ISSLS PRIZE IN BASIC SCIENCE 2017: Intervertebral disc/bone marrow cross-talk with Modic changes

Are Modic changes associated with intervertebral disc cytokine profiles?

(2017) Gregory D. Schroeder et al.   Spine Journal

Pathobiology of Modic changes

(2016) Stefan Dudli et al.   EUROPEAN SPINE JOURNAL

Chronic low back pain in relation to Modic changes, bony endplate lesions, and disc degeneration in a prospective MRI study

(2016) Katariina Luoma et al.   EUROPEAN SPINE JOURNAL

Neurotrophin-3 Induces BMP-2 and VEGF Activities and Promotes the Bony Repair of Injured Growth Plate Cartilage and Bone in Rats

(2016) Yu-Wen Su et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal

(2016) Eric M. Pietras et al.   NATURE CELL BIOLOGY

Blocking the tropomyosin receptor kinase A (TrkA) receptor inhibits pain behaviour in two rat models of osteoarthritis

(2015) Lilian N Nwosu et al.   ANNALS OF THE RHEUMATIC DISEASES

Association between changes in lumbar Modic changes and low back symptoms over a two-year period

(2015) Jyri Järvinen et al.   BMC MUSCULOSKELETAL DISORDERS

Osteoclast activators are elevated in intervertebral disks with Modic changes among patients operated for herniated nucleus pulposus

(2015) Matias Torkki et al.   EUROPEAN SPINE JOURNAL

Role of Erk1/2 Signaling in the Regulation of NeutrophilVersusMonocyte Development in Response to G-CSF and M-CSF

(2015) Nan Hu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analgesia via blockade of NGF/TrkA signaling does not influence fracture healing in mice

(2015) Anna E. Rapp et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Leukocytes Enhance Inflammatory and Catabolic Degenerative Changes in the Intervertebral Disc After Endplate Fracture In Vitro Without Infiltrating the Disc

(2015) Stefan Dudli et al.   SPINE

Progranulin Knockout Accelerates Intervertebral Disc Degeneration in Aging Mice

(2015) Yun-peng Zhao et al.   Scientific Reports

BDNF and its TrkB receptor in human fracture healing

(2014) Olaf Kilian et al.   ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER

Endplate changes following discectomy: natural history and associations between imaging and clinical data

(2014) Bradley K. Weiner et al.   EUROPEAN SPINE JOURNAL

Modic (endplate) changes in the lumbar spine: bone micro-architecture and remodelling

(2014) Egon Perilli et al.   EUROPEAN SPINE JOURNAL

Pro-inflammatory cytokines: Emerging players regulating HSC function in normal and diseased hematopoiesis

(2014) Cristina Mirantes et al.   EXPERIMENTAL CELL RESEARCH

The association between Modic changes and pain during 1-year follow-up in patients with lumbar radicular pain

(2014) Elina Iordanova Schistad et al.   SKELETAL RADIOLOGY

Type 1 Modic changes was a significant risk factor for 1-year outcome in sick-listed low back pain patients: a nested cohort study using magnetic resonance imaging of the lumbar spine

(2014) Ole Kudsk Jensen et al.   Spine Journal

Gene silencing of the BDNF/TrkB axis in multiple myeloma blocks bone destruction and tumor burden in vitro and in vivo

(2013) Li-Sha Ai et al.   INTERNATIONAL JOURNAL OF CANCER

M-CSF instructs myeloid lineage fate in single haematopoietic stem cells

(2013) Noushine Mossadegh-Keller et al.   NATURE

Innervation of pathologies in the lumbar vertebral end plate and intervertebral disc

(2013) Aaron J. Fields et al.   Spine Journal

Regulation of wound healing and organ fibrosis by toll-like receptors

(2012) Peter Huebener et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Theo Vos et al.   LANCET

Sustained blockade of neurotrophin receptors TrkA, TrkB and TrkC reduces non-malignant skeletal pain but not the maintenance of sensory and sympathetic nerve fibers

(2010) Joseph R. Ghilardi et al.   BONE

IL-4 induces neutrophilic maturation of HL-60 cells and activation of human peripheral blood neutrophils

(2010) L. A. BOBER et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Rheumatoid anemia

(2010) Charles Masson   JOINT BONE SPINE

CCR2 mediates hematopoietic stem and progenitor cell trafficking to sites of inflammation in mice

(2010) Yue Si et al.   JOURNAL OF CLINICAL INVESTIGATION

Neurotrophins Regulate Bone Marrow Stromal Cell IL-6 Expression through the MAPK Pathway

(2010) Fariba Rezaee et al.   PLoS One

Characteristics and natural course of vertebral endplate signal (Modic) changes in the Danish general population

(2009) Tue S Jensen et al.   BMC MUSCULOSKELETAL DISORDERS

Modic Changes on MR Images as Studied with Provocative Diskography: Clinical Relevance—A Retrospective Study of 2457 Disks

(2009) Kerry J. Thompson et al.   RADIOLOGY

Vertebral endplate signal changes (Modic change): a systematic literature review of prevalence and association with non-specific low back pain

(2008) Tue Secher Jensen et al.   EUROPEAN SPINE JOURNAL

Cellular and molecular mechanisms of fibrosis

(2007) TA Wynn   JOURNAL OF PATHOLOGY