N-terminally extended analogues of the K+channel toxin fromStichodactyla helianthusas potent and selective blockers of the voltage-gated potassium channel Kv1.3

Blocking KV1.3 Channels Inhibits Th2 Lymphocyte Function and Treats a Rat Model of Asthma

(2014) Shyny Koshy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression of T-cell KV1.3 potassium channel correlates with pro-inflammatory cytokines and disease activity in ulcerative colitis

(2014) Lars Koch Hansen et al.   Journal of Crohns & Colitis

Margatoxin is a non-selective inhibitor of human Kv1.3 K+ channels

(2014) Adam Bartok et al.   TOXICON

Blockade of Kv1.3 Potassium Channels Inhibits Differentiation and Granzyme B Secretion of Human CD8+ T Effector Memory Lymphocytes

(2013) Lina Hu et al.   PLoS One

A Potent and Selective Peptide Blocker of the Kv1.3 Channel: Prediction from Free-Energy Simulations and Experimental Confirmation

(2013) M. Harunur Rashid et al.   PLoS One

Blocking KCa3.1 Channels Increases Tumor Cell Killing by a Subpopulation of Human Natural Killer Lymphocytes

(2013) Shyny Koshy et al.   PLoS One

Probing water micro-solvation in proteins by water catalysed proton-transfer tautomerism

(2013) Jiun-Yi Shen et al.   Nature Communications

Kv1.1 and Kv1.2: Similar channels, different seizure models

(2012) Carol A. Robbins et al.   EPILEPSIA

Granzyme B-Induced Neurotoxicity Is Mediated via Activation of PAR-1 Receptor and Kv1.3 Channel

(2012) Tongguang Wang et al.   PLoS One

Expression and isotopic labelling of the potassium channel blocker ShK toxin as a thioredoxin fusion protein in bacteria

(2012) Shih Chieh Chang et al.   TOXICON

Geoepidemiology, gender and autoimmune disease

(2011) Luca Moroni et al.   AUTOIMMUNITY REVIEWS

Development of a sea anemone toxin as an immunomodulator for therapy of autoimmune diseases

(2011) Victor Chi et al.   TOXICON

Demyelination as a complication of new immunomodulatory treatments

(2010) Andreas P Lysandropoulos et al.   CURRENT OPINION IN NEUROLOGY

Defining and analyzing geoepidemiology and human autoimmunity

(2010) Yinon Shapira et al.   JOURNAL OF AUTOIMMUNITY

Energy Matrix of Structurally Important Side-Chain/Side-Chain Interactions in Proteins

(2010) Karel Berka et al.   Journal of Chemical Theory and Computation

The Beneficial Effect of Blocking Kv1.3 in the Psoriasiform SCID Mouse Model

(2010) Amos Gilhar et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Blood–brain barrier disruption and enhanced vascular permeability in the multiple sclerosis model EAE

(2010) Jami Bennett et al.   JOURNAL OF NEUROIMMUNOLOGY

Activated T-Cells Inhibit Neurogenesis by Releasing Granzyme B: Rescue by Kv1.3 Blockers

(2010) T. Wang et al.   JOURNAL OF NEUROSCIENCE

Kv1.1 Potassium Channel Deficiency Reveals Brain-Driven Cardiac Dysfunction as a Candidate Mechanism for Sudden Unexplained Death in Epilepsy

(2010) E. Glasscock et al.   JOURNAL OF NEUROSCIENCE

Data exclusivity for biologics

(2010) Henry Grabowski et al.   NATURE REVIEWS DRUG DISCOVERY

Cardiotoxicity and other adverse events associated with mitoxantrone treatment for MS

(2010) E. Kingwell et al.   NEUROLOGY

Risks vs benefits of glatiramer acetate: a changing perspective as new therapies emerge for multiple sclerosis

(2010) Kenneth Johnson   Therapeutics and Clinical Risk Management

Engineering a Stable and Selective Peptide Blocker of the Kv1.3 Channel in T Lymphocytes

(2009) M. W. Pennington et al.   MOLECULAR PHARMACOLOGY

Voltage-gated potassium channels as therapeutic targets

(2009) Heike Wulff et al.   NATURE REVIEWS DRUG DISCOVERY

Imaging of Effector Memory T Cells during a Delayed-Type Hypersensitivity Reaction and Suppression by Kv1.3 Channel Block

(2008) Melanie P. Matheu et al.   IMMUNITY

Expansion of CD4+CD28− T cells producing high levels of interferon-γ in peripheral blood of patients with multiple sclerosis

(2008) Y Miyazaki et al.   Multiple Sclerosis Journal

Azatryptophans endow proteins with intrinsic blue fluorescence

(2008) S. Lepthien et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA