Green Toxicology: a strategy for sustainable chemical and material development

A multi-laboratory evaluation of microelectrode array-based measurements of neural network activity for acute neurotoxicity testing

(2017) Andrea Vassallo et al.   NEUROTOXICOLOGY

Case studies putting the decision-making framework for the grouping and testing of nanomaterials (DF4nanoGrouping) into practice

(2016) Josje H.E. Arts et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Intra- and inter-laboratory reproducibility and accuracy of the LuSens assay: A reporter gene-cell line to detect keratinocyte activation by skin sensitizers

(2016) Tzutzuy Ramirez et al.   TOXICOLOGY IN VITRO

Making big sense from big data in toxicology by read-across

(2016) Thomas Hartung   ALTEX-Alternatives to Animal Experimentation

Re-evaluation of animal numbers and costs for in vivo tests to accomplish REACH legislation requirements for chemicals - a report by the Transatlantic Think Tank for Toxicology (t4)

(2016) Costanza Rovida   ALTEX-Alternatives to Animal Experimentation

Food for thought … on in silico methods in toxicology

(2016) Thomas Hartung   ALTEX-Alternatives to Animal Experimentation

Food for thought … on alternative methods for nanoparticle safety testing

(2016) Thomas Hartung   ALTEX-Alternatives to Animal Experimentation

Sameness: The regulatory crux with nanomaterial identity and grouping schemes for hazard assessment

(2015) Tobias Walser et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

A decision-making framework for the grouping and testing of nanomaterials (DF4nanoGrouping)

(2015) Josje H.E. Arts et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Assessing skin sensitization hazard in mice and men using non-animal test methods

(2015) Daniel Urbisch et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Use of the ES-D3 cell differentiation assay, combined with the BeWo transport model, to predict relative in vivo developmental toxicity of antifungal compounds

(2015) Hequn Li et al.   TOXICOLOGY IN VITRO

Toxicity testing in the 21st century beyond environmental chemicals

(2015) Costanza Rovida   ALTEX-Alternatives to Animal Experimentation

Grouping and Read-Across Approaches for Risk Assessment of Nanomaterials

(2015) Agnes Oomen et al.   International Journal of Environmental Research and Public Health

Using physiologically-based pharmacokinetic-guided “body-on-a-chip” systems to predict mammalian response to drug and chemical exposure

(2014) Jong Hwan Sung et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

A strategy for grouping of nanomaterials based on key physico-chemical descriptors as a basis for safer-by-design NMs

(2014) Iseult Lynch et al.   Nano Today

ITS-NANO - Prioritising nanosafety research to develop a stakeholder driven intelligent testing strategy

(2014) Vicki Stone et al.   Particle and Fibre Toxicology

Applying Adverse Outcome Pathways (AOPs) to support Integrated Approaches to Testing and Assessment (IATA)

(2014) Knut Erik Tollefsen et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Adverse Outcome Pathway (AOP) Development I: Strategies and Principles

(2014) Daniel L. Villeneuve et al.   TOXICOLOGICAL SCIENCES

LuSens: A keratinocyte based ARE reporter gene assay for use in integrated testing strategies for skin sensitization hazard identification

(2014) Tzutzuy Ramirez et al.   TOXICOLOGY IN VITRO

Read-across approaches - misconceptions, promises and challenges ahead

(2014) Grace Patlewicz   ALTEX-Alternatives to Animal Experimentation

Pathways of Toxicity

(2014) Andre Kleensang et al.   ALTEX-Alternatives to Animal Experimentation

NeuroChip: A Microfluidic Electrophysiological Device for Genetic and Chemical Biology Screening of Caenorhabditis elegans Adult and Larvae

(2013) Chunxiao Hu et al.   PLoS One

Erratum to “Applicability of in vitro tests for skin irritation and corrosion to regulatory classification schemes: Substantiating test strategies with data from routine studies” [Regul. Toxicol. Pharmacol. (2012) 402–414]

(2013) Susanne N. Kolle et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Glucose conjugation for the specific targeting and treatment of cancer

(2013) Emilia C. Calvaresi et al.   Chemical Science

Non-animal test methods for predicting skin sensitization potentials

(2012) Annette Mehling et al.   ARCHIVES OF TOXICOLOGY

Glufosfamide: can we improve the process of anticancer agent development?

(2012) Denis Lacombe   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Length-dependent pleural inflammation and parietal pleural responses after deposition of carbon nanotubes in the pulmonary airspaces of mice

(2012) Fiona A. Murphy et al.   Nanotoxicology

Autophagy and lysosomal dysfunction as emerging mechanisms of nanomaterial toxicity

(2012) Stephan T Stern et al.   Particle and Fibre Toxicology

A testing strategy for the identification of mammalian, systemic endocrine disruptors with particular focus on steroids

(2012) Susanne N. Kolle et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Green Chemistry and Green Engineering: A Framework for Sustainable Technology Development

(2011) Martin J. Mulvihill et al.   Annual Review of Environment and Resources

The validated embryonic stem cell test to predict embryotoxicity in vitro

(2011) Andrea E M Seiler et al.   Nature Protocols

Zebrafish (Danio rerio) embryos as a model for testing proteratogens

(2011) Stefan Weigt et al.   TOXICOLOGY

Linking energy metabolism to dysfunctions in mitochondrial respiration – A metabolomics in vitro approach

(2011) G.U. Balcke et al.   TOXICOLOGY LETTERS

From 3D cell culture to organs-on-chips

(2011) Dongeun Huh et al.   TRENDS IN CELL BIOLOGY

Alternative in vitro assays in nanomaterial toxicology

(2011) Thomas Hartung et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Incorporation of in silico biodegradability screening in early drug development—a feasible approach?

(2010) Thomas Steger-Hartmann et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Adverse outcome pathways and ecological risk assessment: Bridging to population-level effects

(2010) Vincent J. Kramer et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment

(2010) Gerald T. Ankley et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Carbon nanotubes degraded by neutrophil myeloperoxidase induce less pulmonary inflammation

(2010) Valerian E. Kagan et al.   Nature Nanotechnology

The intra- and inter-laboratory reproducibility and predictivity of the KeratinoSens assay to predict skin sensitizers in vitro: Results of a ring-study in five laboratories

(2010) Natsch Andreas et al.   TOXICOLOGY IN VITRO

Green Chemistry: Principles and Practice

(2009) Paul Anastas et al.   CHEMICAL SOCIETY REVIEWS

Toxicology for the twenty-first century

(2009) Thomas Hartung   NATURE

Chemical regulators have overreached

(2009) Thomas Hartung et al.   NATURE

Alternative methods to safety studies in experimental animals: role in the risk assessment of chemicals under the new European Chemicals Legislation (REACH)

(2008) W. Lilienblum et al.   ARCHIVES OF TOXICOLOGY

The 24 Principles of Green Engineering and Green Chemistry: “IMPROVEMENTS PRODUCTIVELY”

(2008) Samantha Y. Tang et al.   GREEN CHEMISTRY

Biodegradation of Single-Walled Carbon Nanotubes through Enzymatic Catalysis

(2008) Brett L. Allen et al.   NANO LETTERS

Biodegradable polymers for food packaging: a review

(2008) Valentina Siracusa et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY