Hookworm Secreted Extracellular Vesicles Interact With Host Cells and Prevent Inducible Colitis in Mice

Organoids: the body builders

(2018) Michael Eisenstein   NATURE METHODS

Excretory/secretory products from the gastrointestinal nematode Trichuris muris

(2017) Lucienne Tritten et al.   EXPERIMENTAL PARASITOLOGY

DeconvolutionLab2: An open-source software for deconvolution microscopy

(2017) Daniel Sage et al.   METHODS

Extracellular Vesicles from a Helminth Parasite Suppress Macrophage Activation and Constitute an Effective Vaccine for Protective Immunity

(2017) Gillian Coakley et al.   Cell Reports

Immune polarization by hookworms: taking cues from T helper type 2, type 2 innate lymphoid cells and alternatively activated macrophages

(2016) Meera G. Nair et al.   IMMUNOLOGY

Extracellular vesicles secreted by Schistosoma mansoni contain protein vaccine candidates

(2016) Javier Sotillo et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Regulation of the host immune system by helminth parasites

(2016) Rick M. Maizels et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Host parasite communications—Messages from helminths for the immune system

(2016) Gillian Coakley et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

PANTHER version 11: expanded annotation data from Gene Ontology and Reactome pathways, and data analysis tool enhancements

(2016) Huaiyu Mi et al.   NUCLEIC ACIDS RESEARCH

Hookworm recombinant protein promotes regulatory T cell responses that suppress experimental asthma

(2016) S. Navarro et al.   Science Translational Medicine

Hookworm infection

(2016) Alex Loukas et al.   Nature Reviews Disease Primers

Parasite Proximity Drives the Expansion of Regulatory T Cells in Peyer's Patches following Intestinal Helminth Infection

(2015) Ilaria Mosconi et al.   INFECTION AND IMMUNITY

Experimental hookworm infection and gluten microchallenge promote tolerance in celiac disease

(2015) John Croese et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Carcinogenic Liver Fluke Secretes Extracellular Vesicles That Promote Cholangiocytes to Adopt a Tumorigenic Phenotype

(2015) Sujittra Chaiyadet et al.   JOURNAL OF INFECTIOUS DISEASES

The Reactome pathway Knowledgebase

(2015) Antonio Fabregat et al.   NUCLEIC ACIDS RESEARCH

Ensembl 2016

(2015) Andrew Yates et al.   NUCLEIC ACIDS RESEARCH

Exosome-like vesicles derived by Schistosoma japonicum adult worms mediates M1 type immune- activity of macrophage

(2015) Lifu Wang et al.   PARASITOLOGY RESEARCH

Exosomes and Other Extracellular Vesicles: The New Communicators in Parasite Infections

(2015) Gillian Coakley et al.   TRENDS IN PARASITOLOGY

Diterpenoid alkaloids of Aconitum laciniatum and mitigation of inflammation by 14-O-acetylneoline in a murine model of ulcerative colitis

(2015) Phurpa Wangchuk et al.   Scientific Reports

Release of Small RNA-containing Exosome-like Vesicles from the Human Filarial Parasite Brugia malayi

(2015) Mostafa Zamanian et al.   PLoS Neglected Tropical Diseases

Probing of a Human Proteome Microarray With a Recombinant Pathogen Protein Reveals a Novel Mechanism by Which Hookworms Suppress B-Cell Receptor Signaling

(2014) Leon Tribolet et al.   JOURNAL OF INFECTIOUS DISEASES

Secreted Proteomes of Different Developmental Stages of the Gastrointestinal NematodeNippostrongylus brasiliensis

(2014) Javier Sotillo et al.   MOLECULAR & CELLULAR PROTEOMICS

Global numbers of infection and disease burden of soil transmitted helminth infections in 2010

(2014) Rachel L Pullan et al.   Parasites & Vectors

Exosomes secreted by nematode parasites transfer small RNAs to mammalian cells and modulate innate immunity

(2014) Amy H. Buck et al.   Nature Communications

Hookworm Excretory/Secretory Products Induce Interleukin-4 (IL-4)+IL-10+CD4+T Cell Responses and Suppress Pathology in a Mouse Model of Colitis

(2013) Ivana Ferreira et al.   INFECTION AND IMMUNITY

Immunomodulation by helminth parasites: Defining mechanisms and mediators

(2013) Henry J. McSorley et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Helminth therapy and multiple sclerosis

(2013) J.O. Fleming   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Grape Exosome-like Nanoparticles Induce Intestinal Stem Cells and Protect Mice From DSS-Induced Colitis

(2013) Songwen Ju et al.   MOLECULAR THERAPY

IL-10 modulates DSS-induced colitis through a macrophage–ROS–NO axis

(2013) B Li et al.   Mucosal Immunology

miRBase: annotating high confidence microRNAs using deep sequencing data

(2013) Ana Kozomara et al.   NUCLEIC ACIDS RESEARCH

RNAs with multiple personalities

(2013) Roy L. Maute et al.   Wiley Interdisciplinary Reviews-RNA

Helminth Infections and Host Immune Regulation

(2012) H. J. McSorley et al.   CLINICAL MICROBIOLOGY REVIEWS

Loss of Interleukin-10 Signaling and Infantile Inflammatory Bowel Disease: Implications for Diagnosis and Therapy

(2012) Daniel Kotlarz et al.   GASTROENTEROLOGY

Suppressive effect of berberine on experimental dextran sulfate sodium-induced colitis

(2012) Tie Hong et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Extracellular Vesicles from Parasitic Helminths Contain Specific Excretory/Secretory Proteins and Are Internalized in Intestinal Host Cells

(2012) Antonio Marcilla et al.   PLoS One

The global burden of neglected tropical diseases

(2012) A. Fenwick   PUBLIC HEALTH

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

(2011) Toshiro Sato et al.   GASTROENTEROLOGY

Hookworm products ameliorate dextran sodium sulfate-induced colitis in BALB/c mice

(2011) Guilherme Grossi Lopes Cançado et al.   INFLAMMATORY BOWEL DISEASES

SCP/TAPS proteins in helminths – Where to from now?

(2011) Cinzia Cantacessi et al.   MOLECULAR AND CELLULAR PROBES

SignalP 4.0: discriminating signal peptides from transmembrane regions

(2011) Thomas Nordahl Petersen et al.   NATURE METHODS

miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades

(2011) Marc R. Friedländer et al.   NUCLEIC ACIDS RESEARCH

SearchGUI: An open-source graphical user interface for simultaneous OMSSA and X!Tandem searches

(2011) Marc Vaudel et al.   PROTEOMICS

Necator americanus and Helminth Co-Infections: Further Down-Modulation of Hookworm-Specific Type 1 Immune Responses

(2011) Stefan Michael Geiger et al.   PLoS Neglected Tropical Diseases

Experimental hookworm infection: a randomized placebo-controlled trial in asthma

(2010) J. R. Feary et al.   CLINICAL AND EXPERIMENTAL ALLERGY

CDD: a Conserved Domain Database for the functional annotation of proteins

(2010) A. Marchler-Bauer et al.   NUCLEIC ACIDS RESEARCH

The Immunology of Human Hookworm Infections.

(2010) Henry J. McSorley et al.   PARASITE IMMUNOLOGY

Expression and immune response analysis of Schistosoma japonicum VAL-1, a homologue of vespid venom allergens

(2010) Jingfang Chen et al.   PARASITOLOGY RESEARCH

Helminth immunoregulation: The role of parasite secreted proteins in modulating host immunity

(2009) James P. Hewitson et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

The roles of eotaxin and the STAT6 signalling pathway in eosinophil recruitment and host resistance to the nematodes Nippostrongylus brasiliensis and Heligmosomoides bakeri

(2009) M.L. Knott et al.   MOLECULAR IMMUNOLOGY

Inflammatory Bowel Disease and Mutations Affecting the Interleukin-10 Receptor

(2009) Erik-Oliver Glocker et al.   NEW ENGLAND JOURNAL OF MEDICINE

UTRdb and UTRsite (RELEASE 2010): a collection of sequences and regulatory motifs of the untranslated regions of eukaryotic mRNAs

(2009) Giorgio Grillo et al.   NUCLEIC ACIDS RESEARCH

Therapeutic potential of helminth soluble proteins in TNBS-induced colitis in mice

(2008) Nathalie E. Ruyssers et al.   INFLAMMATORY BOWEL DISEASES

Proteomics Analysis of the Excretory/Secretory Component of the Blood-feeding Stage of the Hookworm,Ancylostoma caninum

(2008) Jason Mulvenna et al.   MOLECULAR & CELLULAR PROTEOMICS

Proteomic analysis of Schistosoma mansoni proteins released during in vitro miracidium-to-sporocyst transformation

(2008) Xiao-Jun Wu et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

High-throughput functional annotation and data mining with the Blast2GO suite

(2008) S. Gotz et al.   NUCLEIC ACIDS RESEARCH

The role of complement in innate, adaptive and eosinophil-dependent immunity to the nematode Nippostrongylus brasiliensis

(2007) Paul R. Giacomin et al.   MOLECULAR IMMUNOLOGY