A workflow for absolute quantitation of large therapeutic proteins in biological samples at intact level using LC-HRMS

Generic method approaches for monoclonal antibody therapeutics analysis using both ligand binding and LC–MS/MS techniques

(2016) Jean W Lee   Bioanalysis

Quantifying Protein Measurands by Peptide Measurements: Where Do Errors Arise?

(2015) Irene van den Broek et al.   JOURNAL OF PROTEOME RESEARCH

Serum apolipoprotein A-1 quantification by LC–MS with a SILAC internal standard reveals reduced levels in smokers

(2015) Qingqing Wang et al.   Bioanalysis

Bioanalytical method validation considerations for LC–MS/MS assays of therapeutic proteins

(2015) Jeffrey X Duggan et al.   Bioanalysis

LC–MS-based quantification of intact proteins: perspective for clinical and bioanalytical applications

(2015) Irene van den Broek et al.   Bioanalysis

Recommendations for Validation of LC-MS/MS Bioanalytical Methods for Protein Biotherapeutics

(2014) Rand Jenkins et al.   AAPS Journal

Strategy to Improve the Quantitative LC-MS Analysis of Molecular Ions Resistant to Gas-Phase Collision Induced Dissociation: Application to Disulfide-Rich Cyclic Peptides

(2014) Eugene Ciccimaro et al.   ANALYTICAL CHEMISTRY

Recent advances in absolute quantification of peptides and proteins using LC-MS

(2014) Stanley (Weihua) Zhang et al.   REVIEWS IN ANALYTICAL CHEMISTRY

The integration of ligand binding and LC-MS-based assays into bioanalytical strategies for protein analysis

(2014) Yan J Zhang et al.   Bioanalysis

Relative Quantitation of Glycoisoforms of Intact Apolipoprotein C3 in Human Plasma by Liquid Chromatography–High-Resolution Mass Spectrometry

(2013) Wenying Jian et al.   ANALYTICAL CHEMISTRY

Liquid chromatography coupled with tandem mass spectrometry for the bioanalysis of proteins in drug development: Practical considerations in assay development and validation

(2013) Guowen Liu et al.   JOURNAL OF CHROMATOGRAPHY A

Bioanalytical LC–MS/MS of protein-based biopharmaceuticals

(2013) Irene van den Broek et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Characterization of the drug-to-antibody ratio distribution for antibody–drug conjugates in plasma/serum

(2013) Keyang Xu et al.   Bioanalysis

Large-molecule quantification: sensitivity and selectivity head-to-head comparison of triple quadrupole with Q-TOF

(2013) Louis-Philippe Morin et al.   Bioanalysis

LC–MS/MS of large molecules in a regulated bioanalytical environment – which acceptance criteria to apply?

(2013) Magnus Knutsson et al.   Bioanalysis

Evaluation of Intact Mass Spectrometry for the Quantitative Analysis of Protein Therapeutics

(2012) Ashley C. Gucinski et al.   ANALYTICAL CHEMISTRY

Biosimilar, Biobetter, and Next Generation Antibody Characterization by Mass Spectrometry

(2012) Alain Beck et al.   ANALYTICAL CHEMISTRY

Internal standards in the quantitative determination of protein biopharmaceuticals using liquid chromatography coupled to mass spectrometry

(2012) Kees J. Bronsema et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Peptide Production and Decay Rates Affect the Quantitative Accuracy of Protein Cleavage Isotope Dilution Mass Spectrometry (PC-IDMS)

(2012) Christopher M. Shuford et al.   MOLECULAR & CELLULAR PROTEOMICS

Characterization of intact antibody–drug conjugates from plasma/serum in vivo by affinity capture capillary liquid chromatography–mass spectrometry

(2011) Keyang Xu et al.   ANALYTICAL BIOCHEMISTRY

Quantitation of a recombinant monoclonal antibody in monkey serum by liquid chromatography–mass spectrometry

(2011) Hongcheng Liu et al.   ANALYTICAL BIOCHEMISTRY

Strategy and Its Implications of Protein Bioanalysis Utilizing High-Resolution Mass Spectrometric Detection of Intact Protein

(2011) Qian Ruan et al.   ANALYTICAL CHEMISTRY

Absolute quantitation of protein therapeutics in biological matrices by enzymatic digestion and LC–MS

(2011) Fumin Li et al.   Bioanalysis

A Rapid, Reproducible, On-the-Fly Orthogonal Array Optimization Method for Targeted Protein Quantification by LC/MS and Its Application for Accurate and Sensitive Quantification of Carbonyl Reductases in Human Liver

(2010) Jin Cao et al.   ANALYTICAL CHEMISTRY

Stable-isotope dilution LC–MS for quantitative biomarker analysis

(2010) Eugene Ciccimaro et al.   Bioanalysis

Mass spectrometry for structural characterization of therapeutic antibodies

(2008) Zhongqi Zhang et al.   MASS SPECTROMETRY REVIEWS

Quantification of human insulin-like growth factor-1 and qualitative detection of its analogues in plasma using liquid chromatography/electrospray ionisation tandem mass spectrometry

(2008) Michael Bredehöft et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY