Sea Anemones: Quiet Achievers in the Field of Peptide Toxins

Peptide therapeutics from venom: Current status and potential

(2018) Michael W. Pennington et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Peptide fingerprinting of the sea anemone Heteractis magnifica mucus revealed neurotoxins, Kunitz-type proteinase inhibitors and a new β-defensin α-amylase inhibitor

(2018) Oksana Sintsova et al.   Journal of Proteomics

Structure, folding and stability of a minimal homologue from Anemonia sulcata of the sea anemone potassium channel blocker ShK

(2018) Bankala Krishnarjuna et al.   PEPTIDES

Revisiting venom of the sea anemone Stichodactyla haddoni : Omics techniques reveal the complete toxin arsenal of a well-studied sea anemone genus

(2017) Bruno Madio et al.   Journal of Proteomics

APETx4, a Novel Sea Anemone Toxin and a Modulator of the Cancer-Relevant Potassium Channel KV10.1

(2017) Lien Moreels et al.   Marine Drugs

Venom-derived peptide inhibitors of voltage-gated potassium channels

(2017) Raymond S. Norton et al.   NEUROPHARMACOLOGY

TRPV1 activation power can switch an action mode for its polypeptide ligands

(2017) Maxim V. Nikolaev et al.   PLoS One

Transcriptomic investigation of wound healing and regeneration in the cnidarian Calliactis polypus

(2017) Zachary K. Stewart et al.   Scientific Reports

Identification of unusual peptides with new Cys frameworks in the venom of the cold-water sea anemone Cnidopus japonicus

(2017) Vladislav V. Babenko et al.   Scientific Reports

Safety and pharmacodynamics of dalazatide, a Kv1.3 channel inhibitor, in the treatment of plaque psoriasis: A randomized phase 1b trial

(2017) Eric J. Tarcha et al.   PLoS One

Insights into the innate immunome of actiniarians using a comparative genomic approach

(2016) Chloé A. van der Burg et al.   BMC GENOMICS

Tissue-Specific Venom Composition and Differential Gene Expression in Sea Anemones

(2016) Jason Macrander et al.   Genome Biology and Evolution

Single-cell genome sequencing: current state of the science

(2016) Charles Gawad et al.   NATURE REVIEWS GENETICS

Evolution of the Cytolytic Pore-Forming Proteins (Actinoporins) in Sea Anemones

(2016) Jason Macrander et al.   Toxins

Tentacle Transcriptome and Venom Proteome of the Pacific Sea Nettle, Chrysaora fuscescens (Cnidaria: Scyphozoa)

(2016) Dalia Ponce et al.   Toxins

A RNA-seq approach to identify putative toxins from acrorhagi in aggressive and non-aggressive Anthopleura elegantissima polyps

(2015) Jason Macrander et al.   BMC GENOMICS

N-terminally extended analogues of the K+channel toxin fromStichodactyla helianthusas potent and selective blockers of the voltage-gated potassium channel Kv1.3

(2015) Shih C. Chang et al.   FEBS Journal

Pharmaceutical Optimization of Peptide Toxins for Ion Channel Targets: Potent, Selective, and Long-Lived Antagonists of Kv1.3

(2015) Justin K. Murray et al.   JOURNAL OF MEDICINAL CHEMISTRY

Development of Highly Selective Kv1.3-Blocking Peptides Based on the Sea Anemone Peptide ShK

(2015) Michael Pennington et al.   Marine Drugs

Production and packaging of a biological arsenal: Evolution of centipede venoms under morphological constraint

(2015) Eivind A. B. Undheim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The genome ofAiptasia, a sea anemone model for coral symbiosis

(2015) Sebastian Baumgarten et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ancient Venom Systems: A Review on Cnidaria Toxins

(2015) Mahdokht Jouiaei et al.   Toxins

Kv1.3 channel-blocking immunomodulatory peptides from parasitic worms: implications for autoimmune diseases

(2014) Sandeep Chhabra et al.   FASEB JOURNAL

Understanding the Molecular Basis of Toxin Promiscuity: The Analgesic Sea Anemone Peptide APETx2 Interacts with Acid-Sensing Ion Channel 3 and hERG Channels via Overlapping Pharmacophores

(2014) Jonas E. Jensen et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Dynamically Evolving Nematocyst Content of an Anthozoan, a Scyphozoan, and a Hydrozoan

(2014) Tamar Rachamim et al.   MOLECULAR BIOLOGY AND EVOLUTION

Margatoxin is a non-selective inhibitor of human Kv1.3 K+ channels

(2014) Adam Bartok et al.   TOXICON

Domain structure and function of matrix metalloprotease 23 (MMP23): role in potassium channel trafficking

(2013) Charles A. Galea et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The proteomic profile of Stichodactyla duerdeni secretion reveals the presence of a novel O-linked glycopeptide

(2013) Juliana Silva Cassoli et al.   Journal of Proteomics

Genetic programs in human and mouse early embryos revealed by single-cell RNA sequencing

(2013) Zhigang Xue et al.   NATURE

A Potent and Selective Peptide Blocker of the Kv1.3 Channel: Prediction from Free-Energy Simulations and Experimental Confirmation

(2013) M. Harunur Rashid et al.   PLoS One

A natural point mutation changes both target selectivity and mechanism of action of sea anemone toxins

(2012) Steve Peigneur et al.   FASEB JOURNAL

A C-terminally amidated analogue of ShK is a potent and selective blocker of the voltage-gated potassium channel Kv1.3

(2012) Michael W. Pennington et al.   FEBS LETTERS

Modulation of neuronal sodium channels by the sea anemone peptide BDS-I

(2012) Pin Liu et al.   JOURNAL OF NEUROPHYSIOLOGY

Analysis of Soluble Protein Contents from the Nematocysts of a Model Sea Anemone Sheds Light on Venom Evolution

(2012) Yehu Moran et al.   MARINE BIOTECHNOLOGY

Sea Anemone (Cnidaria, Anthozoa, Actiniaria) Toxins: An Overview

(2012) Bárbara Frazão et al.   Marine Drugs

Australian carybdeid jellyfish causing “Irukandji syndrome”

(2012) James Tibballs et al.   TOXICON

A systems genetic analysis of high density lipoprotein metabolism and network preservation across mouse models

(2011) Peter Langfelder et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Actinia ebhayiensis sp. nov., a new species of sea anemone (Anthozoa: Actiniaria: Actiniidae) from South Africa

(2011) Renata Schama et al.   JOURNAL OF THE MARINE BIOLOGICAL ASSOCIATION OF THE UNITED KINGDOM

Peptide fingerprinting of the neurotoxic fractions isolated from the secretions of sea anemones Stichodactyla helianthus and Bunodosoma granulifera. New members of the APETx-like family identified by a 454 pyrosequencing approach

(2011) Armando Alexei Rodríguez et al.   PEPTIDES

Development of a sea anemone toxin as an immunomodulator for therapy of autoimmune diseases

(2011) Victor Chi et al.   TOXICON

The functional network of ion channels in T lymphocytes

(2009) Michael D. Cahalan et al.   IMMUNOLOGICAL REVIEWS

Potassium Channel Modulation by a Toxin Domain in Matrix Metalloprotease 23

(2009) Srikant Rangaraju et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Engineering a Stable and Selective Peptide Blocker of the Kv1.3 Channel in T Lymphocytes

(2009) M. W. Pennington et al.   MOLECULAR PHARMACOLOGY

Novel peptide toxins recently isolated from sea anemones

(2009) Kazuo Shiomi   TOXICON

Discovery and characterization of cnidarian peptide toxins that affect neuronal potassium ion channels

(2009) Olga Castañeda et al.   TOXICON

Structural diversity, systematics, and evolution of cnidae

(2009) Daphne Gail Fautin   TOXICON

Structures of sea anemone toxins

(2009) Raymond S. Norton   TOXICON

WGCNA: an R package for weighted correlation network analysis

(2008) Peter Langfelder et al.   BMC BIOINFORMATICS

Proteomics of the neurotoxic fraction from the sea anemone Bunodosoma cangicum venom: Novel peptides belonging to new classes of toxins

(2008) André Junqueira Zaharenko et al.   Comparative Biochemistry and Physiology D-Genomics & Proteomics

Analgesic Compound from Sea AnemoneHeteractis crispaIs the First Polypeptide Inhibitor of Vanilloid Receptor 1 (TRPV1)

(2008) Yaroslav A. Andreev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY