Review: Abnormal B Cell Development in Systemic Lupus Erythematosus: What the Genetics Tell Us

Abnormal hematopoiesis and autoimmunity in human subjects with germline IKZF1 mutations

(2017) Akihiro Hoshino et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Aiolos Overexpression in Systemic Lupus Erythematosus B Cell Subtypes and BAFF-Induced Memory B Cell Differentiation Are Reduced by CC-220 Modulation of Cereblon Activity

(2017) Yumi Nakayama et al.   JOURNAL OF IMMUNOLOGY

Lyn and Fyn function as molecular switches that control immunoreceptors to direct homeostasis or inflammation

(2017) Sanae Ben Mkaddem et al.   Nature Communications

The BANK1 SLE-risk variants are associated with alterations in peripheral B cell signaling and development in humans

(2016) Elizabeth M. Dam et al.   CLINICAL IMMUNOLOGY

The SLE variant Ala71Thr of BLK severely decreases protein abundance and binding to BANK1 through impairment of the SH3 domain function

(2016) A Díaz-Barreiro et al.   GENES AND IMMUNITY

Protein tyrosine phosphatase PTPN22 has dual roles in promoting pathogen versus homeostatic-driven CD8 T-cell responses

(2016) Tatiana Jofra et al.   IMMUNOLOGY AND CELL BIOLOGY

The genetic basis of systemic lupus erythematosus: What are the risk factors and what have we learned

(2016) Maria Teruel et al.   JOURNAL OF AUTOIMMUNITY

B-cell subsets, signaling and their roles in secretion of autoantibodies

(2016) S Iwata et al.   LUPUS

Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus

(2016) David L Morris et al.   NATURE GENETICS

Systemic lupus erythematosus

(2016) Arvind Kaul et al.   Nature Reviews Disease Primers

Lupus Risk Variant Increases pSTAT1 Binding and Decreases ETS1 Expression

(2015) Xiaoming Lu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

UBE2L3 Polymorphism Amplifies NF-κB Activation and Promotes Plasma Cell Development, Linking Linear Ubiquitination to Multiple Autoimmune Diseases

(2015) Myles J. Lewis et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Requirement for Transcription FactorEts1in B Cell Tolerance to Self-Antigens

(2015) Lisa Russell et al.   JOURNAL OF IMMUNOLOGY

Autoimmune Disease-Associated Haplotypes ofBLKExhibit Lowered Thresholds for B Cell Activation and Expansion of Ig Class-Switched B Cells

(2015) Kim R. Simpfendorfer et al.   Arthritis & Rheumatology

Defects in Germinal Center Selection in SLE

(2015) Megan Woods et al.   Frontiers in Immunology

T/B-cell interactions are more transient in response to weak stimuli in SLE-prone mice

(2014) Parisa Sinai et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

MHC associations with clinical and autoantibody manifestations in European SLE

(2014) D L Morris et al.   GENES AND IMMUNITY

Bone marrow analysis of immune cells and apoptosis in patients with systemic lupus erythematosus

(2014) JW Park et al.   LUPUS

Single nucleotide polymorphisms in genes encoding toll-like receptors 7, 8 and 9 in Danish patients with systemic lupus erythematosus

(2014) C. Enevold et al.   MOLECULAR BIOLOGY REPORTS

Genetic and epigenetic fine mapping of causal autoimmune disease variants

(2014) Kyle Kai-How Farh et al.   NATURE

Stage-specific control of early B cell development by the transcription factor Ikaros

(2014) Tanja A Schwickert et al.   NATURE IMMUNOLOGY

Autoantibodies from long-lived ‘memory’ plasma cells of NZB/W mice drive immune complex nephritis

(2013) Qingyu Cheng et al.   ANNALS OF THE RHEUMATIC DISEASES

Aberrant B Cell Selection and Activation in Systemic Lupus Erythematosus

(2013) Laurens P. Kil et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Neutrophil-Mediated IFN Activation in the Bone Marrow Alters B Cell Development in Human and Murine Systemic Lupus Erythematosus

(2013) A. Palanichamy et al.   JOURNAL OF IMMUNOLOGY

The Genotype-Tissue Expression (GTEx) project

(2013) John Lonsdale et al.   NATURE GENETICS

Systematic identification of trans eQTLs as putative drivers of known disease associations

(2013) Harm-Jan Westra et al.   NATURE GENETICS

The establishment of early B cell tolerance in humans: lessons from primary immunodeficiency diseases

(2012) Eric Meffre   Annals of the New York Academy of Sciences

CSK regulatory polymorphism is associated with systemic lupus erythematosus and influences B-cell signaling and activation

(2012) Nataly Manjarrez-Orduño et al.   NATURE GENETICS

Chromatin marks identify critical cell types for fine mapping complex trait variants

(2012) Gosia Trynka et al.   NATURE GENETICS

Plasma cells in systemic lupus erythematosus: The long and short of it all

(2011) Zheng Liu et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The dual effect of the lupus-associated polymorphism rs10516487 on BANK1 gene expression and protein localization

(2011) S V Kozyrev et al.   GENES AND IMMUNITY

The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humans

(2011) Laurence Menard et al.   JOURNAL OF CLINICAL INVESTIGATION

The role of defective clearance of apoptotic cells in systemic autoimmunity

(2010) Luis E. Muñoz et al.   Nature Reviews Rheumatology

Genetic associations of LYN with systemic lupus erythematosus

(2009) R Lu et al.   GENES AND IMMUNITY

Cutting Edge: The PTPN22 Allelic Variant Associated with Autoimmunity Impairs B Cell Signaling

(2009) A. F. Arechiga et al.   JOURNAL OF IMMUNOLOGY

Activated memory B cell subsets correlate with disease activity in systemic lupus erythematosus: Delineation by expression of CD27, IgD, and CD95

(2008) Annett M. Jacobi et al.   ARTHRITIS AND RHEUMATISM

Cytokine-producing B lymphocytes—key regulators of immunity

(2008) Frances E Lund   CURRENT OPINION IN IMMUNOLOGY

IRAK-4- and MyD88-Dependent Pathways Are Essential for the Removal of Developing Autoreactive B Cells in Humans

(2008) Isabelle Isnardi et al.   IMMUNITY

Association of the co-stimulator OX40L with systemic lupus erythematosus

(2008) Harinder Manku et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Unknown

(2008) Jie Zhang et al.   MOLECULAR MEDICINE

Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci

(2008) John B Harley et al.   NATURE GENETICS

Regulation of B cell fate commitment and immunoglobulin heavy-chain gene rearrangements by Ikaros

(2008) Damien Reynaud et al.   NATURE IMMUNOLOGY

The genetics of SLE: an update in the light of genome-wide association studies

(2008) B. Rhodes et al.   RHEUMATOLOGY