Metabolomics Guides Rational Development of a Simplified Cell Culture Medium for Drug Screening against Trypanosoma brucei

Evaluation of Coupling Reversed Phase, Aqueous Normal Phase, and Hydrophilic Interaction Liquid Chromatography with Orbitrap Mass Spectrometry for Metabolomic Studies of Human Urine

(2012) Tong Zhang et al.   ANALYTICAL CHEMISTRY

IDEOM: an Excel interface for analysis of LC–MS-based metabolomics data

(2012) Darren J. Creek et al.   BIOINFORMATICS

Antiparasitic agents: new drugs on the horizon

(2012) Pascal Mäser et al.   CURRENT OPINION IN PHARMACOLOGY

Proliferating bloodstream-form Trypanosoma brucei use a negligible part of consumed glucose for anabolic processes

(2012) Jurgen R. Haanstra et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Thede novoand salvage pathways of GDP-mannose biosynthesis are both sufficient for the growth of bloodstream-formTrypanosoma brucei

(2012) Sabine Kuettel et al.   MOLECULAR MICROBIOLOGY

High-throughput decoding of antitrypanosomal drug efficacy and resistance

(2012) Sam Alsford et al.   NATURE

Untargeted Metabolomics Reveals a Lack Of Synergy between Nifurtimox and Eflornithine against Trypanosoma brucei

(2012) Isabel M. Vincent et al.   PLoS Neglected Tropical Diseases

Application of a resazurin-based high-throughput screening assay for the identification and progression of new treatments for human African trypanosomiasis

(2012) Tana Bowling et al.   International Journal for Parasitology-Drugs and Drug Resistance

PeakML/mzMatch: A File Format, Java Library, R Library, and Tool-Chain for Mass Spectrometry Data Analysis

(2011) Richard A. Scheltema et al.   ANALYTICAL CHEMISTRY

Toward Global Metabolomics Analysis with Hydrophilic Interaction Liquid Chromatography–Mass Spectrometry: Improved Metabolite Identification by Retention Time Prediction

(2011) Darren J. Creek et al.   ANALYTICAL CHEMISTRY

Metabolomics Profiling of Cell Culture Media Leading to the Identification of Riboflavin Photosensitized Degradation of Tryptophan Causing Slow Growth in Cell Culture

(2011) Li Zang et al.   ANALYTICAL CHEMISTRY

Trypanocidal Furamidine Analogues: Influence of Pyridine Nitrogens on Trypanocidal Activity, Transport Kinetics, and Resistance Patterns

(2011) Christopher P. Ward et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Drug resistance in human African trypanosomiasis

(2011) Michael P Barrett et al.   Future Microbiology

Development of novel drugs for human African trypanosomiasis

(2011) Reto Brun et al.   Future Microbiology

Isotopomer Profiling ofLeishmania mexicanaPromastigotes Reveals Important Roles for Succinate Fermentation and Aspartate Uptake in Tricarboxylic Acid Cycle (TCA) Anaplerosis, Glutamate Synthesis, and Growth

(2011) Eleanor C. Saunders et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolomic analysis of trypanosomatid protozoa

(2011) Darren J. Creek et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

SCYX-7158, an Orally-Active Benzoxaborole for the Treatment of Stage 2 Human African Trypanosomiasis

(2011) Robert T. Jacobs et al.   PLoS Neglected Tropical Diseases

Advances in mass spectrometry applied to pharmaceutical metabolomics

(2010) Dieter M. Drexler et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Towards an unbiased metabolic profiling of protozoan parasites: optimisation of a Leishmania sampling protocol for HILIC-orbitrap analysis

(2010) Ruben t’Kindt et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Fermentanomics: Monitoring Mammalian Cell Cultures with NMR Spectroscopy

(2010) Scott A. Bradley et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Lipid metabolism in Trypanosoma brucei

(2010) Terry K. Smith et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Development of an Alamar Blue™ Viability Assay in 384-Well Format for High Throughput Whole Cell Screening of Trypanosoma brucei brucei Bloodstream Form Strain 427

(2009) Melissa L. Sykes et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Mass-spectrometry-based metabolomics: limitations and recommendations for future progress with particular focus on nutrition research

(2009) Augustin Scalbert et al.   Metabolomics

Simple data-reduction method for high-resolution LC–MS data in metabolomics

(2009) RA Scheltema et al.   Bioanalysis

Global Metabolic Profiling ofEscherichia coliCultures:  an Evaluation of Methods for Quenching and Extraction of Intracellular Metabolites

(2008) Catherine L. Winder et al.   ANALYTICAL CHEMISTRY

Antiparasitic compounds that target DNA

(2008) W. David Wilson et al.   BIOCHIMIE

Highly sensitive feature detection for high resolution LC/MS

(2008) Ralf Tautenhahn et al.   BMC BIOINFORMATICS

Chemical and genetic validation of dihydrofolate reductase–thymidylate synthase as a drug target in African trypanosomes

(2008) Natasha Sienkiewicz et al.   MOLECULAR MICROBIOLOGY

A domino effect in antifolate drug action in Escherichia coli

(2008) Yun Kyung Kwon et al.   Nature Chemical Biology

HMDB: a knowledgebase for the human metabolome

(2008) D. S. Wishart et al.   NUCLEIC ACIDS RESEARCH

Global metabolic responses of mice to Trypanosoma brucei brucei infection

(2008) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA