Neferine ameliorates cardiomyoblast apoptosis induced by doxorubicin: possible role in modulating NADPH oxidase/ROS-mediated NFκB redox signaling cascade

Neferine prevents NF-κB translocation and protects muscle cells from oxidative stress and apoptosis induced by hypoxia

(2016) Rathinasamy Baskaran et al.   BIOFACTORS

Jujuboside A Protects H9C2 Cells from Isoproterenol-Induced Injury via Activating PI3K/Akt/mTOR Signaling Pathway

(2016) Dandan Han et al.   Evidence-based Complementary and Alternative Medicine

Redox signaling in the cardiomyocyte: From physiology to failure

(2016) Celio X.C. Santos et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Neferine inhibits proliferation and collagen synthesis induced by high glucose in cardiac fibroblasts and reduces cardiac fibrosis in diabetic mice

(2016) Xue Liu et al.   Oncotarget

Maternal inflammation activated ROS-p38 MAPK predisposes offspring to heart damages caused by isoproterenol via augmenting ROS generation

(2016) Qi Zhang et al.   Scientific Reports

NOX2 amplifies acetaldehyde-mediated cardiomyocyte mitochondrial dysfunction in alcoholic cardiomyopathy

(2016) Moritz Brandt et al.   Scientific Reports

Reactive oxygen species, nutrition, hypoxia and diseases: Problems solved?

(2015) Agnes Görlach et al.   Redox Biology

Resveratrol decreases fructose-induced oxidative stress, mediated by NADPH oxidase via an AMPK-dependent mechanism

(2014) Pei-Wen Cheng et al.   BRITISH JOURNAL OF PHARMACOLOGY

Quercetin attenuates doxorubicin cardiotoxicity by modulating Bmi-1 expression

(2014) Qinghua Dong et al.   BRITISH JOURNAL OF PHARMACOLOGY

Loss of NOX2 (gp91phox) prevents oxidative stress and progression to advanced heart failure

(2014) Nirmal Parajuli et al.   CLINICAL SCIENCE

Doxorubicin induced apoptosis was potentiated by neferine in human lung adenocarcima, A549 cells

(2014) Paramasivan Poornima et al.   FOOD AND CHEMICAL TOXICOLOGY

Role of mitochondrial oxidative stress in hypertension

(2013) Sergey I. Dikalov et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Nox2-Induced Production of Mitochondrial Superoxide in Angiotensin II-Mediated Endothelial Oxidative Stress and Hypertension

(2013) Sergey I. Dikalov et al.   ANTIOXIDANTS & REDOX SIGNALING

Neferine, an alkaloid from lotus seed embryo, inhibits human lung cancer cell growth by MAPK activation and cell cycle arrest

(2013) Paramasivan Poornima et al.   BIOFACTORS

Neferine exerts its antithrombotic effect by inhibiting platelet aggregation and promoting dissociation of platelet aggregates

(2013) Ya-Jun Zhou et al.   THROMBOSIS RESEARCH

NADPH Oxidases in Heart Failure: Poachers or Gamekeepers?

(2012) Min Zhang et al.   ANTIOXIDANTS & REDOX SIGNALING

Protective Effect of Neferine Against Isoproterenol-Induced Cardiac Toxicity

(2012) Gurusamy Lalitha et al.   Cardiovascular Toxicology

Comparative Effects of Liensinine and Neferine on the Human Ether-a-go-go-related Gene Potassium Channel and Pharmacological Activity Analysis

(2012) Zeng-Xiang Dong et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Doxorubicin-induced cardiomyopathy: From molecular mechanisms to therapeutic strategies

(2012) Yanti Octavia et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Cardiomyocyte-specific I B kinase (IKK)/NF- B activation induces reversible inflammatory cardiomyopathy and heart failure

(2012) H. J. Maier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Taurine suppresses doxorubicin-triggered oxidative stress and cardiac apoptosis in rat via up-regulation of PI3-K/Akt and inhibition of p53, p38-JNK

(2011) Joydeep Das et al.   BIOCHEMICAL PHARMACOLOGY

Cross talk between mitochondria and NADPH oxidases

(2011) Sergey Dikalov   FREE RADICAL BIOLOGY AND MEDICINE

In search of new therapeutic targets and strategies for heart failure: recent advances in basic science

(2011) Ajay M Shah et al.   LANCET

Oxidation of CaMKII determines the cardiotoxic effects of aldosterone

(2011) B Julie He et al.   NATURE MEDICINE

NADPH Oxidase-Mediated Redox Signaling: Roles in Cellular Stress Response, Stress Tolerance, and Tissue Repair

(2011) F. Jiang et al.   PHARMACOLOGICAL REVIEWS

Anti-amnesic activity of neferine with antioxidant and anti-inflammatory capacities, as well as inhibition of ChEs and BACE1

(2010) Hyun Ah Jung et al.   LIFE SCIENCES

NADPH oxidases participate to doxorubicin-induced cardiac myocyte apoptosis

(2009) Mylène Gilleron et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Early alterations in heart gene expression profiles associated with doxorubicin cardiotoxicity in rats

(2009) Karol L. Thompson et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Neferine, a bisbenzylisoquinline alkaloid attenuates bleomycin-induced pulmonary fibrosis

(2009) Libo Zhao et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Neferine enhances insulin sensitivity in insulin resistant rats

(2009) Yang Pan et al.   JOURNAL OF ETHNOPHARMACOLOGY

Compartmentalization of Redox Signaling Through NADPH Oxidase–Derived ROS

(2008) Masuko Ushio-Fukai   ANTIOXIDANTS & REDOX SIGNALING

Ginkgo biloba extract 761 reduces doxorubicin-induced apoptotic damage in rat hearts and neonatal cardiomyocytes

(2008) T.-J. Liu et al.   CARDIOVASCULAR RESEARCH

Morphological alterations induced by doxorubicin on H9c2 myoblasts: nuclear, mitochondrial, and cytoskeletal targets

(2008) Vilma A. Sardão et al.   CELL BIOLOGY AND TOXICOLOGY

NF-κB dictates the degradation pathway of IκBα

(2008) Erika Mathes et al.   EMBO JOURNAL

Toll-like receptor-4 deficiency attenuates doxorubicin-induced cardiomyopathy in mice

(2008) Alexander Riad et al.   EUROPEAN JOURNAL OF HEART FAILURE

Involvement of Nox2 NADPH Oxidase in Adverse Cardiac Remodeling After Myocardial Infarction

(2008) Yee H. Looi et al.   HYPERTENSION