The role of proteases in regulating Eph/ephrin signaling

Regulation of Receptor Tyrosine Kinase Ligand Processing

(2014) C. Adrain et al.   Cold Spring Harbor Perspectives in Biology

Protein trafficking and maturation regulate intramembrane proteolysis

(2013) Yuichi Morohashi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Role of the EphB2 receptor in autophagy, apoptosis and invasion in human breast cancer cells

(2013) Sahiti Chukkapalli et al.   EXPERIMENTAL CELL RESEARCH

EphA2 cleavage by MT1-MMP triggers single cancer cell invasion via homotypic cell repulsion

(2013) Nami Sugiyama et al.   JOURNAL OF CELL BIOLOGY

EphrinA/EphA-induced ectodomain shedding of neural cell adhesion molecule regulates growth cone repulsion through ADAM10 metalloprotease

(2013) Leann H. Brennaman et al.   JOURNAL OF NEUROCHEMISTRY

Membrane-Proximal Domain of a Disintegrin and Metalloprotease-17 Represents the Putative Molecular Switch of Its Shedding Activity Operated by Protein-disulfide Isomerase

(2013) Stefan Düsterhöft et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

ADAM12-cleaved ephrin-A1 contributes to lung metastasis

(2013) K Ieguchi et al.   ONCOGENE

Who decides when to cleave an ectodomain?

(2013) Monika Hartmann et al.   TRENDS IN BIOCHEMICAL SCIENCES

Involvement of the γ-Secretase-Mediated EphA4 Signaling Pathway in Synaptic Pathogenesis of Alzheimer's Disease

(2012) Chiyuki Matsui et al.   BRAIN PATHOLOGY

Alzheimer's disease, β-amyloid, glutamate, NMDA receptors and memantine - searching for the connections

(2012) Wojciech Danysz et al.   BRITISH JOURNAL OF PHARMACOLOGY

Polysialylated NCAM and EphrinA/EphA Regulate Synaptic Development of GABAergic Interneurons in Prefrontal Cortex

(2012) Leann H. Brennaman et al.   CEREBRAL CORTEX

Activity-Based Probes for the Study of Proteases: Recent Advances and Developments

(2012) Sevnur Serim et al.   ChemMedChem

Ectodomain shedding and ADAMs in development

(2012) S. Weber et al.   DEVELOPMENT

Protease signalling: the cutting edge

(2012) Boris Turk et al.   EMBO JOURNAL

Antibodies binding the ADAM10 substrate recognition domain inhibit Eph function

(2012) L. Atapattu et al.   JOURNAL OF CELL SCIENCE

EphrinA1 Is Released in Three Forms from Cancer Cells by Matrix Metalloproteases

(2012) A. Beauchamp et al.   MOLECULAR AND CELLULAR BIOLOGY

Hyperactivation of constitutively dimerized oncogenic EGF receptors by autocrine loops

(2012) J A G C Laisney et al.   ONCOGENE

Eph-dependent cell-cell adhesion and segregation in development and cancer

(2011) Eva Nievergall et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Eph receptors at synapses: Implications in neurodegenerative diseases

(2011) Yu Chen et al.   CELLULAR SIGNALLING

Translocation of the Cytoplasmic Domain of ADAM13 to the Nucleus Is Essential for Calpain8-a Expression and Cranial Neural Crest Cell Migration

(2011) Hélène Cousin et al.   DEVELOPMENTAL CELL

Mammalian EGF receptor activation by the rhomboid protease RHBDL2

(2011) Colin Adrain et al.   EMBO REPORTS

Presenilin1/γ-secretase promotes the EphB2-induced phosphorylation of ephrinB2 by regulating phosphoprotein associated with glycosphingolipid-enriched microdomains/Csk binding protein

(2011) Anastasios Georgakopoulos et al.   FASEB JOURNAL

Cleavage of Neuregulin-1 by BACE1 or ADAM10 Protein Produces Differential Effects on Myelination

(2011) Xiaoyang Luo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuropsin—A possible modulator of synaptic plasticity

(2011) Sadao Shiosaka et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Regulated intramembrane proteolysis - lessons from amyloid precursor protein processing

(2011) Stefan F. Lichtenthaler et al.   JOURNAL OF NEUROCHEMISTRY

New insights into parasite rhomboid proteases

(2011) Joana M. Santos et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

ADAM12 Produced by Tumor Cells Rather than Stromal Cells Accelerates Breast Tumor Progression

(2011) C. Frohlich et al.   MOLECULAR CANCER RESEARCH

Neuropsin cleaves EphB2 in the amygdala to control anxiety

(2011) Benjamin K. Attwood et al.   NATURE

Cleavage of E-cadherin by ADAM10 mediates epithelial cell sorting downstream of EphB signalling

(2011) Guiomar Solanas et al.   NATURE CELL BIOLOGY

Physiological functions of the amyloid precursor protein secretases ADAM10, BACE1, and Presenilin

(2011) Johannes Prox et al.   EXPERIMENTAL BRAIN RESEARCH

Thiol isomerases negatively regulate the cellular shedding activity of ADAM17

(2010) Sofie H. Willems et al.   BIOCHEMICAL JOURNAL

Structure, mechanism and inhibition of γ-secretase and presenilin-like proteases

(2010) Michael S. Wolfe   BIOLOGICAL CHEMISTRY

Matrix Metalloproteinases: Regulators of the Tumor Microenvironment

(2010) Kai Kessenbrock et al.   CELL

ADAM13 Induces Cranial Neural Crest by Cleaving Class B Ephrins and Regulating Wnt Signaling

(2010) Shuo Wei et al.   DEVELOPMENTAL CELL

ADAM10 is the physiologically relevant, constitutive α-secretase of the amyloid precursor protein in primary neurons

(2010) Peer-Hendrik Kuhn et al.   EMBO JOURNAL

The “A Disintegrin And Metalloproteases” ADAM10 and ADAM17: Novel drug targets with therapeutic potential?

(2010) Paul Saftig et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Active Metalloproteases of the A Disintegrin And Metalloprotease (ADAM) Family: Biological Function and Structure

(2010) Theo Klein et al.   JOURNAL OF PROTEOME RESEARCH

γ-secretases: from cell biology to therapeutic strategies

(2010) Bruno A Bergmans et al.   LANCET NEUROLOGY

The Transmembrane Adaptor Cbp/PAG1 Controls the Malignant Potential of Human Non-Small Cell Lung Cancers That Have c-Src Upregulation

(2010) T. Kanou et al.   MOLECULAR CANCER RESEARCH

Emerging principles in protease-based drug discovery

(2010) Marcin Drag et al.   NATURE REVIEWS DRUG DISCOVERY

Restriction of Receptor Movement Alters Cellular Response: Physical Force Sensing by EphA2

(2010) K. Salaita et al.   SCIENCE

Active-site determinants of substrate recognition by the metalloproteinases TACE and ADAM10

(2009) Cristina I. Caescu et al.   BIOCHEMICAL JOURNAL

EphA2 Reexpression Prompts Invasion of Melanoma Cells Shifting from Mesenchymal to Amoeboid-like Motility Style

(2009) M. Parri et al.   CANCER RESEARCH

Suppression of gastric cancer dissemination by ephrin-B1-derived peptide

(2009) Masamitsu Tanaka et al.   CANCER SCIENCE

ADAM19/Adamalysin 19 Structure, Function, and Role as a Putative Target in Tumors and Inflammatory Diseases

(2009) Bin Qi et al.   CURRENT PHARMACEUTICAL DESIGN

Synaptic activity prompts γ-secretase–mediated cleavage of EphA4 and dendritic spine formation

(2009) Eiji Inoue et al.   JOURNAL OF CELL BIOLOGY

Regulation of Mature ADAM17 by Redox Agents for L-Selectin Shedding

(2009) Y. Wang et al.   JOURNAL OF IMMUNOLOGY

Cytoplasmic Relaxation of Active Eph Controls Ephrin Shedding by ADAM10

(2009) Peter W. Janes et al.   PLOS BIOLOGY

ADAM proteases: ligand processing and modulation of the Notch pathway

(2008) A. Zolkiewska   CELLULAR AND MOLECULAR LIFE SCIENCES

Ephrin-B2-induced Cleavage of EphB2 Receptor Is Mediated by Matrix Metalloproteinases to Trigger Cell Repulsion

(2008) Kai-Ti Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteases: Multifunctional Enzymes in Life and Disease

(2008) Carlos López-Otín et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extracellular Cleavage of Cadherin-11 by ADAM Metalloproteases Is Essential for Xenopus Cranial Neural Crest Cell Migration

(2008) Catherine McCusker et al.   MOLECULAR BIOLOGY OF THE CELL

The many facets of Notch ligands

(2008) B D'Souza et al.   ONCOGENE

Meltrin β/ADAM19 Interacting with EphA4 in Developing Neural Cells Participates in Formation of the Neuromuscular Junction

(2008) Norihiro Yumoto et al.   PLoS One

The good, the bad and the ugly substrates for ADAM10 and ADAM17 in brain pathology, inflammation and cancer

(2008) Jessica Pruessmeyer et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The “A Disintegrin And Metalloprotease” (ADAM) family of sheddases: Physiological and cellular functions

(2008) Karina Reiss et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Clipping, shedding and RIPping keep immunity on cue

(2008) Gillian Murphy et al.   TRENDS IN IMMUNOLOGY