When Dicty Met Myco, a (Not So) Romantic Story about One Amoeba and Its Intracellular Pathogen

Formation of the Legionella -containing vacuole: phosphoinositide conversion, GTPase modulation and ER dynamics

(2018) Bernhard Steiner et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Eat Prey, Live: Dictyostelium discoideum As a Model for Cell-Autonomous Defenses

(2018) Joe Dan Dunn et al.   Frontiers in Immunology

Characterization of a secretory hydrolase fromMycobacterium tuberculosissheds critical insight into host lipid utilization byM. tuberculosis

(2017) Khundrakpam Herojit Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Statistical analysis of genetic interactions in Tn-Seq data

(2017) Michael A. DeJesus et al.   NUCLEIC ACIDS RESEARCH

Inhibitors of Mycobacterium marinum virulence identified in a Dictyostelium discoideum host model

(2017) Hajer Ouertatani-Sakouhi et al.   PLoS One

Mycobacterial ESX-1 secretion system mediates host cell lysis through bacterium contact-dependent gross membrane disruptions

(2017) William H. Conrad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Enigmatic Esx Proteins: Looking Beyond Mycobacteria

(2017) Meera Unnikrishnan et al.   TRENDS IN MICROBIOLOGY

Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis

(2017) Michael A. DeJesus et al.   mBio

The Cell Wall Lipid PDIM Contributes to Phagosomal Escape and Host Cell Exit of Mycobacterium tuberculosis

(2017) Jeff Quigley et al.   mBio

Regulation of phagocyte triglyceride by a STAT-ATG2 pathway controls mycobacterial infection

(2017) Claire B. Péan et al.   Nature Communications

Active nuclear transcriptome analysis reveals inflammasome-dependent mechanism for early neutrophil response to Mycobacterium marinum

(2017) Amy Kenyon et al.   Scientific Reports

Mycobacterium marinum Degrades Both Triacylglycerols and Phospholipids from Its Dictyostelium Host to Synthesise Its Own Triacylglycerols and Generate Lipid Inclusions

(2017) Caroline Barisch et al.   PLoS Pathogens

Mycobacterium marinum antagonistically induces an autophagic response while repressing the autophagic flux in a TORC1- and ESX-1-dependent manner

(2017) Elena Cardenal-Muñoz et al.   PLoS Pathogens

Resolving host–pathogen interactions by dual RNA-seq

(2017) Alexander J. Westermann et al.   PLoS Pathogens

Rv3723/LucA coordinates fatty acid and cholesterol uptake in Mycobacterium tuberculosis

(2017) Evgeniya V Nazarova et al.   eLife

Nramp1 and NrampB Contribute to Resistance against Francisella in Dictyostelium

(2017) Yannick Brenz et al.   Frontiers in Cellular and Infection Microbiology

LUBAC-synthesized linear ubiquitin chains restrict cytosol-invading bacteria by activating autophagy and NF-κB

(2017) Jessica Noad et al.   Nature Microbiology

Integration of Metabolomics and Transcriptomics Reveals a Complex Diet of Mycobacterium tuberculosis during Early Macrophage Infection

(2017) Michael Zimmermann et al.   mSystems

Methods to Monitor and Quantify Autophagy in the Social Amoeba Dictyostelium discoideum

(2017) Eunice Domínguez-Martín et al.   Cells

WhiB4 Regulates the PE/PPE Gene Family and is Essential for Virulence of Mycobacterium marinum

(2017) Jing Wu et al.   Scientific Reports

Autophagy in Dictyostelium: Mechanisms, regulation and disease in a simple biomedical model

(2016) Ana Mesquita et al.   Autophagy

Reliable handling of highly A/T-rich genomic DNA for efficient generation of knockin strains of Dictyostelium discoideum

(2016) Asuka Mukai et al.   BMC BIOTECHNOLOGY

TRIMs and Galectins Globally Cooperate and TRIM16 and Galectin-3 Co-direct Autophagy in Endomembrane Damage Homeostasis

(2016) Santosh Chauhan et al.   DEVELOPMENTAL CELL

Recruitment of TBK1 to cytosol‐invading Salmonella induces WIPI2‐dependent antibacterial autophagy

(2016) Teresa LM Thurston et al.   EMBO JOURNAL

A microfluidic cell-trapping device for single-cell tracking of host–microbe interactions

(2016) Matthieu J. Delincé et al.   LAB ON A CHIP

ESX secretion systems: mycobacterial evolution to counter host immunity

(2016) Matthias I. Gröschel et al.   NATURE REVIEWS MICROBIOLOGY

Mycobacterium marinum mmar_2318 and mmar_2319 are Responsible for Lipooligosaccharide Biosynthesis and Virulence Toward Dictyostelium

(2016) Yi-Yin Chen et al.   Frontiers in Microbiology

Mycobacterial escape from macrophage phagosomes to the cytoplasm represents an alternate adaptation mechanism

(2016) Shilpa V. Jamwal et al.   Scientific Reports

EsxA membrane-permeabilizing activity plays a key role in mycobacterial cytosolic translocation and virulence: effects of single-residue mutations at glutamine 5

(2016) Qi Zhang et al.   Scientific Reports

Dissection of Francisella-Host Cell Interactions in Dictyostelium discoideum

(2015) Elisabeth O. Lampe et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Leaps and lulls in the developmental transcriptome of Dictyostelium discoideum

(2015) Rafael David Rosengarten et al.   BMC GENOMICS

Lipid metabolism and Type VII secretion systems dominate the genome scale virulence profile of Mycobacterium tuberculosis in human dendritic cells

(2015) Tom A Mendum et al.   BMC GENOMICS

Antioxidant Role for Lipid Droplets in a Stem Cell Niche of Drosophila

(2015) Andrew P. Bailey et al.   CELL

Autophagy Proteins Promote Repair of Endosomal Membranes Damaged by the Salmonella Type Three Secretion System 1

(2015) Saskia Kreibich et al.   Cell Host & Microbe

The Oxidative Stress Network of Mycobacterium tuberculosis Reveals Coordination between Radical Detoxification Systems

(2015) Subhalaxmi Nambi et al.   Cell Host & Microbe

Lipid droplet dynamics at early stages ofMycobacterium marinuminfection inDictyostelium

(2015) Caroline Barisch et al.   CELLULAR MICROBIOLOGY

Chemotaxis of a model organism: progress with Dictyostelium

(2015) John ME Nichols et al.   CURRENT OPINION IN CELL BIOLOGY

Regulated Degradation: Controlling the Stability of Autophagy Gene Transcripts

(2015) Hitoshi Nakatogawa   DEVELOPMENTAL CELL

Genome-Wide Transposon Mutagenesis Indicates that Mycobacterium marinum Customizes Its Virulence Mechanisms for Survival and Replication in Different Hosts

(2015) Eveline M. Weerdenburg et al.   INFECTION AND IMMUNITY

CpsA, a LytR-CpsA-Psr Family Protein in Mycobacterium marinum, Is Required for Cell Wall Integrity and Virulence

(2015) Qinglan Wang et al.   INFECTION AND IMMUNITY

Phenotypic resistance in mycobacteria: is it because I am old or fat that I resist you?

(2015) Robert J. H. Hammond et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity

(2015) Tomonori Kimura et al.   JOURNAL OF CELL BIOLOGY

Comparative Sigma Factor-mRNA Levels in Mycobacterium marinum under Stress Conditions and during Host Infection

(2015) B. M. Fredrik Pettersson et al.   PLoS One

The autophagic machinery ensures nonlytic transmission of mycobacteria

(2015) Lilli Gerstenmaier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nutrition-based evolution of intracellular pathogens

(2015) Yousef Abu Kwaik   Environmental Microbiology Reports

RNA sequencing provides exquisite insight into the manipulation of the alveolar macrophage by tubercle bacilli

(2015) Nicolas C. Nalpas et al.   Scientific Reports

Dissecting the function of Atg1 complex inDictyosteliumautophagy reveals a connection with the pentose phosphate pathway enzyme transketolase

(2015) Ana Mesquita et al.   Open Biology

Essential Role of the ESX-5 Secretion System in Outer Membrane Permeability of Pathogenic Mycobacteria

(2015) Louis S. Ates et al.   PLoS Genetics

Host Delivery of Favorite Meals for Intracellular Pathogens

(2015) Yousef Abu Kwaik et al.   PLoS Pathogens

Cytosolic Access of Mycobacterium tuberculosis: Critical Impact of Phagosomal Acidification Control and Demonstration of Occurrence In Vivo

(2015) Roxane Simeone et al.   PLoS Pathogens

Cell signaling during development of Dictyostelium

(2014) William F. Loomis   DEVELOPMENTAL BIOLOGY

TRIM Proteins Regulate Autophagy and Can Target Autophagic Substrates by Direct Recognition

(2014) Michael A. Mandell et al.   DEVELOPMENTAL CELL

Mycobacterium tuberculosis Strains Lacking Surface Lipid Phthiocerol Dimycocerosate Are Susceptible to Killing by an Early Innate Host Response

(2014) Tracey A. Day et al.   INFECTION AND IMMUNITY

Amoebae as a tool to isolate new bacterial species, to discover new virulence factors and to study the host–pathogen interactions

(2014) Nicolo Tosetti et al.   MICROBIAL PATHOGENESIS

Establishment and Validation of Whole-Cell Based Fluorescence Assays to Identify Anti-Mycobacterial Compounds Using the Acanthamoeba castellanii - Mycobacterium marinum Host-Pathogen System

(2014) Sébastien Kicka et al.   PLoS One

Vmp1 Regulates PtdIns3P Signaling During Autophagosome Formation inDictyostelium discoideum

(2014) Javier Calvo-Garrido et al.   TRAFFIC

Mycobacterial Esx-3 Requires Multiple Components for Iron Acquisition

(2014) M. S. Siegrist et al.   mBio

Imaging cytosolic translocation of Mycobacteria with two-photon fluorescence resonance energy transfer microscopy

(2014) Yassel Acosta et al.   Biomedical Optics Express

Interaction of Mycobacterium tuberculosis with Host Cell Death Pathways

(2014) L. Srinivasan et al.   Cold Spring Harbor Perspectives in Medicine

The Mycobacterial Cell Envelope--Lipids

(2014) M. Jackson   Cold Spring Harbor Perspectives in Medicine

Take five — Type VII secretion systems of Mycobacteria

(2013) Edith N.G. Houben et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Bayesian analysis of gene essentiality based on sequencing of transposon insertion libraries

(2013) Michael A. DeJesus et al.   BIOINFORMATICS

A Hidden Markov Model for identifying essential and growth-defect regions in bacterial genomes from transposon insertion sequencing data

(2013) Michael A DeJesus et al.   BMC BIOINFORMATICS

WASH-driven actin polymerization is required for efficient mycobacterial phagosome maturation arrest

(2013) Margot Kolonko et al.   CELLULAR MICROBIOLOGY

The role of ‘eat-me’ signals and autophagy cargo receptors in innate immunity

(2013) Keith B. Boyle et al.   CURRENT OPINION IN MICROBIOLOGY

Dictyostelium Lipid Droplets Host Novel Proteins

(2013) Xiaoli Du et al.   EUKARYOTIC CELL

Reversible Lipid Accumulation and Associated Division Arrest of Mycobacterium avium in Lipoprotein-Induced Foamy Macrophages May Resemble Key Events during Latency and Reactivation of Tuberculosis

(2013) Irène Caire-Brändli et al.   INFECTION AND IMMUNITY

IntracellularMycobacterium tuberculosisExploits Host-derived Fatty Acids to Limit Metabolic Stress

(2013) Wonsik Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mycobacteria manipulate macrophage recruitment through coordinated use of membrane lipids

(2013) C. J. Cambier et al.   NATURE

Transposon insertion sequencing: a new tool for systems-level analysis of microorganisms

(2013) Tim van Opijnen et al.   NATURE REVIEWS MICROBIOLOGY

The biophysics and cell biology of lipid droplets

(2013) Abdou Rachid Thiam et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Revealing of Mycobacterium marinum Transcriptome by RNA-seq

(2013) Sen Wang et al.   PLoS One

The ESX-3 Secretion System Is Necessary for Iron and Zinc Homeostasis in Mycobacterium tuberculosis

(2013) Agnese Serafini et al.   PLoS One

ESX-1-induced apoptosis during mycobacterial infection: to be or not to be, that is the question

(2013) Nacho Aguiló et al.   Frontiers in Cellular and Infection Microbiology

ESX-1 dependent impairment of autophagic flux byMycobacterium tuberculosisin human dendritic cells

(2012) Alessandra Romagnoli et al.   Autophagy

Amino Acid Starvation Induced by Invasive Bacterial Pathogens Triggers an Innate Host Defense Program

(2012) Ivan Tattoli et al.   Cell Host & Microbe

ESX-1-mediated translocation to the cytosol controls virulence of mycobacteria

(2012) Diane Houben et al.   CELLULAR MICROBIOLOGY

The ESCRT machinery

(2012) Oliver Schmidt et al.   CURRENT BIOLOGY

Both Phthiocerol Dimycocerosates and Phenolic Glycolipids Are Required for Virulence of Mycobacterium marinum

(2012) Jia Yu et al.   INFECTION AND IMMUNITY

TOR complex 2 (TORC2) in Dictyostelium suppresses phagocytic nutrient capture independently of TORC1-mediated nutrient sensing

(2012) D. Rosel et al.   JOURNAL OF CELL SCIENCE

Deciphering the contribution of lipid droplets in leprosy: multifunctional organelles with roles in Mycobacterium leprae pathogenesis

(2012) Katherine Antunes de Mattos et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

Prison Break: Pathogens' Strategies To Egress from Host Cells

(2012) Nikolas Friedrich et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Mycobacterium tuberculosisWhiB4 regulates oxidative stress response to modulate survival and disseminationin vivo

(2012) Manbeena Chawla et al.   MOLECULAR MICROBIOLOGY

Disruption of the ESX-5 system of Mycobacterium tuberculosis causes loss of PPE protein secretion, reduction of cell wall integrity and strong attenuation

(2012) Daria Bottai et al.   MOLECULAR MICROBIOLOGY

Salmonella Inhibits Retrograde Trafficking of Mannose-6-Phosphate Receptors and Lysosome Function

(2012) K. McGourty et al.   SCIENCE

Phagosomal Rupture by Mycobacterium tuberculosis Results in Toxicity and Host Cell Death

(2012) Roxane Simeone et al.   PLoS Pathogens

Global Assessment of Genomic Regions Required for Growth in Mycobacterium tuberculosis

(2012) Yanjia J. Zhang et al.   PLoS Pathogens

Mycobacterium marinum Causes a Latent Infection that Can Be Reactivated by Gamma Irradiation in Adult Zebrafish

(2012) Mataleena Parikka et al.   PLoS Pathogens

The bacterial and cellular determinants controlling the recruitment of mTOR to the Salmonella-containing vacuole

(2012) I. Tattoli et al.   Biology Open

The induction of autophagy by mechanical stress

(2011) Jason S. King et al.   Autophagy

Mycobacterium marinum induces a marked LC3 recruitment to its containing phagosome that depends on a functional ESX-1 secretion system

(2011) María Cecilia Lerena et al.   CELLULAR MICROBIOLOGY

The Professional Phagocyte Dictyostelium discoideum as a Model Host for Bacterial Pathogens

(2011) Salvatore Bozzaro et al.   CURRENT DRUG TARGETS

Nuclear organization and transcriptional dynamics in Dictyostelium

(2011) Michelle Stevense et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Efficient generation of gene knockout plasmids for Dictyostelium discoideum using one-step cloning

(2011) Stephan Wiegand et al.   GENOMICS

Comparative Genomics of the Dormancy Regulons in Mycobacteria

(2011) A. Gerasimova et al.   JOURNAL OF BACTERIOLOGY

A Mycobacterium marinum TesA mutant defective for major cell wall-associated lipids is highly attenuated in Dictyostelium discoideum and zebrafish embryos

(2011) Laeticia Alibaud et al.   MOLECULAR MICROBIOLOGY

High-Resolution Phenotypic Profiling Defines Genes Essential for Mycobacterial Growth and Cholesterol Catabolism

(2011) Jennifer E. Griffin et al.   PLoS Pathogens

Autophagy in Dictyostelium: Genes and pathways, cell death and infection

(2010) Javier Calvo-Garrido et al.   Autophagy

Autophagy dysfunction and ubiquitin-positive protein aggregates in Dictyostelium cells lacking Vmp1

(2010) Javier Calvo-Garrido et al.   Autophagy

Role of magnesium and a phagosomal P-type ATPase in intracellular bacterial killing

(2010) Emmanuelle Lelong et al.   CELLULAR MICROBIOLOGY

WASH and the Arp2/3 complex regulate endosome shape and trafficking

(2010) Steve N. Duleh et al.   Cytoskeleton

Effect of Starvation on the Endocytic Pathway in Dictyostelium Cells

(2010) Ewan W. Smith et al.   EUKARYOTIC CELL

Molecular characterization of the evolution of phagosomes

(2010) Jonathan Boulais et al.   Molecular Systems Biology

Dictyostelium amoebae and neutrophils can swim

(2010) N. P. Barry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dictyostelium as a model for human lysosomal and trafficking diseases

(2010) Markus Maniak   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Rab7: roles in membrane trafficking and disease

(2009) Ming Zhang et al.   BIOSCIENCE REPORTS

Proteomic analysis of Legionella-containing phagosomes isolated from Dictyostelium

(2009) Olga Shevchuk et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Triacylglycerol Utilization Is Required for Regrowth of In Vitro Hypoxic Nonreplicating Mycobacterium bovis Bacillus Calmette-Guerin

(2009) K. L. Low et al.   JOURNAL OF BACTERIOLOGY

Characterization of a Mycobacterium tuberculosis ESX-3 Conditional Mutant: Essentiality and Rescue by Iron and Zinc

(2009) A. Serafini et al.   JOURNAL OF BACTERIOLOGY

Potential role for ESAT6 in dissemination ofM. tuberculosisvia human lung epithelial cells

(2009) Arvind G. Kinhikar et al.   MOLECULAR MICROBIOLOGY

Foamy macrophages and the progression of the human tuberculosis granuloma

(2009) David G Russell et al.   NATURE IMMUNOLOGY

The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria

(2009) Teresa L M Thurston et al.   NATURE IMMUNOLOGY

Tn-seq: high-throughput parallel sequencing for fitness and genetic interaction studies in microorganisms

(2009) Tim van Opijnen et al.   NATURE METHODS

Mycobacterial Esx-3 is required for mycobactin-mediated iron acquisition

(2009) M. S. Siegrist et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Infection by Tubercular Mycobacteria Is Spread by Nonlytic Ejection from Their Amoeba Hosts

(2009) M. Hagedorn et al.   SCIENCE

Proteome Analysis of Legionella Vacuoles Purified by Magnetic Immunoseparation Reveals Secretory and Endosomal GTPases

(2009) Simon Urwyler et al.   TRAFFIC

Phthiocerol Dimycocerosates of M. tuberculosis Participate in Macrophage Invasion by Inducing Changes in the Organization of Plasma Membrane Lipids

(2009) Catherine Astarie-Dequeker et al.   PLoS Pathogens

Polar Localization of Virulence-Related Esx-1 Secretion in Mycobacteria

(2009) Fredric Carlsson et al.   PLoS Pathogens

Atg5-Independent Sequestration of Ubiquitinated Mycobacteria

(2009) Cathleen A. Collins et al.   PLoS Pathogens

Systematic Genetic Nomenclature for Type VII Secretion Systems

(2009) Wilbert Bitter et al.   PLoS Pathogens

Comparative pathogenesis of Mycobacterium marinum and Mycobacterium tuberculosis

(2008) David M. Tobin et al.   CELLULAR MICROBIOLOGY

Regulation of contractile vacuole formation and activity in Dictyostelium

(2008) Fei Du et al.   EMBO JOURNAL

Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis

(2008) T. P. Stinear et al.   GENOME RESEARCH

Mycobacterium tuberculosis strains disrupted in mce3 and mce4 operons are attenuated in mice

(2008) R. H. Senaratne et al.   JOURNAL OF MEDICAL MICROBIOLOGY

An extrachromosomal, inducible expression system for Dictyostelium discoideum

(2008) Douwe M. Veltman et al.   PLASMID

A new set of small, extrachromosomal expression vectors for Dictyostelium discoideum

(2008) Douwe M. Veltman et al.   PLASMID

Mycobacterial persistence requires the utilization of host cholesterol

(2008) A. K. Pandey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Foamy Macrophages from Tuberculous Patients' Granulomas Constitute a Nutrient-Rich Reservoir for M. tuberculosis Persistence

(2008) Pascale Peyron et al.   PLoS Pathogens