Exosome: Function and Role in Cancer Metastasis and Drug Resistance

Exosomes isolated from cancer patients’ sera transfer malignant traits and confer the same phenotype of primary tumors to oncosuppressor-mutated cells

(2017) Mohamed Abdouh et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Exosome-Transmitted lncARSR Promotes Sunitinib Resistance in Renal Cancer by Acting as a Competing Endogenous RNA

(2016) Le Qu et al.   CANCER CELL

Exosomal microRNA Biomarkers: Emerging Frontiers in Colorectal and Other Human Cancers

(2016) Oscar A. Tovar-Camargo et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Extracellular vesicles in ovarian cancer: applications to tumor biology, immunotherapy and biomarker discovery

(2016) Muhammad Nawaz et al.   Expert Review of Proteomics

Protein content and functional characteristics of serum-purified exosomes from patients with colorectal cancer revealed by quantitative proteomics

(2016) Yanyu Chen et al.   INTERNATIONAL JOURNAL OF CANCER

Transfer of malignant trait to BRCA1 deficient human fibroblasts following exposure to serum of cancer patients

(2016) Dana Hamam et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Down-regulation of MALAT1 inhibits cervical cancer cell invasion and metastasis by inhibition of epithelial–mesenchymal transition

(2016) Ruili Sun et al.   Molecular BioSystems

Circulating long non-coding RNAs in cancer: current status and future perspectives

(2016) Peng Qi et al.   Molecular Cancer

Barriers to horizontal cell transformation by extracellular vesicles containing oncogenic H-ras

(2016) Tae Hoon Lee et al.   Oncotarget

Exosomal long noncoding RNA CRNDE-h as a novel serum-based biomarker for diagnosis and prognosis of colorectal cancer

(2016) Tong Liu et al.   Oncotarget

Expression of the Long Non-Coding RNA HOTAIR Correlates with Disease Progression in Bladder Cancer and Is Contained in Bladder Cancer Patient Urinary Exosomes

(2016) Claudia Berrondo et al.   PLoS One

A novel TP53 pathway influences the HGS-mediated exosome formation in colorectal cancer

(2016) Yulin Sun et al.   Scientific Reports

A novel platform for cancer therapy using extracellular vesicles

(2015) Naoomi Tominaga et al.   ADVANCED DRUG DELIVERY REVIEWS

Effects of Decitabine on Invasion and Exosomal Expression of miR-200c and miR-141 in Oxaliplatin-Resistant Colorectal Cancer Cells

(2015) Shota Tanaka et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Extracellular vesicle long noncoding RNA as potential biomarkers of liver cancer

(2015) Swathi Mohankumar et al.   Briefings in Functional Genomics

The emergence of long non-coding RNAs in the tumorigenesis of hepatocellular carcinoma

(2015) Xin Yang et al.   CANCER LETTERS

Exosome mediated communication within the tumor microenvironment

(2015) Lara Milane et al.   JOURNAL OF CONTROLLED RELEASE

CD90+ liver cancer cells modulate endothelial cell phenotype through the release of exosomes containing H19 lncRNA

(2015) Alice Conigliaro et al.   Molecular Cancer

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

(2015) Bruno Costa-Silva et al.   NATURE CELL BIOLOGY

Biomarkers of colorectal cancer: Recent advances and future challenges

(2015) Caroline Coghlin et al.   Proteomics Clinical Applications

Intercellular Transfer of Cancer Drug Resistance Traits by Extracellular Vesicles

(2015) Diana Sousa et al.   TRENDS IN MOLECULAR MEDICINE

Circulating microRNAs and long non-coding RNAs in gastric cancer diagnosis: An update and review

(2015) Ya-Kai Huang   WORLD JOURNAL OF GASTROENTEROLOGY

KRAS-dependent sorting of miRNA to exosomes

(2015) Diana J Cha et al.   eLife

Overexpression of the microRNA miR-433 promotes resistance to paclitaxel through the induction of cellular senescence in ovarian cancer cells

(2015) Karolina Weiner-Gorzel et al.   Cancer Medicine

Exosomal Tumor MicroRNA Modulates Premetastatic Organ Cells

(2015) Sanyukta Rana et al.   NEOPLASIA

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

Molecular characterization of exosome-like vesicles from breast cancer cells

(2014) Stefan Kruger et al.   BMC CANCER

miRNA biogenesis: Biological impact in the development of cancer

(2014) Sandra L Romero-Cordoba et al.   CANCER BIOLOGY & THERAPY

Cancer-Secreted miR-105 Destroys Vascular Endothelial Barriers to Promote Metastasis

(2014) Weiying Zhou et al.   CANCER CELL

The Risk-Associated Long Noncoding RNA NBAT-1 Controls Neuroblastoma Progression by Regulating Cell Proliferation and Neuronal Differentiation

(2014) Gaurav Kumar Pandey et al.   CANCER CELL

A Long Noncoding RNA Activated by TGF-β Promotes the Invasion-Metastasis Cascade in Hepatocellular Carcinoma

(2014) Ji-hang Yuan et al.   CANCER CELL

Exosome-mediated crosstalk between chronic myelogenous leukemia cells and human bone marrow stromal cells triggers an Interleukin 8-dependent survival of leukemia cells

(2014) Chiara Corrado et al.   CANCER LETTERS

Exosome Transfer from Stromal to Breast Cancer Cells Regulates Therapy Resistance Pathways

(2014) Mirjam C. Boelens et al.   CELL

Double-stranded DNA in exosomes: a novel biomarker in cancer detection

(2014) Basant Kumar Thakur et al.   CELL RESEARCH

Novel Insights Into the Role of MicroRNA in Lung Cancer Resistance to Treatment and Targeted Therapy

(2014) Zhaohui Gong et al.   CURRENT CANCER DRUG TARGETS

Long non-coding RNA UCA1 increases chemoresistance of bladder cancer cells by regulating Wnt signaling

(2014) Yu Fan et al.   FEBS Journal

Identification of Double-stranded Genomic DNA Spanning All Chromosomes with MutatedKRASandp53DNA in the Serum Exosomes of Patients with Pancreatic Cancer

(2014) Christoph Kahlert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

miR-200–containing extracellular vesicles promote breast cancer cell metastasis

(2014) Minh T.N. Le et al.   JOURNAL OF CLINICAL INVESTIGATION

Transfer of malignant trait to immortalized human cells following exposure to human cancer serum

(2014) Mohamed Abdouh et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Ovarian cancer cell invasiveness is associated with discordant exosomal sequestration of Let-7 miRNA and miR-200

(2014) Miharu Kobayashi et al.   Journal of Translational Medicine

Bioactive Exosomes: Possibilities for Diagnosis and Management of Bladder Cancer

(2014) Jonathan M. Street et al.   JOURNAL OF UROLOGY

Bladder Cancer Exosomes Contain EDIL-3/Del1 and Facilitate Cancer Progression

(2014) Carla J. Beckham et al.   JOURNAL OF UROLOGY

Non-coding RNAs as biomarkers for metastatic prostate cancer

(2014) William Robert Veltri   LANCET ONCOLOGY

Combined detection of serum exosomal miR-21 and HOTAIR as diagnostic and prognostic biomarkers for laryngeal squamous cell carcinoma

(2014) Jingting Wang et al.   MEDICAL ONCOLOGY

WNT5A induces release of exosomes containing pro-angiogenic and immunosuppressive factors from malignant melanoma cells

(2014) Elin J Ekström et al.   Molecular Cancer

LincRNA-p21 Activates p21 In cis to Promote Polycomb Target Gene Expression and to Enforce the G1/S Checkpoint

(2014) Nadya Dimitrova et al.   MOLECULAR CELL

Exosomes from Drug-Resistant Breast Cancer Cells Transmit Chemoresistance by a Horizontal Transfer of MicroRNAs

(2014) Wei-xian Chen et al.   PLoS One

Deep Sequencing of RNA from Three Different Extracellular Vesicle (EV) Subtypes Released from the Human LIM1863 Colon Cancer Cell Line Uncovers Distinct Mirna-Enrichment Signatures

(2014) Hong Ji et al.   PLoS One

Upregulation of the long noncoding RNA HOTAIR predicts recurrence in stage Ta/T1 bladder cancer

(2014) Ting-Hua Yan et al.   TUMOR BIOLOGY

Exosome in Tumour Microenvironment: Overview of the Crosstalk between Normal and Cancer Cells

(2014) Catarina Roma-Rodrigues et al.   Biomed Research International

Extracellular vesicle-mediated transfer of long non-coding RNA ROR modulates chemosensitivity in human hepatocellular cancer

(2014) Kenji Takahashi et al.   FEBS Open Bio

The Emerging Role of Exosomes in Epithelial–Mesenchymal-Transition in Cancer

(2014) Laura Jayne Vella   Frontiers in Oncology

Cardiac myocyte exosomes: stability, HSP60, and proteomics

(2013) Z. A. Malik et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Exosomes as new vesicular lipid transporters involved in cell–cell communication and various pathophysiologies

(2013) Michel Record et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Characterization of human plasma-derived exosomal RNAs by deep sequencing

(2013) Xiaoyi Huang et al.   BMC GENOMICS

The Origins of Tumor-Promoting Inflammation

(2013) Tanya Bondar et al.   CANCER CELL

Exosomes Derived from Hypoxic Leukemia Cells Enhance Tube Formation in Endothelial Cells

(2013) Hiroko Tadokoro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extracellular vesicles: Exosomes, microvesicles, and friends

(2013) Graça Raposo et al.   JOURNAL OF CELL BIOLOGY

Exosome-like Nanoparticles from Intestinal Mucosal Cells Carry Prostaglandin E2 and Suppress Activation of Liver NKT Cells

(2013) Z.-B. Deng et al.   JOURNAL OF IMMUNOLOGY

Exosomes in tumor microenvironment influence cancer progression and metastasis

(2013) Christoph Kahlert et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Comparisons of microRNA Patterns in Plasma before and after Tumor Removal Reveal New Biomarkers of Lung Squamous Cell Carcinoma

(2013) Vasily N. Aushev et al.   PLoS One

Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development

(2013) P. Kucharzewska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteome profiling of exosomes derived from human primary and metastatic colorectal cancer cells reveal differential expression of key metastatic factors and signal transduction components

(2013) Hong Ji et al.   PROTEOMICS

Neoplastic Reprogramming of Patient-Derived Adipose Stem Cells by Prostate Cancer Cell-Associated Exosomes

(2013) Zakaria Y. Abd Elmageed et al.   STEM CELLS

Extracellular vesicle-mediated transfer of donor genomic DNA to recipient cells is a novel mechanism for genetic influence between cells

(2013) Jin Cai et al.   Journal of Molecular Cell Biology

Signaling Pathways in Exosomes Biogenesis, Secretion and Fate

(2013) Lorena Urbanelli et al.   Genes

The multifaceted exosome: Biogenesis, role in normal and aberrant cellular function, and frontiers for pharmacological and biomarker opportunities

(2012) Saumya Pant et al.   BIOCHEMICAL PHARMACOLOGY

Hypoxic enhancement of exosome release by breast cancer cells

(2012) Hamish W King et al.   BMC CANCER

Rab27a Supports Exosome-Dependent and -Independent Mechanisms That Modify the Tumor Microenvironment and Can Promote Tumor Progression

(2012) A. Bobrie et al.   CANCER RESEARCH

Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration

(2012) Valbona Luga et al.   CELL

Microparticles: biomarkers and beyond

(2012) Dylan Burger et al.   CLINICAL SCIENCE

Restoration of full-length APC protein in SW480 colon cancer cells induces exosome-mediated secretion of DKK-4

(2012) Justin W. E. Lim et al.   ELECTROPHORESIS

The long non-coding RNAs, a new cancer diagnostic and therapeutic gold mine

(2012) Peng Qi et al.   MODERN PATHOLOGY

Get on the exosome bus with ALIX

(2012) James H. Hurley et al.   NATURE CELL BIOLOGY

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

(2012) Héctor Peinado et al.   NATURE MEDICINE

Exosomes secreted from human colorectal cancer cell lines contain mRNAs, microRNAs and natural antisense RNAs, that can transfer into the human hepatoma HepG2 and lung cancer A549 cell lines

(2012) MITSURU CHIBA et al.   ONCOLOGY REPORTS

The Majority of MicroRNAs Detectable in Serum and Saliva Is Concentrated in Exosomes

(2012) Alessia Gallo et al.   PLoS One

Urinary exosomes: A reservoir for biomarker discovery and potential mediators of intrarenal signalling

(2012) James W. Dear et al.   PROTEOMICS

Recent advances on the role of tumor exosomes in immunosuppression and disease progression

(2012) Paola Filipazzi et al.   SEMINARS IN CANCER BIOLOGY

Exosomes as intercellular signalosomes and pharmacological effectors

(2011) Michel Record et al.   BIOCHEMICAL PHARMACOLOGY

Identification of nucleotide patterns enriched in secreted RNAs as putative cis-acting elements targeting them to exosome nano-vesicles

(2011) Arsen O Batagov et al.   BMC GENOMICS

TGF-beta signalling in colon carcinogenesis

(2011) Pavlos Lampropoulos et al.   CANCER LETTERS

Exosomes Released by Melanoma Cells Prepare Sentinel Lymph Nodes for Tumor Metastasis

(2011) J. L. Hood et al.   CANCER RESEARCH

Chromatin modifying protein 1A (Chmp1A) of the endosomal sorting complex required for transport (ESCRT)-III family activates ataxia telangiectasia mutated (ATM) for PanC-1 cell growth inhibition

(2011) Sumanth Manohar et al.   CELL CYCLE

The Roles of Tumor-Derived Exosomes in Cancer Pathogenesis

(2011) Chenjie Yang et al.   Clinical & Developmental Immunology

Analysis of exosome release and its prognostic value in human colorectal cancer

(2011) J. Silva et al.   GENES CHROMOSOMES & CANCER

Potential role of HER2-overexpressing exosomes in countering trastuzumab-based therapy

(2011) Valentina Ciravolo et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Differential expression of miR-144* as a novel fecal-based diagnostic marker for colorectal cancer

(2011) Murugan Kalimutho et al.   JOURNAL OF GASTROENTEROLOGY

S100A8/A9 Activate Key Genes and Pathways in Colon Tumor Progression

(2011) M. Ichikawa et al.   MOLECULAR CANCER RESEARCH

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

ExoCarta 2012: database of exosomal proteins, RNA and lipids

(2011) S. Mathivanan et al.   NUCLEIC ACIDS RESEARCH

The New Faces of Endocytosis in Signaling

(2011) Anna Hupalowska et al.   TRAFFIC

Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences

(2011) Leonora Balaj et al.   Nature Communications

Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells

(2011) María Mittelbrunn et al.   Nature Communications

Cancer Exosomes Trigger Fibroblast to Myofibroblast Differentiation

(2010) J. Webber et al.   CANCER RESEARCH

A Large Intergenic Noncoding RNA Induced by p53 Mediates Global Gene Repression in the p53 Response

(2010) Maite Huarte et al.   CELL

Secretory Mechanisms and Intercellular Transfer of MicroRNAs in Living Cells

(2010) Nobuyoshi Kosaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exosomes: Extracellular organelles important in intercellular communication

(2010) Suresh Mathivanan et al.   Journal of Proteomics

The Nuclear-Retained Noncoding RNA MALAT1 Regulates Alternative Splicing by Modulating SR Splicing Factor Phosphorylation

(2010) Vidisha Tripathi et al.   MOLECULAR CELL

Secreted Monocytic miR-150 Enhances Targeted Endothelial Cell Migration

(2010) Yujing Zhang et al.   MOLECULAR CELL

Let-7 MicroRNA Family Is Selectively Secreted into the Extracellular Environment via Exosomes in a Metastatic Gastric Cancer Cell Line

(2010) Keiichi Ohshima et al.   PLoS One

Exosomes Communicate Protective Messages during Oxidative Stress; Possible Role of Exosomal Shuttle RNA

(2010) Maria Eldh et al.   PLoS One

Analysis conditions for proteomic profiling of mammalian tissue and cell extracts with antibody microarrays

(2010) Mohamed Saiel Saeed Alhamdani et al.   PROTEOMICS

Advances in membranous vesicle and exosome proteomics improving biological understanding and biomarker discovery

(2010) Francesca Raimondo et al.   PROTEOMICS

Epithelial–mesenchymal transition with expression of SNAI1-induced chemoresistance in colorectal cancer

(2009) Hiromitsu Hoshino et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Colorectal cancer cell-derived microvesicles are enriched in cell cycle-related mRNAs that promote proliferation of endothelial cells

(2009) Bok Hong et al.   BMC GENOMICS

Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability

(2009) F. Colotta et al.   CARCINOGENESIS

Exosomes in Tumour Immunity

(2009) Aled Clayton et al.   Current Oncology

Exosomes: proteomic insights and diagnostic potential

(2009) Richard J Simpson et al.   Expert Review of Proteomics

Proteomic Analysis of Human Parotid Gland Exosomes by Multidimensional Protein Identification Technology (MudPIT)

(2009) Mireya Gonzalez-Begne et al.   JOURNAL OF PROTEOME RESEARCH

Activated T cells recruit exosomes secreted by dendritic cells via LFA-1

(2008) E. N. M. Nolte-'t Hoen et al.   BLOOD

Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large B-cell lymphoma

(2008) Charles H. Lawrie et al.   BRITISH JOURNAL OF HAEMATOLOGY

Mature miR-184 as Potential Oncogenic microRNA of Squamous Cell Carcinoma of Tongue

(2008) T.-S. Wong et al.   CLINICAL CANCER RESEARCH

MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer

(2008) Douglas D. Taylor et al.   GYNECOLOGIC ONCOLOGY

Extracellular plasma RNA from colon cancer patients is confined in a vesicle-like structure and is mRNA-enriched

(2008) J. M. Garcia et al.   RNA