LiverSex Computational Model: Sexual Aspects in Hepatic Metabolism and Abnormalities

Roles of G protein-coupled estrogen receptor GPER in metabolic regulation

(2018) Geetanjali Sharma et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

A framework for modelling the biomechanical behaviour of the human liver during breathing in real time using machine learning

(2017) D. Lorente et al.   EXPERT SYSTEMS WITH APPLICATIONS

Large-scale computational models of liver metabolism: How far from the clinics?

(2017) Tanja Cvitanović et al.   HEPATOLOGY

Sex differences and sex hormones in anxiety-like behavior of aging rats

(2017) Emese Domonkos et al.   HORMONES AND BEHAVIOR

Gender disparity in hepatocellular carcinoma (HCC): multiple underlying mechanisms

(2017) Bo Zheng et al.   Science China-Life Sciences

Disrupting Hepatocyte Cyp51 from Cholesterol Synthesis Leads to Progressive Liver Injury in the Developing Mouse and Decreases RORC Signalling

(2017) Žiga Urlep et al.   Scientific Reports

A “systems medicine” approach to the study of non-alcoholic fatty liver disease

(2016) Salvatore Petta et al.   DIGESTIVE AND LIVER DISEASE

Role of Dietary Fructose and Hepatic De Novo Lipogenesis in Fatty Liver Disease

(2016) Samir Softic et al.   DIGESTIVE DISEASES AND SCIENCES

Monoacylglycerol lipase promotes progression of hepatocellular carcinoma via NF-κB-mediated epithelial-mesenchymal transition

(2016) Weiping Zhu et al.   Journal of Hematology & Oncology

Bias in the reporting of sex and age in biomedical research on mouse models

(2016) Oscar Flórez-Vargas et al.   eLife

How to study the impact of sex and gender in medical research: a review of resources

(2016) Alyson J. McGregor et al.   Biology of Sex Differences

Sexual Dimorphism in Circadian Physiology Is Altered in LXRα Deficient Mice

(2016) Céline Feillet et al.   PLoS One

Correction: Chemical and Hormonal Effects on STAT5b- Dependent Sexual Dimorphism of the Liver Transcriptome

(2016) Keiyu Oshida et al.   PLoS One

From whole body to cellular models of hepatic triglyceride metabolism: man has got to know his limitations

(2015) Charlotte J. Green et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

De novolipogenesis in the liver in health and disease: more than just a shunting yard for glucose

(2015) Francis W. B. Sanders et al.   BIOLOGICAL REVIEWS

Lessons from Hepatocyte-Specific Cyp51 Knockout Mice: Impaired Cholesterol Synthesis Leads to Oval Cell-Driven Liver Injury

(2015) Gregor Lorbek et al.   Scientific Reports

Sexual Dimorphism of Adipose and Hepatic Aquaglyceroporins in Health and Metabolic Disorders

(2015) Amaia Rodríguez et al.   Frontiers in Endocrinology

The virtual liver: state of the art and future perspectives

(2014) Dirk Drasdo et al.   ARCHIVES OF TOXICOLOGY

KEGG-PATH: Kyoto encyclopedia of genes and genomes-based pathway analysis using a path analysis model

(2014) Junli Du et al.   Molecular BioSystems

Identification of anticancer drugs for hepatocellular carcinoma through personalized genome-scale metabolic modeling

(2014) R. Agren et al.   Molecular Systems Biology

Genome-scale metabolic modelling of hepatocytes reveals serine deficiency in patients with non-alcoholic fatty liver disease

(2014) Adil Mardinoglu et al.   Nature Communications

SteatoNet: The First Integrated Human Metabolic Model with Multi-layered Regulation to Investigate Liver-Associated Pathologies

(2014) Adviti Naik et al.   PLoS Computational Biology

Prevalence and Risk Factors for the Development of Nonalcoholic Fatty Liver Disease in a Nonobese Chinese Population: the Zhejiang Zhenhai Study

(2013) Chengfu Xu et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Free radical biology for medicine: learning from nonalcoholic fatty liver disease

(2013) Gaetano Serviddio et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sex Differences in the Hepatic Cholesterol Sensing Mechanisms in Mice

(2013) Gregor Lorbek et al.   MOLECULES

Sexually Dimorphic Genome-Wide Binding of Retinoid X Receptor alpha (RXRα) Determines Male-Female Differences in the Expression of Hepatic Lipid Processing Genes in Mice

(2013) Astrid Kosters et al.   PLoS One

Constraining the metabolic genotype–phenotype relationship using a phylogeny of in silico methods

(2012) Nathan E. Lewis et al.   NATURE REVIEWS MICROBIOLOGY

PGC-1α Induces Mitochondrial and Myokine Transcriptional Programs and Lipid Droplet and Glycogen Accumulation in Cultured Human Skeletal Muscle Cells

(2012) Emma Mormeneo et al.   PLoS One

Tetradian oscillation of estrogen receptor   is necessary to prevent liver lipid deposition

(2012) A. Villa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analysis of the steady-state relations and control-algorithm characterisation in a mathematical model of cholesterol biosynthesis

(2012) Aleš Belič et al.   SIMULATION MODELLING PRACTICE AND THEORY

Aging is a risk factor of nonalcoholic fatty liver disease in premenopausal women

(2012) Masahide Hamaguchi   WORLD JOURNAL OF GASTROENTEROLOGY

The virtual liver: a multidisciplinary, multilevel challenge for systems biology

(2012) Hermann-Georg Holzhütter et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Sex differences in nuclear receptor-regulated liver metabolic pathways

(2011) Gianpaolo Rando et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Young women partition fatty acids towards ketone body production rather than VLDL-TAG synthesis, compared with young men

(2011) Kyriakoula Marinou et al.   BRITISH JOURNAL OF NUTRITION

Hepatic fatty acid partitioning

(2011) Leanne Hodson et al.   CURRENT OPINION IN LIPIDOLOGY

Sensitivity analysis approaches applied to systems biology models

(2011) Z. Zi   IET Systems Biology

Sex Differences in Lipid and Lipoprotein Metabolism: It's Not Just about Sex Hormones

(2011) Xuewen Wang et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Abrogation of growth hormone secretion rescues fatty liver in mice with hepatocyte-specific deletion of JAK2

(2011) Brandon C. Sos et al.   JOURNAL OF CLINICAL INVESTIGATION

Dynamic, Sex-Differential STAT5 and BCL6 Binding to Sex-Biased, Growth Hormone-Regulated Genes in Adult Mouse Liver

(2011) Y. Zhang et al.   MOLECULAR AND CELLULAR BIOLOGY

Genome-Wide Profiling of Liver X Receptor, Retinoid X Receptor, and Peroxisome Proliferator-Activated Receptor   in Mouse Liver Reveals Extensive Sharing of Binding Sites

(2011) M. Boergesen et al.   MOLECULAR AND CELLULAR BIOLOGY

Human Fatty Liver Disease: Old Questions and New Insights

(2011) J. C. Cohen et al.   SCIENCE

Endocrine Disrupting Chemicals Targeting Estrogen Receptor Signaling: Identification and Mechanisms of Action

(2010) Erin K. Shanle et al.   CHEMICAL RESEARCH IN TOXICOLOGY

GH-Dependent STAT5 Signaling Plays an Important Role in Hepatic Lipid Metabolism

(2010) Johanna L. Barclay et al.   ENDOCRINOLOGY

Nonoxidative Free Fatty Acid Disposal Is Greater in Young Women than Men

(2010) Christina Koutsari et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Reactome: a database of reactions, pathways and biological processes

(2010) D. Croft et al.   NUCLEIC ACIDS RESEARCH

A feed-forward loop amplifies nutritional regulation of PNPLA3

(2010) Yongcheng Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Monoacylglycerol Lipase Regulates a Fatty Acid Network that Promotes Cancer Pathogenesis

(2009) Daniel K. Nomura et al.   CELL

Liver-specific Deletion of the Growth Hormone Receptor Reveals Essential Role of Growth Hormone Signaling in Hepatic Lipid Metabolism

(2009) Yong Fan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sex Differences in the Expression of Hepatic Drug Metabolizing Enzymes

(2009) D. J. Waxman et al.   MOLECULAR PHARMACOLOGY

Sensitivity analysis: from model parameters to system behaviour

(2008) Brian Ingalls   Essays in Biochemistry

Alterations in Adipose Tissue and Hepatic Lipid Kinetics in Obese Men and Women With Nonalcoholic Fatty Liver Disease

(2007) Elisa Fabbrini et al.   GASTROENTEROLOGY