Polymorphic factor H-binding activity of CspA protects Lyme borreliae from the host complement in feeding ticks to facilitate tick-to-host transmission

Eliminating Factor H-Binding Activity of Borrelia burgdorferi CspZ Combined with Virus-Like Particle Conjugation Enhances Its Efficacy as a Lyme Disease Vaccine

(2018) Ashley L. Marcinkiewicz et al.   Frontiers in Immunology

Live-vaccinia virus encapsulation in pH-sensitive polymer increases safety of a reservoir-targeted Lyme disease vaccine by targeting gastrointestinal release

(2016) Aurelie Kern et al.   VACCINE

Hide and Seek: How Lyme Disease Spirochetes Overcome Complement Attack

(2016) Peter Kraiczy   Frontiers in Immunology

Lyme borreliosis

(2016) Allen C. Steere et al.   Nature Reviews Disease Primers

Host cell heparan sulfate glycosaminoglycans are ligands for OspF-related proteins of the Lyme disease spirochete

(2015) Yi-Pin Lin et al.   CELLULAR MICROBIOLOGY

Glycosaminoglycan binding byBorrelia burgdorferiadhesin BBK32 specifically and uniquely promotes joint colonization

(2015) Yi-Pin Lin et al.   CELLULAR MICROBIOLOGY

A Short-Term Borrelia burgdorferi Infection Model Identifies Tissue Tropisms and Bloodstream Survival Conferred by Adhesion Proteins

(2015) Jennifer A. Caine et al.   INFECTION AND IMMUNITY

Complement System Part I – Molecular Mechanisms of Activation and Regulation

(2015) Nicolas S. Merle et al.   Frontiers in Immunology

Bacterial self-defence: howEscherichia colievades serum killing

(2014) Helen Miajlovic et al.   FEMS MICROBIOLOGY LETTERS

Strain-Specific Variation of the Decorin-Binding Adhesin DbpA Influences the Tissue Tropism of the Lyme Disease Spirochete

(2014) Yi-Pin Lin et al.   PLoS Pathogens

Versatile Roles of CspA Orthologs in Complement Inactivation of Serum-Resistant Lyme Disease Spirochetes

(2013) Claudia Hammerschmidt et al.   INFECTION AND IMMUNITY

Human complement control and complement evasion by pathogenic microbes – Tipping the balance

(2013) Peter F. Zipfel et al.   MOLECULAR IMMUNOLOGY

Complement evasion by Borrelia burgdorferi: it takes three to tango

(2013) Steven W. de Taeye et al.   TRENDS IN PARASITOLOGY

CspA from Borrelia burgdorferi Inhibits the Terminal Complement Pathway

(2013) T. Hallstrom et al.   mBio

Genetics ofBorrelia burgdorferi

(2012) Dustin Brisson et al.   Annual Review of Genetics

Contribution of the Infection-Associated Complement Regulator-Acquiring Surface Protein 4 (ErpC) to Complement Resistance ofBorrelia burgdorferi

(2012) Claudia Hammerschmidt et al.   Clinical & Developmental Immunology

The role of Borrelia burgdorferi outer surface proteins

(2012) Melisha R. Kenedy et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Variable regions in the sushi domains 6–7 and 19–20 of factor H in animals and human lead to change in the affinity to factor H binding protein of Borrelia

(2012) Mangesh Bhide et al.   Journal of Proteomics

The β3-integrin ligand ofBorrelia burgdorferiis critical for infection of mice but not ticks

(2012) Laura C. Ristow et al.   MOLECULAR MICROBIOLOGY

Vascular binding of a pathogen under shear force through mechanistically distinct sequential interactions with host macromolecules

(2012) Tara J. Moriarty et al.   MOLECULAR MICROBIOLOGY

Of ticks, mice and men: understanding the dual-host lifestyle of Lyme disease spirochaetes

(2012) Justin D. Radolf et al.   NATURE REVIEWS MICROBIOLOGY

Complement regulator-acquiring surface proteins of Borrelia burgdorferi: Structure, function and regulation of gene expression

(2012) Peter Kraiczy et al.   Ticks and Tick-Borne Diseases

Campylobacter Polysaccharide Capsules: Virulence and Vaccines

(2012) Patricia Guerry et al.   Frontiers in Cellular and Infection Microbiology

The Hybrid Histidine Kinase Hk1 Is Part of a Two-Component System That Is Essential for Survival of Borrelia burgdorferi in Feeding Ixodes scapularis Ticks

(2011) Melissa J. Caimano et al.   INFECTION AND IMMUNITY

A Surface Enolase Participates in Borrelia burgdorferi-Plasminogen Interaction and Contributes to Pathogen Survival within Feeding Ticks

(2011) Sarah Veloso Nogueira et al.   INFECTION AND IMMUNITY

The coenzyme A disulphide reductase of Borrelia burgdorferi is important for rapid growth throughout the enzootic cycle and essential for infection of the mammalian host

(2011) Christian H. Eggers et al.   MOLECULAR MICROBIOLOGY

Borrelia burgdorferi BBA52 is a potential target for transmission blocking Lyme disease vaccine

(2011) Manish Kumar et al.   VACCINE

Identification and functional characterisation of Complement Regulator Acquiring Surface Protein-1 of serum resistant Borrelia garinii OspA serotype 4

(2010) Nathalie D. van Burgel et al.   BMC MICROBIOLOGY

Complement Regulator–Acquiring Surface Protein 1 ofBorrelia burgdorferiBinds to Human Bone Morphogenic Protein 2, Several Extracellular Matrix Proteins, and Plasminogen

(2010) Teresia Hallström et al.   JOURNAL OF INFECTIOUS DISEASES

Complement: a key system for immune surveillance and homeostasis

(2010) Daniel Ricklin et al.   NATURE IMMUNOLOGY

Complement Factor H-Related Proteins CFHR2 and CFHR5 Represent Novel Ligands for the Infection-Associated CRASP Proteins of Borrelia burgdorferi

(2010) Corinna Siegel et al.   PLoS One

Human Complement Regulators C4b-Binding Protein and C1 Esterase Inhibitor Interact with a Novel Outer Surface Protein of Borrelia recurrentis

(2010) Sonja Grosskinsky et al.   PLoS Neglected Tropical Diseases

CspA-Mediated Binding of Human Factor H Inhibits Complement Deposition and Confers Serum Resistance in Borrelia burgdorferi

(2009) M. R. Kenedy et al.   INFECTION AND IMMUNITY

Mutational analyses of the BbCRASP-1 protein of Borrelia burgdorferi identify residues relevant for the architecture and binding of host complement regulators FHL-1 and factor H

(2009) Peter Kraiczy et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Borrelia burgdorferi bba74 Is Expressed Exclusively during Tick Feeding and Is Regulated by Both Arthropod- and Mammalian Host-Specific Signals

(2009) V. B. Mulay et al.   JOURNAL OF BACTERIOLOGY

GuaA and GuaB Are Essential for Borrelia burgdorferi Survival in the Tick-Mouse Infection Cycle

(2009) M. W. Jewett et al.   JOURNAL OF BACTERIOLOGY

Fibronectin Binds to and Induces Conformational Change in a Disordered Region of Leptospiral Immunoglobulin-like Protein B

(2009) Yi-Pin Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

C3b deposition on human erythrocytes induces the formation of a membrane skeleton–linked protein complex

(2009) Pallop Karnchanaphanurach et al.   JOURNAL OF CLINICAL INVESTIGATION

Live imaging reveals a biphasic mode of dissemination of Borrelia burgdorferi within ticks

(2009) Star M. Dunham-Ems et al.   JOURNAL OF CLINICAL INVESTIGATION

Preparing serum for functional complement assays

(2009) P.J. Lachmann   JOURNAL OF IMMUNOLOGICAL METHODS

BosR (BB0647) governs virulence expression in Borrelia burgdorferi

(2009) Zhiming Ouyang et al.   MOLECULAR MICROBIOLOGY

Rrp1, a cyclic-di-GMP-producing response regulator, is an important regulator ofBorrelia burgdorfericore cellular functions

(2009) Elizabeth A. Rogers et al.   MOLECULAR MICROBIOLOGY

Borrelia burgdorferismall lipoprotein Lp6.6 is a member of multiple protein complexes in the outer membrane and facilitates pathogen transmission from ticks to mice

(2009) Kamoltip Promnares et al.   MOLECULAR MICROBIOLOGY

Complement evasion by human pathogens

(2008) John D. Lambris et al.   NATURE REVIEWS MICROBIOLOGY

Borrelia burgdorferi Complement Regulator-Acquiring Surface Protein 2 Does Not Contribute to Complement Resistance or Host Infectivity

(2008) Adam S. Coleman et al.   PLoS One