A whole-molecule immunocapture LC–MS approach for the in vivo quantitation of biotherapeutics

Rapid and improved characterization of therapeutic antibodies and antibody related products using IdeS digestion and subunit analysis

(2016) Jonathan Sjögren et al.   ANALYST

Application of high-resolution MS for development of peptide and large-molecule drug candidates

(2016) John F Kellie et al.   Bioanalysis

Bioanalytical method validation considerations for LC–MS/MS assays of therapeutic proteins

(2015) Jeffrey X Duggan et al.   Bioanalysis

Recommendations for Validation of LC-MS/MS Bioanalytical Methods for Protein Biotherapeutics

(2014) Rand Jenkins et al.   AAPS Journal

Applying Label-Free Quantitation to Top Down Proteomics

(2014) Ioanna Ntai et al.   ANALYTICAL CHEMISTRY

Middle-Down Analysis of Monoclonal Antibodies with Electron Transfer Dissociation Orbitrap Fourier Transform Mass Spectrometry

(2014) Luca Fornelli et al.   ANALYTICAL CHEMISTRY

Quantitative Measurement of Intact Alpha-Synuclein Proteoforms from Post-Mortem Control and Parkinson's Disease Brain Tissue by Intact Protein Mass Spectrometry

(2014) John F. Kellie et al.   Scientific Reports

Structural comparison of two anti-CD20 monoclonal antibody drug products using middle-down mass spectrometry

(2013) Bo Wang et al.   ANALYST

Protein Analysis by Shotgun/Bottom-up Proteomics

(2013) Yaoyang Zhang et al.   CHEMICAL REVIEWS

Bioanalytical LC–MS/MS of protein-based biopharmaceuticals

(2013) Irene van den Broek et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Simultaneous determination and validated quantification of human insulin and its synthetic analogues in human blood serum by immunoaffinity purification and liquid chromatography-mass spectrometry

(2012) Cornelius Hess et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Clinical Pharmacokinetic Assessment of an Anti-MAdCAM Monoclonal Antibody Therapeutic by LC-MS/MS

(2012) Mireia Fernández Ocaña et al.   ANALYTICAL CHEMISTRY

Evaluation of Intact Mass Spectrometry for the Quantitative Analysis of Protein Therapeutics

(2012) Ashley C. Gucinski et al.   ANALYTICAL CHEMISTRY

Comparison of triple quadrupole and high-resolution TOF-MS for quantification of peptides

(2012) Lieve Dillen et al.   Bioanalysis

Replacing immunoassays with tryptic digestion-peptide immunoaffinity enrichment and LC–MS/MS

(2012) Jessica O Becker et al.   Bioanalysis

Fast analysis of recombinant monoclonal antibodies using IdeS proteolytic digestion and electrospray mass spectrometry

(2011) Guillaume Chevreux et al.   ANALYTICAL BIOCHEMISTRY

Robust Analysis of the Yeast Proteome under 50 kDa by Molecular-Mass-Based Fractionation and Top-Down Mass Spectrometry

(2011) John F. Kellie et al.   ANALYTICAL CHEMISTRY

On the Scalability and Requirements of Whole Protein Mass Spectrometry

(2011) Philip D. Compton et al.   ANALYTICAL CHEMISTRY

Mapping intact protein isoforms in discovery mode using top-down proteomics

(2011) John C. Tran et al.   NATURE

Mass spectrometric immunoassay of intact insulin and related variants for population proteomics studies

(2011) Paul E. Oran et al.   Proteomics Clinical Applications

Absolute quantitation of protein therapeutics in biological matrices by enzymatic digestion and LC–MS

(2011) Fumin Li et al.   Bioanalysis

Bioanalytical approaches to analyzing peptides and proteins by LC–MS/MS

(2011) Matthew Ewles et al.   Bioanalysis

The emerging process of Top Down mass spectrometry for protein analysis: biomarkers, protein-therapeutics, and achieving high throughput

(2010) John F. Kellie et al.   Molecular BioSystems

Developing Multiplexed Assays for Troponin I and Interleukin-33 in Plasma by Peptide Immunoaffinity Enrichment and Targeted Mass Spectrometry

(2009) E. Kuhn et al.   CLINICAL CHEMISTRY

Comprehensive mass-spectrometry-based proteome quantification of haploid versus diploid yeast

(2008) Lyris M. F. de Godoy et al.   NATURE