EsxA membrane-permeabilizing activity plays a key role in mycobacterial cytosolic translocation and virulence: effects of single-residue mutations at glutamine 5

Characterization of differential pore-forming activities of ESAT-6 proteins fromMycobacterium tuberculosisandMycobacterium smegmatis

(2016) Xiuli Peng et al.   FEBS LETTERS

Mycobacterium tuberculosis Meets the Cytosol: The Role of cGAS in Anti-mycobacterial Immunity

(2015) Laleh Majlessi et al.   Cell Host & Microbe

The Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate Autophagy

(2015) Robert O. Watson et al.   Cell Host & Microbe

Mycobacterium tuberculosis Differentially Activates cGAS- and Inflammasome-Dependent Intracellular Immune Responses through ESX-1

(2015) Ruth Wassermann et al.   Cell Host & Microbe

Cyclic GMP-AMP Synthase Is an Innate Immune DNA Sensor for Mycobacterium tuberculosis

(2015) Angela C. Collins et al.   Cell Host & Microbe

Characterization ofMycobacterium tuberculosisEsxA Membrane Insertion

(2015) Yue Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cytosolic Access of Mycobacterium tuberculosis: Critical Impact of Phagosomal Acidification Control and Demonstration of Occurrence In Vivo

(2015) Roxane Simeone et al.   PLoS Pathogens

Host Evasion and Exploitation Schemes of Mycobacterium tuberculosis

(2014) C.J. Cambier et al.   CELL

Macrophage-pathogen interactions in infectious diseases: new therapeutic insights from the zebrafish host model

(2014) V. Torraca et al.   Disease Models & Mechanisms

CFP-10 from Mycobacterium tuberculosis Selectively Activates Human Neutrophils through a Pertussis Toxin-Sensitive Chemotactic Receptor

(2014) Amanda Welin et al.   INFECTION AND IMMUNITY

Homeostasis of N-α-Terminal Acetylation of EsxA Correlates with Virulence in Mycobacterium marinum

(2014) Felix Mba Medie et al.   INFECTION AND IMMUNITY

A Novel ESX-1 Locus Reveals that Surface-Associated ESX-1 Substrates Mediate Virulence in Mycobacterium marinum

(2014) G. M. Kennedy et al.   JOURNAL OF BACTERIOLOGY

Mycobacterium tuberculosis Subverts the TLR-2 - MyD88 Pathway to Facilitate Its Translocation into the Cytosol

(2014) Md. Aejazur Rahman et al.   PLoS One

Imaging cytosolic translocation of Mycobacteria with two-photon fluorescence resonance energy transfer microscopy

(2014) Yassel Acosta et al.   Biomedical Optics Express

The ESAT-6 Protein of Mycobacterium tuberculosis Interacts with Beta-2-Microglobulin (β2M) Affecting Antigen Presentation Function of Macrophage

(2014) Gopalkrishna Sreejit et al.   PLoS Pathogens

Mycobacteria manipulate macrophage recruitment through coordinated use of membrane lipids

(2013) C. J. Cambier et al.   NATURE

Evaluation of the pathogenesis and treatment of Mycobacterium marinum infection in zebrafish

(2013) Kevin Takaki et al.   Nature Protocols

Tuberculosis

(2013) Alimuddin Zumla et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tuberculosis vaccines: time to reset the paradigm?: Table 1

(2013) Ajit Lalvani et al.   THORAX

Extracellular M. tuberculosis DNA Targets Bacteria for Autophagy by Activating the Host DNA-Sensing Pathway

(2012) Robert O. Watson et al.   CELL

Mycobacterium Tuberculosis Activates the DNA-Dependent Cytosolic Surveillance Pathway within Macrophages

(2012) Paolo S. Manzanillo et al.   Cell Host & Microbe

ESX-1-mediated translocation to the cytosol controls virulence of mycobacteria

(2012) Diane Houben et al.   CELLULAR MICROBIOLOGY

Innate Immune Response to Streptococcus iniae Infection in Zebrafish Larvae

(2012) Elizabeth A. Harvie et al.   INFECTION AND IMMUNITY

Mycobacterium tuberculosisESAT-6 Exhibits a Unique Membrane-interacting Activity That Is Not Found in Its Ortholog from Non-pathogenicMycobacterium smegmatis

(2012) Joaquin De Leon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phagosomal Rupture by Mycobacterium tuberculosis Results in Toxicity and Host Cell Death

(2012) Roxane Simeone et al.   PLoS Pathogens

Imaging the assembly, structure and activity of type III secretion systems

(2009) Jost Enninga et al.   CELLULAR MICROBIOLOGY

Tuberculous Granuloma Induction via Interaction of a Bacterial Secreted Protein with Host Epithelium

(2009) H. E. Volkman et al.   SCIENCE

Polar Localization of Virulence-Related Esx-1 Secretion in Mycobacteria

(2009) Fredric Carlsson et al.   PLoS Pathogens

Regulation of Protein Secretion by … Protein Secretion?

(2008) Krishnamohan Atmakuri et al.   Cell Host & Microbe

Comparative pathogenesis of Mycobacterium marinum and Mycobacterium tuberculosis

(2008) David M. Tobin et al.   CELLULAR MICROBIOLOGY

Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis

(2008) T. P. Stinear et al.   GENOME RESEARCH

Evidence for Pore Formation in Host Cell Membranes by ESX-1-Secreted ESAT-6 and Its Role in Mycobacterium marinum Escape from the Vacuole

(2008) J. Smith et al.   INFECTION AND IMMUNITY

Phenylalanine-427 of anthrax protective antigen functions in both pore formation and protein translocation

(2008) J. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA