Indoxyl Sulfate Downregulates Expression of Mas Receptor via OAT3/AhR/Stat3 Pathway in Proximal Tubular Cells

CREB, NF-κB, and NADPH oxidase coordinately upregulate indoxyl sulfate-induced angiotensinogen expression in proximal tubular cells

(2013) Hidehisa Shimizu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

ACE2, angiotensin-(1-7) and Mas receptor axis in inflammation and fibrosis

(2013) AC Simões e Silva et al.   BRITISH JOURNAL OF PHARMACOLOGY

Angiotensin (1–7) counteracts the negative effect of angiotensin II on insulin signalling in HUVECs

(2013) Eliezer Joseph Tassone et al.   CARDIOVASCULAR RESEARCH

Indolic uremic solutes increase tissue factor production in endothelial cells by the aryl hydrocarbon receptor pathway

(2013) Bertrand Gondouin et al.   KIDNEY INTERNATIONAL

ACE2 alterations in kidney disease

(2013) M. J. Soler et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Stat3 Contributes to Indoxyl Sulfate-Induced Inflammatory and Fibrotic Gene Expression and Cellular Senescence

(2012) Hidehisa Shimizu et al.   AMERICAN JOURNAL OF NEPHROLOGY

The aryl hydrocarbon receptor: a molecular pathway for the environmental control of the immune response

(2012) Francisco J. Quintana   IMMUNOLOGY

Angiotensin-converting enzyme 2, angiotensin-(1–7) and Mas: new players of the renin–angiotensin system

(2012) Robson A S Santos et al.   JOURNAL OF ENDOCRINOLOGY

Podocyte-specific overexpression of human angiotensin-converting enzyme 2 attenuates diabetic nephropathy in mice

(2012) Renisha Nadarajah et al.   KIDNEY INTERNATIONAL

Uremic Toxins Induce Kidney Fibrosis by Activating Intrarenal Renin–Angiotensin–Aldosterone System Associated Epithelial-to-Mesenchymal Transition

(2012) Chiao-Yin Sun et al.   PLoS One

Angiotensin Converting Enzyme 2, Angiotensin-(1-7), and Receptor Mas Axis in the Kidney

(2012) Sergio Veloso Brant Pinheiro et al.   International Journal of Hypertension

Activation of Intrarenal Renin-Angiotensin System during Metabolic Acidosis

(2011) Hwee-Yeong Ng et al.   AMERICAN JOURNAL OF NEPHROLOGY

Indoxyl Sulfate Reduces Klotho Expression and Promotes Senescence in the Kidneys of Hypertensive Rats

(2011) Ayinuer Adijiang et al.   JOURNAL OF RENAL NUTRITION

AST-120 Ameliorates Epithelial-to-Mesenchymal Transition and Interstitial Fibrosis in the Kidneys of Chronic Kidney Disease Rats

(2011) Dilinaer Bolati et al.   JOURNAL OF RENAL NUTRITION

Biosynthetic Pathways and the Role of the Mas Receptor in the Effects of Angiotensin-(1–7) in Smooth Muscles

(2011) Marcio Augusto Fressatto de Godoy et al.   International Journal of Hypertension

Senescence and dysfunction of proximal tubular cells are associated with activated p53 expression by indoxyl sulfate

(2010) Hidehisa Shimizu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Angiotensin-(1–7) infusion is associated with increased blood pressure and adverse cardiac remodelling in rats with subtotal nephrectomy

(2010) Elena Velkoska et al.   CLINICAL SCIENCE

Indoxyl Sulfate Is a Nephro-Vascular Toxin

(2010) Toshimitsu Niwa   JOURNAL OF RENAL NUTRITION

Angiotensin (1−7) prevent heart dysfunction and left ventricular remodeling caused by renal dysfunction in 5/6 nephrectomy mice

(2009) Yiwen Li et al.   HYPERTENSION RESEARCH

Genetic deletion of the angiotensin-(1–7) receptor Mas leads to glomerular hyperfiltration and microalbuminuria

(2009) Sérgio V.B. Pinheiro et al.   KIDNEY INTERNATIONAL

Ah receptor represses acute-phase response gene expression without binding to its cognate response element

(2009) Rushang D Patel et al.   LABORATORY INVESTIGATION

Angiotensin-(1–7) and the G Protein-Coupled Receptor Mas Are Key Players in Renal Inflammation

(2009) Vanesa Esteban et al.   PLoS One

Angiotensin II Up-Regulates Angiotensin I-Converting Enzyme (ACE), but Down-Regulates ACE2 via the AT1-ERK/p38 MAP Kinase Pathway

(2008) Vijay Koka et al.   AMERICAN JOURNAL OF PATHOLOGY

Angiotensin-(1-7) as an antihypertensive, antifibrotic target

(2008) Michael J. Katovich et al.   CURRENT HYPERTENSION REPORTS