Mechanisms of Parkinson’s disease-related proteins in mediating secondary brain damage after cerebral ischemia

Vascular Risk Profiles for Dementia and Alzheimer's Disease in Very Old People: A Population-Based Longitudinal Study

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Activation of tyrosine kinase c-Abl contributes to α-synuclein–induced neurodegeneration

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Poststroke Induction of  -Synuclein Mediates Ischemic Brain Damage

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microRNA-155 Regulates Alpha-Synuclein-Induced Inflammatory Responses in Models of Parkinson Disease

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Protein Profile and Morphological Alterations in Penumbra after Focal Photothrombotic Infarction in the Rat Cerebral Cortex

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A comparative study of the amount of α-synuclein in ischemic stroke and Parkinson’s disease

(2016) Hui-Qing Zhao et al.   NEUROLOGICAL SCIENCES

Regenerative repair of Pifithrin-α in cerebral ischemia via VEGF dependent manner

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GSK-3β downregulates Nrf2 in cultured cortical neurons and in a rat model of cerebral ischemia-reperfusion

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Roles of PTEN-induced putative kinase 1 and dynamin-related protein 1 in transient global ischemia-induced hippocampal neuronal injury

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The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

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LRRK2 A419V variant is a risk factor for Parkinson's disease in Asian population

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Resveratrol neuroprotection in stroke and traumatic CNS injury

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KTKEGV repeat motifs are key mediators of normal α-synuclein tetramerization: Their mutation causes excess monomers and neurotoxicity

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Aggregated α-synuclein and complex I deficiency: exploration of their relationship in differentiated neurons

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Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation

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Endoplasmic reticulum stress induced by tunicamycin and thapsigargin protects against transient ischemic brain injury

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Effect of Sex and Age Interactions on Functional Outcome after Stroke

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α-Synuclein oligomers distinctively permeabilize complex model membranes

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DJ-1 Is a Copper Chaperone Acting on SOD1 Activation

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Transnitrosylation from DJ-1 to PTEN Attenuates Neuronal Cell Death in Parkinson's Disease Models

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Crosstalk Between Endoplasmic Reticulum Stress, Oxidative Stress, and Autophagy: Potential Therapeutic Targets for Acute CNS Injuries

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Ubiquitin is phosphorylated by PINK1 to activate parkin

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Alpha-synuclein-induced neurodegeneration is exacerbated in PINK1 knockout mice

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Parkin loss of function contributes to RTP801 elevation and neurodegeneration in Parkinson’s disease

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DJ-1 interactions with α-synuclein attenuate aggregation and cellular toxicity in models of Parkinson’s disease

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Oxidation and nitration of α-synuclein and their implications in neurodegenerative diseases

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Cerebral ischemia-reperfusion-induced autophagy protects against neuronal injury by mitochondrial clearance

(2013) Xiangnan Zhang et al.   Autophagy

Stable overexpression of DJ-1 protects H9c2 cells against oxidative stress under a hypoxia condition

(2013) Hai-Hong Yu et al.   CELL BIOCHEMISTRY AND FUNCTION

Oxygen-Glucose-Deprived Rat Primary Neural Cells Exhibit DJ-1 Translocation into Healthy Mitochondria: A Potent Stroke Therapeutic Target

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Leucine-rich repeat kinase 2 regulates tau phosphorylation through direct activation of glycogen synthase kinase-3β

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Identification of the recognition sequence and target proteins for DJ-1 protease

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TRAP1 rescues PINK1 loss-of-function phenotypes

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The Parkinson's disease-associated genePINK1protects neurons from ischemic damage by decreasing mitochondrial translocation of the fission promoter Drp1

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Mutant Huntingtin Alters Retrograde Transport of TrkB Receptors in Striatal Dendrites

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Alpha-synuclein Post-translational Modifications as Potential Biomarkers for Parkinson Disease and Other Synucleinopathies

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DJ-1 ameliorates ischemic cell death in vitro possibly via mitochondrial pathway

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A novel  -synuclein missense mutation in Parkinson disease

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Polo-like kinase 2 regulates selective autophagic  -synuclein clearance and suppresses its toxicity in vivo

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PINK1-Phosphorylated Mitofusin 2 Is a Parkin Receptor for Culling Damaged Mitochondria

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Leucine-Rich Repeat Kinase 2 for Beginners: Six Key Questions

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Loss of substance P and inflammation precede delayed neurodegeneration in the substantia nigra after cerebral ischemia

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Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia

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DJ-1 induces thioredoxin 1 expression through the Nrf2 pathway

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α-Synuclein in Central Nervous System and from Erythrocytes, Mammalian Cells, andEscherichia coliExists Predominantly as Disordered Monomer

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Accumulation of Toxic  -Synuclein Oligomer within Endoplasmic Reticulum Occurs in  -Synucleinopathy In Vivo

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Elucidating the Role of C-Terminal Post-Translational Modifications Using Protein Semisynthesis Strategies: α-Synuclein Phosphorylation at Tyrosine 125

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PGD Synthase and PGD2in Immune Resposne

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Oxidized DJ-1 Inhibits p53 by Sequestering p53 from Promoters in a DNA-Binding Affinity-Dependent Manner

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Extracellular signal-regulated kinase is involved in alpha-synuclein-induced mitochondrial dynamic disorders by regulating dynamin-like protein 1

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LRRK2 Phosphorylates Tubulin-Associated Tau but Not the Free Molecule: LRRK2-Mediated Regulation of the Tau-Tubulin Association and Neurite Outgrowth

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Role of Alpha-Synuclein Protein Levels in Mitochondrial Morphology and Cell Survival in Cell Lines

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Loss of DJ-1 Does Not Affect Mitochondrial Respiration but Increases ROS Production and Mitochondrial Permeability Transition Pore Opening

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An extracellular mechanism that can explain the neurotoxic effects of α-synuclein aggregates in the brain

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Parkin, PINK1 and mitochondrial integrity: emerging concepts of mitochondrial dysfunction in Parkinson’s disease

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PARIS (ZNF746) Repression of PGC-1α Contributes to Neurodegeneration in Parkinson's Disease

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Stimulatory effect of α-synuclein on the tau-phosphorylation by GSK-3β

(2011) Fumitaka Kawakami et al.   FEBS Journal

Parkin promotes the ubiquitination and degradation of the mitochondrial fusion factor mitofusin 1

(2011) Liliane Glauser et al.   JOURNAL OF NEUROCHEMISTRY

Authentically Phosphorylated  -Synuclein at Ser129 Accelerates Neurodegeneration in a Rat Model of Familial Parkinson's Disease

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Neuroprotective effect of a new DJ-1-binding compound against neurodegeneration in Parkinson's disease and stroke model rats

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α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

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Tau phosphorylation and neuronal apoptosis induced by the blockade of PP2A preferentially involve GSK3β

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What Genetics Tells us About the Causes and Mechanisms of Parkinson's Disease

(2011) Olga Corti et al.   PHYSIOLOGICAL REVIEWS

A soluble  -synuclein construct forms a dynamic tetramer

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In vivo demonstration that  -synuclein oligomers are toxic

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p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both

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Tau phosphorylation in hippocampus results in toxic gain-of-function

(2010) Jesús Avila et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Differential Effects of Divalent Manganese and Magnesium on the Kinase Activity of Leucine-Rich Repeat Kinase 2 (LRRK2)

(2010) Brian Lovitt et al.   BIOCHEMISTRY

Redox Reactions of the α-Synuclein−Cu2+Complex and Their Effects on Neuronal Cell Viability

(2010) Chengshan Wang et al.   BIOCHEMISTRY

The N-Terminus of the Intrinsically Disordered Protein α-Synuclein Triggers Membrane Binding and Helix Folding

(2010) Tim Bartels et al.   BIOPHYSICAL JOURNAL

Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1

(2010) Frits Kamp et al.   EMBO JOURNAL

Parkinson disease protein DJ-1 converts from a zymogen to a protease by carboxyl-terminal cleavage

(2010) Jue Chen et al.   HUMAN MOLECULAR GENETICS

Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy

(2010) Matthew E. Gegg et al.   HUMAN MOLECULAR GENETICS

Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics

(2010) I. Irrcher et al.   HUMAN MOLECULAR GENETICS

DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy

(2010) Kelly Jean Thomas et al.   HUMAN MOLECULAR GENETICS

Post-transcriptional Regulation of α-Synuclein Expression by mir-7 and mir-153

(2010) Epaminondas Doxakis   JOURNAL OF BIOLOGICAL CHEMISTRY

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

(2010) Noriyuki Matsuda et al.   JOURNAL OF CELL BIOLOGY

Alpha-Synuclein Aggregation Induced by Brief Ischemia Negatively Impacts Neuronal Survival in vivo: A Study in [A30P]alpha-Synuclein Transgenic Mouse

(2010) Isin Unal-Cevik et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Insight into the mode of action of the LRRK2 Y1699C pathogenic mutant

(2010) Veronique Daniëls et al.   JOURNAL OF NEUROCHEMISTRY

Copper binding regulates intracellular alpha-synuclein localisation, aggregation and toxicity

(2010) Xiaoyan Wang et al.   JOURNAL OF NEUROCHEMISTRY

Mitochondrial alpha-synuclein accumulation impairs complex I function in dopaminergic neurons and results in increased mitophagy in vivo

(2010) Shankar J. Chinta et al.   NEUROSCIENCE LETTERS

Oxidative Stress Induction of DJ-1 Protein in Reactive Astrocytes Scavenges Free Radicals and Reduces Cell Injury

(2010) Takashi Yanagida et al.   Oxidative Medicine and Cellular Longevity

Reduced Basal Autophagy and Impaired Mitochondrial Dynamics Due to Loss of Parkinson's Disease-Associated Protein DJ-1

(2010) Guido Krebiehl et al.   PLoS One

Membrane Permeabilization by Oligomeric α-Synuclein: In Search of the Mechanism

(2010) Bart D. van Rooijen et al.   PLoS One

Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function

(2010) H. S. Ko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function

(2010) L.-Y. Hao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DJ-1 binds to mitochondrial complex I and maintains its activity

(2009) Takuya Hayashi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

α-Synuclein contributes to GSK-3β-catalyzed Tau phosphorylation in Parkinson’s disease models

(2009) Tetyana Duka et al.   FASEB JOURNAL

Unique copper-induced oligomers mediate alpha-synuclein toxicity

(2009) Josephine A. Wright et al.   FASEB JOURNAL

Inactivation of Mycobacterium tuberculosis mannosyltransferase pimB reduces the cell wall lipoarabinomannan and lipomannan content and increases the rate of bacterial-induced human macrophage cell death

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Mitochondrial dynamics-fusion, fission, movement, and mitophagy-in neurodegenerative diseases

(2009) H. Chen et al.   HUMAN MOLECULAR GENETICS

Formation of a Stabilized Cysteine Sulfinic Acid Is Critical for the Mitochondrial Function of the Parkinsonism Protein DJ-1

(2009) Jeff Blackinton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The LRRK2 G2019S mutation as the cause of Parkinson’s disease in Ashkenazi Jews

(2009) Avner Thaler et al.   JOURNAL OF NEURAL TRANSMISSION

Dissembled DJ-1 high molecular weight complex in cortex mitochondria from Parkinson's disease patients

(2009) Hikmet Nural et al.   Molecular Neurodegeneration

Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease

(2009) Wataru Satake et al.   NATURE GENETICS

Genome-wide association study reveals genetic risk underlying Parkinson's disease

(2009) Javier Simón-Sánchez et al.   NATURE GENETICS

PINK1 Defect Causes Mitochondrial Dysfunction, Proteasomal Deficit and α-Synuclein Aggregation in Cell Culture Models of Parkinson's Disease

(2009) Wencheng Liu et al.   PLoS One

Repression of  -synuclein expression and toxicity by microRNA-7

(2009) E. Junn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease

(2008) Owen A. Ross et al.   ANNALS OF NEUROLOGY

Vascular Parkinsonism: A Clinical Review

(2008) Hani T.S. Benamer et al.   EUROPEAN NEUROLOGY

Sumoylation is critical for DJ-1 to repress p53 transcriptional activity

(2008) Jun Fan et al.   FEBS LETTERS

Pink1 suppresses α-synuclein-induced phenotypes in a Drosophila model of Parkinson’s disease

(2008) Amy M. Todd et al.   GENOME

Mitochondrial Import and Accumulation of α-Synuclein Impair Complex I in Human Dopaminergic Neuronal Cultures and Parkinson Disease Brain

(2008) Latha Devi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY

Brain-derived neurotrophic factor over-expression in the forebrain ameliorates Huntington’s disease phenotypes in mice

(2008) Kusumika Gharami et al.   JOURNAL OF NEUROCHEMISTRY

Proteomic Analysis of Oxidative Stress-Responsive Proteins in Human Pneumocytes: Insight into the Regulation of DJ-1 Expression

(2008) Xunbao Duan et al.   JOURNAL OF PROTEOME RESEARCH

Site-Specific Interactions of Cu(II) with α and β-Synuclein: Bridging the Molecular Gap between Metal Binding and Aggregation

(2008) Andrés Binolfi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study

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Formation of Toxic Oligomeric α-Synuclein Species in Living Cells

(2008) Tiago Fleming Outeiro et al.   PLoS One

Brain prostaglandin formation is increased by α-synuclein gene-ablation during global ischemia

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