LRRK2 Contributes to Secondary Brain Injury Through a p38/Drosha Signaling Pathway After Traumatic Brain Injury in Rats

Dimethyl Fumarate Attenuates Neuroinflammation and Neurobehavioral Deficits Induced by Experimental Traumatic Brain Injury

(2018) Giovanna Casili et al.   JOURNAL OF NEUROTRAUMA

Mechanisms of Parkinson’s disease-related proteins in mediating secondary brain damage after cerebral ischemia

(2017) TaeHee Kim et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Interactions between Sirt1 and MAPKs regulate astrocyte activation induced by brain injury in vitro and in vivo

(2017) Dan Li et al.   Journal of Neuroinflammation

Pre-ischemia melatonin treatment alleviated acute neuronal injury after ischemic stroke by inhibiting endoplasmic reticulum stress-dependent autophagy via PERK and IRE1 signalings

(2017) Dayun Feng et al.   JOURNAL OF PINEAL RESEARCH

RNase III nucleases from diverse kingdoms serve as antiviral effectors

(2017) Lauren C. Aguado et al.   NATURE

Pathophysiology of Traumatic Brain Injury

(2017) Kirsty J. Dixon   Physical Medicine and Rehabilitation Clinics of North America

The evidence for a microRNA product of human DROSHA gene

(2017) Peter Mechtler et al.   RNA Biology

SIRT1 plays a neuroprotective role in traumatic brain injury in rats via inhibiting the p38 MAPK pathway

(2016) Hong Yang et al.   ACTA PHARMACOLOGICA SINICA

Activation of Alpha 7 Cholinergic Nicotinic Receptors Reduce Blood–Brain Barrier Permeability following Experimental Traumatic Brain Injury

(2016) Pramod K. Dash et al.   JOURNAL OF NEUROSCIENCE

Inhibition of mammalian target of rapamycin attenuates early brain injury through modulating microglial polarization after experimental subarachnoid hemorrhage in rats

(2016) Wanchun You et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Leucine-rich repeat kinase 2 and Parkinson's disease

(2016) Un-Beom Kang et al.   PROTEOMICS

Recombinant Osteopontin Stabilizes Smooth Muscle Cell Phenotype via Integrin Receptor/Integrin-Linked Kinase/Rac-1 Pathway After Subarachnoid Hemorrhage in Rats

(2016) Jiang Wu et al.   STROKE

Transient receptor potential channel 1/4 reduces subarachnoid hemorrhage-induced early brain injury in rats via calcineurin-mediated NMDAR and NFAT dephosphorylation

(2016) Zhong Wang et al.   Scientific Reports

A phosphomimetic mutant TDP-43 (S409/410E) induces Drosha instability and cytotoxicity in Neuro 2A cells

(2015) Ki Yoon Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Function and dysfunction of leucine-rich repeat kinase 2 (LRRK2): Parkinson's disease and beyond

(2015) Jae Ryul Bae et al.   BMB Reports

LRRK2 Pathways Leading to Neurodegeneration

(2015) Mark R. Cookson   Current Neurology and Neuroscience Reports

Stress Induces p38 MAPK-Mediated Phosphorylation and Inhibition of Drosha-Dependent Cell Survival

(2015) Qian Yang et al.   MOLECULAR CELL

Role of Neurexin-1β and Neuroligin-1 in Cognitive Dysfunction After Subarachnoid Hemorrhage in Rats

(2015) Haitao Shen et al.   STROKE

LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity

(2014) Loukia Parisiadou et al.   NATURE NEUROSCIENCE

ERKed by LRRK2: A cell biological perspective on hereditary and sporadic Parkinson's disease

(2013) Manish Verma et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Neuroprotective effects of ebselen in traumatic brain injury model: involvement of nitric oxide and p38 mitogen-activated protein kinase signalling pathway

(2013) Liang Wei et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

High mobility group box protein-1 promotes cerebral edema after traumatic brain injury via activation of toll-like receptor 4

(2013) Melissa D. Laird et al.   GLIA

Signaling by p38 MAPK Stimulates Nuclear Localization of the Microprocessor Component p68 for Processing of Selected Primary MicroRNAs

(2013) S. Hong et al.   Science Signaling

Mechanisms of LRRK2-Mediated Neurodegeneration

(2012) Elpida Tsika et al.   Current Neurology and Neuroscience Reports

LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1

(2012) X. Wang et al.   HUMAN MOLECULAR GENETICS

LRRK2 Inhibition Attenuates Microglial Inflammatory Responses

(2012) M. S. Moehle et al.   JOURNAL OF NEUROSCIENCE

Parkinson's disease-linked leucine-rich repeat kinase 2(R1441G) mutation increases proinflammatory cytokine release from activated primary microglial cells and resultant neurotoxicity

(2012) F. Gillardon et al.   NEUROSCIENCE

Impaired Inflammatory Responses in Murine Lrrk2-Knockdown Brain Microglia

(2012) Beomsue Kim et al.   PLoS One

MKK6 binds and regulates expression of Parkinson’s disease-related protein LRRK2

(2010) Cindy H. Hsu et al.   JOURNAL OF NEUROCHEMISTRY

LRRK2 and the Stress Response: Interaction with MKKs and JNK-Interacting Proteins

(2010) C.H. Hsu et al.   Neurodegenerative Diseases

Transient Focal Ischemia Induces Extensive Temporal Changes in Rat Cerebral MicroRNAome

(2009) Ashuthosh Dharap et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The Parkinson disease-associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7,in vitro

(2009) Christian Johannes Gloeckner et al.   JOURNAL OF NEUROCHEMISTRY

Leucine-Rich Repeat Kinase 2 Regulates the Progression of Neuropathology Induced by Parkinson's-Disease-Related Mutant α-synuclein

(2009) Xian Lin et al.   NEURON