Homeostasis of Second Messenger Cyclic-di-AMP Is Critical for Cyanobacterial Fitness and Acclimation to Abiotic Stress

Cyclic di-AMP Acts as an Extracellular Signal That Impacts Bacillus subtilis Biofilm Formation and Plant Attachment

(2018) Loni Townsley et al.   mBio

High-throughput interaction screens illuminate the role of c-di-AMP in cyanobacterial nighttime survival

(2018) Benjamin E. Rubin et al.   PLoS Genetics

The protein Slr1143 is an active diguanylate cyclase in Synechocystis sp. PCC 6803 and interacts with the photoreceptor Cph2

(2017) Veronika Angerer et al.   MICROBIOLOGY-SGM

c-di-AMP modulatesListeria monocytogenescentral metabolism to regulate growth, antibiotic resistance and osmoregulation

(2017) Aaron T. Whiteley et al.   MOLECULAR MICROBIOLOGY

Versatile modes of cellular regulation via cyclic dinucleotides

(2017) Petya Violinova Krasteva et al.   Nature Chemical Biology

Cyclic di-GMP: second messenger extraordinaire

(2017) Urs Jenal et al.   NATURE REVIEWS MICROBIOLOGY

A New Second Messenger: Bacterial c-di-AMP

(2016) Tiwei Fu et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Too much of a good thing: regulated depletion of c-di-AMP in the bacterial cytoplasm

(2016) TuAnh Ngoc Huynh et al.   CURRENT OPINION IN MICROBIOLOGY

New Insights into the Cyclic Di-adenosine Monophosphate (c-di-AMP) Degradation Pathway and the Requirement of the Cyclic Dinucleotide for Acid Stress Resistance inStaphylococcus aureus

(2016) Lisa Bowman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of biofilm formation and cellular buoyancy through modulating intracellular cyclic di-GMP levels in engineered cyanobacteria

(2015) Marco Agostoni et al.   BIOTECHNOLOGY AND BIOENGINEERING

DisA and c-di-AMP act at the intersection between DNA-damage response and stress homeostasis in exponentially growing Bacillus subtilis cells

(2015) Carolina Gándara et al.   DNA REPAIR

Functional Analysis of a c-di-AMP-specific Phosphodiesterase MsPDE from Mycobacterium smegmatis

(2015) Qing Tang et al.   International Journal of Biological Sciences

Phenotypes Associated with the Essential Diadenylate Cyclase CdaA and Its Potential Regulator CdaR in the Human Pathogen Listeria monocytogenes

(2015) Jeanine Rismondo et al.   JOURNAL OF BACTERIOLOGY

An Essential Poison: Synthesis and Degradation of Cyclic Di-AMP in Bacillus subtilis

(2015) Jan Gundlach et al.   JOURNAL OF BACTERIOLOGY

Binding of Cyclic Di-AMP to the Staphylococcus aureus Sensor Kinase KdpD Occurs via the Universal Stress Protein Domain and Downregulates the Expression of the Kdp Potassium Transporter

(2015) Joana A. Moscoso et al.   JOURNAL OF BACTERIOLOGY

Cyclic-di-AMP synthesis by the diadenylate cyclase CdaA is modulated by the peptidoglycan biosynthesis enzyme GlmM in L actococcus lactis

(2015) Yan Zhu et al.   MOLECULAR MICROBIOLOGY

A jack of all trades: the multiple roles of the unique essential second messenger cyclic di-AMP

(2015) Fabian M. Commichau et al.   MOLECULAR MICROBIOLOGY

A bacterial cyclic dinucleotide activates the cytosolic surveillance pathway and mediates innate resistance to tuberculosis

(2015) Bappaditya Dey et al.   NATURE MEDICINE

Three cyanobacteriochromes work together to form a light color-sensitive input system for c-di-GMP signaling of cell aggregation

(2015) Gen Enomoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An HD-domain phosphodiesterase mediates cooperative hydrolysis of c-di-AMP to affect bacterial growth and virulence

(2015) TuAnh Ngoc Huynh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional analysis of the sporulation-specific diadenylate cyclase CdaS in Bacillus thuringiensis

(2015) Cao Zheng et al.   Frontiers in Microbiology

Chemical lysis of cyanobacteria

(2015) Kunal K. Mehta et al.   Journal of Biological Engineering

Intracellular Concentrations of Borrelia burgdorferi Cyclic Di-AMP Are Not Changed by Altered Expression of the CdaA Synthase

(2015) Christina R. Savage et al.   PLoS One

Metabolomic analysis of the salt-sensitive mutants reveals changes in amino acid and fatty acid composition important to long-term salt stress in Synechocystis sp. PCC 6803

(2014) Jiangxin Wang et al.   FUNCTIONAL & INTEGRATIVE GENOMICS

DhhP, a Cyclic di-AMP Phosphodiesterase of Borrelia burgdorferi, Is Essential for Cell Growth and Virulence

(2014) Meiping Ye et al.   INFECTION AND IMMUNITY

Control of the Diadenylate Cyclase CdaS inBacillus subtilis

(2014) Felix M. P. Mehne et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyanobacteriochrome SesA Is a Diguanylate Cyclase That Induces Cell Aggregation inThermosynechococcus

(2014) Gen Enomoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional analysis of c-di-AMP phosphodiesterase, GdpP, in Streptococcus suis serotype 2

(2014) Bin Du et al.   MICROBIOLOGICAL RESEARCH

Deletion of the cyclic di-AMP phosphodiesterase gene (cnpB) inMycobacterium tuberculosisleads to reduced virulence in a mouse model of infection

(2014) Jun Yang et al.   MOLECULAR MICROBIOLOGY

DEOP: a database on osmoprotectants and associated pathways

(2014) Salim Bougouffa et al.   Database-The Journal of Biological Databases and Curation

Salinity impacts photosynthetic pigmentation and cellular morphology changes by distinct mechanisms in Fremyella diplosiphon

(2013) Shailendra P. Singh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Two DHH Subfamily 1 Proteins in Streptococcus pneumoniae Possess Cyclic Di-AMP Phosphodiesterase Activity and Affect Bacterial Growth and Virulence

(2013) Y. Bai et al.   JOURNAL OF BACTERIOLOGY

Cyclic Di-AMP Impairs Potassium Uptake Mediated by a Cyclic Di-AMP Binding Protein in Streptococcus pneumoniae

(2013) Y. Bai et al.   JOURNAL OF BACTERIOLOGY

Radiation-sensitive Gene A (RadA) Targets DisA, DNA Integrity Scanning Protein A, to Negatively Affect Cyclic Di-AMP Synthesis Activity inMycobacterium smegmatis

(2013) Lei Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Riboswitches in eubacteria sense the second messenger c-di-AMP

(2013) James W Nelson et al.   Nature Chemical Biology

Cyclic di-AMP: another second messenger enters the fray

(2013) Rebecca M. Corrigan et al.   NATURE REVIEWS MICROBIOLOGY

Multidisciplinary Evidences that Synechocystis PCC6803 Exopolysaccharides Operate in Cell Sedimentation and Protection against Salt and Metal Stresses

(2013) Thichakorn Jittawuttipoka et al.   PLoS One

Mutation in the C-Di-AMP Cyclase dacA Affects Fitness and Resistance of Methicillin Resistant Staphylococcus aureus

(2013) Vanina Dengler et al.   PLoS One

Streptococcus pyogenes c-di-AMP Phosphodiesterase, GdpP, Influences SpeB Processing and Virulence

(2013) Kyu Hong Cho et al.   PLoS One

Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing

(2013) P. M. Shih et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systematic identification of conserved bacterial c-di-AMP receptor proteins

(2013) R. M. Corrigan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Occurrence of Cyclic di-GMP-Modulating Output Domains in Cyanobacteria: an Illuminating Perspective

(2013) M. Agostoni et al.   mBio

STING-Dependent Recognition of Cyclic di-AMP Mediates Type I Interferon Responses during Chlamydia trachomatis Infection

(2013) J. R. Barker et al.   mBio

Cyclic di-AMP Is Critical for Listeria monocytogenes Growth, Cell Wall Homeostasis, and Establishment of Infection

(2013) C. E. Witte et al.   mBio

Heat Resistance and Salt Hypersensitivity in Lactococcus lactis Due to Spontaneous Mutation ofllmg_1816(gdpP) Induced by High-Temperature Growth

(2012) William M. Smith et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Salinisation of rivers: An urgent ecological issue

(2012) Miguel Cañedo-Argüelles et al.   ENVIRONMENTAL POLLUTION

Cyclic Di-AMP Homeostasis inBacillus subtilis

(2012) Felix M. P. Mehne et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Light-induced alteration of c-di-GMP level controls motility of Synechocystis sp. PCC 6803

(2012) Philipp Savakis et al.   MOLECULAR MICROBIOLOGY

Effects of salt stress and rhizobial inoculation on growth and nitrogen fixation of three peanut cultivars

(2012) M. R. El-Akhal et al.   PLANT BIOLOGY

Quantification of high-specificity cyclic diguanylate signaling

(2012) J. P. Massie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ocean Salinities Reveal Strong Global Water Cycle Intensification During 1950 to 2000

(2012) P. J. Durack et al.   SCIENCE

c-di-AMP reports DNA integrity during sporulation in Bacillus subtilis

(2011) Yaara Oppenheimer-Shaanan et al.   EMBO REPORTS

Analysis of the role of Bacillus subtilis σM in β-lactam resistance reveals an essential role for c-di-AMP in peptidoglycan homeostasis

(2011) Yun Luo et al.   MOLECULAR MICROBIOLOGY

c-di-AMP Is a New Second Messenger in Staphylococcus aureus with a Role in Controlling Cell Size and Envelope Stress

(2011) Rebecca M. Corrigan et al.   PLoS Pathogens

FdTonB is involved in the photoregulation of cellular morphology during complementary chromatic adaptation in Fremyella diplosiphon

(2009) B. Pattanaik et al.   MICROBIOLOGY-SGM

Structural Biochemistry of a Bacterial Checkpoint Protein Reveals Diadenylate Cyclase Activity Regulated by DNA Recombination Intermediates

(2008) Gregor Witte et al.   MOLECULAR CELL

Great Times for Small Molecules: c-di-AMP, a Second Messenger Candidate in Bacteria and Archaea

(2008) U. Romling   Science Signaling