Mechanistic Diversity of RadicalS-Adenosylmethionine (SAM)-dependent Methylation

Biosynthesis of the Structurally Unique Polycyclopropanated Polyketide-Nucleoside Hybrid Jawsamycin (FR-900848)

(2014) Tomoshige Hiratsuka et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Radical S-Adenosylmethionine Enzymes

(2014) Joan B. Broderick et al.   CHEMICAL REVIEWS

Identification of a Unique Radical S-Adenosylmethionine Methylase Likely Involved in Methanopterin Biosynthesis in Methanocaldococcus jannaschii

(2014) K. D. Allen et al.   JOURNAL OF BACTERIOLOGY

Characterization of a Cross-Linked Protein–Nucleic Acid Substrate Radical in the Reaction Catalyzed by RlmN

(2014) Alexey Silakov et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Initial characterization of Fom3 from Streptomyces wedmorensis: The methyltransferase in fosfomycin biosynthesis

(2013) Kylie D. Allen et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

The Mechanisms of Radical SAM/Cobalamin Methylations: An Evolving Working Hypothesis.

(2013) K. K. Jason Chan et al.   CHEMBIOCHEM

Radical SAM-mediated methylation reactions

(2013) Danica Galonić Fujimori   CURRENT OPINION IN CHEMICAL BIOLOGY

GenK-Catalyzed C-6′ Methylation in the Biosynthesis of Gentamicin: Isolation and Characterization of a Cobalamin-Dependent Radical SAM Enzyme

(2013) Hak Joong Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A substrate radical intermediate in catalysis by the antibiotic resistance protein Cfr

(2013) Tyler L Grove et al.   Nature Chemical Biology

The Structure–Function Linkage Database

(2013) Eyal Akiva et al.   NUCLEIC ACIDS RESEARCH

S-adenosyl-L-homocysteine hydrolase and methylation disorders: Yeast as a model system

(2012) Oksana Tehlivets et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Identification and function of auxiliary iron–sulfur clusters in radical SAM enzymes

(2012) Nicholas D. Lanz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Covalent Intermediate in the Catalytic Mechanism of the Radical S-Adenosyl-l-methionine Methyl Synthase RlmN Trapped by Mutagenesis

(2012) Kevin P. McCusker et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Characterization of Yatakemycin Gene Cluster Revealing a Radical S-Adenosylmethionine Dependent Methyltransferase and Highlighting Spirocyclopropane Biosynthesis

(2012) Wei Huang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Radical SAM enzymes in methylation and methylthiolation

(2012) Rachel U. Hutcheson et al.   Metallomics

Thiostrepton tryptophan methyltransferase expands the chemistry of radical SAM enzymes

(2012) Stéphane Pierre et al.   Nature Chemical Biology

The Escherichia coli RlmN methyltransferase is a dual-specificity enzyme that modifies both rRNA and tRNA and controls translational accuracy

(2012) A. Benitez-Paez et al.   RNA

Radical-Mediated Enzymatic Methylation: A Tale of Two SAMS

(2011) Qi Zhang et al.   ACCOUNTS OF CHEMICAL RESEARCH

In Vitro Phosphinate Methylation by PhpK fromKitasatospora phosalacinea

(2011) Williard J. Werner et al.   BIOCHEMISTRY

S-Adenosylmethionine-dependent alkylation reactions: When are radical reactions used?

(2011) Hening Lin   BIOORGANIC CHEMISTRY

Cfr and RlmN Contain a Single [4Fe-4S] Cluster, which Directs Two Distinct Reactivities forS-Adenosylmethionine: Methyl Transfer by SN2 Displacement and Radical Generation

(2011) Tyler L. Grove et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

InterPro in 2011: new developments in the family and domain prediction database

(2011) S. Hunter et al.   NUCLEIC ACIDS RESEARCH

RNA methylation by Radical SAM enzymes RlmN and Cfr proceeds via methylene transfer and hydride shift

(2011) F. Yan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Radically Different Mechanism for S-Adenosylmethionine-Dependent Methyltransferases

(2011) T. L. Grove et al.   SCIENCE

Structural Basis for Methyl Transfer by a Radical SAM Enzyme

(2011) A. K. Boal et al.   SCIENCE

The key function of a conserved and modified rRNA residue in the ribosomal response to the nascent peptide

(2010) Nora Vázquez-Laslop et al.   EMBO JOURNAL

RlmN and Cfr are Radical SAM Enzymes Involved in Methylation of Ribosomal RNA

(2010) Feng Yan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Anaerobic functionalization of unactivated C–H bonds

(2009) Squire J Booker   CURRENT OPINION IN CHEMICAL BIOLOGY

Thiostrepton Biosynthesis: Prototype for a New Family of Bacteriocins

(2009) Wendy L. Kelly et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Recent advances in thiopeptideantibiotic biosynthesis

(2009) Chaoxuan Li et al.   NATURAL PRODUCT REPORTS

Insights into the structure, function and evolution of the radical-SAM 23S rRNA methyltransferase Cfr that confers antibiotic resistance in bacteria

(2009) Katarzyna H. Kaminska et al.   NUCLEIC ACIDS RESEARCH

Identification of 8-methyladenosine as the modification catalyzed by the radical SAM methyltransferase Cfr that confers antibiotic resistance in bacteria

(2009) A. M. B. Giessing et al.   RNA

Transcriptional and Translational Control of the mlr Operon, Which Confers Resistance to Seven Classes of Protein Synthesis Inhibitors

(2008) L. K. Smith et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY