Rare human Caspase-6-R65W and Caspase-6-G66R variants identify a novel regulatory region of Caspase-6 activity

Caspase-6 Undergoes a Distinct Helix-Strand Interconversion upon Substrate Binding

(2017) Kevin B. Dagbay et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caspase vinyl sulfone small molecule inhibitors prevent axonal degeneration in human neurons and reverse cognitive impairment in Caspase-6-overexpressing mice

(2017) Prateep Pakavathkumar et al.   Molecular Neurodegeneration

Reprogramming Caspase-7 Specificity by Regio-Specific Mutations and Selection Provides Alternate Solutions for Substrate Recognition

(2016) Maureen E. Hill et al.   ACS Chemical Biology

Cacidases: caspases can cleave after aspartate, glutamate and phosphoserine residues

(2016) J E Seaman et al.   CELL DEATH AND DIFFERENTIATION

Caspases Connect Cell-Death Signaling to Organismal Homeostasis

(2016) Lorenzo Galluzzi et al.   IMMUNITY

Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles

(2016) Olivier Julien et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modifying Caspase-3 Activity by Altering Allosteric Networks

(2014) Christine Cade et al.   BIOCHEMISTRY

Caspase-6 activity in the CA1 region of the hippocampus induces age-dependent memory impairment

(2014) A C LeBlanc et al.   CELL DEATH AND DIFFERENTIATION

Caspase 6 Regulates B Cell Activation and Differentiation into Plasma Cells

(2014) C. Watanabe et al.   JOURNAL OF IMMUNOLOGY

Human Procaspase-1 Variants with Decreased Enzymatic Activity Are Associated with Febrile Episodes and May Contribute to Inflammation via RIP2 and NF- B Signaling

(2014) M. C. Heymann et al.   JOURNAL OF IMMUNOLOGY

Inflammation-Induced Tumorigenesis in Mouse Colon Is Caspase-6 Independent

(2014) Bénédicte Foveau et al.   PLoS One

Caspase-mediated cleavage of actin and tubulin is a common feature and sensitive marker of axonal degeneration in neural development and injury

(2014) Jennifer D Sokolowski et al.   Acta Neuropathologica Communications

Caspase-6 activity predicts lower episodic memory ability in aged individuals

(2013) Jasmine Ramcharitar et al.   NEUROBIOLOGY OF AGING

Expression and Activation of Caspase-6 in Human Fetal and Adult Tissues

(2013) Nelly Godefroy et al.   PLoS One

Distinct pathways mediate axon degeneration during apoptosis and axon-specific pruning

(2013) Corey L. Cusack et al.   Nature Communications

Structural insights into the calcium-dependent interaction between calbindin-D28K and caspase-3

(2012) Benjamin G. Bobay et al.   FEBS LETTERS

Rescue from excitotoxicity and axonal degeneration accompanied by age-dependent behavioral and neuroanatomical alterations in caspase-6-deficient mice

(2012) Valeria Uribe et al.   HUMAN MOLECULAR GENETICS

Naturally Occurring Genetic Variants of Human Caspase-1 Differ Considerably in Structure and the Ability to Activate Interleukin-1β

(2012) Hella Luksch et al.   HUMAN MUTATION

Inhibitory Mechanism of Caspase-6 Phosphorylation Revealed by Crystal Structures, Molecular Dynamics Simulations, and Biochemical Assays

(2012) Qin Cao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Zinc-mediated Allosteric Inhibition of Caspase-6

(2012) Elih M. Velázquez-Delgado et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Caspase Cascade Regulating Developmental Axon Degeneration

(2012) D. J. Simon et al.   JOURNAL OF NEUROSCIENCE

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

(2012) Thorlakur Jonsson et al.   NATURE

Allosteric peptides bind a caspase zymogen and mediate caspase tetramerization

(2012) Karen Stanger et al.   Nature Chemical Biology

Mechanistic and Structural Understanding of Uncompetitive Inhibitors of Caspase-6

(2012) Christopher E. Heise et al.   PLoS One

Phosphorylation Regulates Assembly of the Caspase-6 Substrate-Binding Groove

(2012) Elih M. Velázquez-Delgado et al.   STRUCTURE

Activation of Specific Apoptotic Caspases with an Engineered Small-Molecule-Activated Protease

(2010) Daniel C. Gray et al.   CELL

Crystal structures of human caspase 6 reveal a new mechanism for intramolecular cleavage self-activation

(2010) Xiao-Jun Wang et al.   EMBO REPORTS

Substrate-Induced Conformational Changes Occur in All Cleaved Forms of Caspase-6

(2010) Sravanti Vaidya et al.   JOURNAL OF MOLECULAR BIOLOGY

Identification of Caspase-6-Mediated Processing of the Valosin Containing Protein (p97) in Alzheimer's Disease: A Novel Link to Dysfunction in Ubiquitin Proteasome System-Mediated Protein Degradation

(2010) D. Halawani et al.   JOURNAL OF NEUROSCIENCE

A method and server for predicting damaging missense mutations

(2010) Ivan A Adzhubei et al.   NATURE METHODS

Familial amyloid precursor protein mutants cause caspase-6-dependent but amyloid β-peptide-independent neuronal degeneration in primary human neuron cultures.

(2010) S N Sivananthan et al.   Cell Death & Disease

The crystal structure of caspase-6, a selective effector of axonal degeneration

(2009) Renato Baumgartner et al.   BIOCHEMICAL JOURNAL

Caspase-6 Activation in Familial Alzheimer Disease Brains Carrying Amyloid Precursor Protein or Presenilin I or Presenilin II Mutations

(2009) Steffen Albrecht et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

APP binds DR6 to trigger axon pruning and neuron death via distinct caspases

(2009) Anatoly Nikolaev et al.   NATURE

Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm

(2009) Prateek Kumar et al.   Nature Protocols

Structural and Biochemical Studies on Procaspase-8: New Insights on Initiator Caspase Activation

(2009) Nadine Keller et al.   STRUCTURE

Self-activation of Caspase-6 in vitro and in vivo: Caspase-6 activation does not induce cell death in HEK293T cells

(2008) Guy Klaiman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Targets of Caspase-6 Activity in Human Neurons and Alzheimer Disease

(2008) Guy Klaiman et al.   MOLECULAR & CELLULAR PROTEOMICS