LC–HRMS quantitation of intact antibody drug conjugate trastuzumab emtansine from rat plasma

Challenges and new frontiers in analytical characterization of antibody-drug conjugates

(2018) Anil Wagh et al.   mAbs

Strategies and challenges for the next generation of antibody–drug conjugates

(2017) Alain Beck et al.   NATURE REVIEWS DRUG DISCOVERY

Structural Characterization of Cross-Linked Species in Trastuzumab Emtansine (Kadcyla)

(2016) Yan Chen et al.   BIOCONJUGATE CHEMISTRY

Cutting-edge mass spectrometry methods for the multi-level structural characterization of antibody-drug conjugates

(2016) Alain Beck et al.   Expert Review of Proteomics

Multiple heart-cutting and comprehensive two-dimensional liquid chromatography hyphenated to mass spectrometry for the characterization of the antibody-drug conjugate ado-trastuzumab emtansine

(2016) Koen Sandra et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

In-depth structural characterization of Kadcyla® (ado-trastuzumab emtansine) and its biosimilar candidate

(2016) Liuxi Chen et al.   mAbs

A workflow for absolute quantitation of large therapeutic proteins in biological samples at intact level using LC-HRMS

(2016) Wenying Jian et al.   Bioanalysis

A whole-molecule immunocapture LC–MS approach for the in vivo quantitation of biotherapeutics

(2016) John F Kellie et al.   Bioanalysis

Absolute Quantitation of Intact Recombinant Antibody Product Variants Using Mass Spectrometry

(2015) Frank D. Macchi et al.   ANALYTICAL CHEMISTRY

Native mass spectrometry and ion mobility characterization of trastuzumab emtansine, a lysine-linked antibody drug conjugate

(2015) Julien Marcoux et al.   PROTEIN SCIENCE

LC–MS-based quantification of intact proteins: perspective for clinical and bioanalytical applications

(2015) Irene van den Broek et al.   Bioanalysis

Recommendations for Validation of LC-MS/MS Bioanalytical Methods for Protein Biotherapeutics

(2014) Rand Jenkins et al.   AAPS Journal

Statistical Modeling of the Drug Load Distribution on Trastuzumab Emtansine (Kadcyla), a Lysine-Linked Antibody Drug Conjugate

(2014) Michael T. Kim et al.   BIOCONJUGATE CHEMISTRY

Characterization of the drug-to-antibody ratio distribution for antibody–drug conjugates in plasma/serum

(2013) Keyang Xu et al.   Bioanalysis

Evaluation of Intact Mass Spectrometry for the Quantitative Analysis of Protein Therapeutics

(2012) Ashley C. Gucinski et al.   ANALYTICAL CHEMISTRY

Characterization of intact antibody–drug conjugates from plasma/serum in vivo by affinity capture capillary liquid chromatography–mass spectrometry

(2011) Keyang Xu et al.   ANALYTICAL BIOCHEMISTRY

Quantitation of a recombinant monoclonal antibody in monkey serum by liquid chromatography–mass spectrometry

(2011) Hongcheng Liu et al.   ANALYTICAL BIOCHEMISTRY

Strategy and Its Implications of Protein Bioanalysis Utilizing High-Resolution Mass Spectrometric Detection of Intact Protein

(2011) Qian Ruan et al.   ANALYTICAL CHEMISTRY

On the Scalability and Requirements of Whole Protein Mass Spectrometry

(2011) Philip D. Compton et al.   ANALYTICAL CHEMISTRY

Absolute quantitation of protein therapeutics in biological matrices by enzymatic digestion and LC–MS

(2011) Fumin Li et al.   Bioanalysis

Targeted Ion Parking for the Quantitation of Biotherapeutic Proteins: Concepts and Preliminary Data

(2010) J. Larry Campbell et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY