Modularized Extracellular Vesicles: The Dawn of Prospective Personalized and Precision Medicine

Platelet-derived Extracellular Vesicles: An Emerging Therapeutic Approach

(2017) Shi-Cong Tao et al.   International Journal of Biological Sciences

Targeted si-RNA with liposomes and exosomes (extracellular vesicles): How to unlock the potential

(2017) Sophia Antimisiaris et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Development of Semiconducting Polymer Nanoparticles for Photoacoustic Imaging

(2017) Dong Cui et al.   MACROMOLECULAR RAPID COMMUNICATIONS

Engineered Exosomes as Vehicles for Biologically Active Proteins

(2017) Ulrich Sterzenbach et al.   MOLECULAR THERAPY

Functional Delivery of Lipid-Conjugated siRNA by Extracellular Vesicles

(2017) Aisling J. O’Loughlin et al.   MOLECULAR THERAPY

Viral effects on the content and function of extracellular vesicles

(2017) Nancy Raab-Traub et al.   NATURE REVIEWS MICROBIOLOGY

Exosomes: Therapy delivery tools and biomarkers of diseases

(2017) Lucio Barile et al.   PHARMACOLOGY & THERAPEUTICS

Prions on the run: How extracellular vesicles serve as delivery vehicles for self-templating protein aggregates

(2017) Shu Liu et al.   Prion

Cellular Functions and Molecular Mechanisms of the ESCRT Membrane-Scission Machinery

(2017) Liliane Christ et al.   TRENDS IN BIOCHEMICAL SCIENCES

Extracellular Vesicles: Unique Intercellular Delivery Vehicles

(2017) Sybren L.N. Maas et al.   TRENDS IN CELL BIOLOGY

Exosomes derived from miR-140-5p-overexpressing human synovial mesenchymal stem cells enhance cartilage tissue regeneration and prevent osteoarthritis of the knee in a rat model

(2017) Shi-Cong Tao et al.   Theranostics

Exosomes derived from platelet-rich plasma promote the re-epithelization of chronic cutaneous wounds via activation of YAP in a diabetic rat model

(2017) Shang-Chun Guo et al.   Theranostics

Recent Advances of Activatable Molecular Probes Based on Semiconducting Polymer Nanoparticles in Sensing and Imaging

(2017) Yan Lyu et al.   Advanced Science

Labeling Extracellular Vesicles for Nanoscale Flow Cytometry

(2017) Aizea Morales-Kastresana et al.   Scientific Reports

Intraparticle Molecular Orbital Engineering of Semiconducting Polymer Nanoparticles as Amplified Theranostics for in Vivo Photoacoustic Imaging and Photothermal Therapy

(2016) Yan Lyu et al.   ACS Nano

Intraparticle Energy Level Alignment of Semiconducting Polymer Nanoparticles to Amplify Chemiluminescence for Ultrasensitive In Vivo Imaging of Reactive Oxygen Species

(2016) Xu Zhen et al.   ACS Nano

Reaction-Based Semiconducting Polymer Nanoprobes for Photoacoustic Imaging of Protein Sulfenic Acids

(2016) Yan Lyu et al.   ACS Nano

Semiconducting Oligomer Nanoparticles as an Activatable Photoacoustic Probe with Amplified Brightness for In Vivo Imaging of pH

(2016) Qingqing Miao et al.   ADVANCED MATERIALS

Activatable Photoacoustic Nanoprobes for In Vivo Ratiometric Imaging of Peroxynitrite

(2016) Jianjian Zhang et al.   ADVANCED MATERIALS

RNAi delivery by exosome-mimetic nanovesicles – Implications for targeting c-Myc in cancer

(2016) Taral R. Lunavat et al.   BIOMATERIALS

Communication by Extracellular Vesicles: Where We Are and Where We Need to Go

(2016) Mercedes Tkach et al.   CELL

TNF-Related Apoptosis-Inducing Ligand (TRAIL)-Armed Exosomes Deliver Proapoptotic Signals to Tumor Site

(2016) L. Rivoltini et al.   CLINICAL CANCER RESEARCH

Mechanistic aspects of mammalian cell size control

(2016) Kazuo Yamamoto et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Extracellular Vesicles and Their Role in Urologic Malignancies

(2016) Kerstin Junker et al.   EUROPEAN UROLOGY

Topically applied lipid- and surfactant-based nanoparticles in the treatment of skin disorders

(2016) Eline Desmet et al.   Expert Opinion on Drug Delivery

Exosomes from Human Synovial-Derived Mesenchymal Stem Cells Prevent Glucocorticoid-Induced Osteonecrosis of the Femoral Head in the Rat

(2016) Shang-Chun Guo et al.   International Journal of Biological Sciences

Focus on Extracellular Vesicles: New Frontiers of Cell-to-Cell Communication in Cancer

(2016) Chiara Ciardiello et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Extracellular vesicles and infectious diseases: new complexity to an old story

(2016) Jeffrey S. Schorey et al.   JOURNAL OF CLINICAL INVESTIGATION

Recent advances of semiconducting polymer nanoparticles in in vivo molecular imaging

(2016) Kanyi Pu et al.   JOURNAL OF CONTROLLED RELEASE

MicroRNAs in extracellular vesicles: potential cancer biomarkers

(2016) Takashi Kinoshita et al.   JOURNAL OF HUMAN GENETICS

Quantification of mitochondrial morphology in neurites of dopaminergic neurons using multiple parameters

(2016) Lyle Wiemerslage et al.   JOURNAL OF NEUROSCIENCE METHODS

Semiconducting Polymer Nanobioconjugates for Targeted Photothermal Activation of Neurons

(2016) Yan Lyu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Reverse-topology membrane scission by the ESCRT proteins

(2016) Johannes Schöneberg et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Extracellular vesicles round off communication in the nervous system

(2016) Vivian Budnik et al.   NATURE REVIEWS NEUROSCIENCE

Human Induced Pluripotent Stem Cells as a Platform for Personalized and Precision Cardiovascular Medicine

(2016) Elena Matsa et al.   PHYSIOLOGICAL REVIEWS

Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes

(2016) Joanna Kowal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Melatonin Treatment Improves Mesenchymal Stem Cells Therapy by Preserving Stemness during Long-term In Vitro Expansion

(2016) Yi Shuai et al.   Theranostics

Recapitulating the Size and Cargo of Tumor Exosomes in a Tissue-Engineered Model

(2016) Aranzazu Villasante et al.   Theranostics

Ultrasound/Magnetic Targeting with SPIO-DOX-Microbubble Complex for Image-Guided Drug Delivery in Brain Tumors

(2016) Ching-Hsiang Fan et al.   Theranostics

Chitosan Wound Dressings Incorporating Exosomes Derived from MicroRNA-126-Overexpressing Synovium Mesenchymal Stem Cells Provide Sustained Release of Exosomes and Heal Full-Thickness Skin Defects in a Diabetic Rat Model

(2016) Shi-Cong Tao et al.   Stem Cells Translational Medicine

Engineering hybrid exosomes by membrane fusion with liposomes

(2016) Yuko T. Sato et al.   Scientific Reports

In Vivo Differentiation of Therapeutic Insulin-Producing Cells from Bone Marrow Cells via Extracellular Vesicle-Mimetic Nanovesicles

(2015) Keunhee Oh et al.   ACS Nano

Extracellular Vesicles: Composition, Biological Relevance, and Methods of Study

(2015) MikoŁaj P. Zaborowski et al.   BIOSCIENCE

In Vivo Imaging Reveals Extracellular Vesicle-Mediated Phenocopying of Metastatic Behavior

(2015) Anoek Zomer et al.   CELL

Relaxation of Loaded ESCRT-III Spiral Springs Drives Membrane Deformation

(2015) Nicolas Chiaruttini et al.   CELL

Exosomes as drug delivery vehicles for Parkinson's disease therapy

(2015) Matthew J. Haney et al.   JOURNAL OF CONTROLLED RELEASE

Small extracellular vesicles as tumor biomarkers for glioblastoma

(2015) Keon Mahmoudi et al.   MOLECULAR ASPECTS OF MEDICINE

Mesenchymal Stem Cell-derived Extracellular Vesicles: Toward Cell-free Therapeutic Applications

(2015) Sweta Rani et al.   MOLECULAR THERAPY

Liposome-Based Engineering of Cells To Package Hydrophobic Compounds in Membrane Vesicles for Tumor Penetration

(2015) Junsung Lee et al.   NANO LETTERS

Glypican-1 identifies cancer exosomes and detects early pancreatic cancer

(2015) Sonia A. Melo et al.   NATURE

Through the wall: extracellular vesicles in Gram-positive bacteria, mycobacteria and fungi

(2015) Lisa Brown et al.   NATURE REVIEWS MICROBIOLOGY

Negative membrane curvature catalyzes nucleation of endosomal sorting complex required for transport (ESCRT)-III assembly

(2015) Il-Hyung Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and membrane remodeling activity of ESCRT-III helical polymers

(2015) J. McCullough et al.   SCIENCE

On being the right (cell) size

(2015) M. B. Ginzberg et al.   SCIENCE

Visualization and tracking of tumour extracellular vesicle delivery and RNA translation using multiplexed reporters

(2015) Charles P. Lai et al.   Nature Communications

Noninvasive imaging of radiolabeled exosome-mimetic nanovesicle using 99mTc-HMPAO

(2015) Do Won Hwang et al.   Scientific Reports

Combined treatment with a pH-sensitive fusogenic peptide and cationic lipids achieves enhanced cytosolic delivery of exosomes

(2015) Ikuhiko Nakase et al.   Scientific Reports

Human bone marrow- and adipose-mesenchymal stem cells secrete exosomes enriched in distinctive miRNA and tRNA species

(2015) Serena Rubina Baglio et al.   Stem Cell Research & Therapy

Chitosan/siRNA Nanoparticles Targeting Cyclooxygenase Type 2 Attenuate Unilateral Ureteral Obstruction-induced Kidney Injury in Mice

(2015) Chuanxu Yang et al.   Theranostics

Magnetic Nanoparticles in Cancer Theranostics

(2015) Oliviero L. Gobbo et al.   Theranostics

MicroRNAs: New Biomarkers for Diagnosis, Prognosis, Therapy Prediction and Therapeutic Tools for Breast Cancer

(2015) Gloria Bertoli et al.   Theranostics

Nucleic Acid Aptamer-Guided Cancer Therapeutics and Diagnostics: the Next Generation of Cancer Medicine

(2015) Dongxi Xiang et al.   Theranostics

Cell or Cell Membrane-Based Drug Delivery Systems

(2015) Songwei Tan et al.   Theranostics

Extracellular vesicle-mediated transfer of functional RNA in the tumor microenvironment

(2015) Kirsten Ridder et al.   OncoImmunology

Dynamic Biodistribution of Extracellular Vesicles in Vivo Using a Multimodal Imaging Reporter

(2014) Charles P. Lai et al.   ACS Nano

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

Surface Functionalization of Exosomes Using Click Chemistry

(2014) Tyson Smyth et al.   BIOCONJUGATE CHEMISTRY

Extracellular vesicles as drug delivery systems: Lessons from the liposome field

(2014) Roy van der Meel et al.   JOURNAL OF CONTROLLED RELEASE

Paclitaxel is incorporated by mesenchymal stromal cells and released in exosomes that inhibit in vitro tumor growth: A new approach for drug delivery

(2014) Luisa Pascucci et al.   JOURNAL OF CONTROLLED RELEASE

Curcumin-primed exosomes mitigate endothelial cell dysfunction during hyperhomocysteinemia

(2014) A. Kalani et al.   LIFE SCIENCES

Systemic exosomal siRNA delivery reduced alpha-synuclein aggregates in brains of transgenic mice

(2014) J. Mark Cooper et al.   MOVEMENT DISORDERS

Could bioengineered exosome-mimetic nanovesicles be an efficient strategy for the delivery of chemotherapeutics?

(2014) Su Chul Jang et al.   Nanomedicine

Extracellular Vesicle-Mediated Transfer of Genetic Information between the Hematopoietic System and the Brain in Response to Inflammation

(2014) Kirsten Ridder et al.   PLOS BIOLOGY

Exosomes as Critical Agents of Cardiac Regeneration Triggered by Cell Therapy

(2014) Ahmed Gamal-Eldin Ibrahim et al.   Stem Cell Reports

Bioinspired Exosome-Mimetic Nanovesicles for Targeted Delivery of Chemotherapeutics to Malignant Tumors

(2013) Su Chul Jang et al.   ACS Nano

Maximizing exosome colloidal stability following electroporation

(2013) Joshua L. Hood et al.   ANALYTICAL BIOCHEMISTRY

A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy

(2013) Yanhua Tian et al.   BIOMATERIALS

Electroporation-induced siRNA precipitation obscures the efficiency of siRNA loading into extracellular vesicles

(2013) Sander A.A. Kooijmans et al.   JOURNAL OF CONTROLLED RELEASE

Dendritic Cell-Derived Exosomes Need To Activate Both T and B Cells To Induce Antitumor Immunity

(2013) T. I. Naslund et al.   JOURNAL OF IMMUNOLOGY

Extracellular vesicles derived from human bone marrow mesenchymal stem cells promote angiogenesis in a rat myocardial infarction model

(2013) Suyan Bian et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Circulating Extracellular Vesicles in Cancer Diagnosis and Monitoring

(2013) Dong-Sic Choi et al.   Molecular Diagnosis & Therapy

Liquid biopsy: monitoring cancer-genetics in the blood

(2013) Emily Crowley et al.   Nature Reviews Clinical Oncology

Extracellular vesicles: biology and emerging therapeutic opportunities

(2013) Samir EL Andaloussi et al.   NATURE REVIEWS DRUG DISCOVERY

Mesenchymal Stem Cells Secrete Immunologically Active Exosomes

(2013) Bin Zhang et al.   STEM CELLS AND DEVELOPMENT

Exosomes released by human umbilical cord mesenchymal stem cells protect against cisplatin-induced renal oxidative stress and apoptosis in vivo and in vitro

(2013) Ying Zhou et al.   Stem Cell Research & Therapy

Exosomes: Current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials

(2012) Alexander V. Vlassov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

RNA expression patterns in serum microvesicles from patients with glioblastoma multiforme and controls

(2012) Mikkel Noerholm et al.   BMC CANCER

Microvesicles Derived from Endothelial Progenitor Cells Enhance Neoangiogenesis of Human Pancreatic Islets

(2012) Vincenzo Cantaluppi et al.   CELL TRANSPLANTATION

Exosomal RNA as biomarkers and the therapeutic potential of exosome vectors

(2012) Cecilia Lässer   EXPERT OPINION ON BIOLOGICAL THERAPY

Genetically Engineered Microvesicles Carrying Suicide mRNA/Protein Inhibit Schwannoma Tumor Growth

(2012) Arda Mizrak et al.   MOLECULAR THERAPY

Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells

(2012) Shin-ichiro Ohno et al.   MOLECULAR THERAPY

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

(2012) Héctor Peinado et al.   NATURE MEDICINE

Exosome-mediated delivery of siRNA in vitro and in vivo

(2012) Samir El-Andaloussi et al.   Nature Protocols

Plasma exosomes can deliver exogenous short interfering RNA to monocytes and lymphocytes

(2012) Jessica Wahlgren et al.   NUCLEIC ACIDS RESEARCH

RhoA triggers a specific signaling pathway that generates transforming microvesicles in cancer cells

(2012) B Li et al.   ONCOGENE

Embryonic Stem Cell-Derived Microvesicles Induce Gene Expression Changes in Müller Cells of the Retina

(2012) Diana Katsman et al.   PLoS One

Solution Structure of the ESCRT-I and -II Supercomplex: Implications for Membrane Budding and Scission

(2012) Evzen Boura et al.   STRUCTURE

Mesenchymal stem cell secreted vesicles provide novel opportunities in (stem) cell-free therapy

(2012) Serena Rubina Baglio et al.   Frontiers in Physiology

Proteomic Analysis of Two Types of Exosomes in Human Whole Saliva

(2011) Yuko Ogawa et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

The Tetraspanin CD63 Regulates ESCRT-Independent and -Dependent Endosomal Sorting during Melanogenesis

(2011) Guillaume van Niel et al.   DEVELOPMENTAL CELL

Protein Targeting to Exosomes/Microvesicles by Plasma Membrane Anchors

(2011) Beiyi Shen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Treatment of Brain Inflammatory Diseases by Delivering Exosome Encapsulated Anti-inflammatory Drugs From the Nasal Region to the Brain

(2011) Xiaoying Zhuang et al.   MOLECULAR THERAPY

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

SiRNA delivery with exosome nanoparticles

(2011) Jasper G van den Boorn et al.   NATURE BIOTECHNOLOGY

Mesenchymal stem cell exosome: a novel stem cell-based therapy for cardiovascular disease

(2011) Ruenn Chai Lai et al.   Regenerative Medicine

The secreted factors responsible for pre-metastatic niche formation: Old sayings and new thoughts

(2011) Héctor Peinado et al.   SEMINARS IN CANCER BIOLOGY

Increasing vaccine potency through exosome antigen targeting

(2011) Zachary C. Hartman et al.   VACCINE

Intracellular and Extracellular MicroRNAs in Breast Cancer

(2010) C. Corcoran et al.   CLINICAL CHEMISTRY

A Novel Nanoparticle Drug Delivery System: The Anti-inflammatory Activity of Curcumin Is Enhanced When Encapsulated in Exosomes

(2010) Dongmei Sun et al.   MOLECULAR THERAPY

Prostate cancer-derived urine exosomes: a novel approach to biomarkers for prostate cancer

(2009) J Nilsson et al.   BRITISH JOURNAL OF CANCER

Two Rabs for exosome release

(2009) Suzanne R. Pfeffer   NATURE CELL BIOLOGY

Rab GTPases as coordinators of vesicle traffic

(2009) Harald Stenmark   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dendritic Cell-Derived Exosomes Promote Natural Killer Cell Activation and Proliferation: A Role for NKG2D Ligands and IL-15Rα

(2009) Sophie Viaud et al.   PLoS One

Endothelial expression of autocrine VEGF upon the uptake of tumor-derived microvesicles containing oncogenic EGFR

(2009) K. Al-Nedawi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Tumor Antigens to Secreted Membrane Vesicles In vivo Induces Efficient Antitumor Immune Responses

(2008) I. S. Zeelenberg et al.   CANCER RESEARCH

Integrated Structural Model and Membrane Targeting Mechanism of the Human ESCRT-II Complex

(2008) Young Jun Im et al.   DEVELOPMENTAL CELL

Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells

(2008) Khalid Al-Nedawi et al.   NATURE CELL BIOLOGY

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE