The virtual liver: state of the art and future perspectives

Protocols for staining of bile canalicular and sinusoidal networks of human, mouse and pig livers, three-dimensional reconstruction and quantification of tissue microarchitecture by image processing and analysis

(2014) Seddik Hammad et al.   ARCHIVES OF TOXICOLOGY

Integrated metabolic spatial-temporal model for the prediction of ammonia detoxification during liver damage and regeneration

(2014) Freimut Schliess et al.   HEPATOLOGY

How predictive quantitative modelling of tissue organisation can inform liver disease pathogenesis

(2014) Dirk Drasdo et al.   JOURNAL OF HEPATOLOGY

A Novel Mitochondrial MAVS/Caspase-8 Platform Links RNA Virus-Induced Innate Antiviral Signaling to Bax/Bak-Independent Apoptosis

(2014) S. El Maadidi et al.   JOURNAL OF IMMUNOLOGY

Endothelial Cell-Derived Angiopoietin-2 Controls Liver Regeneration as a Spatiotemporal Rheostat

(2014) J. Hu et al.   SCIENCE

A Multi-Scale Model of Hepcidin Promoter Regulation Reveals Factors Controlling Systemic Iron Homeostasis

(2014) Guillem Casanovas et al.   PLoS Computational Biology

Spatio-Temporal Simulation of First Pass Drug Perfusion in the Liver

(2014) Lars Ole Schwen et al.   PLoS Computational Biology

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

(2013) Patricio Godoy et al.   ARCHIVES OF TOXICOLOGY

A theoretical study of lipid accumulation in the liver—implications for nonalcoholic fatty liver disease

(2013) J. Schleicher et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Apoptosis induced by the fungal pathogen gliotoxin requires a triple phosphorylation of Bim by JNK

(2013) A Geissler et al.   CELL DEATH AND DIFFERENTIATION

Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis

(2013) Bi-Sen Ding et al.   NATURE

A community-driven global reconstruction of human metabolism

(2013) Ines Thiele et al.   NATURE BIOTECHNOLOGY

ABCC11/MRP8 polymorphisms affect 5-fluorouracil-induced severe toxicity and hepatic expression

(2013) Tarek Magdy et al.   PHARMACOGENOMICS

Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation

(2013) Ulrich M. Zanger et al.   PHARMACOLOGY & THERAPEUTICS

Pharmacokinetics explain in vivo/in vitro discrepancies of carcinogen-induced gene expression alterations in rat liver and cultivated hepatocytes

(2012) Markus Schug et al.   ARCHIVES OF TOXICOLOGY

The extended TILAR approach: a novel tool for dynamic modeling of the transcription factor network regulating the adaption to in vitro cultivation of murine hepatocytes

(2012) Sebastian Vlaic et al.   BMC Systems Biology

In Vitro - In Vivo Correlation of Gene Expression Alterations Induced by Liver Carcinogens

(2012) T. Heise et al.   CURRENT MEDICINAL CHEMISTRY

An integrative model links multiple inputs and signaling pathways to the onset of DNA synthesis in hepatocytes

(2012) Jérémy Huard et al.   FEBS Journal

Kinetic Modeling of Human Hepatic Glucose Metabolism in Type 2 Diabetes Mellitus Predicts Higher Risk of Hypoglycemic Events in Rigorous Insulin Therapy

(2012) Matthias König et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rab5 is necessary for the biogenesis of the endolysosomal system in vivo

(2012) Anja Zeigerer et al.   NATURE

Choline-releasing glycerophosphodiesterase EDI3 drives tumor cell migration and metastasis

(2012) J. D. Stewart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantifying the Contribution of the Liver to Glucose Homeostasis: A Detailed Kinetic Model of Human Hepatic Glucose Metabolism

(2012) Matthias König et al.   PLoS Computational Biology

Integrating Cellular Metabolism into a Multiscale Whole-Body Model

(2012) Markus Krauss et al.   PLoS Computational Biology

A systems biology approach to dynamic modeling and inter-subject variability of statin pharmacokinetics in human hepatocytes

(2011) Joachim Bucher et al.   BMC Systems Biology

A methionine-choline-deficient diet elicits NASH in the immunodeficient mouse featuring a model for hepatic cell transplantation

(2011) Sandra Pelz et al.   EXPERIMENTAL CELL RESEARCH

Distinct Functions of the Mitogen-activated Protein Kinase-activated Protein (MAPKAP) Kinases MK2 and MK3

(2011) Christian Ehlting et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A physiologically based toxicokinetic modelling approach to predict relevant concentrations for in vitro testing

(2010) Hans Mielke et al.   ARCHIVES OF TOXICOLOGY

Transcription factors ETF, E2F, and SP-1 are involved in cytokine-independent proliferation of murine hepatocytes

(2010) Sebastian Zellmer et al.   HEPATOLOGY

HepatoNet1: a comprehensive metabolic reconstruction of the human hepatocyte for the analysis of liver physiology

(2010) Christoph Gille et al.   Molecular Systems Biology

Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration

(2010) Bi-Sen Ding et al.   NATURE

Prediction and validation of cell alignment along microvessels as order principle to restore tissue architecture in liver regeneration

(2010) S. Hoehme et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SMAD7 controls iron metabolism as a potent inhibitor of hepcidin expression

(2009) K. Mleczko-Sanecka et al.   BLOOD

A systems biological approach suggests that transcriptional feedback regulation by dual-specificity phosphatase 6 shapes extracellular signal-related kinase activity in RAS-transformed fibroblasts

(2009) Nils Blüthgen et al.   FEBS Journal

Hepatocyte-Specific Smad7 Expression Attenuates TGF-β–Mediated Fibrogenesis and Protects Against Liver Damage

(2008) Steven Dooley et al.   GASTROENTEROLOGY

Switch from type II to I Fas/CD95 death signaling on in vitro culturing of primary hepatocytes

(2008) Dorothée Walter et al.   HEPATOLOGY