Carboxylic Acids as Directing Groups for C−H Bond Functionalization

Regioselective C−H Hydroarylation of Internal Alkynes with Arenecarboxylates: Carboxylates as Deciduous Directing Groups

(2016) Liangbin Huang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ruthenium(II)-Catalyzed Decarboxylative C−H Activation: Versatile Routes tometa-Alkenylated Arenes

(2016) N. Y. Phani Kumar et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium(II)-Catalyzed Tandem Synthesis of Acenes Using Carboxylic Acids as Traceless Directing Groups

(2016) Kiho Kim et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mild metal-catalyzed C–H activation: examples and concepts

(2016) T. Gensch et al.   CHEMICAL SOCIETY REVIEWS

Iron-Catalyzed Ortho C–H Methylation of Aromatics Bearing a Simple Carbonyl Group with Methylaluminum and Tridentate Phosphine Ligand

(2016) Rui Shang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Room-temperature cobalt-catalyzed arylation of aromatic acids: overriding the ortho-selectivity via the oxidative assembly of carboxylate and aryl titanate reagents using oxygen

(2016) Kun-Ming Liu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Rhodium-Catalyzed Oxidative Coupling of Benzoic Acids with Terminal Alkynes: An Efficient Access to 3-Ylidenephthalides

(2016) Yang Liu et al.   ORGANOMETALLICS

Carboxylic Acids as Traceless Directing Groups for the Rhodium(III)-Catalyzed Decarboxylative CH Arylation of Thiophenes

(2015) Yuanfei Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of Dibenzo[c,e]oxepin-5(7H)-ones from Benzyl Thioethers and Carboxylic Acids: Rhodium-Catalyzed Double CH Activation Controlled by Different Directing Groups

(2015) Xi-Sha Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ruthenium Oxidase Catalysis for Site-Selective C-H Alkenylations with Ambient O2 as the Sole Oxidant

(2015) Alexander Bechtoldt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rhodium(I)-Catalyzed Regiospecific Dimerization of Aromatic Acids: Two Direct CH Bond Activations in Water

(2015) Hang Gong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ruthenium(II)-Catalyzed CH Activation/Alkyne Annulation by Weak Coordination with O2as the Sole Oxidant

(2015) Svenja Warratz et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Iridium-Catalyzedortho-Arylation of Benzoic Acids with Arenediazonium Salts

(2015) Liangbin Huang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rhodium(III)-CatalyzedorthoCH Heteroarylation of (Hetero)aromatic Carboxylic Acids: A Rapid and Concise Access to π-Conjugated Poly-heterocycles

(2015) Xurong Qin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium-catalysed decarboxylative nitrile insertion via C–H activation or self-coupling of indole-2-carboxylic acids: a new route to indolocarbolines and triindoles

(2015) R. N. Prasad Tulichala et al.   CHEMICAL COMMUNICATIONS

Coupling of carboxylic acids with internal alkynes by supported ruthenium catalysts: direct and selective syntheses of multi-substituted phthalide derivatives

(2015) Hiroki Miura et al.   CHEMICAL COMMUNICATIONS

Salicylic acids as readily available starting materials for the synthesis of meta-substituted biaryls

(2015) Junfei Luo et al.   CHEMICAL COMMUNICATIONS

Rhodium(III)-Catalyzed [4+1] Annulation of Aromatic and Vinylic Carboxylic Acids with Allenes: An Efficient Method Towards Vinyl-Substituted Phthalides and 2-Furanones

(2015) Parthasarathy Gandeepan et al.   CHEMISTRY-A EUROPEAN JOURNAL

Direct CH Amidation of Benzoic Acids to Introducemeta- andpara-Amino Groups by Tandem Decarboxylation

(2015) Donggun Lee et al.   CHEMISTRY-A EUROPEAN JOURNAL

RhIII-Catalyzed C−H Olefination of Benzoic Acids under Mild Conditions using Oxygen as the Sole Oxidant

(2015) Quandi Jiang et al.   Chemistry-An Asian Journal

A Domino Oxidation/Arylation/Protodecarboxylation Reaction of Salicylaldehydes: Expanded Access tometa-Arylphenols

(2015) Junfei Luo et al.   Chemistry-An Asian Journal

Facile, One-Pot, and Gram-Scale Synthesis of 3,4,5-Triiodoanisole through a C-H Iodination/ipso-Iododecarboxylation Strategy: Potential Application towards 3,4,5-Trisubstituted Anisoles

(2015) Raed M. Al-Zoubi et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Practical Pd(II)-Catalyzed C–H Alkylation with Epoxides: One-Step Syntheses of 3,4-Dihydroisocoumarins

(2015) Guolin Cheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Monoselective o-C–H Functionalizations of Mandelic Acid and α-Phenylglycine

(2015) Navid Dastbaravardeh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rh(III)-Catalyzed Decarboxylative ortho-Heteroarylation of Aromatic Carboxylic Acids by Using the Carboxylic Acid as a Traceless Directing Group

(2015) Xurong Qin et al.   ORGANIC LETTERS

Ambient-Temperature Ortho C–H Arylation of Benzoic Acids with Aryl Iodides with Ligand-Supported Palladium Catalyst

(2015) Changlei Zhu et al.   ORGANIC LETTERS

Ru(II)-catalyzed ortho-amidation and decarboxylation of aromatic acids: a versatile route to meta-substituted N-aryl benzamides

(2015) Xian-Ying Shi et al.   Science China-Chemistry

Transition-metal-catalyzed etherification of unactivated CH bonds

(2015) Bin Liu et al.   TETRAHEDRON LETTERS

A mild and efficient carboxylate-directed C–H arylation of aryl carboxylic acids with iodobenzenes in water

(2015) Zhongmiao Xu et al.   TETRAHEDRON LETTERS

A Rhodium-Catalyzed Cascade Cyclization: Direct Synthesis ofN-Substituted Phthalimides from Isocyanates and Benzoic Acids

(2014) Xian-Ying Shi et al.   ADVANCED SYNTHESIS & CATALYSIS

Carboxylate-Directed CH Functionalization

(2014) Guangfa Shi et al.   ADVANCED SYNTHESIS & CATALYSIS

[RhIII(Cp*)]-Catalyzedortho-Selective Direct C(sp2)H Bond Amidation/Amination of Benzoic Acids byN-Chlorocarbamates andN-Chloromorpholines. A Versatile Synthesis of Functionalized Anthranilic Acids

(2014) Fo-Ning Ng et al.   CHEMISTRY-A EUROPEAN JOURNAL

A Convenient Synthesis ofN-Aryl Benzamides by Rhodium-Catalyzedortho-Amidation and Decarboxylation of Benzoic Acids

(2014) Xian-Ying Shi et al.   CHEMISTRY-A EUROPEAN JOURNAL

Rh(III)-Catalyzed Oxidative Coupling of Benzoic Acids with Geminal-Substituted Vinyl Acetates: Synthesis of 3-Substituted Isocoumarins

(2014) Mingliang Zhang et al.   JOURNAL OF ORGANIC CHEMISTRY

Overriding Ortho–Para Selectivity via a Traceless Directing Group Relay Strategy: The Meta-Selective Arylation of Phenols

(2014) Junfei Luo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rh(III)-Catalyzed Decarboxylative Coupling of Acrylic Acids with Unsaturated Oxime Esters: Carboxylic Acids Serve as Traceless Activators

(2014) Jamie M. Neely et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An organic cation as a silver(i) analogue for the arylation of sp2 and sp3 C–H bonds with iodoarenes

(2014) Carlos Arroniz et al.   Chemical Science

CH Functionalization Logic Enables Synthesis of (+)-Hongoquercin A and Related Compounds

(2013) Brandon R. Rosen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Cross-Dehydrogenative Coupling of C sp 3H Bonds: A Versatile Strategy for CC Bond Formations

(2013) Simon A. Girard et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rhodium-Catalyzedortho Acylation of Aromatic Carboxylic Acids

(2013) Patrizia Mamone et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium-Catalyzedortho-Selective CH Deuteration of Arenes: Evidence for Superior Reactivity of Weakly Coordinated Palladacycles

(2013) Sandy Ma et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of Aryl Ethers from Benzoates through Carboxylate-Directed CH-Activating Alkoxylation with Concomitant Protodecarboxylation

(2013) Sukalyan Bhadra et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium-Catalyzed CHorthoArylation of Benzoic Acids with Diaryliodonium Salts in Water

(2013) Zhiqing Wu et al.   ChemCatChem

One-Pot Synthesis of 3-Alkylidenephthalides from Benzoic Acids by a Rhodium-Catalyzedortho-CH Acylation Process

(2013) Grégory Danoun et al.   CHEMISTRY-A EUROPEAN JOURNAL

One-Step Synthesis of Isocoumarins and 3-Benzylidenephthalides via Ligandless Pd-Catalyzed Oxidative Coupling of Benzoic Acids and Vinylarenes

(2013) Debkumar Nandi et al.   JOURNAL OF ORGANIC CHEMISTRY

Rhodium-Catalyzed C3-Selective Alkenylation of Substituted Thiophene-2-carboxylic Acids and Related Compounds

(2013) Tomonori Iitsuka et al.   JOURNAL OF ORGANIC CHEMISTRY

Rhodium- and Iridium-Catalyzed Dehydrogenative Cyclization through Double C–H Bond Cleavages To Produce Fluorene Derivatives

(2013) Masaki Itoh et al.   JOURNAL OF ORGANIC CHEMISTRY

Pd(II)-Catalyzed ortho- or meta-C–H Olefination of Phenol Derivatives

(2013) Hui-Xiong Dai et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ligand-Accelerated ortho-C–H Alkylation of Arylcarboxylic Acids using Alkyl Boron Reagents

(2013) Peter S. Thuy-Boun et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palladium-Catalyzed Chemoselective Decarboxylative Ortho Acylation of Benzoic Acids with α-Oxocarboxylic Acids

(2013) Jinmin Miao et al.   ORGANIC LETTERS

Direct ortho-Arylation of ortho-Substituted Benzoic Acids: Overriding Pd-Catalyzed Protodecarboxylation

(2013) Carlos Arroniz et al.   ORGANIC LETTERS

Cp*IrIII-Catalyzed Oxidative Coupling of Benzoic Acids with Alkynes

(2013) Daniel A. Frasco et al.   ACS Catalysis

Water as a green solvent for efficient synthesis of isocoumarins through microwave-accelerated and Rh/Cu-catalyzed C–H/O–H bond functionalization

(2013) Qiu Li et al.   RSC Advances

A Novel Rhodium-Catalyzed Cascade Cyclization: Direct Synthesis of 3-Substituted Phthalides from Aldehydes and Aromatic Acids

(2012) Xianying Shi et al.   ADVANCED SYNTHESIS & CATALYSIS

Beyond Directing Groups: Transition-Metal-Catalyzed CH Activation of Simple Arenes

(2012) Nadine Kuhl et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A convenient synthesis of anthranilic acids by Pd-catalyzed direct intermolecular ortho-C–H amidation of benzoic acids

(2012) Ka-Ho Ng et al.   CHEMICAL COMMUNICATIONS

Ruthenium(II)-Catalyzed C–H Bond Activation and Functionalization

(2012) Percia Beatrice Arockiam et al.   CHEMICAL REVIEWS

Palladium-Catalyzed Annulation of Allenes with Indole-2-carboxylic Acid Derivatives: Synthesis of Indolo[2,3-c]pyrane-1-ones via Ar–I Reactivity or C–H Functionalization

(2012) R. Rama Suresh et al.   JOURNAL OF ORGANIC CHEMISTRY

Ruthenium-catalyzed C–H/O–H and C–H/N–H bond functionalizations: oxidative annulations of cyclopropyl-substituted alkynes

(2012) Monica Deponti et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Enantioselective Total Synthesis of (+)-Lithospermic Acid

(2012) Arun K. Ghosh et al.   ORGANIC LETTERS

Versatile Synthesis of Isocoumarins and α-Pyrones by Ruthenium-Catalyzed Oxidative C–H/O–H Bond Cleavages

(2012) Lutz Ackermann et al.   ORGANIC LETTERS

Innate and Guided C–H Functionalization Logic

(2011) Tobias Brückl et al.   ACCOUNTS OF CHEMICAL RESEARCH

Weak Coordination as a Powerful Means for Developing Broadly Useful C–H Functionalization Reactions

(2011) Keary M. Engle et al.   ACCOUNTS OF CHEMICAL RESEARCH

Removable Directing Groups in Organic Synthesis and Catalysis

(2011) Géraldine Rousseau et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Carboxylic Acids as Traceless Directing Groups for Formal meta-Selective Direct Arylation

(2011) Josep Cornella et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rhenium-catalyzed allylation of C–H bonds of benzoic and acrylic acids

(2011) Yoichiro Kuninobu et al.   CHEMICAL COMMUNICATIONS

Regioselective synthesis of isocoumarins by ruthenium-catalyzed aerobic oxidative cyclization of aromatic acids with alkynes

(2011) Ravi Kiran Chinnagolla et al.   CHEMICAL COMMUNICATIONS

Carboxylate-Assisted Transition-Metal-Catalyzed C−H Bond Functionalizations: Mechanism and Scope

(2011) Lutz Ackermann   CHEMICAL REVIEWS

Transition metal-catalyzed arylation of unactivated C(sp3)–H bonds

(2011) Olivier Baudoin   CHEMICAL SOCIETY REVIEWS

Syntheses of Prekinamycin and a Tetracyclic Quinone from Common Synthetic Intermediates

(2011) Shingo Kimura et al.   HELVETICA CHIMICA ACTA

Rhodium-Catalyzed Regioselective Olefination Directed by a Carboxylic Group

(2011) Satoshi Mochida et al.   JOURNAL OF ORGANIC CHEMISTRY

Ligand-Accelerated Cross-Coupling of C(sp2)–H Bonds with Arylboron Reagents

(2011) Keary M. Engle et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Highly Convergent Total Synthesis of (+)-Lithospermic Acid via a Late-Stage Intermolecular C−H Olefination

(2011) Dong-Hui Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ruthenium-Catalyzed Oxidative C–H Bond Alkenylations in Water: Expedient Synthesis of Annulated Lactones

(2011) Lutz Ackermann et al.   ORGANIC LETTERS

Ruthenium-Catalyzed Oxidative Vinylation of Heteroarene Carboxylic Acids with Alkenes via Regioselective C−H Bond Cleavage

(2011) Takumi Ueyama et al.   ORGANIC LETTERS

C–H Bond Functionalization of Benzoic Acid: Catalytic Synthesis of 2-Hydroxy-6H-benzo[c]chromen-6-ones Using (Cp*IrCl2)2

(2011) Kristi L. Engelman et al.   ORGANOMETALLICS

Constructing Multiply Substituted Arenes Using Sequential Palladium(II)-Catalyzed CH Olefination

(2010) Keary M. Engle et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Generation of benzyne from benzoic acid using C–H activation

(2010) Alastair A. Cant et al.   CHEMICAL COMMUNICATIONS

Palladium-Catalyzed Ligand-Directed C−H Functionalization Reactions

(2010) Thomas W. Lyons et al.   CHEMICAL REVIEWS

Ligand-Accelerated C−H Activation Reactions: Evidence for a Switch of Mechanism

(2010) Keary M. Engle et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palladium-Catalyzed Intermolecular Decarboxylative Coupling of 2-Phenylbenzoic Acids with Alkynes via C−H and C−C Bond Activation

(2010) Congyang Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Expedient Drug Synthesis and Diversification via ortho-C−H Iodination using Recyclable PdI2as the Precatalyst

(2010) Tian-Sheng Mei et al.   ORGANIC LETTERS

Synthesis of Stilbene and Distyrylbenzene Derivatives through Rhodium-CatalyzedOrtho-Olefination and Decarboxylation of Benzoic Acids

(2010) Satoshi Mochida et al.   ORGANIC LETTERS

Transition-Metal-Catalyzed Regioselective Arylation and Vinylation of Carboxylic Acids

(2010) Tetsuya Satoh et al.   SYNTHESIS-STUTTGART

Palladium- and Copper-Catalyzed Arylation of Carbon−Hydrogen Bonds

(2009) Olafs Daugulis et al.   ACCOUNTS OF CHEMICAL RESEARCH

Palladium(II)-CatalyzedorthoAlkylation of Benzoic Acids with Alkyl Halides

(2009) Yang-Hui Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Iron-Promotedortho- and/oripso-Hydroxylation of Benzoic Acids with H2O2

(2009) Olga V. Makhlynets et al.   CHEMISTRY-A EUROPEAN JOURNAL

Total Synthesis of the Aspercyclides

(2009) Jiří Pospíšil et al.   CHEMISTRY-A EUROPEAN JOURNAL

Waste-Free Synthesis of Condensed Heterocyclic Compounds by Rhodium-Catalyzed Oxidative Coupling of Substituted Arene or Heteroarene Carboxylic Acids with Alkynes

(2009) Masaki Shimizu et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Functionalized α-Pyrone and Butenolide Derivatives by Rhodium-Catalyzed Oxidative Coupling of Substituted Acrylic Acids with Alkynes and Alkenes

(2009) Satoshi Mochida et al.   JOURNAL OF ORGANIC CHEMISTRY

Pd(II)-Catalyzed Hydroxylation of Arenes with 1 atm of O2or Air

(2009) Yang-Hui Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Pd(II)-Catalyzed Enantioselective C−H Olefination of Diphenylacetic Acids

(2009) Bing-Feng Shi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of Condensed Heteroaromatic Compounds by Palladium-Catalyzed Oxidative Coupling of Heteroarene Carboxylic Acids with Alkynes

(2009) Mana Yamashita et al.   ORGANIC LETTERS

Ligand-Enabled Reactivity and Selectivity in a Synthetically Versatile Aryl C-H Olefination

(2009) D.-H. Wang et al.   SCIENCE

PdII‐Catalyzed MonoselectiveorthoHalogenation of CH Bonds Assisted by Counter Cations: A Complementary Method to Directedortho Lithiation

(2008) Tian‐Sheng Mei et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Versatile Pd(II)-Catalyzed C−H Activation/Aryl−Aryl Coupling of Benzoic and Phenyl Acetic Acids

(2008) Dong-Hui Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of 1,2- and 1,3-Dicarboxylic Acids via Pd(II)-Catalyzed Carboxylation of Aryl and Vinyl C−H Bonds

(2008) Ramesh Giri et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rhodium- and iridium-catalyzed oxidative coupling of benzoic acids with alkynes and alkenes

(2008) Tetsuya Satoh et al.   PURE AND APPLIED CHEMISTRY