A lesson for site-selective C–H functionalization on 2-pyridones: radical, organometallic, directing group and steric controls

A Mild Rhodium Catalyzed Direct Synthesis of Quinolones from Pyridones: Application in the Detection of Nitroaromatics

(2017) Aniruddha Biswas et al.   JOURNAL OF ORGANIC CHEMISTRY

Rhodium(III)-Catalyzed C6-Selective Arylation of 2-Pyridones and Related Heterocycles Using Quinone Diazides: Syntheses of Heteroarylated Phenols

(2017) Debapratim Das et al.   JOURNAL OF ORGANIC CHEMISTRY

Cobalt/Copper-Cocatalyzed Synthesis of Imidazo[1,2-a:3,4-a′]dipyridiniums from 2H-[1,2′-Bipyridin]-2-ones and 2-Bromoacetophenones

(2017) Ting Li et al.   JOURNAL OF ORGANIC CHEMISTRY

Nickel-Catalyzed Directed C6-Selective C–H Alkylation of 2-Pyridones with Dienes and Activated Alkenes

(2017) Wataru Miura et al.   JOURNAL OF ORGANIC CHEMISTRY

Ruthenium-catalyzed site-selective C–H arylation of 2-pyridones and 1-isoquinolinones

(2017) K. Anil Kumar et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Directed Zincation or Magnesiation of the 2-Pyridone and 2,7-Naphthyridone Scaffold Using TMP Bases

(2017) Dorothée S. Ziegler et al.   ORGANIC LETTERS

Manganese(I)-Catalyzed C–H 3,3-Difluoroallylation of Pyridones and Indoles

(2017) Jiabin Ni et al.   ORGANIC LETTERS

Aromatic C–H σ-Bond Activation by Ni0, Pd0, and Pt0 Alkene Complexes: Concerted Oxidative Addition to Metal vs Ligand-to-Ligand H Transfer Mechanism

(2017) Shuwei Tang et al.   ORGANOMETALLICS

Iridium-Catalyzed Site-Selective C–H Borylation of 2-Pyridones

(2017) Koji Hirano et al.   SYNTHESIS-STUTTGART

Fine Design of Photoredox Systems for Catalytic Fluoromethylation of Carbon–Carbon Multiple Bonds

(2016) Takashi Koike et al.   ACCOUNTS OF CHEMICAL RESEARCH

Metal-Catalyzed Annulations through Activation and Cleavage of C−H Bonds

(2016) Moisés Gulías et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Simple and Versatile Amide Directing Group for C−H Functionalizations

(2016) Ru-Yi Zhu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Carbon–Carbon Bond Forming Reactions via Photogenerated Intermediates

(2016) Davide Ravelli et al.   CHEMICAL REVIEWS

Alkenylation of Arenes and Heteroarenes with Alkynes

(2016) Vadim P. Boyarskiy et al.   CHEMICAL REVIEWS

Transition metal-catalysed couplings between arenes and strained or reactive rings: combination of C–H activation and ring scission

(2016) Fen Wang et al.   CHEMICAL SOCIETY REVIEWS

Carboxylic Acids as Directing Groups for C−H Bond Functionalization

(2016) Martin Pichette Drapeau et al.   CHEMISTRY-A EUROPEAN JOURNAL

Highly C3-Selective Direct Alkylation and Arylation of 2-Pyridones under Visible-Light-Promoted Photoredox Catalysis

(2016) Masahiro Miura et al.   HETEROCYCLES

C6-Selective Direct Alkylation of Pyridones with Diazo Compounds under Rh(III)-Catalyzed Mild Conditions

(2016) Debapratim Das et al.   JOURNAL OF ORGANIC CHEMISTRY

Formal Gold- and Rhodium-Catalyzed Regiodivergent C–H Alkynylation of 2-Pyridones

(2016) Yunyun Li et al.   JOURNAL OF ORGANIC CHEMISTRY

Rhodium-Catalyzed/Copper-Mediated Tandem C(sp2)–H Alkynylation and Annulation: Synthesis of 11-Acylated Imidazo[1,2-a:3,4-a′]dipyridin-5-ium-4-olates from 2H-[1,2′-Bipyridin]-2-ones and Propargyl Alcohols

(2016) Ting Li et al.   ORGANIC LETTERS

Rhodium(III)-Catalyzed Site-Selective C–H Alkylation and Arylation of Pyridones Using Organoboron Reagents

(2016) Panfeng Peng et al.   ORGANIC LETTERS

Rhodium-Catalyzed C6-Selective C–H Borylation of 2-Pyridones

(2016) Wataru Miura et al.   ORGANIC LETTERS

Regioselective α-arylation of coumarins and 2-pyridones with phenylhydrazines under transition-metal-free conditions

(2016) Parul Chauhan et al.   RSC Advances

Construction of N-containing heterocycles via oxidative intramolecular N–H/X–H coupling

(2015) Jiwen Yuan et al.   CHEMICAL COMMUNICATIONS

Recent Advances in Copper-mediated Direct Biaryl Coupling

(2015) Koji Hirano et al.   CHEMISTRY LETTERS

Copper-Mediated C6-Selective Dehydrogenative Heteroarylation of 2-Pyridones with 1,3-Azoles

(2014) Riko Odani et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium catalyzed C3-arylation of 4-hydroxy-2-pyridones

(2014) Elissavet E. Anagnostaki et al.   CHEMICAL COMMUNICATIONS

Copper-Catalyzed C–H Functionalization Reactions: Efficient Synthesis of Heterocycles

(2014) Xun-Xiang Guo et al.   CHEMICAL REVIEWS

Iron-Catalyzed Regioselective Direct Arylation at the C-3 Position of N-Alkyl-2-pyridone

(2014) Atanu Modak et al.   JOURNAL OF ORGANIC CHEMISTRY

Manganese-Mediated C3-Selective Direct Alkylation and Arylation of 2-Pyridones with Diethyl Malonates and Arylboronic Acids

(2014) Akihiro Nakatani et al.   JOURNAL OF ORGANIC CHEMISTRY

Linear-Selective Hydroarylation of Unactivated Terminal and Internal Olefins with Trifluoromethyl-Substituted Arenes

(2014) Joseph S. Bair et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Visible Light Photoredox Catalysis with Transition Metal Complexes: Applications in Organic Synthesis

(2013) Christopher K. Prier et al.   CHEMICAL REVIEWS

Nickel-Catalyzed Direct Alkylation of Heterocycles with α-Bromo Carbonyl Compounds: C3-Selective Functionalization of 2-Pyridones

(2013) Akihiro Nakatani et al.   CHEMISTRY-A EUROPEAN JOURNAL

Efficacy of cytisine in helping smokers quit: systematic review and meta-analysis

(2013) Peter Hajek et al.   THORAX

Modular Synthesis of Phenanthridine Derivatives by Oxidative Cyclization of 2-Isocyanobiphenyls with Organoboron Reagents

(2012) Mamoru Tobisu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Synthesis and Biosynthetic Implications of (+)-Fusarisetin A

(2012) Jun Yin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Alkylation of Pyridone Derivatives By Nickel/Lewis Acid Catalysis

(2012) Ryuichi Tamura et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

CH Bond Functionalization: Emerging Synthetic Tools for Natural Products and Pharmaceuticals

(2012) Junichiro Yamaguchi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Discovery of 2-(2-Oxo-1-phenyl-5-pyridin-2-yl-1,2-dihydropyridin-3-yl)benzonitrile (Perampanel): A Novel, Noncompetitive α-Amino-3-hydroxy-5-methyl-4-isoxazolepropanoic Acid (AMPA) Receptor Antagonist

(2012) Shigeki Hibi et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Biomimetic Route for Construction of the [4+2] and [3+2] Core Skeletons of Dimeric Pyrrole–Imidazole Alkaloids and Asymmetric Synthesis of Ageliferins

(2012) Xiao Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Manganese(III) Acetate Mediated Oxidative Radical Cyclizations. Toward Vicinal All-Carbon Quaternary Stereocenters

(2012) Angus W.J. Logan et al.   ORGANIC LETTERS

Palladium-catalyzed selective oxidative olefination and arylation of 2-pyridones

(2012) Yuye Chen et al.   Chemical Science

Organocatalysis and CH Activation Meet Radical- and Electron-Transfer Reactions

(2011) Armido Studer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bond Formations between Two Nucleophiles: Transition Metal Catalyzed Oxidative Cross-Coupling Reactions

(2011) Chao Liu et al.   CHEMICAL REVIEWS

Regioselectivity of the borylation of alkanes and arenes

(2011) John F. Hartwig   CHEMICAL SOCIETY REVIEWS

Formal Inverse Sonogashira Reaction: Direct Alkynylation of Arenes and Heterocycles with Alkynyl Halides

(2010) Alexander S. Dudnik et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Pd-catalyzed oxidative coupling with organometallic reagents via C–H activation

(2010) Chang-Liang Sun et al.   CHEMICAL COMMUNICATIONS

Metal-catalyzed direct alkylations of (hetero)arenes via C–H bond cleavages with unactivated alkyl halides

(2010) Lutz Ackermann   CHEMICAL COMMUNICATIONS

Palladium-Catalyzed Ligand-Directed C−H Functionalization Reactions

(2010) Thomas W. Lyons et al.   CHEMICAL REVIEWS

Visible light photoredox catalysis: applications in organic synthesis

(2010) Jagan M. R. Narayanam et al.   CHEMICAL SOCIETY REVIEWS

Oxidative Coupling of Aromatic Substrates with Alkynes and Alkenes under Rhodium Catalysis

(2010) Tetsuya Satoh et al.   CHEMISTRY-A EUROPEAN JOURNAL

Visible light photocatalysis as a greener approach to photochemical synthesis

(2010) Tehshik P. Yoon et al.   Nature Chemistry

Radical Addition of Arylboronic Acids to Various Olefins under Oxidative Conditions

(2010) Arne Dickschat et al.   ORGANIC LETTERS

Direct C-H Bond Arylation of (Hetero)arenes with Aryl and Heteroarylboronic Acids

(2010) Sankar Guchhait et al.   SYNTHESIS-STUTTGART

Palladium- and Copper-Catalyzed Arylation of Carbon−Hydrogen Bonds

(2009) Olafs Daugulis et al.   ACCOUNTS OF CHEMICAL RESEARCH

Transition-Metal-Catalyzed Direct Arylation of (Hetero)Arenes by CH Bond Cleavage

(2009) Lutz Ackermann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium(II)-Catalyzed CH Activation/CC Cross-Coupling Reactions: Versatility and Practicality

(2009) Xiao Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

C−H Activation for the Construction of C−B Bonds

(2009) Ibraheem A. I. Mkhalid et al.   CHEMICAL REVIEWS

Trifluoromethylation of various aromatic compounds by CF3I in the presence of Fe(II) compound, H2O2 and dimethylsulfoxide

(2009) Tatsuhito Kino et al.   JOURNAL OF FLUORINE CHEMISTRY

Direct Alkenylation and Alkylation of Pyridone Derivatives by Ni/AlMe3Catalysis

(2009) Yoshiaki Nakao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Transition-Metal-Catalyzed Carbon-Carbon Bond Formation via Carbon-Hydrogen Bond Cleavage

(2008) Fumitoshi Kakiuchi et al.   SYNTHESIS-STUTTGART