Protein tyrosine phosphatase PTPN22 has dual roles in promoting pathogen versus homeostatic-driven CD8 T-cell responses

PTPN22 controls virally-induced autoimmune diabetes by modulating cytotoxic T lymphocyte responses in an epitope-specific manner

(2015) Georgia Fousteri et al.   CLINICAL IMMUNOLOGY

Autoimmunity-associated protein tyrosine phosphatase PEP negatively regulates IFN-α receptor signaling

(2015) Derek A. Holmes et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Role ofPTPN22Risk Variant in the Development of Autoimmunity: Finding Common Ground between Mouse and Human

(2015) David J. Rawlings et al.   JOURNAL OF IMMUNOLOGY

The protein tyrosine phosphatase PTPN22 controls forkhead box protein 3 T regulatory cell induction but is dispensable for T helper type 1 cell polarization

(2014) G. Fousteri et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

STAT1 Signaling in CD8 T Cells Is Required for Their Clonal Expansion and Memory Formation Following Viral Infection In Vivo

(2014) M. Quigley et al.   JOURNAL OF IMMUNOLOGY

The tyrosine phosphatase PTPN22 discriminates weak self peptides from strong agonist TCR signals

(2014) Robert J Salmond et al.   NATURE IMMUNOLOGY

PTPN22: the archetypal non-HLA autoimmunity gene

(2014) Stephanie M. Stanford et al.   Nature Reviews Rheumatology

Roles of the protein tyrosine phosphatase PTPN22 in immunity and autoimmunity

(2013) Georgia Fousteri et al.   CLINICAL IMMUNOLOGY

The Autoimmunity-Associated Gene PTPN22 Potentiates Toll-like Receptor-Driven, Type 1 Interferon-Dependent Immunity

(2013) Yaya Wang et al.   IMMUNITY

A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models

(2013) Xuezhi Dai et al.   JOURNAL OF CLINICAL INVESTIGATION

CD8 T Cell Memory to a Viral Pathogen Requires Trans Cosignaling between HVEM and BTLA

(2013) Rachel Flynn et al.   PLoS One

Enforced IL-10 Expression Confers Type 1 Regulatory T Cell (Tr1) Phenotype and Function to Human CD4+ T Cells

(2012) Grazia Andolfi et al.   MOLECULAR THERAPY

The autoimmune disease–associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness

(2011) Jinyi Zhang et al.   NATURE GENETICS