Prions on the run: How extracellular vesicles serve as delivery vehicles for self-templating protein aggregates

Extracellular Vesicles: Unique Intercellular Delivery Vehicles

(2017) Sybren L.N. Maas et al.   TRENDS IN CELL BIOLOGY

PRNP/prion protein regulates the secretion of exosomes modulating CAV1/caveolin-1-suppressed autophagy

(2016) Marcos V. S. Dias et al.   Autophagy

Exosome secretion is a key pathway for clearance of pathological TDP-43

(2016) Yohei Iguchi et al.   BRAIN

Prion-like domains as epigenetic regulators, scaffolds for subcellular organization, and drivers of neurodegenerative disease

(2016) Zachary M. March et al.   BRAIN RESEARCH

Introduction to Extracellular Vesicles: Biogenesis, RNA Cargo Selection, Content, Release, and Uptake

(2016) Erik R. Abels et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Exosomes in the Pathology of Neurodegenerative Diseases

(2016) Jason Howitt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extracellular Vesicles Exploit Viral Entry Routes for Cargo Delivery

(2016) Helena M. van Dongen et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Horizontal Transmission of Cytosolic Sup35 Prions by Extracellular Vesicles

(2016) Shu Liu et al.   mBio

Efficient inhibition of infectious prions multiplication and release by targeting the exosomal pathway

(2015) Didier Vilette et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

More than just trash bins? Potential roles for extracellular vesicles in the vertical and horizontal transmission of yeast prions

(2015) Mehdi Kabani et al.   CURRENT GENETICS

Mechanisms of RNA loading into exosomes

(2015) Teresa Janas et al.   FEBS LETTERS

TDP-43 is intercellularly transmitted across axon terminals

(2015) Marisa S. Feiler et al.   JOURNAL OF CELL BIOLOGY

The multivesicular body is the major internal site of prion conversion

(2015) Y.-I. Yim et al.   JOURNAL OF CELL SCIENCE

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

From molecule to molecule and cell to cell: Prion-like mechanisms in amyotrophic lateral sclerosis

(2015) Leslie I. Grad et al.   NEUROBIOLOGY OF DISEASE

Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines

(2015) Ikrame Lazar et al.   Pigment Cell & Melanoma Research

Sup35p in Its Soluble and Prion States Is Packaged inside Extracellular Vesicles

(2015) Mehdi Kabani et al.   mBio

Exposure to ALS-FTD-CSF generates TDP-43 aggregates in glioblastoma cells through exosomes and TNTs-like structure

(2015) Xuebing Ding et al.   Oncotarget

Prion strains are differentially released through the exosomal pathway

(2014) Zaira E. Arellano-Anaya et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The Neutral Sphingomyelinase Pathway Regulates Packaging of the Prion Protein into Exosomes

(2014) Belinda B. Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

First Demonstration of Transmissible Spongiform Encephalopathy-associated Prion Protein (PrPTSE) in Extracellular Vesicles from Plasma of Mice Infected with Mouse-adapted Variant Creutzfeldt-Jakob Disease byin VitroAmplification

(2014) Paula Saá et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ComplexN-Linked Glycans Serve as a Determinant for Exosome/Microvesicle Cargo Recruitment

(2014) Yaxuan Liang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exosome Uptake through Clathrin-mediated Endocytosis and Macropinocytosis and Mediating miR-21 Delivery

(2014) Tian Tian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Post-Translational Modifications of Exosomal Proteins

(2014) Olga Moreno-Gonzalo et al.   Frontiers in Immunology

Stages of pTDP-43 pathology in amyotrophic lateral sclerosis

(2013) Johannes Brettschneider et al.   ANNALS OF NEUROLOGY

CD169 mediates the capture of exosomes in spleen and lymph node

(2013) S. C. Saunderson et al.   BLOOD

Exosome Uptake Depends on ERK1/2-Heat Shock Protein 27 Signaling and Lipid Raft-mediated Endocytosis Negatively Regulated by Caveolin-1

(2013) Katrin J. Svensson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stress granules as crucibles of ALS pathogenesis

(2013) Yun R. Li et al.   JOURNAL OF CELL BIOLOGY

Extracellular vesicles: Exosomes, microvesicles, and friends

(2013) Graça Raposo et al.   JOURNAL OF CELL BIOLOGY

Exosome release from infected dendritic cells: A clue for a fast spread of prions in the periphery?

(2013) Peter-Christian Klöhn et al.   JOURNAL OF INFECTION

Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS

(2013) Hong Joo Kim et al.   NATURE

Life cycle of cytosolic prions

(2013) Julia Hofmann et al.   Prion

Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity

(2013) H. C. Christianson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell-to-cell propagation of infectious cytosolic protein aggregates

(2013) J. P. Hofmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular Aspects of Prion Replication In Vitro

(2013) Andrea Grassmann et al.   Viruses-Basel

Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs

(2013) Carolina Villarroya-Beltri et al.   Nature Communications

Prion-like Properties of Pathological TDP-43 Aggregates from Diseased Brains

(2013) Takashi Nonaka et al.   Cell Reports

Evaluating the role of the FUS/TLS-related gene EWSR1 in amyotrophic lateral sclerosis

(2012) Julien Couthouis et al.   HUMAN MOLECULAR GENETICS

Toward tailored exosomes: The exosomal tetraspanin web contributes to target cell selection

(2012) Sanyukta Rana et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Cellular Model of TAR DNA-binding Protein 43 (TDP-43) Aggregation Based on Its C-terminal Gln/Asn-rich Region

(2012) Mauricio Budini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prions are a common mechanism for phenotypic inheritance in wild yeasts

(2012) Randal Halfmann et al.   NATURE

Separate mechanisms act concurrently to shed and release the prion protein from the cell

(2012) Lotta Wik et al.   Prion

Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes

(2011) A. Montecalvo et al.   BLOOD

The Seeds of Neurodegeneration: Prion-like Spreading in ALS

(2011) Magdalini Polymenidou et al.   CELL

The Tetraspanin CD63 Regulates ESCRT-Independent and -Dependent Endosomal Sorting during Melanogenesis

(2011) Guillaume van Niel et al.   DEVELOPMENTAL CELL

LMP1 association with CD63 in endosomes and secretion via exosomes limits constitutive NF-κB activation

(2011) Frederik J Verweij et al.   EMBO JOURNAL

Protein Targeting to Exosomes/Microvesicles by Plasma Membrane Anchors

(2011) Beiyi Shen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Seeding Reaction Recapitulates Intracellular Formation of Sarkosyl-insoluble Transactivation Response Element (TAR) DNA-binding Protein-43 Inclusions

(2011) Yoshiaki Furukawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteolipidic Composition of Exosomes Changes during Reticulocyte Maturation

(2011) Kévin Carayon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis

(2011) D. Fitzner et al.   JOURNAL OF CELL SCIENCE

A yeast functional screen predicts new candidate ALS disease genes

(2011) J. Couthouis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Suicidal [PSI+] is a lethal yeast prion

(2011) R. P. McGlinchey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular prion protein released on exosomes from macrophages binds to Hsp70

(2010) G. Wang et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Hsp70 binds to PrPCin the process of PrPCrelease via exosomes from THP-1 monocytes

(2010) Gui‑hua Wang et al.   CELL BIOLOGY INTERNATIONAL

Outer membrane vesicles function as offensive weapons in host–parasite interactions

(2010) Atsuo Amano et al.   MICROBES AND INFECTION

Conversion of a yeast prion protein to an infectious form in bacteria

(2010) S. J. Garrity et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular Internalization of Exosomes Occurs Through Phagocytosis

(2010) Du Feng et al.   TRAFFIC

A Systematic Survey Identifies Prions and Illuminates Sequence Features of Prionogenic Proteins

(2009) Simon Alberti et al.   CELL

Compositional Determinants of Prion Formation in Yeast

(2009) J. A. Toombs et al.   MOLECULAR AND CELLULAR BIOLOGY

The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins

(2009) Camilla Raiborg et al.   NATURE

Prions hijack tunnelling nanotubes for intercellular spread

(2009) Karine Gousset et al.   NATURE CELL BIOLOGY

Paracrine Diffusion of PrPC and Propagation of Prion Infectivity by Plasma Membrane-Derived Microvesicles

(2009) Vincenzo Mattei et al.   PLoS One

An Analytical Solution to the Kinetics of Breakable Filament Assembly

(2009) T. P. J. Knowles et al.   SCIENCE

Mouse neuroblastoma cells release prion infectivity associated with exosomal vesicles

(2008) Sandrine Alais et al.   BIOLOGY OF THE CELL

Immunolocalisation of PrPSc in scrapie-infected N2a mouse neuroblastoma cells by light and electron microscopy

(2008) Nathalie M. Veith et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

The yeast Sup35NM domain propagates as a prion in mammalian cells

(2008) C. Krammer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE

Enrichment of prion protein in exosomes derived from ovine cerebral spinal fluid

(2008) Laura J. Vella et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Acute cellular uptake of abnormal prion protein is cell type and scrapie-strain independent

(2008) Christopher S. Greil et al.   VIROLOGY