Donor Age of Human Platelet Lysate Affects Proliferation and Differentiation of Mesenchymal Stem Cells

How to track cellular aging of mesenchymal stromal cells?

(2016) Wolfgang Wagner et al.   Aging-US

Replicative senescence of mesenchymal stem cells causes DNA-methylation changes which correlate with repressive histone marks

(2016) Anne Schellenberg et al.   Aging-US

Platelet lysate from whole blood-derived pooled platelet concentrates and apheresis-derived platelet concentrates for the isolation and expansion of human bone marrow mesenchymal stromal cells: production process, content and identification of active components

(2012) Natalie Fekete et al.   CYTOTHERAPY

Ex vivo expansion of mesenchymal stromal cells

(2011) Maria Ester Bernardo et al.   BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY

Expansion of Adipose Mesenchymal Stromal Cells is Affected by Human Platelet Lysate and Plating Density

(2011) Dominik Cholewa et al.   CELL TRANSPLANTATION

Epidermal growth factor, basic fibroblast growth factor and platelet-derived growth factor-bb can substitute for fetal bovine serum and compete with human platelet-rich plasma in the ex vivo expansion of mesenchymal stromal cells derived from adipose tissue

(2011) Katia Chieregato et al.   CYTOTHERAPY

Population dynamics of mesenchymal stromal cells during culture expansion

(2011) Anne Schellenberg et al.   CYTOTHERAPY

MicroRNAs are shaping the hematopoietic landscape

(2011) U. Bissels et al.   HAEMATOLOGICA

Differential effect of platelet-rich plasma and fetal calf serum on bone marrow-derived human mesenchymal stromal cells expanded in vitro

(2011) Anja Goedecke et al.   Journal of Tissue Engineering and Regenerative Medicine

Specific Age-Associated DNA Methylation Changes in Human Dermal Fibroblasts

(2011) Carmen M. Koch et al.   PLoS One

Wnt/β-Catenin Signaling Induces the Aging of Mesenchymal Stem Cells through the DNA Damage Response and the p53/p21 Pathway

(2011) Da-yong Zhang et al.   PLoS One

Influence of Platelet-Derived Growth Factor-AB on Tissue Development in Autologous Platelet-Rich Plasma Gels

(2011) Simone Wirz et al.   TISSUE ENGINEERING PART A

Platelet-lysate-Expanded Mesenchymal Stromal Cells as a Salvage Therapy for Severe Resistant Graft-versus-Host Disease in a Pediatric Population

(2010) Giovanna Lucchini et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Impact of individual platelet lysates on isolation and growth of human mesenchymal stromal cells

(2010) Patrick Horn et al.   CYTOTHERAPY

Sera from young and older humans equally sustain proliferation and differentiation of human myoblasts

(2010) Tomasz George et al.   EXPERIMENTAL GERONTOLOGY

Different Facets of Aging in Human Mesenchymal Stem Cells

(2010) Wolfgang Wagner et al.   TISSUE ENGINEERING PART B-REVIEWS

DNA methylation pattern changes upon long-term culture and aging of human mesenchymal stromal cells

(2009) Simone Bork et al.   AGING CELL

Protocols to detect senescence-associated beta-galactosidase (SA-βgal) activity, a biomarker of senescent cells in culture and in vivo

(2009) Florence Debacq-Chainiaux et al.   Nature Protocols

Aging and Replicative Senescence Have Related Effects on Human Stem and Progenitor Cells

(2009) Wolfgang Wagner et al.   PLoS One

Human Alternatives to Fetal Bovine Serum for the Expansion of Mesenchymal Stromal Cells from Bone Marrow

(2009) Karen Bieback et al.   STEM CELLS

Platelet-Derived Growth Factor Receptor Signaling Is Not Involved in Osteogenic Differentiation of Human Mesenchymal Stem Cells

(2009) Akhilesh Kumar et al.   TISSUE ENGINEERING PART A

Age-related intrinsic changes in human bone-marrow-derived mesenchymal stem cells and their differentiation to osteoblasts

(2008) Shuanhu Zhou et al.   AGING CELL

PDGF, TGF- , and FGF signaling is important for differentiation and growth of mesenchymal stem cells (MSCs): transcriptional profiling can identify markers and signaling pathways important in differentiation of MSCs into adipogenic, chondrogenic, and osteogenic lineages

(2008) F. Ng et al.   BLOOD

Treatment of refractory acute GVHD with third-party MSC expanded in platelet lysate-containing medium

(2008) M von Bonin et al.   BONE MARROW TRANSPLANTATION

Heterogeneity of mesenchymal stromal cell preparations

(2008) A.D. Ho et al.   CYTOTHERAPY

PDGF Receptor β Is a Potent Regulator of Mesenchymal Stromal Cell Function

(2008) Ayano Tokunaga et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Replicative Senescence of Mesenchymal Stem Cells: A Continuous and Organized Process

(2008) Wolfgang Wagner et al.   PLoS One

Involvement of Adipogenic Potential of Human Bone Marrow Mesenchymal Stem Cells (MSCs) in Osteoporosis

(2008) J. Rodriguez et al.   Current Stem Cell Research & Therapy