The Blood-Brain Barrier and the EphR/Ephrin System: Perspectives on a Link Between Neurovascular and Neuropsychiatric Disorders

Social stress induces neurovascular pathology promoting depression

(2017) Caroline Menard et al.   NATURE NEUROSCIENCE

Glial influences on BBB functions and molecular players in immune cell trafficking

(2016) Marc-André Lécuyer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Glial-endothelial crosstalk regulates blood–brain barrier function

(2016) Lara Cheslow et al.   CURRENT OPINION IN PHARMACOLOGY

Potential Pathways for CNS Drug Delivery Across the Blood-Cerebrospinal Fluid Barrier

(2016) Nathalie Strazielle et al.   CURRENT PHARMACEUTICAL DESIGN

Delayed astrocytic contact with cerebral blood vessels in FGF-2 deficient mice does not compromise permeability properties at the developing blood-brain barrier

(2016) Norman R. Saunders et al.   Developmental Neurobiology

CSF, blood-brain barrier, and brain drug delivery

(2016) William M. Pardridge   Expert Opinion on Drug Delivery

EphB2 in the Medial Prefrontal Cortex Regulates Vulnerability to Stress

(2016) Ruo-Xi Zhang et al.   NEUROPSYCHOPHARMACOLOGY

Genetic Contributions of Inflammation to Depression

(2016) Jacob Barnes et al.   NEUROPSYCHOPHARMACOLOGY

Fluoxetine Requires the Endfeet Protein Aquaporin-4 to Enhance Plasticity of Astrocyte Processes

(2016) Barbara Di Benedetto et al.   Frontiers in Cellular Neuroscience

Restraint Stress-Induced Morphological Changes at the Blood-Brain Barrier in Adult Rats

(2016) Petra Sántha et al.   Frontiers in Molecular Neuroscience

The interface of depression and cardiovascular disease: therapeutic implications

(2015) Fred Seligman et al.   Annals of the New York Academy of Sciences

Neuroimmune mechanisms of depression

(2015) Georgia E Hodes et al.   NATURE NEUROSCIENCE

Disruption in the Blood-Brain Barrier: The Missing Link between Brain and Body Inflammation in Bipolar Disorder?

(2015) Jay P. Patel et al.   NEURAL PLASTICITY

Individual Differences in the Neurobiology of Social Stress: Implications for Depression-Cardiovascular Disease Comorbidity

(2014) Susan Wood   Current Neuropharmacology

TNF-α-mediated adhesion of monocytes to endothelial cells—The role of ephrinA1

(2014) Georg Ende et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The Ephrin-A5/EphA4 Interaction Modulates Neurogenesis and Angiogenesis by the p-Akt and p-ERK Pathways in a Mouse Model of TLE

(2014) Yi Shu et al.   MOLECULAR NEUROBIOLOGY

Astrocytic modulation of blood brain barrier: perspectives on Parkinson’s disease

(2014) Ricardo Cabezas et al.   Frontiers in Cellular Neuroscience

The role of proteases in regulating Eph/ephrin signaling

(2014) Lakmali Atapattu et al.   Cell Adhesion & Migration

Regulation of signaling interactions and receptor endocytosis in growing blood vessels

(2014) Mara E Pitulescu et al.   Cell Adhesion & Migration

Protein trafficking and maturation regulate intramembrane proteolysis

(2013) Yuichi Morohashi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Ephrin-A1/EphA4-mediated adhesion of monocytes to endothelial cells

(2013) Stefanie Jellinghaus et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Glial influence on the blood brain barrier

(2013) Jorge Ivan Alvarez et al.   GLIA

P-glycoprotein ABCB1: a major player in drug handling by mammals

(2013) Piet Borst et al.   JOURNAL OF CLINICAL INVESTIGATION

Expression of Ephrin Receptors and Ligands in Postmortem Brains of HIV-Infected Subjects With and Without Cognitive Impairment

(2013) Vadim Yuferov et al.   Journal of Neuroimmune Pharmacology

TNF-α/NF-κB Signaling in the CNS: Possible Connection to EPHB2

(2013) Paul D. Pozniak et al.   Journal of Neuroimmune Pharmacology

Neuroinflammation and psychiatric illness

(2013) Souhel Najjar et al.   Journal of Neuroinflammation

Development, maintenance and disruption of the blood-brain barrier

(2013) Birgit Obermeier et al.   NATURE MEDICINE

Evidence That the EphA2 Receptor Exacerbates Ischemic Brain Injury

(2013) John Thundyil et al.   PLoS One

Eph Receptor Signaling and Ephrins

(2013) E. M. Lisabeth et al.   Cold Spring Harbor Perspectives in Biology

Coverage of Blood Vessels by Astrocytic Endfeet Is Reduced in Major Depressive Disorder

(2012) Grazyna Rajkowska et al.   BIOLOGICAL PSYCHIATRY

Ectodomain shedding and ADAMs in development

(2012) S. Weber et al.   DEVELOPMENT

Eph/ephrin signalling during development

(2012) R. Klein   DEVELOPMENT

Overview and introduction: The blood-brain barrier in health and disease

(2012) N. Joan Abbott et al.   EPILEPSIA

The Neuroprotective Functions of Transforming Growth Factor Beta Proteins

(2012) Arpád Dobolyi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Concepts and consequences of Eph receptor clustering

(2012) Peter W. Janes et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Extracellular matrix and matrix receptors in blood-brain barrier formation and stroke

(2011) Kim M. Baeten et al.   Developmental Neurobiology

Eph receptors and ephrins in neuron-astrocyte communication at synapses

(2011) Keith K. Murai et al.   GLIA

Interleukin (IL)-6, tumour necrosis factor alpha (TNF-α) and soluble interleukin-2 receptors (sIL-2R) are elevated in patients with major depressive disorder: A meta-analysis and meta-regression

(2011) Yang Liu et al.   JOURNAL OF AFFECTIVE DISORDERS

Tight junction proteins expression and modulation in immune cells and multiple sclerosis

(2011) Ilana Mandel et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Inactivation of EphA2 promotes tight junction formation and impairs angiogenesis in brain endothelial cells

(2011) Na Zhou et al.   MICROVASCULAR RESEARCH

Neuropsin cleaves EphB2 in the amygdala to control anxiety

(2011) Benjamin K. Attwood et al.   NATURE

The Hedgehog Pathway Promotes Blood-Brain Barrier Integrity and CNS Immune Quiescence

(2011) J. I. Alvarez et al.   SCIENCE

Ephs and ephrins in cancer: Ephrin-A1 signalling

(2011) Amanda Beauchamp et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

VEGF in the nervous system

(2011) Jeffrey M. Rosenstein et al.   Organogenesis

Cytokine levels in the blood may distinguish suicide attempters from depressed patients

(2010) Shorena Janelidze et al.   BRAIN BEHAVIOR AND IMMUNITY

Looking at the blood–brain barrier: Molecular anatomy and possible investigation approaches

(2010) Filipa Lourenço Cardoso et al.   BRAIN RESEARCH REVIEWS

Matrix Metalloproteinases: Regulators of the Tumor Microenvironment

(2010) Kai Kessenbrock et al.   CELL

Participation of the second extracellular loop of claudin-5 in paracellular tightening against ions, small and large molecules

(2010) Christian Piehl et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Eph/ephrin molecules--a hub for signaling and endocytosis

(2010) M. E. Pitulescu et al.   GENES & DEVELOPMENT

Ephrin-B2 regulates endothelial cell morphology and motility independently of Eph-receptor binding

(2010) M. L. Bochenek et al.   JOURNAL OF CELL SCIENCE

Active Metalloproteases of the A Disintegrin And Metalloprotease (ADAM) Family: Biological Function and Structure

(2010) Theo Klein et al.   JOURNAL OF PROTEOME RESEARCH

γ-secretases: from cell biology to therapeutic strategies

(2010) Bruno A Bergmans et al.   LANCET NEUROLOGY

Ephrin-B2 regulates VEGFR2 function in developmental and tumour angiogenesis

(2010) Suphansa Sawamiphak et al.   NATURE

Pericytes are required for blood–brain barrier integrity during embryogenesis

(2010) Richard Daneman et al.   NATURE

Restriction of Receptor Movement Alters Cellular Response: Physical Force Sensing by EphA2

(2010) K. Salaita et al.   SCIENCE

Impaired Hippocampal Neurogenesis and Vascular Formation inEphrin-A5-Deficient Mice

(2010) Yoshinobu Hara et al.   STEM CELLS

Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression

(2009) Andrew H. Miller et al.   BIOLOGICAL PSYCHIATRY

Brain angiogenesis in developmental and pathological processes: regulation, molecular and cellular communication at the neurovascular interface

(2009) Hye Shin Lee et al.   FEBS Journal

Ephrin-B3 reverse signaling through Grb4 and cytoskeletal regulators mediates axon pruning

(2009) Nan-Jie Xu et al.   NATURE NEUROSCIENCE

Endothelial EphA receptor stimulation increases lung vascular permeability

(2008) Jacqueline Larson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Eph-Ephrin Bidirectional Signaling in Physiology and Disease

(2008) Elena B. Pasquale   CELL

Functional implications for Kir4.1 channels in glial biology: from K+buffering to cell differentiation

(2008) Michelle L. Olsen et al.   JOURNAL OF NEUROCHEMISTRY

Eph, a Protein Family Coming of Age: More Confusion, Insight, or Complexity?

(2008) M. Lackmann et al.   Science Signaling

Neuroglia: the 150 years after

(2008) Helmut Kettenmann et al.   TRENDS IN NEUROSCIENCES

From inflammation to sickness and depression: when the immune system subjugates the brain

(2007) Robert Dantzer et al.   NATURE REVIEWS NEUROSCIENCE