Benznidazole Biotransformation and Multiple Targets in Trypanosoma cruzi Revealed by Metabolomics

Metabolomics Guides Rational Development of a Simplified Cell Culture Medium for Drug Screening against Trypanosoma brucei

(2013) Darren J. Creek et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Unveiling Benznidazole's mechanism of action through overexpression of DNA repair proteins inTrypanosoma cruzi

(2013) Matheus Andrade Rajão et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Benznidazole and Posaconazole in Experimental Chagas Disease: Positive Interaction in Concomitant and Sequential Treatments

(2013) Lívia de Figueiredo Diniz et al.   PLoS Neglected Tropical Diseases

Evaluation of Coupling Reversed Phase, Aqueous Normal Phase, and Hydrophilic Interaction Liquid Chromatography with Orbitrap Mass Spectrometry for Metabolomic Studies of Human Urine

(2012) Tong Zhang et al.   ANALYTICAL CHEMISTRY

Assessing the Essentiality of Leishmania donovani Nitroreductase and Its Role in Nitro Drug Activation

(2012) S. Wyllie et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Phase II Dose-Ranging Trial of the Early Bactericidal Activity of PA-824

(2012) Andreas H. Diacon et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IDEOM: an Excel interface for analysis of LC–MS-based metabolomics data

(2012) Darren J. Creek et al.   BIOINFORMATICS

MetaboAnalyst 2.0--a comprehensive server for metabolomic data analysis

(2012) J. Xia et al.   NUCLEIC ACIDS RESEARCH

Untargeted Metabolomics Reveals a Lack Of Synergy between Nifurtimox and Eflornithine against Trypanosoma brucei

(2012) Isabel M. Vincent et al.   PLoS Neglected Tropical Diseases

PeakML/mzMatch: A File Format, Java Library, R Library, and Tool-Chain for Mass Spectrometry Data Analysis

(2011) Richard A. Scheltema et al.   ANALYTICAL CHEMISTRY

Toward Global Metabolomics Analysis with Hydrophilic Interaction Liquid Chromatography–Mass Spectrometry: Improved Metabolite Identification by Retention Time Prediction

(2011) Darren J. Creek et al.   ANALYTICAL CHEMISTRY

Activation of Benznidazole by Trypanosomal Type I Nitroreductases Results in Glyoxal Formation

(2011) Belinda S. Hall et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Profiling the Reactive Metabolites of Xenobiotics Using Metabolomic Technologies

(2011) Feng Li et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Trypanocidal Activity of Nitroaromatic Prodrugs: Current Treatments and Future Perspectives

(2011) Shane R. Wilkinson et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Nifurtimox Activation by Trypanosomal Type I Nitroreductases Generates Cytotoxic Nitrile Metabolites

(2011) Belinda S. Hall et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

iPath2.0: interactive pathway explorer

(2011) Takuji Yamada et al.   NUCLEIC ACIDS RESEARCH

Metabolic Variation during Development in Culture of Leishmania donovani Promastigotes

(2011) Ana Marta Silva et al.   PLoS Neglected Tropical Diseases

Towards an unbiased metabolic profiling of protozoan parasites: optimisation of a Leishmania sampling protocol for HILIC-orbitrap analysis

(2010) Ruben t’Kindt et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Chagas disease

(2010) Anis Rassi et al.   LANCET

Metabolomic systems biology of trypanosomes

(2010) MICHAEL P. BARRETT et al.   PARASITOLOGY

Metabolomics to Unveil and Understand Phenotypic Diversity between Pathogen Populations

(2010) Ruben t'Kindt et al.   PLoS Neglected Tropical Diseases

Fexinidazole – A New Oral Nitroimidazole Drug Candidate Entering Clinical Development for the Treatment of Sleeping Sickness

(2010) Els Torreele et al.   PLoS Neglected Tropical Diseases

Specific chemotherapy of Chagas disease: Relevance, current limitations and new approaches

(2009) Julio A. Urbina   ACTA TROPICA

Nifurtimox-eflornithine combination therapy for second-stage African Trypanosoma brucei gambiense trypanosomiasis: a multicentre, randomised, phase III, non-inferiority trial

(2009) Gerardo Priotto et al.   LANCET

The BENEFIT trial: testing the hypothesis that trypanocidal therapy is beneficial for patients with chronic Chagas heart disease

(2009) J Antonio Marin-Neto et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

Trichomonas vaginalis: metronidazole and other nitroimidazole drugs are reduced by the flavin enzyme thioredoxin reductase and disrupt the cellular redox system. Implications for nitroimidazole toxicity and resistance

(2009) David Leitsch et al.   MOLECULAR MICROBIOLOGY

KEGG for representation and analysis of molecular networks involving diseases and drugs

(2009) Minoru Kanehisa et al.   NUCLEIC ACIDS RESEARCH

MetaboAnalyst: a web server for metabolomic data analysis and interpretation

(2009) J. Xia et al.   NUCLEIC ACIDS RESEARCH

Electron microscopy and cytochemistry analysis of the endocytic pathway of pathogenic protozoa

(2009) Wanderley de Souza et al.   PROGRESS IN HISTOCHEMISTRY AND CYTOCHEMISTRY

Buthionine Sulfoximine Has Anti-Trypanosoma cruzi Activity in a Murine Model of Acute Chagas' Disease and Enhances the Efficacy of Nifurtimox

(2008) M. Faundez et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Multiple NADPH–cytochrome P450 reductases from Trypanosoma cruzi

(2008) Patricio Portal et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes

(2008) Shane R. Wilkinson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolomic profiling using Orbitrap Fourier transform mass spectrometry with hydrophilic interaction chromatography: a method with wide applicability to analysis of biomolecules

(2008) A. Kamleh et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

PA-824 Kills Nonreplicating Mycobacterium tuberculosis by Intracellular NO Release

(2008) R. Singh et al.   SCIENCE

Peroxiredoxins from Trypanosoma cruzi: Virulence factors and drug targets for treatment of Chagas disease?

(2007) María Dolores Piñeyro et al.   GENE