In-depth structural characterization of Kadcyla® (ado-trastuzumab emtansine) and its biosimilar candidate

Characterization of Intact Antibody Drug Conjugate Variants Using Microfluidic Capillary Electrophoresis–Mass Spectrometry

(2016) Erin A. Redman et al.   ANALYTICAL CHEMISTRY

Characterization of antibody–drug conjugates by mass spectrometry: advances and future trends

(2016) Richard Y.-C. Huang et al.   DRUG DISCOVERY TODAY

Cutting-edge mass spectrometry methods for the multi-level structural characterization of antibody-drug conjugates

(2016) Alain Beck et al.   Expert Review of Proteomics

Quantitative analysis of maytansinoid (DM1) in human serum by on-line solid phase extraction coupled with liquid chromatography tandem mass spectrometry - Method validation and its application to clinical samples

(2016) Olivier Heudi et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Qualitative and quantitative characterization of protein biotherapeutics with liquid chromatography mass spectrometry

(2016) Miao Qu et al.   MASS SPECTROMETRY REVIEWS

Structural Characterization of a Monoclonal Antibody–Maytansinoid Immunoconjugate

(2015) Quanzhou Luo et al.   ANALYTICAL CHEMISTRY

Cutting-edge mass spectrometry characterization of originator, biosimilar and biobetter antibodies

(2015) Alain Beck et al.   JOURNAL OF MASS SPECTROMETRY

Utility of Ion Mobility Mass Spectrometry for Drug-to-Antibody Ratio Measurements in Antibody-Drug Conjugates

(2015) Richard Y.-C. Huang et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

A sensitive multidimensional method for the detection, characterization, and quantification of trace free drug species in antibody-drug conjugate samples using mass spectral detection

(2015) Robert E. Birdsall et al.   mAbs

A rapid on-line method for mass spectrometric confirmation of a cysteine-conjugated antibody-drug-conjugate structure using multidimensional chromatography

(2015) Robert E Birdsall et al.   mAbs

Statistics of the Distribution of the Abundance of Molecules with Various Drug Loads in Maytansinoid Antibody–Drug Conjugates

(2015) Victor S. Goldmacher et al.   MOLECULAR PHARMACEUTICS

Native mass spectrometry and ion mobility characterization of trastuzumab emtansine, a lysine-linked antibody drug conjugate

(2015) Julien Marcoux et al.   PROTEIN SCIENCE

A Mechanistic Pharmacokinetic Model Elucidating the Disposition of Trastuzumab Emtansine (T-DM1), an Antibody–Drug Conjugate (ADC) for Treatment of Metastatic Breast Cancer

(2014) Brendan Bender et al.   AAPS Journal

Statistical Modeling of the Drug Load Distribution on Trastuzumab Emtansine (Kadcyla), a Lysine-Linked Antibody Drug Conjugate

(2014) Michael T. Kim et al.   BIOCONJUGATE CHEMISTRY

Rapid comparison of a candidate biosimilar to an innovator monoclonal antibody with advanced liquid chromatography and mass spectrometry technologies

(2014) Hongwei Xie et al.   mAbs

Physicochemical characterization of Remsima®

(2014) Soon Kwan Jung et al.   mAbs

Assessment of chemical modifications of sites in the CDRs of recombinant antibodies

(2014) Markus Haberger et al.   mAbs

Conjugation Site Heterogeneity Causes Variable Electrostatic Properties in Fc Conjugates

(2013) Nicholas J. Boylan et al.   BIOCONJUGATE CHEMISTRY

Location Matters: Site of Conjugation Modulates Stability and Pharmacokinetics of Antibody Drug Conjugates

(2013) Pavel Strop et al.   CHEMISTRY & BIOLOGY

Antibody-drug conjugates

(2013) Alain Beck et al.   mAbs

Profiling Antibody Drug Conjugate Positional Isomers: A System-of-Equations Approach

(2012) Lan N. Le et al.   ANALYTICAL CHEMISTRY

Analytical methods for physicochemical characterization of antibody drug conjugates

(2011) Aditya Wakankar et al.   mAbs

Physicochemical Stability of the Antibody−Drug Conjugate Trastuzumab-DM1: Changes due to Modification and Conjugation Processes

(2010) Aditya A. Wakankar et al.   BIOCONJUGATE CHEMISTRY

Large-Scale Identification and Quantification of Covalent Modifications in Therapeutic Proteins

(2009) Zhongqi Zhang   ANALYTICAL CHEMISTRY

Synthesis and Preliminary Biological Evaluation of High-Drug-Load Paclitaxel-Antibody Conjugates for Tumor-Targeted Chemotherapy

(2009) Sherly Quiles et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting HER2-Positive Breast Cancer with Trastuzumab-DM1, an Antibody-Cytotoxic Drug Conjugate

(2008) G. D. Lewis Phillips et al.   CANCER RESEARCH

Contribution of Variable Domains to the Stability of Humanized IgG1 Monoclonal Antibodies

(2007) Roxana M. Ionescu et al.   JOURNAL OF PHARMACEUTICAL SCIENCES