Mendelian randomization in multiple sclerosis: A causal role for vitamin D and obesity?

Evidence for a causal relationship between low vitamin D, high BMI, and pediatric-onset MS

(2017) Milena A. Gianfrancesco et al.   NEUROLOGY

Effect of a single dose of the interleukin-6 receptor antagonist tocilizumab on inflammation and troponin T release in patients with non-ST-elevation myocardial infarction: a double-blind, randomized, placebo-controlled phase 2 trial

(2016) Ola Kleveland et al.   EUROPEAN HEART JOURNAL

Trends in Obesity Among Adults in the United States, 2005 to 2014

(2016) Katherine M. Flegal et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Interactions between genetic, lifestyle and environmental risk factors for multiple sclerosis

(2016) Tomas Olsson et al.   Nature Reviews Neurology

Neonatal vitamin D status and risk of multiple sclerosis

(2016) Nete Munk Nielsen et al.   NEUROLOGY

Obesity and Multiple Sclerosis: A Mendelian Randomization Study

(2016) Lauren E. Mokry et al.   PLOS MEDICINE

Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index

(2015) Janine F. Felix et al.   HUMAN MOLECULAR GENETICS

Mendelian randomization: where are we now and where are we going?

(2015) S. Burgess et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression

(2015) J. Bowden et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Mendelian Randomization - the Key to Understanding Aspects of Parkinson's Disease Causation?

(2015) Alastair J. Noyce et al.   MOVEMENT DISORDERS

Body mass index during adolescence, rather than childhood, is critical in determining MS risk

(2015) AK Hedström et al.   Multiple Sclerosis Journal

Population attributable fractions and joint effects of key risk factors for multiple sclerosis

(2015) IAF van der Mei et al.   Multiple Sclerosis Journal

Genetic studies of body mass index yield new insights for obesity biology

(2015) Adam E. Locke et al.   NATURE

Vitamin D and Risk of Multiple Sclerosis: A Mendelian Randomization Study

(2015) Lauren E. Mokry et al.   PLOS MEDICINE

Body mass index during adolescence, rather than childhood, is critical in determining MS risk

(2015) AK Hedström et al.   Multiple Sclerosis Journal

Population attributable fractions and joint effects of key risk factors for multiple sclerosis

(2015) IAF van der Mei et al.   Multiple Sclerosis Journal

Mendelian randomization: genetic anchors for causal inference in epidemiological studies

(2014) G. Davey Smith et al.   HUMAN MOLECULAR GENETICS

Mendelian randomisation applied to drug development in cardiovascular disease: a review

(2014) Lauren E Mokry et al.   JOURNAL OF MEDICAL GENETICS

Interaction between adolescent obesity and HLA risk genes in the etiology of multiple sclerosis

(2014) A. K. Hedstrom et al.   NEUROLOGY

Early-life hygiene-related factors affect risk of central nervous system demyelination and asthma differentially

(2013) A.-M. Hughes et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Lack of adiponectin leads to increased lymphocyte activation and increased disease severity in a mouse model of multiple sclerosis

(2013) Laura Piccio et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Reproduction and the risk of multiple sclerosis

(2013) Melinda Magyari et al.   Multiple Sclerosis Journal

Reverse causality behind the association between reproductive history and MS

(2013) AK Hedström et al.   Multiple Sclerosis Journal

Childhood body mass index and multiple sclerosis risk: a long-term cohort study

(2013) Kassandra L Munger et al.   Multiple Sclerosis Journal

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

(2013) Ashley H Beecham et al.   NATURE GENETICS

Childhood obesity and risk of pediatric multiple sclerosis and clinically isolated syndrome

(2013) J. Pakpoor et al.   NEUROLOGY

Childhood obesity and risk of pediatric multiple sclerosis and clinically isolated syndrome

(2013) A. Langer-Gould et al.   NEUROLOGY

Causal Relationship between Obesity and Vitamin D Status: Bi-Directional Mendelian Randomization Analysis of Multiple Cohorts

(2013) Karani S. Vimaleswaran et al.   PLOS MEDICINE

The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis

(2012)   LANCET

High rates of physician services utilization at least five years before multiple sclerosis diagnosis

(2012) Ruth Ann Marrie et al.   Multiple Sclerosis Journal

Evaluation of the relationship between leptin, resistin, adiponectin and natural regulatory T cells in relapsing-remitting multiple sclerosis

(2012) Łukasz Kraszula et al.   Neurologia i Neurochirurgia Polska

Vitamin D as a protective factor in multiple sclerosis

(2012) J. Salzer et al.   NEUROLOGY

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

(2011) Stephen Sawcer et al.   NATURE

Association between Common Variation at the FTO Locus and Changes in Body Mass Index from Infancy to Late Childhood: The Complex Nature of Genetic Association through Growth and Development

(2011) Ulla Sovio et al.   PLoS Genetics

Power and instrument strength requirements for Mendelian randomization studies using multiple genetic variants

(2010) Brandon L Pierce et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Body size and risk of MS in two cohorts of US women

(2009) K. L. Munger et al.   NEUROLOGY

Serum 25-hydroxyvitamin D status of the US population: 1988–1994 compared with 2000–2004

(2008) Anne C Looker et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology

(2007) Debbie A. Lawlor et al.   STATISTICS IN MEDICINE