Benzoxaborole treatment perturbs S-adenosyl-L-methionine metabolism in Trypanosoma brucei

A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue

(2017) Ebere Sonoiki et al.   Nature Communications

Phenotypic, chemical and functional characterization of cyclic nucleotide phosphodiesterase 4 (PDE4) as a potential anthelmintic drug target

(2017) Thavy Long et al.   PLoS Neglected Tropical Diseases

Cryptosporidium and Toxoplasma Parasites Are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase

(2016) Andrés Palencia et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Untargeted Metabolomics To Ascertain Antibiotic Modes of Action

(2016) Isabel M. Vincent et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Benzoxaborole as a new chemotype for carbonic anhydrase inhibition

(2016) Vincenzo Alterio et al.   CHEMICAL COMMUNICATIONS

Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy

(2016) Ludovica Morera et al.   Clinical Epigenetics

Discovery of an orally bioavailable isoxazoline benzoxaborole ( AN8030 ) as a long acting animal ectoparasiticide

(2015) Yong-Kang Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

MetaboAnalyst 3.0—making metabolomics more meaningful

(2015) Jianguo Xia et al.   NUCLEIC ACIDS RESEARCH

The MetaCyc database of metabolic pathways and enzymes and the BioCyc collection of pathway/genome databases

(2015) Ron Caspi et al.   NUCLEIC ACIDS RESEARCH

Genomic and Proteomic Studies on the Mode of Action of Oxaboroles against the African Trypanosome

(2015) Deuan C. Jones et al.   PLoS Neglected Tropical Diseases

InterProScan 5: genome-scale protein function classification

(2014) P. Jones et al.   BIOINFORMATICS

Tavaborole: First Global Approval

(2014) Anthony Markham   DRUGS

Regulation ofS-Adenosylhomocysteine Hydrolase by Lysine Acetylation

(2014) Yun Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanistic Diversity of RadicalS-Adenosylmethionine (SAM)-dependent Methylation

(2014) Matthew R. Bauerle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SMART: recent updates, new developments and status in 2015

(2014) Ivica Letunic et al.   NUCLEIC ACIDS RESEARCH

Analogues of the Natural Product Sinefungin as Inhibitors of EHMT1 and EHMT2

(2014) Kanchan Devkota et al.   ACS Medicinal Chemistry Letters

Benznidazole Biotransformation and Multiple Targets in Trypanosoma cruzi Revealed by Metabolomics

(2014) Andrea Trochine et al.   PLoS Neglected Tropical Diseases

ComparativeIn VitroActivities of GSK2251052, a Novel Boron-Containing Leucyl-tRNA Synthetase Inhibitor, against 916 Anaerobic Organisms

(2013) Ellie J. C. Goldstein et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Metabolomics Guides Rational Development of a Simplified Cell Culture Medium for Drug Screening against Trypanosoma brucei

(2013) Darren J. Creek et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Discovery of a Novel Class of Boron-Based Antibacterials with Activity against Gram-Negative Bacteria

(2013) Vincent Hernandez et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Methionine salvage andS-adenosylmethionine: essential links between sulfur, ethylene and polyamine biosynthesis

(2013) Margret Sauter et al.   BIOCHEMICAL JOURNAL

Structure–activity relationships of 6-(aminomethylphenoxy)-benzoxaborole derivatives as anti-inflammatory agent

(2013) Tsutomu Akama et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Pfam: the protein families database

(2013) Robert D. Finn et al.   NUCLEIC ACIDS RESEARCH

DNA Break Site at Fragile Subtelomeres Determines Probability and Mechanism of Antigenic Variation in African Trypanosomes

(2013) Lucy Glover et al.   PLoS Pathogens

mzMatch–ISO: an R tool for the annotation and relative quantification of isotope-labelled mass spectrometry data

(2012) Achuthanunni Chokkathukalam et al.   BIOINFORMATICS

IDEOM: an Excel interface for analysis of LC–MS-based metabolomics data

(2012) Darren J. Creek et al.   BIOINFORMATICS

Management of trypanosomiasis and leishmaniasis

(2012) M. P. Barrett et al.   BRITISH MEDICAL BULLETIN

A cross-platform toolkit for mass spectrometry and proteomics

(2012) Matthew C Chambers et al.   NATURE BIOTECHNOLOGY

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Spliced leader RNA silencing (SLS) - a programmed cell death pathway in Trypanosoma brucei that is induced upon ER stress

(2012) Shulamit Michaeli   Parasites & Vectors

Untargeted Metabolomics Reveals a Lack Of Synergy between Nifurtimox and Eflornithine against Trypanosoma brucei

(2012) Isabel M. Vincent et al.   PLoS Neglected Tropical Diseases

PeakML/mzMatch: A File Format, Java Library, R Library, and Tool-Chain for Mass Spectrometry Data Analysis

(2011) Richard A. Scheltema et al.   ANALYTICAL CHEMISTRY

Drug resistance in human African trypanosomiasis

(2011) Michael P Barrett et al.   Future Microbiology

High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome

(2011) S. Alsford et al.   GENOME RESEARCH

Activity and Safety of Synthetic Lectins Based on Benzoboroxole-Functionalized Polymers for Inhibition of HIV Entry

(2011) Alamelu Mahalingam et al.   MOLECULAR PHARMACEUTICS

Comprehensive Structural and Substrate Specificity Classification of the Saccharomyces cerevisiae Methyltransferome

(2011) Tomasz Wlodarski et al.   PLoS One

SCYX-7158, an Orally-Active Benzoxaborole for the Treatment of Stage 2 Human African Trypanosomiasis

(2011) Robert T. Jacobs et al.   PLoS Neglected Tropical Diseases

Discovery of Novel Orally Bioavailable Oxaborole 6-Carboxamides That Demonstrate Cure in a Murine Model of Late-Stage Central Nervous System African Trypanosomiasis

(2010) B. Nare et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Uncovering the Human Methyltransferasome

(2010) Tanya C. Petrossian et al.   MOLECULAR & CELLULAR PROTEOMICS

Chaperone Requirements for Biosynthesis of the Trypanosome Variant Surface Glycoprotein

(2010) Mark C. Field et al.   PLoS One

Persistent ER Stress Induces the Spliced Leader RNA Silencing Pathway (SLS), Leading to Programmed Cell Death in Trypanosoma brucei

(2010) Hanoch Goldshmidt et al.   PLoS Pathogens

TriTrypDB: a functional genomic resource for the Trypanosomatidae

(2009) Martin Aslett et al.   NUCLEIC ACIDS RESEARCH

KEGG Atlas mapping for global analysis of metabolic pathways

(2008) S. Okuda et al.   NUCLEIC ACIDS RESEARCH

Population genetics of Trypanosoma brucei gambiense, the agent of sleeping sickness in Western Africa

(2008) M. Koffi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA