SteatoNet: The First Integrated Human Metabolic Model with Multi-layered Regulation to Investigate Liver-Associated Pathologies

Genome-scale metabolic modelling of hepatocytes reveals serine deficiency in patients with non-alcoholic fatty liver disease

(2014) Adil Mardinoglu et al.   Nature Communications

Cardiovascular and Systemic Risk in Nonalcoholic Fatty Liver Disease - Atherosclerosis as a Major Player in the Natural Course of NAFLD

(2013) Amedeo Lonardo et al.   CURRENT PHARMACEUTICAL DESIGN

Genomic aspects of NAFLD pathogenesis

(2013) Adviti Naik et al.   GENOMICS

The burden of liver disease in Europe: A review of available epidemiological data

(2013) Martin Blachier et al.   JOURNAL OF HEPATOLOGY

Bridging the layers: towards integration of signal transduction, regulation and metabolism into mathematical models

(2013) Emanuel Gonçalves et al.   Molecular BioSystems

Molecular Interactions between NAFLD and Xenobiotic Metabolism

(2013) Adviti Naik et al.   Frontiers in Genetics

Adiponutrin Functions as a Nutritionally Regulated Lysophosphatidic Acid Acyltransferase

(2012) Manju Kumari et al.   Cell Metabolism

Increased Hepatic Synthesis and Dysregulation of Cholesterol Metabolism Is Associated with the Severity of Nonalcoholic Fatty Liver Disease

(2012) Hae-Ki Min et al.   Cell Metabolism

Skeletal Muscle Insulin Resistance Promotes Increased Hepatic De Novo Lipogenesis, Hyperlipidemia, and Hepatic Steatosis in the Elderly

(2012) C. Flannery et al.   DIABETES

A monocarboxylate transporter required for hepatocyte secretion of ketone bodies during fasting

(2012) S. E. Hugo et al.   GENES & DEVELOPMENT

Absence of adipose triglyceride lipase protects from hepatic endoplasmic reticulum stress in mice

(2012) Claudia D. Fuchs et al.   HEPATOLOGY

The diagnosis and management of non-alcoholic fatty liver disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association

(2012) Naga Chalasani et al.   HEPATOLOGY

Analysis of the steady-state relations and control-algorithm characterisation in a mathematical model of cholesterol biosynthesis

(2012) Aleš Belič et al.   SIMULATION MODELLING PRACTICE AND THEORY

The virtual liver: a multidisciplinary, multilevel challenge for systems biology

(2012) Hermann-Georg Holzhütter et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

The benefits of being transient: isotope-based metabolic flux analysis at the short time scale

(2011) Katharina Nöh et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Enhanced Fatty Acid Flux Triggered by Adiponectin Overexpression

(2011) Shoba Shetty et al.   ENDOCRINOLOGY

Hepatic Free Cholesterol Accumulates in Obese, Diabetic Mice and Causes Nonalcoholic Steatohepatitis

(2011) Derrick M. Van Rooyen et al.   GASTROENTEROLOGY

Peroxisome proliferator-activated receptor-α agonist, Wy 14 643, improves metabolic indices, steatosis and ballooning in diabetic mice with non-alcoholic steatohepatitis

(2011) Claire Z Larter et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits

(2011) Elizabeth K. Speliotes et al.   PLoS Genetics

Adipose Tissue Dysfunction Signals Progression of Hepatic Steatosis Towards Nonalcoholic Steatohepatitis in C57Bl/6 Mice

(2010) C. Duval et al.   DIABETES

Inhibition of Human Sterol  7-Reductase and Other Postlanosterol Enzymes by LK-980, a Novel Inhibitor of Cholesterol Synthesis

(2010) J. Acimovic et al.   DRUG METABOLISM AND DISPOSITION

Molecular therapy for obesity and diabetes based on a long-term increase in hepatic fatty-acid oxidation

(2010) Josep M. Orellana-Gavaldà et al.   HEPATOLOGY

Effects of nuclear receptor FXR on the regulation of liver lipid metabolism in patients with non-alcoholic fatty liver disease

(2010) Zhao-Xia Yang et al.   Hepatology International

The N-terminal Region of Comparative Gene Identification-58 (CGI-58) Is Important for Lipid Droplet Binding and Activation of Adipose Triglyceride Lipase

(2010) Astrid Gruber et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HepatoNet1: a comprehensive metabolic reconstruction of the human hepatocyte for the analysis of liver physiology

(2010) Christoph Gille et al.   Molecular Systems Biology

Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin

(2010) William L Holland et al.   NATURE MEDICINE

A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans

(2009) A. Kotronen et al.   DIABETOLOGIA

Biochemical and physiological function of stearoyl-CoA desaturase

(2008) Chad M. Paton et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Hepatic Stearoyl-CoA Desaturase (SCD)-1 Activity and Diacylglycerol but Not Ceramide Concentrations Are Increased in the Nonalcoholic Human Fatty Liver

(2008) A. Kotronen et al.   DIABETES

ChREBP: A Glucose-activated Transcription Factor Involved in the Development of Metabolic Syndrome

(2008) Katsumi IIZUKA et al.   ENDOCRINE JOURNAL

Changes in satiety hormones and expression of genes involved in glucose and lipid metabolism in rats weaned onto diets high in fibre or protein reflect susceptibility to increased fat mass in adulthood

(2008) Alannah D. Maurer et al.   JOURNAL OF PHYSIOLOGY-LONDON

Comparative Proteomic Phenotyping of Cell Lines and Primary Cells to Assess Preservation of Cell Type-specific Functions

(2008) Cuiping Pan et al.   MOLECULAR & CELLULAR PROTEOMICS

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

(2008) Stefano Romeo et al.   NATURE GENETICS