Autoimmune Disease-Associated Haplotypes ofBLKExhibit Lowered Thresholds for B Cell Activation and Expansion of Ig Class-Switched B Cells

Two Functional Lupus-Associated BLK Promoter Variants Control Cell-Type- and Developmental-Stage-Specific Transcription

(2014) Joel M. Guthridge et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Reduced B Lymphoid Kinase (Blk) Expression Enhances Proinflammatory Cytokine Production and Induces Nephrosis in C57BL/6-lpr/lpr Mice

(2014) Elizabeth M. Samuelson et al.   PLoS One

Tyrosine Phosphatase PTPN22: Multifunctional Regulator of Immune Signaling, Development, and Disease

(2013) Nunzio Bottini et al.   Annual Review of Immunology

Genome-Wide Association Study of Dermatomyositis Reveals Genetic Overlap With Other Autoimmune Disorders

(2013) Frederick W. Miller et al.   ARTHRITIS AND RHEUMATISM

Genetics of rheumatoid arthritis contributes to biology and drug discovery

(2013) Yukinori Okada et al.   NATURE

Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome

(2013) Christopher J Lessard et al.   NATURE GENETICS

Fine mapping and conditional analysis identify a new mutation in the autoimmunity susceptibility gene BLK that leads to reduced half-life of the BLK protein

(2012) Angélica M Delgado-Vega et al.   ANNALS OF THE RHEUMATIC DISEASES

Intravenous golimumab is effective in patients with active rheumatoid arthritis despite methotrexate therapy with responses as early as week 2: results of the phase 3, randomised, multicentre, double-blind, placebo-controlled GO-FURTHER trial

(2012) Michael E Weinblatt et al.   ANNALS OF THE RHEUMATIC DISEASES

The autoimmunity-associated BLK haplotype exhibits cis-regulatory effects on mRNA and protein expression that are prominently observed in B cells early in development

(2012) Kim R. Simpfendorfer et al.   HUMAN MOLECULAR GENETICS

CSK regulatory polymorphism is associated with systemic lupus erythematosus and influences B-cell signaling and activation

(2012) Nataly Manjarrez-Orduño et al.   NATURE GENETICS

Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis

(2012) Yi-Ching Lee et al.   NATURE GENETICS

Transcription factor and chromatin features predict genes associated with eQTLs

(2012) Dennis Wang et al.   NUCLEIC ACIDS RESEARCH

ENCODE Data in the UCSC Genome Browser: year 5 update

(2012) Kate R. Rosenbloom et al.   NUCLEIC ACIDS RESEARCH

Genome-wide association study of rheumatoid arthritis in Koreans: Population-specific loci as well as overlap with European susceptibility loci

(2011) Jan Freudenberg et al.   ARTHRITIS AND RHEUMATISM

Blk haploinsufficiency impairs the development, but enhances the functional responses, of MZ B cells

(2011) Elizabeth M Samuelson et al.   IMMUNOLOGY AND CELL BIOLOGY

The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humans

(2011) Laurence Menard et al.   JOURNAL OF CLINICAL INVESTIGATION

Altered B Cell Homeostasis Is Associated with Type I Diabetes and Carriers of the PTPN22 Allelic Variant

(2011) T. Habib et al.   JOURNAL OF IMMUNOLOGY

A linear complexity phasing method for thousands of genomes

(2011) Olivier Delaneau et al.   NATURE METHODS

The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

(2010) A. McKenna et al.   GENOME RESEARCH

Association ofSTAT4andBLK, but notBANK1orIRF5, with primary antiphospholipid syndrome

(2009) Hong Yin et al.   ARTHRITIS AND RHEUMATISM

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS

Fast and accurate short read alignment with Burrows-Wheeler transform

(2009) H. Li et al.   BIOINFORMATICS

Association of the C8orf13-BLK region with systemic sclerosis in North-American and European populations

(2009) Pravitt Gourh et al.   JOURNAL OF AUTOIMMUNITY

REL, encoding a member of the NF-κB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis

(2009) Peter K Gregersen et al.   NATURE GENETICS

Global patterns of cis variation in human cells revealed by high-density allelic expression analysis

(2009) Bing Ge et al.   NATURE GENETICS

Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus

(2009) Jian-Wen Han et al.   NATURE GENETICS

Immunoglobulin D enhances immune surveillance by activating antimicrobial, proinflammatory and B cell–stimulating programs in basophils

(2009) Kang Chen et al.   NATURE IMMUNOLOGY

Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus

(2008) Robert R Graham et al.   NATURE GENETICS

Association of Systemic Lupus Erythematosus withC8orf13–BLKandITGAM–ITGAX

(2008) Geoffrey Hom et al.   NEW ENGLAND JOURNAL OF MEDICINE

Efficient generation of monoclonal antibodies from single human B cells by single cell RT-PCR and expression vector cloning

(2007) Thomas Tiller et al.   JOURNAL OF IMMUNOLOGICAL METHODS