J Smith et al. BMC Systems Biology
- An Estimate of the Burden of Chagas Disease in the United States
- (2009) Caryn Bern et al. CLINICAL INFECTIOUS DISEASES
- AMP-Activated Protein Kinase-Deficient Mice Are Resistant to the Metabolic Effects of Resveratrol
- (2009) J.-H. Um et al. DIABETES
- Trypanosoma cruzi infection disturbs mitochondrial membrane potential and ROS production rate in cardiomyocytes
- (2009) Shivali Gupta et al. FREE RADICAL BIOLOGY AND MEDICINE
- Specific SIRT1 Activation Mimics Low Energy Levels and Protects against Diet-Induced Metabolic Disorders by Enhancing Fat Oxidation
- (2008) Jérôme N. Feige et al. Cell Metabolism
- Resveratrol Inhibits Cardiac Hypertrophy via AMP-activated Protein Kinase and Akt
- (2008) Anita Y. M. Chan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Tissue-specific oxidative imbalance and mitochondrial dysfunction during Trypanosoma cruzi infection in mice
- (2008) J WEN et al. MICROBES AND INFECTION
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now