The SLE variant Ala71Thr of BLK severely decreases protein abundance and binding to BANK1 through impairment of the SH3 domain function

Concordance of Increased B1 Cell Subset and Lupus Phenotypes in Mice and Humans Is Dependent on BLK Expression Levels

(2015) Ying-Yu Wu et al.   JOURNAL OF IMMUNOLOGY

The Phyre2 web portal for protein modeling, prediction and analysis

(2015) Lawrence A Kelley et al.   Nature Protocols

Dysfunctional BLK in common variable immunodeficiency perturbs B-cell proliferation and ability to elicit antigen-specific CD4+ T-cell help

(2015) Ewoud B. Compeer et al.   Oncotarget

Autoimmune Disease-Associated Haplotypes ofBLKExhibit Lowered Thresholds for B Cell Activation and Expansion of Ig Class-Switched B Cells

(2015) Kim R. Simpfendorfer et al.   Arthritis & Rheumatology

Two Functional Lupus-Associated BLK Promoter Variants Control Cell-Type- and Developmental-Stage-Specific Transcription

(2014) Joel M. Guthridge et al.   AMERICAN JOURNAL OF HUMAN GENETICS

CD22 and Siglec-G regulate inhibition of B-cell signaling by sialic acid ligand binding and control B-cell tolerance

(2014) L. Nitschke   GLYCOBIOLOGY

Genome-Wide Association Study of Dermatomyositis Reveals Genetic Overlap With Other Autoimmune Disorders

(2013) Frederick W. Miller et al.   ARTHRITIS AND RHEUMATISM

The epidermal Integrin beta-1 and p75NTR positive cells proliferating and migrating during wound healing produce various growth factors, while the expression of p75NTR is decreased in patients with chronic skin ulcers

(2013) Yohei Iwata et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Genetics of rheumatoid arthritis contributes to biology and drug discovery

(2013) Yukinori Okada et al.   NATURE

BANK1 and BLK Act through Phospholipase C Gamma 2 in B-Cell Signaling

(2013) Manuel Bernal-Quirós et al.   PLoS One

Epistatic Interaction between BANK1 and BLK in Rheumatoid Arthritis: Results from a Large Trans-Ethnic Meta-Analysis

(2013) Emmanuelle Génin et al.   PLoS One

Fine mapping and conditional analysis identify a new mutation in the autoimmunity susceptibility gene BLK that leads to reduced half-life of the BLK protein

(2012) Angélica M Delgado-Vega et al.   ANNALS OF THE RHEUMATIC DISEASES

SH3 domain ligand binding: What's the consensus and where's the specificity?

(2012) Kalle Saksela et al.   FEBS LETTERS

The autoimmunity-associated BLK haplotype exhibits cis-regulatory effects on mRNA and protein expression that are prominently observed in B cells early in development

(2012) Kim R. Simpfendorfer et al.   HUMAN MOLECULAR GENETICS

Regulation of the Src Family Kinases by Csk

(2012) Masato Okada   International Journal of Biological Sciences

A genome-wide association study identifies three new risk loci for Kawasaki disease

(2012) Yoshihiro Onouchi et al.   NATURE GENETICS

Lck, Membrane Microdomains, and TCR Triggering Machinery: Defining the New Rules of Engagement

(2012) Dominik Filipp et al.   Frontiers in Immunology

Genetic and physical interaction of the B-cell systemic lupus erythematosus-associated genesBANK1andBLK

(2011) Casimiro Castillejo-López et al.   ANNALS OF THE RHEUMATIC DISEASES

Genome-wide association study of rheumatoid arthritis in Koreans: Population-specific loci as well as overlap with European susceptibility loci

(2011) Jan Freudenberg et al.   ARTHRITIS AND RHEUMATISM

Blk haploinsufficiency impairs the development, but enhances the functional responses, of MZ B cells

(2011) Elizabeth M Samuelson et al.   IMMUNOLOGY AND CELL BIOLOGY

Evaluation of 19 Autoimmune Disease-associated Loci with Rheumatoid Arthritis in a Colombian Population: Evidence for Replication and Gene-Gene Interaction

(2011) H. A. DESHMUKH et al.   JOURNAL OF RHEUMATOLOGY

Association of EBF1, FAM167A(C8orf13)-BLK and TNFSF4 gene variants with primary Sjögren's syndrome

(2010) G Nordmark et al.   GENES AND IMMUNITY

Crystal Structure of the Src Family Kinase Hck SH3-SH2 Linker Regulatory Region Supports an SH3-dominant Activation Mechanism

(2010) John J. Alvarado et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Lyn kinase C-lobe mediates Golgi export of Lyn through conformation-dependent ACSL3 association

(2010) Y. Obata et al.   JOURNAL OF CELL SCIENCE

BANK1 functional variants are associated with susceptibility to diffuse systemic sclerosis in Caucasians

(2009) B. Rueda et al.   ANNALS OF THE RHEUMATIC DISEASES

Requirement of the SH4 and tyrosine-kinase domains but not the kinase activity of Lyn for its biosynthetic targeting to caveolin-positive Golgi membranes

(2009) Kikuko Ikeda et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Tyrosine kinases and their substrates in B lymphocytes

(2009) Tomohiro Kurosaki et al.   IMMUNOLOGICAL REVIEWS

Association of the C8orf13-BLK region with systemic sclerosis in North-American and European populations

(2009) Pravitt Gourh et al.   JOURNAL OF AUTOIMMUNITY

Differential trafficking of Src, Lyn, Yes and Fyn is specified by the state of palmitoylation in the SH4 domain

(2009) I. Sato et al.   JOURNAL OF CELL SCIENCE

REL, encoding a member of the NF-κB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis

(2009) Peter K Gregersen et al.   NATURE GENETICS

A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus

(2009) Vesela Gateva et al.   NATURE GENETICS

Global patterns of cis variation in human cells revealed by high-density allelic expression analysis

(2009) Bing Ge et al.   NATURE GENETICS

Conserved principles of mammalian transcriptional regulation revealed by RNA half-life

(2009) Caroline C. Friedel et al.   NUCLEIC ACIDS RESEARCH

Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus

(2008) Sergey V Kozyrev et al.   NATURE GENETICS

Association of Systemic Lupus Erythematosus withC8orf13–BLKandITGAM–ITGAX

(2008) Geoffrey Hom et al.   NEW ENGLAND JOURNAL OF MEDICINE