Big-data and machine learning to revamp computational toxicology and its use in risk assessment

The Threshold of Toxicological Concern for prenatal developmental toxicity in rats and rabbits

(2017) B. van Ravenzwaay et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Green Toxicology—Know Early About and Avoid Toxic Product Liabilities

(2017) Alexandra Maertens et al.   TOXICOLOGICAL SCIENCES

Opinion versus evidence for the need to move away from animal testing

(2017) Thomas Hartung   ALTEX-Alternatives to Animal Experimentation

The need for strategic development of safety sciences

(2017) Francois Busquet   ALTEX-Alternatives to Animal Experimentation

Computational approaches to chemical hazard assessment

(2017) Thomas Luechtefeld   ALTEX-Alternatives to Animal Experimentation

Thresholds of Toxicological Concern – Setting a threshold for testing below which there is little concern

(2017) Thomas Hartung   ALTEX-Alternatives to Animal Experimentation

Green Toxicology: a strategy for sustainable chemical and material development

(2017) Sarah E. Crawford et al.   Environmental Sciences Europe

ToxCast Chemical Landscape: Paving the Road to 21st Century Toxicology

(2016) Ann M. Richard et al.   CHEMICAL RESEARCH IN TOXICOLOGY

What determines skin sensitization potency: Myths, maybes and realities. The 500 molecular weight cut-off: An updated analysis

(2016) Jeremy M. Fitzpatrick et al.   JOURNAL OF APPLIED TOXICOLOGY

Systematically evaluating read-across prediction and performance using a local validity approach characterized by chemical structure and bioactivity information

(2016) Imran Shah et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

A crystal ball for chemical safety

(2016) T. Rabesandratana   SCIENCE

The Emergence of Systematic Review in Toxicology

(2016) Martin L. Stephens et al.   TOXICOLOGICAL SCIENCES

Making big sense from big data in toxicology by read-across

(2016) Thomas Hartung   ALTEX-Alternatives to Animal Experimentation

Toward Good Read-Across Practice (GRAP) guidance

(2016) Nicholas Ball   ALTEX-Alternatives to Animal Experimentation

Supporting read-across using biological data

(2016) Hao Zhu   ALTEX-Alternatives to Animal Experimentation

Re-evaluation of animal numbers and costs for in vivo tests to accomplish REACH legislation requirements for chemicals - a report by the Transatlantic Think Tank for Toxicology (t4)

(2016) Costanza Rovida   ALTEX-Alternatives to Animal Experimentation

Food for thought … on in silico methods in toxicology

(2016) Thomas Hartung   ALTEX-Alternatives to Animal Experimentation

Food for thought … on alternative methods for chemical safety testing

(2016) Thomas Hartung   ALTEX-Alternatives to Animal Experimentation

Evidence-based toxicology – the toolbox of validation for the 21st century?

(2016) Thomas Hartung   ALTEX-Alternatives to Animal Experimentation

Regulating Chemicals: Law, Science, and the Unbearable Burdens of Regulation

(2015) Ellen K. Silbergeld et al.   Annual Review of Public Health

Bayesian integrated testing strategy (ITS) for skin sensitization potency assessment: a decision support system for quantitative weight of evidence and adaptive testing strategy

(2015) Joanna S. Jaworska et al.   ARCHIVES OF TOXICOLOGY

Chemical Safety Assessment Using Read-Across: Assessing the Use of Novel Testing Methods to Strengthen the Evidence Base for Decision Making

(2015) Elisabet Berggren et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Probabilistic hazard assessment for skin sensitization potency by dose-response modeling using feature elimination instead of quantitative structure-activity relationships

(2015) Thomas Luechtefeld et al.   JOURNAL OF APPLIED TOXICOLOGY

Toxicity testing in the 21st century beyond environmental chemicals

(2015) Costanza Rovida   ALTEX-Alternatives to Animal Experimentation

From “weight of evidence” to quantitative data integration using multicriteria decision analysis and Bayesian methods

(2015) Igor Linkov   ALTEX-Alternatives to Animal Experimentation

Big Data in Chemical Toxicity Research: The Use of High-Throughput Screening Assays To Identify Potential Toxicants

(2014) Hao Zhu et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Profiling Animal Toxicants by Automatically Mining Public Bioassay Data: A Big Data Approach for Computational Toxicology

(2014) Jun Zhang et al.   PLoS One

Applying Adverse Outcome Pathways (AOPs) to support Integrated Approaches to Testing and Assessment (IATA)

(2014) Knut Erik Tollefsen et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

The added value of the 90-day repeated dose oral toxicity test for industrial chemicals with a low (sub)acute toxicity profile in a high quality dataset

(2014) Katy Taylor et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Look back in anger – what clinical studies tell us about preclinical work

(2014) Thomas Hartung   ALTEX-Alternatives to Animal Experimentation

Food for Thought … Mechanistic Validation

(2014) Thomas Hartung   ALTEX-Alternatives to Animal Experimentation

Integrated testing strategies for safety assessments

(2014) Thomas Hartung   ALTEX-Alternatives to Animal Experimentation

Read-across approaches - misconceptions, promises and challenges ahead

(2014) Grace Patlewicz   ALTEX-Alternatives to Animal Experimentation

Green Toxicology

(2014) Alexandra Maertens   ALTEX-Alternatives to Animal Experimentation

Retrospective analysis of the Draize test for serious eye damage/eye irritation: importance of understanding the in vivo endpoints under UN GHS/EU CLP for the development and evaluation of in vitro test methods

(2013) Els Adriaens et al.   ARCHIVES OF TOXICOLOGY

Validation and quality control of replacement alternatives – current status and future challenges

(2012) Marcel Leist et al.   Toxicology Research

Best Practices for QSAR Model Development, Validation, and Exploitation

(2010) Alexander Tropsha   Molecular Informatics

Chemical regulators have overreached

(2009) Thomas Hartung et al.   NATURE

ECVAM’s ongoing activities in the area of acute oral toxicity

(2009) Agnieszka Kinsner-Ovaskainen et al.   TOXICOLOGY IN VITRO

Fast unfolding of communities in large networks

(2008) Vincent D Blondel et al.   JOURNAL OF STATISTICAL MECHANICS-THEORY AND EXPERIMENT

Estimation of acute oral toxicity using the No Observed Adverse Effect Level (NOAEL) from the 28 day repeated dose toxicity studies in rats

(2008) Anna Bulgheroni et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY