Validation and quality control of replacement alternatives – current status and future challenges

The dawning of a new age of toxicology

(2016) Marcel Leist   ALTEX-Alternatives to Animal Experimentation

Food for thought ... on animal tests

(2016) Thomas Hartung   ALTEX-Alternatives to Animal Experimentation

The biological and ethical basis of the use of human embryonic stem cells for in vitro test systems or cell therapy

(2016) Marcel Leist   ALTEX-Alternatives to Animal Experimentation

Quantitation of angiogenesis and antiangiogenesis in vivo, ex vivo and in vitro – an overview

(2016) Mahtab Bahramsoltani   ALTEX-Alternatives to Animal Experimentation

Food for thought … on evidence-based toxicology

(2016) Thomas Hartung   ALTEX-Alternatives to Animal Experimentation

Political incentives towards replacing animal testing in nanotechnology

(2016) Ursula Sauer   ALTEX-Alternatives to Animal Experimentation

Animal and non-animal experiments in nanotechnology – the results of a critical literature survey

(2016) Ursula Sauer   ALTEX-Alternatives to Animal Experimentation

Food for thought ... considerations and guidelines for basic test method descriptions in toxicology

(2016) Marcel Leist   ALTEX-Alternatives to Animal Experimentation

Integrated Testing Strategy (ITS) – Opportunities to better use existing data and guide future testing in toxicology

(2016) Joanna Jaworska   ALTEX-Alternatives to Animal Experimentation

Serum-free cell culture: the serum-free media interactive online database

(2016) Daniel Brunner   ALTEX-Alternatives to Animal Experimentation

Food for thought … on alternative methods for chemical safety testing

(2016) Thomas Hartung   ALTEX-Alternatives to Animal Experimentation

The Center for Alternatives to Animal Testing – Europe (CAAT-EU): a transatlantic bridge for the paradigm shift in toxicology

(2016) Mardas Daneshian   ALTEX-Alternatives to Animal Experimentation

Comparative analysis of the revised Directive 2010/63/EU for the protection of laboratory animals with its predecessor 86/609/EEC – a t4 report

(2016) Thomas Hartung   ALTEX-Alternatives to Animal Experimentation

A mechanistic redefinition of adverse effects – a key step in the toxicity testing paradigm shift

(2016) Kim Boekelheide   ALTEX-Alternatives to Animal Experimentation

Food for thought … on alternative methods for nanoparticle safety testing

(2016) Thomas Hartung   ALTEX-Alternatives to Animal Experimentation

First alternative method validated by a retrospective weight-of-evidence approach to replace the Draize eye test for the identification of non-irritant substances for a defined applicability domain

(2016) Thomas Hartung   ALTEX-Alternatives to Animal Experimentation

Food for thought … why no new in vitro tests will be done for REACH by registrants

(2016) Costanza Rovida   ALTEX-Alternatives to Animal Experimentation

The botulinum neurotoxin LD50 test - problems and solutions

(2016) Silke Bitz   ALTEX-Alternatives to Animal Experimentation

Courage for simplification and imperfection in the 21st century assessment of “Endocrine disruption”

(2016) Daniel Dietrich   ALTEX-Alternatives to Animal Experimentation

Non-invasive genotyping of transgenic mice: comparison of different commercial kits and required amounts

(2016) Melanie Hamann   ALTEX-Alternatives to Animal Experimentation

Evidence-based toxicology – the toolbox of validation for the 21st century?

(2016) Thomas Hartung   ALTEX-Alternatives to Animal Experimentation

Developmental neurotoxicity testing: recommendations for developing alternative methods for the screening and prioritization of chemicals

(2014) Kevin Crofton   ALTEX-Alternatives to Animal Experimentation

An expert consortium review of the EC-commissioned report “Alternative (Non-Animal) Methods for Cosmetics Testing: Current Status and Future Prospects – 2010”

(2014) Thomas Hartung   ALTEX-Alternatives to Animal Experimentation

Local Lymph Node Assay: how testing laboratories apply OECD TG 429 for REACH purposes

(2014) Costanza Rovida   ALTEX-Alternatives to Animal Experimentation

On mapping the human toxome

(2014) Thomas Hartung   ALTEX-Alternatives to Animal Experimentation

Monocyte Activation Test (MAT) reliably detects pyrogens in parenteral formulations of human serum albumin

(2014) Rolando Perdomo-Morales   ALTEX-Alternatives to Animal Experimentation

How are reproductive toxicity and developmental toxicity addressed in REACH dossiers?

(2014) Costanza Rovida   ALTEX-Alternatives to Animal Experimentation

Can case study approaches speed implementation of the NRC report: “Toxicity Testing in the 21st Century: A Vision and a Strategy?”

(2014) Melvin Andersen   ALTEX-Alternatives to Animal Experimentation

Formation of mechanistic categories and local models to facilitate the prediction of toxicity

(2014) Mark Cronin   ALTEX-Alternatives to Animal Experimentation

ECVAM prevalidation of three cell transformation assays

(2014) Philippe Vanparys   ALTEX-Alternatives to Animal Experimentation

Skin sensitisation: the Colipa strategy for developing and evaluating non-animal test methods for risk assessment

(2014) Gavin Maxwell   ALTEX-Alternatives to Animal Experimentation

A critique of the EC’s expert (draft) reports on the status of alternatives for cosmetics testing to meet the 2013 deadline

(2014) Katy Taylor   ALTEX-Alternatives to Animal Experimentation

A framework program for the teaching of alternative methods (replacement, reduction, refinement) to animal experimentation

(2014) Mardas Daneshian   ALTEX-Alternatives to Animal Experimentation

Alternatives to the use of fetal bovine serum: human platelet lysates as a serum substitute in cell culture media

(2014) Caroline Rauch   ALTEX-Alternatives to Animal Experimentation

Integrating non-animal test information into an adaptive testing strategy – skin sensitization proof of concept case

(2014) Joanna Jaworska   ALTEX-Alternatives to Animal Experimentation

Nanotoxicology: “the end of the beginning” – Signs on the roadmap to a strategy for assuring the safe application and use of nanomaterials

(2014) Ellen Silbergeld   ALTEX-Alternatives to Animal Experimentation

Critical evaluation of the use of dogs in biomedical research and testing in Europe

(2014) Nina Hasiwa   ALTEX-Alternatives to Animal Experimentation

The automated FADU-assay, a potential high-throughput in vitro method for early screening of DNA breakage

(2014) María Moreno-Villanueva   ALTEX-Alternatives to Animal Experimentation

...on validation. A puzzle or a mystery: an approach founded on new science

(2014) Neil Wilcox   ALTEX-Alternatives to Animal Experimentation

Assessment of stress in laboratory beagle dogs constrained by a Pavlov sling

(2014) Jenny Stracke   ALTEX-Alternatives to Animal Experimentation

Current standing and future prospects for the technologies proposed to transform toxicity testing in the 21st century

(2014) Erwin van Vliet   ALTEX-Alternatives to Animal Experimentation

Examining the regulatory value of multi-route mammalian acute systemic toxicity studies

(2014) Troy Seidle   ALTEX-Alternatives to Animal Experimentation

A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing

(2014) David Basketter   ALTEX-Alternatives to Animal Experimentation

Compound selection for in vitro modeling of developmental neurotoxicity

(2012) Suzanne Kadereit   Frontiers in Bioscience-Landmark

Highlight report: towards the replacement of in vivo repeated dose systemic toxicity testing

(2011) Jan G. Hengstler et al.   ARCHIVES OF TOXICOLOGY

Alternative (non-animal) methods for cosmetics testing: current status and future prospects—2010

(2011) Sarah Adler et al.   ARCHIVES OF TOXICOLOGY

The Incorporation of Lysine into the Peroxidase Peptide Reactivity Assay for Skin Sensitization Assessments

(2011) John A. Troutman et al.   TOXICOLOGICAL SCIENCES

Sensitivity of Dopaminergic Neuron Differentiation from Stem Cells to Chronic Low-Dose Methylmercury Exposure

(2011) Bastian Zimmer et al.   TOXICOLOGICAL SCIENCES

Assessment of Chemical-Induced Impairment of Human Neurite Outgrowth by Multiparametric Live Cell Imaging in High-Density Cultures

(2011) Nina V. Stiegler et al.   TOXICOLOGICAL SCIENCES

Prenatal Organochlorine Exposure and Behaviors Associated With Attention Deficit Hyperactivity Disorder in School-Aged Children

(2010) S. K. Sagiv et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Coordinated waves of gene expression during neuronal differentiation of embryonic stem cells as basis for novel approaches to developmental neurotoxicity testing

(2010) B Zimmer et al.   CELL DEATH AND DIFFERENTIATION

Increased Risk of ADHD Associated With Early Exposure to Pesticides, PCBs

(2010) Bridget M. Kuehn   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Locomotor activity in zebrafish embryos: A new method to assess developmental neurotoxicity

(2010) Ingrid W.T. Selderslaghs et al.   NEUROTOXICOLOGY AND TERATOLOGY

Optimization of chemically defined cell culture media – Replacing fetal bovine serum in mammalian in vitro methods

(2010) J. van der Valk et al.   TOXICOLOGY IN VITRO

In vitro developmental neurotoxicity (DNT) testing: Relevant models and endpoints

(2009) Anna K. Bal-Price et al.   NEUROTOXICOLOGY

Development of a screening assay to identify teratogenic and embryotoxic chemicals using the zebrafish embryo

(2009) Ingrid W.T. Selderslaghs et al.   REPRODUCTIVE TOXICOLOGY

A proposed eye irritation testing strategy to reduce and replace in vivo studies using Bottom–Up and Top–Down approaches

(2009) Laurie Scott et al.   TOXICOLOGY IN VITRO

A Retrospective Performance Assessment of the Developmental Neurotoxicity Study in Support of OECD Test Guideline 426

(2008) Susan L. Makris et al.   ENVIRONMENTAL HEALTH PERSPECTIVES