Article
Pharmacology & Pharmacy
Emad Molaei, Ali Molaei, A. Wallace Hayes, Gholamreza Karimi
Summary: Studies have shown that Resolvin D1 has the potential to inhibit inflammation, promote resolution and modulation of inflammation, and may have potential therapeutic value in treating acute lung injury.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Kranti A. Mapuskar, Gabriela Vasquez-Martinez, Gabriel Mayoral-Andrade, Ann Tomanek-Chalkley, Diana Zepeda-Orozco, Bryan G. Allen
Summary: Chronic kidney disease (CKD) increases the risk of end-stage renal disease (ESRD) and its associated morbidity and mortality. CKD can lead to metabolic perturbations and oxidative stress, resulting in increased production of reactive oxygen species (ROS) in the kidneys. Mitochondrial oxidative metabolism plays a role in the pathology of CKD, and targeting mitochondria may be a potential treatment approach to delay CKD progression.
Review
Biochemistry & Molecular Biology
Keiko Hosohata, Tanisorn Harnsirikarn, Susama Chokesuwattanaskul
Summary: This review summarizes the involvement and importance of ferroptosis in acute kidney injury through oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Katerina Hadrava Vanova, Chunzhang Yang, Leah Meuter, Jiri Neuzil, Karel Pacak
Summary: Pheochromocytoma (PHEO) and paraganglioma (PGL) are rare neuroendocrine tumors derived from neural crest cells, with a subset of patients at risk for metastatic disease, especially those with succinate dehydrogenase subunit B mutations. These tumors exhibit redox imbalance, suggesting therapeutic strategies targeting reactive oxygen species production may be promising.
Review
Medicine, Research & Experimental
Ankush Kumar Jha, Shobhit Gairola, Sourav Kundu, Pakpi Doye, Abu Mohammad Syed, Chetan Ram, Upadhyayula Suryanarayana Murty, V. G. M. Naidu, Bidya Dhar Sahu
Summary: This review emphasizes the role of TLR4 signaling pathway in AKI and highlights potential compounds of natural and synthetic origin that can avert renal TLR4 signaling and offer protection against AKI in preclinical models. Targeting TLR4 and its downstream effectors could serve as an effective therapeutic intervention to prevent renal inflammation and subsequent kidney damage.
Review
Cell Biology
Shulei Gong, Shiyang Wang, Mingrui Shao
Summary: This review primarily discusses the biological function of NOX4 in tumorigenesis and progression, including its role in activating oncogenic signaling pathways, rewiring the metabolic phenotype, and mediating immune response. NOX4 is considered a promising therapeutic target.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Medicine, Research & Experimental
Jinrui Wei, Yan Zhang, Haopeng Li, Fuquan Wang, Shanglong Yao
Summary: This review focuses on the role and mechanism of TLR4 in various diseases, aiming to provide new research directions and therapeutic targets for clinical intervention.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Medicine, Research & Experimental
Yawei Bi, Xiao Lei, Ningli Chai, Enqiang Linghu
Summary: NOX4 is upregulated in pancreatic cancer and primarily produces hydrogen peroxide, exhibiting different properties from other NOX family subtypes. Recent studies suggest that NOX4 promotes pancreatic cancer occurrence and development, making it a potential therapeutic target in pancreatic cancer.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
David Weissman, Christoph Maack
Summary: Heart failure is a growing health burden globally, characterized by alterations in excitation-contraction coupling, cardiac energy deficit, and oxidative stress. While targeting metabolism may provide prognostic benefits, treatments specifically targeting reactive oxygen species (ROS) are still in preclinical stages. More research is needed in this area to develop effective therapies for heart failure.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Zilong Li, Qianwen Zhao, Yunjie Lu, Yangxi Zhang, Luyang Li, Min Li, Xuemin Chen, Donglin Sun, Yunfei Duan, Yong Xu
Summary: This study elucidates a novel mechanism by which BRG1 regulates ROS accumulation, identifying DDIT4 as a transcriptional target of BRG1 and showing that it drives ROS production through facilitating the assembly of the p38-MAPK signaling complex via S-nitrosylation. Additionally, bioactive compounds interacting with DDIT4 are identified and confirmed to attenuate hepatic ROS production and ameliorate liver injury by influencing DDIT4 S-nitrosylation. Moreover, a positive correlation between ROS levels and BRG1/DDIT4/S-nitrosylated DDIT4 levels is observed in human liver biopsy specimens.
Article
Biochemistry & Molecular Biology
Philipp Heher, Massimo Ganassi, Adelheid Weidinger, Elise N. Engquist, Johanna Pruller, Thuy Hang Nguyen, Alexandra Tassin, Anne-Emilie Decleves, Kamel Mamchaoui, Christopher R. S. Banerji, Johannes Grillari, Andrey V. Kozlov, Peter S. Zammit
Summary: FSHD is characterized by oxidative stress induced by DUX4, leading to metabolic dysfunction and impaired mitochondrial function. Increased mitochondrial ROS levels in FSHD muscle cells are associated with elevated steady-state mitochondrial membrane potential. DUX4 triggers mitochondrial membrane polarization, resulting in mitochondrial ROS generation and apoptosis.
Review
Cell Biology
Mariya Farooq, Maria Batool, Moon Suk Kim, Sangdun Choi
Summary: Toll-like receptors play a crucial role in immune responses and have the potential to be used as therapeutic agents or vaccine adjuvants for cancers and infections. They may also be a promising approach in treating autoimmune diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Xiaonan Li, Donghui Cao, Siming Sun, Yuehui Wang
Summary: Dysregulation of reactive oxygen species (ROS) production and ROS-regulated pathways in cancer cells can have dual effects on cancer progression, either promoting transformation/proliferation or inducing cell death. Targeting ROS is a promising strategy for cancer treatment, and ginsenosides and related drug carriers have shown potential in modulating multiple signaling pathways to induce apoptosis, regulate cell cycle, invasion, and metastasis, and enhance drug sensitivity in different cancers. This review focuses on the pro- and anticancer effects of ROS and summarizes the mechanisms and recent advances in ginsenosides for anticancer therapy by targeting ROS, providing insights for future studies.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Plant Sciences
Su Yin Phua, Barbara De Smet, Claire Remacle, Kai Xun Chan, Frank Van Breusegem
Summary: The evolution of photosynthesis in plants has been crucial but has also led to challenges in the form of reactive oxygen species (ROS) production. Multiple forms of ROS are generated in various plant cell compartments, requiring a sophisticated network of ROS detoxification and signaling tailored to individual organelles to safeguard the cell as a whole.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Article
Medicine, Research & Experimental
Riane Richard, Shaker Mousa
Summary: Alzheimer's disease is the sixth leading cause of death in the United States, with an estimated 20 million patients by 2050. This study examines the role of necroptosis in the development of Alzheimer's disease and finds that it plays a crucial role due to factors such as hyperglycemia, reactive oxygen species, inflammation, and insulin resistance.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
