Biologic therapies to enhance intervertebral disc repair

ISSLS PRIZE IN BASIC SCIENCE 2017: Intervertebral disc/bone marrow cross-talk with Modic changes

(2017) Stefan Dudli et al.   EUROPEAN SPINE JOURNAL

Human-Based Biological and Biomimetic Autologous Therapies for Musculoskeletal Tissue Regeneration

(2017) Sabino Padilla et al.   TRENDS IN BIOTECHNOLOGY

Pathobiology of Modic changes

(2016) Stefan Dudli et al.   EUROPEAN SPINE JOURNAL

A new strategy to tackle severe knee osteoarthritis: Combination of intra-articular and intraosseous injections of Platelet Rich Plasma

(2016) Mikel Sánchez et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Platelet-rich plasma, a source of autologous growth factors and biomimetic scaffold for peripheral nerve regeneration

(2016) Mikel Sánchez et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Intradiscal platelet-rich plasma (PRP) injections for discogenic low back pain: an update

(2016) Michael Monfett et al.   INTERNATIONAL ORTHOPAEDICS

The role of TGF-β1/Smad2/3 pathway in platelet-rich plasma in retarding intervertebral disc degeneration

(2016) Huilin Yang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Molecular mechanisms of biological aging in intervertebral discs

(2016) Nam V. Vo et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Mesenchymal stem cells in regenerative medicine: Focus on articular cartilage and intervertebral disc regeneration

(2016) Stephen M. Richardson et al.   METHODS

Intervertebral disc regeneration using platelet-rich plasma-containing bone marrow-derived mesenchymal stem cells: A preliminary investigation

(2016) SHAN-ZHENG WANG et al.   Molecular Medicine Reports

A regenerative approach towards recovering the mechanical properties of degenerated intervertebral discs: Genipin and platelet-rich plasma therapies

(2016) Mohammad Nikkhoo et al.   PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART H-JOURNAL OF ENGINEERING IN MEDICINE

Lumbar Intradiskal Platelet-Rich Plasma (PRP) Injections: A Prospective, Double-Blind, Randomized Controlled Study

(2016) Yetsa A. Tuakli-Wosornu et al.   PM&R

Differential expression of p38 MAPK α, β, γ, δ isoforms in nucleus pulposus modulates macrophage polarization in intervertebral disc degeneration

(2016) Chen Yang et al.   Scientific Reports

The Effects of Platelet-Rich Plasma on Halting the Progression in Porcine Intervertebral Disc Degeneration

(2015) Hongsik Cho et al.   ARTIFICIAL ORGANS

Study design: in vitro and in vivo assessment of bone morphogenic protein 2 combined with platelet-rich plasma on treatment of disc degeneration

(2015) Yang Hou et al.   INTERNATIONAL ORTHOPAEDICS

Hepatocyte growth factor/c-met promotes proliferation, suppresses apoptosis, and improves matrix metabolism in rabbit nucleus pulposus cells in vitro

(2015) Hidenobu Ishibashi et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Stem cell therapy for intervertebral disc regeneration: obstacles and solutions

(2015) Daisuke Sakai et al.   Nature Reviews Rheumatology

Mechanics and biology in intervertebral disc degeneration: a vicious circle

(2015) P.-P.A. Vergroesen et al.   OSTEOARTHRITIS AND CARTILAGE

Leukocytes Enhance Inflammatory and Catabolic Degenerative Changes in the Intervertebral Disc After Endplate Fracture In Vitro Without Infiltrating the Disc

(2015) Stefan Dudli et al.   SPINE

The association of combination of disc degeneration, end plate signal change, and Schmorl node with low back pain in a large population study: the Wakayama Spine Study

(2015) Masatoshi Teraguchi et al.   Spine Journal

TGF-βl Suppresses Inflammation in Cell Therapy for Intervertebral Disc Degeneration

(2015) Huilin Yang et al.   Scientific Reports

Inhibitory Effects of Platelet-Rich Plasma on Intervertebral Disc Degeneration: A Preclinical Study in a Rabbit Model

(2015) Wangping Yin   MEDICAL SCIENCE MONITOR

Leukocyte Inclusion within a Platelet Rich Plasma-Derived Fibrin Scaffold Stimulates a More Pro-Inflammatory Environment and Alters Fibrin Properties

(2015) Eduardo Anitua et al.   PLoS One

Role of platelet-released growth factors in detoxification of reactive oxygen species in osteoblasts

(2014) Mersedeh Tohidnezhad et al.   BONE

Why do some intervertebral discs degenerate, when others (in the same spine) do not?

(2014) Michael A. Adams et al.   CLINICAL ANATOMY

Platelet-rich plasma induces annulus fibrosus cell proliferation and matrix production

(2014) T. N. Pirvu et al.   EUROPEAN SPINE JOURNAL

Expression and regulation of toll-like receptors (TLRs) in human intervertebral disc cells

(2014) Marina Klawitter et al.   EUROPEAN SPINE JOURNAL

Production and expression of RANTES (CCL5) by human disc cells and modulation by IL-1-β and TNF-α in 3D culture

(2014) Helen E. Gruber et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Platelet-rich Plasma in Orthopaedic Applications

(2014) Sabino Padilla et al.   JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS

Intervertebral disc regeneration: do nutrients lead the way?

(2014) Yong-Can Huang et al.   Nature Reviews Rheumatology

Cytotoxic Effects of the Radiocontrast Agent Iotrolan and Anesthetic Agents Bupivacaine and Lidocaine in Three-Dimensional Cultures of Human Intervertebral Disc Nucleus Pulposus Cells: Identification of the Apoptotic Pathways

(2014) Koji Iwasaki et al.   PLoS One

Inflammation Induces Irreversible Biophysical Changes in Isolated Nucleus Pulposus Cells

(2014) Robert Maidhof et al.   PLoS One

Inflammatory Cytokines Associated with Degenerative Disc Disease Control Aggrecanase-1 (ADAMTS-4) Expression in Nucleus Pulposus Cells through MAPK and NF-κB

(2013) Ye Tian et al.   AMERICAN JOURNAL OF PATHOLOGY

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Mechanical loading of the intervertebral disc: from the macroscopic to the cellular level

(2013) Cornelia Neidlinger-Wilke et al.   EUROPEAN SPINE JOURNAL

Antibiotic treatment in patients with chronic low back pain and vertebral bone edema (Modic type 1 changes): a double-blind randomized clinical controlled trial of efficacy

(2013) Hanne B. Albert et al.   EUROPEAN SPINE JOURNAL

Anti-inflammatory effect of platelet-rich plasma on nucleus pulposus cells with response of TNF-α and IL-1

(2013) Ho-Joong Kim et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

High-throughput proteomic characterization of plasma rich in growth factors (PRGF-Endoret)-derived fibrin clot interactome

(2013) Eduardo Anitua et al.   Journal of Tissue Engineering and Regenerative Medicine

Role of cytokines in intervertebral disc degeneration: pain and disc content

(2013) Makarand V. Risbud et al.   Nature Reviews Rheumatology

Heparin-binding domain of fibrin(ogen) binds growth factors and promotes tissue repair when incorporated within a synthetic matrix

(2013) M. M. Martino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytotoxicity of local anesthetics and nonionic contrast agents on bovine intervertebral disc cells cultured in a three-dimensional culture system

(2013) Ana V. Chee et al.   Spine Journal

Enhancing intervertebral disc repair and regeneration through biology: platelet-rich plasma as an alternative strategy

(2013) Shan-Zheng Wang et al.   ARTHRITIS RESEARCH & THERAPY

Hyaluronic acid fragments enhance the inflammatory and catabolic response in human intervertebral disc cells through modulation of toll-like receptor 2 signalling pathways

(2013) Lilian Quero et al.   ARTHRITIS RESEARCH & THERAPY

The cytokine and chemokine expression profile of nucleus pulposus cells: implications for degeneration and regeneration of the intervertebral disc

(2013) Kate L E Phillips et al.   ARTHRITIS RESEARCH & THERAPY

The pathogenesis of degeneration of the intervertebral disc and emerging therapies in the management of back pain

(2012) S. P. F. Hughes et al.   JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME

Osteoarthritis of the spine: the facet joints

(2012) Alfred C. Gellhorn et al.   Nature Reviews Rheumatology

Donor Age of Human Platelet Lysate Affects Proliferation and Differentiation of Mesenchymal Stem Cells

(2012) Michael Lohmann et al.   PLoS One

ISSLS Prize Winner

(2012) Yue Wang et al.   SPINE

Effect of autologous platelet-rich plasma-releasate on intervertebral disc degeneration in the rabbit anular puncture model: a preclinical study

(2012) Shuji Obata et al.   ARTHRITIS RESEARCH & THERAPY

Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc

(2012) Daisuke Sakai et al.   Nature Communications

The balance between adipogenesis and osteogenesis in bone regeneration by platelet-rich plasma for age-related osteoporosis

(2011) Hen-Yu Liu et al.   BIOMATERIALS

Is the spinal motion segment a diarthrodial polyaxial joint: What a nice nucleus like you doing in a joint like this?

(2011) Irving M. Shapiro et al.   BONE

Exogenous and autocrine growth factors stimulate human intervertebral disc cell proliferation via the ERK and Akt pathways

(2011) Harris Pratsinis et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Evaluation of platelet-rich plasma and hydrostatic pressure regarding cell differentiation in nucleus pulposus tissue engineering

(2011) Antje Mietsch et al.   Journal of Tissue Engineering and Regenerative Medicine

Degenerative Magnetic Resonance Imaging Changes in Patients With Chronic Low Back Pain

(2011) Dean Chou et al.   SPINE

Platelets, inflammation and tissue regeneration

(2011) Alan Nurden   THROMBOSIS AND HAEMOSTASIS

Platelets in Regeneration

(2010) Konstantinos Stellos et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Isolation and Characterization of Mesenchymal Stromal Cells From Human Degenerated Nucleus Pulposus

(2010) Juan F. Blanco et al.   SPINE

Alterations in gene expression in response to compression of nucleus pulposus cells

(2010) Gwendolyn A. Sowa et al.   Spine Journal

Load and the spine. How does the Goldilocks principle apply?

(2010) Jeffrey C. Lotz   Spine Journal

Intervertebral disc regeneration in an ex vivo culture system using mesenchymal stem cells and platelet-rich plasma

(2009) Wei-Hong Chen et al.   BIOMATERIALS

Fibroblastic response to treatment with different preparations rich in growth factors

(2009) E. Anitua et al.   CELL PROLIFERATION

Physical activity and low back pain: A U-shaped relation?

(2009) Hans Heneweer et al.   PAIN

Characterization of In Vivo Effects of Platelet-Rich Plasma and Biodegradable Gelatin Hydrogel Microspheres on Degenerated Intervertebral Discs

(2009) Kazuhide Sawamura et al.   TISSUE ENGINEERING PART A

New Challenges for Intervertebral Disc Treatment Using Regenerative Medicine

(2009) Koichi Masuda et al.   TISSUE ENGINEERING PART B-REVIEWS

Vertebral endplate signal changes (Modic change): a systematic literature review of prevalence and association with non-specific low back pain

(2008) Tue Secher Jensen et al.   EUROPEAN SPINE JOURNAL

Biological repair of the degenerated intervertebral disc by the injection of growth factors

(2008) Koichi Masuda   EUROPEAN SPINE JOURNAL

Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus

(2008) Ning Wang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Intervertebral disc cells as competent phagocytes in vitro: implications for cell death in disc degeneration

(2008) Philip Jones et al.   ARTHRITIS RESEARCH & THERAPY