HIV Persistence in Adipose Tissue Reservoirs

Metabolically active CD4+ T cells expressing Glut1 and OX40 preferentially harbor HIV during in vitro infection

(2017) Clovis S. Palmer et al.   FEBS LETTERS

Adipose Type One Innate Lymphoid Cells Regulate Macrophage Homeostasis through Targeted Cytotoxicity

(2017) Selma Boulenouar et al.   IMMUNITY

Adipose Tissue is Enriched for Activated and Late-differentiated CD8+ T cells, and Shows Distinct CD8+ Receptor Usage, Compared to Blood in HIV-infected Persons

(2017) John R. Koethe et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Exosomes from uninfected cells activate transcription of latent HIV-1.

(2017) Robert A. Barclay et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adipose tissue B2 cells promote insulin resistance through leukotriene LTB4/LTB4R1 signaling

(2017) Wei Ying et al.   JOURNAL OF CLINICAL INVESTIGATION

CD4+ Cell infiltration into subcutaneous adipose tissue is not indicative of productively infected cells during acute SHIV infection

(2017) Denise C. Hsu et al.   JOURNAL OF MEDICAL PRIMATOLOGY

Adipocytes Sequester and Metabolize the Chemotherapeutic Daunorubicin

(2017) Xia Sheng et al.   MOLECULAR CANCER RESEARCH

Metabolic regulation of inflammation

(2017) Timo Gaber et al.   Nature Reviews Rheumatology

Assessment of metabolic and mitochondrial dynamics in CD4+ and CD8+ T cells in virologically suppressed HIV-positive individuals on combination antiretroviral therapy

(2017) Jesse J. R. Masson et al.   PLoS One

Extracellular Vesicles: Novel Mediators of Cell Communication In Metabolic Disease

(2017) Isabel Huang-Doran et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Adipocyte–Tumor Cell Metabolic Crosstalk in Breast Cancer

(2017) Andrew J. Hoy et al.   TRENDS IN MOLECULAR MEDICINE

Adipose Tissue: A Safe Haven for Parasites?

(2017) Herbert B. Tanowitz et al.   TRENDS IN PARASITOLOGY

Adipocyte adaptive immunity mediates diet-induced adipose inflammation and insulin resistance by decreasing adipose Treg cells

(2017) Tuo Deng et al.   Nature Communications

Type-2 innate lymphoid cells control the development of atherosclerosis in mice

(2017) Stephen A. Newland et al.   Nature Communications

Effects of exosome on the activation of CD4+ T cells in rhesus macaques: a potential application for HIV latency reactivation

(2017) Xiaowu Hong et al.   Scientific Reports

Compartment-specific distribution of human intestinal innate lymphoid cells is altered in HIV patients under effective therapy

(2017) Benjamin Krämer et al.   PLoS Pathogens

Mycobacterium tuberculosis infection modulates adipose tissue biology

(2017) Macarena Beigier-Bompadre et al.   PLoS Pathogens

Adipose Tissue Inflammation Induces B Cell Inflammation and Decreases B Cell Function in Aging

(2017) Daniela Frasca et al.   Frontiers in Immunology

Sugar or Fat?—Metabolic Requirements for Immunity to Viral Infections

(2017) Hesham M. Shehata et al.   Frontiers in Immunology

HIV-1 viral protein R (Vpr) induces fatty liver in mice via LXRα and PPARα dysregulation: implications for HIV-specific pathogenesis of NAFLD

(2017) Neeti Agarwal et al.   Scientific Reports

Obesity, Inflammation, and Cancer

(2016) Tuo Deng et al.   Annual Review of Pathology-Mechanisms of Disease

Adipocyte Exosomes Promote Melanoma Aggressiveness through Fatty Acid Oxidation: A Novel Mechanism Linking Obesity and Cancer

(2016) Ikrame Lazar et al.   CANCER RESEARCH

The mTOR Complex Controls HIV Latency

(2016) Emilie Besnard et al.   Cell Host & Microbe

Physiological and pathological impact of exosomes of adipose tissue

(2016) Yan Zhang et al.   CELL PROLIFERATION

CCR7 Maintains Nonresolving Lymph Node and Adipose Inflammation in Obesity

(2016) Jason Hellmann et al.   DIABETES

Innate Lymphoid Cells Are Depleted Irreversibly during Acute HIV-1 Infection in the Absence of Viral Suppression

(2016) Henrik N. Kløverpris et al.   IMMUNITY

Adipose-Resident Group 1 Innate Lymphoid Cells Promote Obesity-Associated Insulin Resistance

(2016) Timothy E. O’Sullivan et al.   IMMUNITY

Dendritic cells and adipose tissue

(2016) Sandeep Sundara Rajan et al.   IMMUNOLOGY

CCR1 antagonism attenuates T cell trafficking to omentum and liver in obesity-associated cancer

(2016) Melissa J Conroy et al.   IMMUNOLOGY AND CELL BIOLOGY

Obesity accelerates T cell senescence in murine visceral adipose tissue

(2016) Kohsuke Shirakawa et al.   JOURNAL OF CLINICAL INVESTIGATION

Adipose Tissue Dendritic Cells Are Independent Contributors to Obesity-Induced Inflammation and Insulin Resistance

(2016) Kae Won Cho et al.   JOURNAL OF IMMUNOLOGY

CD25+FoxP3+Memory CD4 T Cells Are Frequent Targets of HIV InfectionIn Vivo

(2016) Mkunde Chachage et al.   JOURNAL OF VIROLOGY

Infectious SIV resides in adipose tissue and induces metabolic defects in chronically infected rhesus macaques

(2016) Jacob Couturier et al.   Retrovirology

Fatty acid metabolic reprogramming via mTOR-mediated inductions of PPARγ directs early activation of T cells

(2016) Mulki Angela et al.   Nature Communications

Adipocytes cause leukemia cell resistance to daunorubicin via oxidative stress response

(2016) Xia Sheng et al.   Oncotarget

Glucose Metabolism in T Cells and Monocytes: New Perspectives in HIV Pathogenesis

(2016) Clovis S. Palmer et al.   EBioMedicine

HIV-1 Vpr reactivates latent HIV-1 provirus by inducing depletion of class I HDACs on chromatin

(2016) Bizhan Romani et al.   Scientific Reports

Human adipose tissue as a reservoir for memory CD4+ T cells and HIV

(2015) Jacob Couturier et al.   AIDS

Limited Ability of Posaconazole To Cure both Acute and Chronic Trypanosoma cruzi Infections Revealed by Highly SensitiveIn VivoImaging

(2015) Amanda Fortes Francisco et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Interaction between human mature adipocytes and lymphocytes induces T-cell proliferation

(2015) Antonella Poloni et al.   CYTOTHERAPY

The Cellular and Molecular Basis of Translational Immunometabolism

(2015) Giuseppe Danilo Norata et al.   IMMUNITY

Large adipocytes function as antigen-presenting cells to activate CD4+ T cells via upregulating MHCII in obesity

(2015) L Xiao et al.   INTERNATIONAL JOURNAL OF OBESITY

T cell metabolism drives immunity

(2015) Michael D. Buck et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Latent HIV-1 is activated by exosomes from cells infected with either replication-competent or defective HIV-1

(2015) Claudia Arenaccio et al.   Retrovirology

Adipose Tissue Is a Neglected Viral Reservoir and an Inflammatory Site during Chronic HIV and SIV Infection

(2015) Abderaouf Damouche et al.   PLoS Pathogens

Glucose Metabolism Regulates T Cell Activation, Differentiation, and Functions

(2015) Clovis S. Palmer et al.   Frontiers in Immunology

Human cytomegalovirus infection of human adipose-derived stromal/stem cells restricts differentiation along the adipogenic lineage

(2015) K. J. Zwezdaryk et al.   Adipocyte

CXCR3 Controls T-Cell Accumulation in Fat Inflammation

(2014) V. Z. Rocha et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Adipose tissue-resident regulatory T cells: phenotypic specialization, functions and therapeutic potential

(2014) Daniela Cipolletta   IMMUNOLOGY

Mycobacterium tuberculosis persistence in various adipose depots of infected mice and the effect of anti-tubercular therapy

(2014) Pooja Agarwal et al.   MICROBES AND INFECTION

Persistent HIV-1 replication is associated with lower antiretroviral drug concentrations in lymphatic tissues

(2014) Courtney V. Fletcher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV-1 pathogenicity and virion production are dependent on the metabolic phenotype of activated CD4+ T cells

(2014) Andrea Hegedus et al.   Retrovirology

An MHC II-Dependent Activation Loop between Adipose Tissue Macrophages and CD4+ T Cells Controls Obesity-Induced Inflammation

(2014) Kae Won Cho et al.   Cell Reports

Hypercytotoxicity and Rapid Loss of NKp44+ Innate Lymphoid Cells during Acute SIV Infection

(2014) Haiying Li et al.   PLoS Pathogens

Bacterial Translocation – Impact on the Adipocyte Compartment

(2014) Tassilo Kruis et al.   Frontiers in Immunology

Increased glucose metabolic activity is associated with CD4+ T-cell activation and depletion during chronic HIV infection

(2013) Clovis S. Palmer et al.   AIDS

Immunological Goings-on in Visceral Adipose Tissue

(2013) Diane Mathis   Cell Metabolism

Adipose Natural Regulatory B Cells Negatively Control Adipose Tissue Inflammation

(2013) Satoshi Nishimura et al.   Cell Metabolism

Class II Major Histocompatibility Complex Plays an Essential Role in Obesity-Induced Adipose Inflammation

(2013) Tuo Deng et al.   Cell Metabolism

Adipose Tissue Macrophages Function As Antigen-Presenting Cells and Regulate Adipose Tissue CD4 + T Cells in Mice

(2013) David L. Morris et al.   DIABETES

Adipocyte-derived lipids modulate CD4+T-cell function

(2013) Andreea Ioan-Facsinay et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Role of HIV and Monocytes/Macrophages in Adipose Tissue Biology

(2013) Cecilia M. Shikuma et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Adipose Tissue and Immune Function: A Review of Evidence Relevant to HIV Infection

(2013) John R. Koethe et al.   JOURNAL OF INFECTIOUS DISEASES

CXCR3 modulates obesity-induced visceral adipose inflammation and systemic insulin resistance

(2013) Jeffrey A. Deiuliis et al.   Obesity

Differences in Visceral Fat and Fat Bacterial Colonization between Ulcerative Colitis and Crohn’s Disease. An In Vivo and In Vitro Study

(2013) Alessandra Zulian et al.   PLoS One

Mesenchymal stem cell derived hematopoietic cells are permissive to HIV-1 infection

(2013) Timo Z Nazari-Shafti et al.   Retrovirology

HIV-1 Vpr Induces Adipose Dysfunction in Vivo Through Reciprocal Effects on PPAR/GR Co-Regulation

(2013) N. Agarwal et al.   Science Translational Medicine

CD4+FOXP3+ Regulatory T-Cell Subsets in Human Immunodeficiency Virus Infection

(2013) Federico Simonetta et al.   Frontiers in Immunology

Localization of breast cancer resistance protein (Bcrp) in endocrine organs and inhibition of its transport activity by steroid hormones

(2012) Anita C. A. Dankers et al.   CELL AND TISSUE RESEARCH

The multidrug resistance protein breast cancer resistance protein (BCRP) protects adipose-derived stem cells against ischemic damage

(2012) A. van Dijk et al.   CELL BIOLOGY AND TOXICOLOGY

CCR5 Plays a Critical Role in Obesity-Induced Adipose Tissue Inflammation and Insulin Resistance by Regulating Both Macrophage Recruitment and M1/M2 Status

(2012) H. Kitade et al.   DIABETES

Identification of Adipose Tissue Dendritic Cells Correlated With Obesity-Associated Insulin-Resistance and Inducing Th17 Responses in Mice and Patients

(2012) A. Bertola et al.   DIABETES

Long-Term Changes in Adiposity and Glycemic Control Are Associated With Past Adenovirus Infection

(2012) W.-Y. Lin et al.   DIABETES CARE

Mast Cells in Human Adipose Tissue: Link with Morbid Obesity, Inflammatory Status, and Diabetes

(2012) Adeline Divoux et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase

(2012) Saswata Talukdar et al.   NATURE MEDICINE

Adipose tissue-resident immune cells: key players in immunometabolism

(2012) Henk S. Schipper et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

HIV-1 Tat protein impairs adipogenesis and induces the expression and secretion of proinflammatory cytokines in human SGBS adipocytes

(2011) Julieta Díaz-Delfín et al.   ANTIVIRAL THERAPY

Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment

(2011) Jacques Amar et al.   EMBO Molecular Medicine

Intracellular Survival ofStaphylococcus aureusin Adipocyte-Like Differentiated 3T3-L1 Cells Is Glucose Dependent and Alters Cytokine, Chemokine, and Adipokine Secretion

(2011) Frank Hanses et al.   ENDOCRINOLOGY

Nef Inhibits Glucose Uptake in Adipocytes and Contributes to Insulin Resistance in Human Immunodeficiency Virus Type I Infection

(2011) Laura Cheney et al.   JOURNAL OF INFECTIOUS DISEASES

Visceral Adipose Inflammation in Obesity Is Associated with Critical Alterations in Tregulatory Cell Numbers

(2011) Jeffrey Deiuliis et al.   PLoS One

Eosinophils Sustain Adipose Alternatively Activated Macrophages Associated with Glucose Homeostasis

(2011) D. Wu et al.   SCIENCE

Obesity Increases the Production of Proinflammatory Mediators from Adipose Tissue T Cells and Compromises TCR Repertoire Diversity: Implications for Systemic Inflammation and Insulin Resistance

(2010) H. Yang et al.   JOURNAL OF IMMUNOLOGY

Circulating Nef Induces Dyslipidemia in Simian Immunodeficiency Virus–Infected Macaques by Suppressing Cholesterol Efflux

(2010) Bela F. Asztalos et al.   JOURNAL OF INFECTIOUS DISEASES

Adipose Tissue Serves as a Reservoir for Recrudescent Rickettsia prowazekii Infection in a Mouse Model

(2010) Yassina Bechah et al.   PLoS One

Sequestration and Tissue Accumulation of Human Malaria Parasites: Can We Learn Anything from Rodent Models of Malaria?

(2010) Blandine Franke-Fayard et al.   PLoS Pathogens

Interplay Between Human Adipocytes and T Lymphocytes in Obesity

(2009) Carine Duffaut et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The accumulation and metabolism of zidovudine in 3T3-F442A pre-adipocytes

(2009) Omar Janneh et al.   BRITISH JOURNAL OF PHARMACOLOGY

Intracellular Infections Enhance Interleukin-6 and Plasminogen Activator Inhibitor 1 Production by Cocultivated Human Adipocytes and THP-1 Monocytes

(2009) J. J. M. Bouwman et al.   Clinical and Vaccine Immunology

Gene Expression and Immunohistochemistry in Adipose Tissue of HIV Type 1–Infected Patients with Nucleoside Analogue Reverse‐Transcriptase Inhibitor–Associated Lipoatrophy

(2009) M. Sievers et al.   JOURNAL OF INFECTIOUS DISEASES

Metabolically Favorable Remodeling of Human Adipose Tissue by Human Adenovirus Type 36

(2008) P. M. Rogers et al.   DIABETES

HIV Replication Enhances Production of Free Fatty Acids, Low Density Lipoproteins and Many Key Proteins Involved in Lipid Metabolism: A Proteomics Study

(2008) Suraiya Rasheed et al.   PLoS One

Human Immunodeficiency Virus (HIV)-1 Viral Protein R Suppresses Transcriptional Activity of Peroxisome Proliferator-Activated Receptor γ and Inhibits Adipocyte Differentiation: Implications for HIV-Associated Lipodystrophy

(2007) Shashi Shrivastav et al.   MOLECULAR ENDOCRINOLOGY