Impact of the Oral Adsorbent AST-120 on Organ-Specific Accumulation of Uremic Toxins: LC-MS/MS and MS Imaging Techniques

Evaluation of the impact of gut microbiota on uremic solute accumulation by a CE-TOFMS–based metabolomics approach

(2017) Eikan Mishima et al.   KIDNEY INTERNATIONAL

p-Cresyl Sulfate

(2017) Tessa Gryp et al.   Toxins

Mass Spectrometry Imaging of Kidney Tissue Sections of Rat Subjected to Unilateral Ureteral Obstruction

(2017) Huihui Liu et al.   Scientific Reports

Role of the Gut Microbiome in Uremia: A Potential Therapeutic Target

(2016) Ali Ramezani et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Mass spectrometry imaging: a novel technology in rheumatology

(2016) Beatriz Rocha et al.   Nature Reviews Rheumatology

Indoxyl sulphate and kidney disease: Causes, consequences and interventions

(2016) Robert J Ellis et al.   NEPHROLOGY

Indoxyl sulfate, not p-cresyl sulfate, is associated with cognitive impairment in early-stage chronic kidney disease

(2016) Yi-Chun Yeh et al.   NEUROTOXICOLOGY

The effects of AST-120 on chronic kidney disease progression in the United States of America: a post hoc subgroup analysis of randomized controlled trials

(2016) Gerald Schulman et al.   BMC Nephrology

Metabolic alterations by indoxyl sulfate in skeletal muscle induce uremic sarcopenia in chronic kidney disease

(2016) Emiko Sato et al.   Scientific Reports

Indoxyl sulfate potentiates skeletal muscle atrophy by inducing the oxidative stress-mediated expression of myostatin and atrogin-1

(2016) Yuki Enoki et al.   Scientific Reports

Indoxyl Sulfate Upregulates Prorenin Expression via Nuclear Factor-κB p65, Signal Transducer and Activator of Transcription 3, and Reactive Oxygen Species in Proximal Tubular Cells

(2015) Shinichi Saito et al.   JOURNAL OF RENAL NUTRITION

Klotho Protects Against Indoxyl Sulphate-Induced Myocardial Hypertrophy

(2015) K. Yang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

AST-120 ameliorates lowered exercise capacity and mitochondrial biogenesis in the skeletal muscle from mice with chronic kidney disease via reducing oxidative stress

(2015) Mikito Nishikawa et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Continuous Reduction of Protein-Bound Uraemic Toxins with Improved Oxidative Stress by Using the Oral Charcoal Adsorbent AST-120 in Haemodialysis Patients

(2015) Suguru Yamamoto et al.   Scientific Reports

p-Cresyl Sulfate Aggravates Cardiac Dysfunction Associated With Chronic Kidney Disease by Enhancing Apoptosis of Cardiomyocytes

(2015) H. Han et al.   Journal of the American Heart Association

Association of Indoxyl Sulfate with Heart Failure among Patients on Hemodialysis

(2014) X.-S. Cao et al.   Clinical Journal of the American Society of Nephrology

Alteration of the Intestinal Environment by Lubiprostone Is Associated with Amelioration of Adenine-Induced CKD

(2014) E. Mishima et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Randomized Placebo-Controlled EPPIC Trials of AST-120 in CKD

(2014) G. Schulman et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Indoxyl Sulfate Induces IL-6 Expression in Vascular Endothelial and Smooth Muscle Cells through OAT3-Mediated Uptake and Activation of AhR/NF-κB Pathway

(2014) Yelixiati Adelibieke et al.   NEPHRON EXPERIMENTAL NEPHROLOGY

p-Cresyl sulfate induces osteoblast dysfunction through activating JNK and p38 MAPK pathways

(2013) Hisae Tanaka et al.   BONE

A novel model of adenine-induced tubulointerstitial nephropathy in mice

(2013) Ting Jia et al.   BMC Nephrology

Uremic osteoporosis

(2013) Junichiro J. Kazama et al.   Kidney International Supplements

The Aryl Hydrocarbon Receptor Complex and the Control of Gene Expression

(2012) Timothy V. Beischlag et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

p-Cresyl Sulfate Promotes Insulin Resistance Associated with CKD

(2012) L. Koppe et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

eNOS Deficiency Acts through Endothelin to Aggravate sFlt-1-Induced Pre-Eclampsia-Like Phenotype

(2012) F. Li et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Uremic Toxins Induce Kidney Fibrosis by Activating Intrarenal Renin–Angiotensin–Aldosterone System Associated Epithelial-to-Mesenchymal Transition

(2012) Chiao-Yin Sun et al.   PLoS One

Matrix Sublimation/Recrystallization for Imaging Proteins by Mass Spectrometry at High Spatial Resolution

(2011) Junhai Yang et al.   ANALYTICAL CHEMISTRY

Update of uremic toxin research by mass spectrometry

(2011) Toshimitsu Niwa   MASS SPECTROMETRY REVIEWS

Role of Indoxyl Sulfate in the Progression of Chronic Kidney Disease and Cardiovascular Disease: Experimental and Clinical Effects of Oral Sorbent AST-120

(2011) Toshimitsu Niwa   THERAPEUTIC APHERESIS AND DIALYSIS

Protein-Bound Uremic Toxins: New Insight from Clinical Studies

(2011) Sophie Liabeuf et al.   Toxins

Spherical Carbon Adsorbent (AST-120) Protects Deterioration of Renal Function in Chronic Kidney Disease Rats through Inhibition of Reactive Oxygen Species Production from Mitochondria and Reduction of Serum Lipid Peroxidation

(2010) Shigeru Owada et al.   NEPHRON EXPERIMENTAL NEPHROLOGY

Effect of a Carbonaceous Oral Adsorbent on the Progression of CKD: A Multicenter, Randomized, Controlled Trial

(2009) Tadao Akizawa et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

The Uremic Toxin 3-Indoxyl Sulfate Is a Potent Endogenous Agonist for the Human Aryl Hydrocarbon Receptor

(2009) Jennifer C. Schroeder et al.   BIOCHEMISTRY

Oral charcoal adsorbent (AST-120) prevents progression of cardiac damage in chronic kidney disease through suppression of oxidative stress

(2009) H. Fujii et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

p-Cresyl sulfate serum concentrations in haemodialysis patients are reduced by the prebiotic oligofructose-enriched inulin

(2009) B. K. I. Meijers et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Effects of Uremic Toxins on Vascular and Bone Remodeling

(2009) Fellype C. Barreto et al.   SEMINARS IN DIALYSIS